GREMLIN Database
THIO2 - Thioredoxin-2
UniProt: P0AGG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11887
Length: 139 (110)
Sequences: 5701 (3774)
Seq/√Len: 359.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_T99_S3.3081.00
46_D101_R2.9541.00
127_P130_P2.6661.00
76_D128_K2.6591.00
40_A88_V2.5291.00
80_E132_D2.2921.00
73_I128_K2.2761.00
42_G97_E2.1781.00
91_N94_A2.1521.00
102_F113_F2.1371.00
80_E128_K2.1321.00
111_M121_M2.0791.00
42_G98_L2.0401.00
125_A130_P1.9921.00
73_I76_D1.9571.00
64_C67_C1.8271.00
42_G95_E1.7771.00
90_V98_L1.7591.00
130_P133_S1.7501.00
56_V74_F1.7401.00
36_E79_Q1.7281.00
58_D89_K1.7141.00
41_T44_T1.6231.00
54_P112_I1.6011.00
55_V88_V1.5861.00
55_V86_R1.5541.00
117_Q120_D1.4631.00
77_V87_F1.4521.00
56_V110_I1.4511.00
62_P91_N1.4351.00
48_L55_V1.3671.00
118_V121_M1.3581.00
74_F87_F1.3521.00
58_D71_A1.3401.00
92_T107_I1.3081.00
57_I113_F1.2901.00
41_T95_E1.2801.00
56_V87_F1.2731.00
77_V128_K1.2561.00
77_V131_F1.2341.00
81_R136_N1.2261.00
39_N89_K1.2261.00
36_E82_S1.2171.00
81_R132_D1.2121.00
38_I48_L1.2091.00
77_V132_D1.1851.00
70_F73_I1.1731.00
56_V112_I1.1671.00
132_D136_N1.1451.00
46_D50_K1.1301.00
85_V135_L1.1221.00
71_A75_E1.1071.00
40_A48_L1.1071.00
70_F110_I1.0931.00
53_L86_R1.0711.00
59_F104_I1.0681.00
45_L59_F1.0611.00
59_F102_F1.0351.00
111_M118_V1.0341.00
95_E98_L0.9891.00
112_I134_W0.9531.00
58_D66_P0.9511.00
128_K132_D0.9381.00
71_A89_K0.9261.00
81_R87_F0.9261.00
96_R100_S0.9261.00
40_A57_I0.9001.00
49_L55_V0.8981.00
112_I135_L0.8841.00
59_F92_T0.8771.00
62_P93_E0.8751.00
75_E89_K0.8561.00
70_F131_F0.8531.00
60_W89_K0.8511.00
77_V81_R0.8311.00
61_A93_E0.8171.00
45_L98_L0.8161.00
66_P106_S0.8081.00
47_K51_D0.8061.00
48_L51_D0.7901.00
122_L130_P0.7801.00
63_W68_R0.7751.00
65_G68_R0.7701.00
73_I127_P0.7611.00
126_V130_P0.7591.00
70_F74_F0.7481.00
97_E100_S0.7421.00
60_W91_N0.7301.00
79_Q82_S0.7281.00
54_P114_K0.7231.00
37_V74_F0.7180.99
35_G75_E0.7170.99
99_S102_F0.7160.99
114_K119_V0.7130.99
53_L84_K0.7130.99
31_D35_G0.7050.99
124_G130_P0.7000.99
73_I77_V0.6970.99
90_V99_S0.6870.99
65_G69_N0.6850.99
122_L134_W0.6840.99
58_D70_F0.6820.99
90_V95_E0.6800.99
74_F135_L0.6790.99
35_G39_N0.6780.99
38_I55_V0.6740.99
92_T104_I0.6600.99
59_F90_V0.6510.99
110_I131_F0.6490.99
30_H34_D0.6430.99
129_A133_S0.6390.99
44_T88_V0.6330.99
114_K117_Q0.6320.99
78_A87_F0.6300.99
48_L86_R0.6290.99
54_P84_K0.6280.99
40_A44_T0.6240.99
58_D67_C0.6200.98
44_T47_K0.6190.98
57_I88_V0.6130.98
62_P107_I0.6120.98
122_L126_V0.6090.98
98_L101_R0.6020.98
45_L57_I0.6020.98
65_G106_S0.6010.98
57_I90_V0.5960.98
116_G120_D0.5950.98
63_W93_E0.5930.98
56_V131_F0.5900.98
56_V135_L0.5830.98
31_D34_D0.5820.98
29_G32_L0.5820.98
95_E99_S0.5760.98
61_A66_P0.5700.97
47_K50_K0.5690.97
37_V89_K0.5620.97
96_R99_S0.5590.97
104_I109_T0.5580.97
59_F111_M0.5520.97
110_I122_L0.5450.97
69_N73_I0.5430.97
59_F113_F0.5420.96
61_A107_I0.5320.96
45_L49_L0.5320.96
45_L48_L0.5300.96
66_P72_P0.5260.96
37_V78_A0.5250.96
33_F82_S0.5190.96
38_I86_R0.5190.96
99_S107_I0.5180.95
131_F135_L0.5180.95
39_N60_W0.5160.95
80_E129_A0.5150.95
54_P115_N0.5140.95
84_K136_N0.5130.95
120_D134_W0.5120.95
46_D102_F0.5120.95
66_P126_V0.5090.95
52_D55_V0.5070.95
93_E96_R0.5070.95
66_P92_T0.5040.95
39_N94_A0.5040.95
81_R85_V0.5030.95
61_A72_P0.5010.95
87_F131_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.7338 99.9 0.264 Contact Map
3f8uA 2 0.7554 99.9 0.265 Contact Map
2b5eA 1 0.8273 99.9 0.276 Contact Map
3apoA 1 0.8705 99.9 0.287 Contact Map
3us3A 2 0.8345 99.9 0.306 Contact Map
1sjiA 2 0.8201 99.9 0.306 Contact Map
4ekzA 1 0.9065 99.8 0.322 Contact Map
3ed3A 1 0.8058 99.8 0.323 Contact Map
3idvA 1 0.8058 99.8 0.341 Contact Map
3t58A 1 0.8058 99.8 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0064 seconds.