GREMLIN Database
TESB - Acyl-CoA thioesterase 2
UniProt: P0AGG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10995
Length: 286 (271)
Sequences: 2179 (1435)
Seq/√Len: 87.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_G80_T5.3481.00
267_T271_V4.8461.00
126_A129_G3.8941.00
243_E268_Q3.5811.00
72_K97_N3.4821.00
179_Q248_S3.4231.00
34_V74_I3.4161.00
237_R253_S3.3321.00
55_R88_S3.2461.00
15_E23_R3.1561.00
74_I94_A3.0761.00
48_K193_R3.0471.00
208_L280_G3.0211.00
44_L57_V2.8891.00
128_D268_Q2.8691.00
245_L273_V2.8331.00
21_L75_I2.8261.00
236_H275_S2.5521.00
40_V200_G2.3711.00
13_N49_E2.3611.00
250_E262_R2.3341.00
83_D90_R2.2501.00
61_H230_D2.2311.00
79_E93_A2.2251.00
18_E75_I2.2151.00
23_R75_I2.1571.00
207_F261_V2.1531.00
68_G101_I2.1361.00
45_Y49_E2.1261.00
17_I23_R2.1231.00
16_K19_E2.0791.00
117_H215_H2.0301.00
199_L274_A1.9731.00
190_D240_N1.9221.00
211_A259_G1.8691.00
66_R99_K1.8581.00
211_A282_M1.8491.00
45_Y197_Y1.8201.00
211_A261_V1.8091.00
18_E95_I1.7891.00
182_I265_F1.7741.00
77_D95_I1.7711.00
239_F273_V1.7541.00
132_S135_Q1.7271.00
117_H251_S1.7161.00
195_H241_L1.7091.00
62_S102_F1.7001.00
176_P214_P1.6841.00
247_Y276_T1.6591.00
18_E21_L1.6451.00
93_A103_Y1.5981.00
57_V196_Q1.5771.00
195_H240_N1.5761.00
247_Y263_G1.5751.00
159_E183_R1.5731.00
50_T90_R1.5701.00
196_Q238_P1.5611.00
126_A268_Q1.5561.00
188_V195_H1.5511.00
112_E283_R1.5501.00
245_L265_F1.5481.00
22_F50_T1.5301.00
69_D72_K1.5011.00
116_E237_R1.4931.00
109_Q112_E1.4640.99
17_I75_I1.4490.99
48_K196_Q1.4280.99
81_L100_P1.3990.99
17_I21_L1.3850.99
131_P139_S1.3800.99
258_R279_E1.3780.99
195_H242_N1.3360.99
164_E179_Q1.3310.99
59_S230_D1.3280.99
13_N45_Y1.3140.99
260_F275_S1.3070.99
248_S264_E1.3060.99
50_T83_D1.2890.99
81_L89_A1.2870.99
34_V68_G1.2790.98
206_N249_V1.2460.98
33_Q67_P1.2280.98
182_I202_A1.2280.98
63_Y230_D1.2240.98
240_N243_E1.2190.98
56_L111_P1.2070.98
119_K264_E1.1890.98
233_M276_T1.1780.97
199_L265_F1.1740.97
21_L77_D1.1680.97
215_H254_A1.1600.97
188_V241_L1.1510.97
117_H252_T1.1370.97
47_A92_V1.1250.97
20_G77_D1.1240.97
87_F109_Q1.1220.96
51_V108_F1.1100.96
250_E264_E1.1010.96
177_H248_S1.0960.96
75_I98_G1.0920.96
69_D97_N1.0910.96
80_T83_D1.0860.96
234_W277_V1.0830.96
237_R255_S1.0720.95
263_G276_T1.0640.95
204_D228_T1.0510.95
65_L81_L1.0250.94
81_L103_Y1.0250.94
35_F205_L1.0180.94
180_V206_N1.0120.94
248_S266_Y1.0010.93
58_H107_S0.9980.93
116_E253_S0.9950.93
93_A100_P0.9930.93
120_T266_Y0.9920.93
228_T232_S0.9900.93
16_K22_F0.9880.93
66_R81_L0.9800.93
257_A284_N0.9770.93
230_D234_W0.9540.92
117_H254_A0.9510.92
199_L241_L0.9420.91
111_P256_S0.9370.91
178_R210_V0.9340.91
135_Q138_Q0.9320.91
116_E255_S0.9300.91
131_P135_Q0.9280.91
65_L89_A0.9270.90
57_V106_A0.9250.90
76_Y94_A0.9230.90
56_L192_L0.9220.90
115_F254_A0.9210.90
115_F217_I0.9190.90
51_V90_R0.9190.90
92_V106_A0.9180.90
95_I100_P0.9120.90
190_D195_H0.9090.90
211_A214_P0.9050.89
85_N110_A0.9040.89
225_Q281_V0.9000.89
162_P165_F0.8920.89
55_R85_N0.8920.89
47_A108_F0.8900.89
109_Q256_S0.8810.88
14_L46_A0.8740.88
203_S231_H0.8710.88
39_V68_G0.8640.87
50_T82_R0.8630.87
189_P195_H0.8620.87
86_S283_R0.8620.87
198_L241_L0.8610.87
207_F276_T0.8580.87
200_G233_M0.8580.87
267_T273_V0.8570.87
95_I98_G0.8560.87
257_A281_V0.8560.87
10_T25_Q0.8550.87
21_L95_I0.8550.87
167_N171_G0.8470.86
9_L13_N0.8460.86
190_D242_N0.8450.86
262_R275_S0.8440.86
35_F204_D0.8440.86
181_W246_L0.8400.86
39_V101_I0.8380.85
127_P181_W0.8370.85
237_R271_V0.8360.85
48_K197_Y0.8350.85
19_E97_N0.8340.85
14_L201_Y0.8330.85
8_L12_L0.8320.85
181_W234_W0.8290.85
24_G76_Y0.8260.85
215_H251_S0.8260.85
15_E21_L0.8260.85
44_L60_F0.8260.85
125_P129_G0.8250.85
40_V62_S0.8220.84
199_L239_F0.8210.84
251_S254_A0.8210.84
7_N10_T0.8190.84
73_P118_Q0.8150.84
67_P227_A0.8140.84
93_A105_T0.8130.84
79_E88_S0.8110.84
162_P168_P0.8070.83
158_L184_A0.8060.83
10_T13_N0.8010.83
109_Q258_R0.7970.82
54_E110_A0.7940.82
82_R89_A0.7900.82
191_D194_V0.7880.82
15_E25_Q0.7870.82
184_A198_L0.7870.82
87_F229_I0.7830.81
159_E162_P0.7780.81
189_P194_V0.7770.81
202_A265_F0.7720.80
37_G204_D0.7700.80
119_K250_E0.7640.80
56_L196_Q0.7620.80
75_I95_I0.7610.79
158_L198_L0.7600.79
239_F243_E0.7590.79
217_I221_E0.7570.79
62_S103_Y0.7560.79
228_T231_H0.7530.79
216_G220_L0.7510.79
68_G74_I0.7480.78
27_E31_L0.7450.78
130_L160_V0.7420.78
120_T123_S0.7400.78
202_A219_F0.7380.77
73_P98_G0.7370.77
192_L196_Q0.7330.77
15_E18_E0.7300.77
204_D229_I0.7220.76
112_E257_A0.7220.76
29_L32_R0.7210.76
168_P209_P0.7210.76
10_T171_G0.7210.76
204_D278_Q0.7200.76
19_E75_I0.7180.75
210_V213_Q0.7150.75
9_L194_V0.7140.75
163_V179_Q0.7130.75
17_I20_G0.7110.75
94_A102_F0.7100.75
127_P268_Q0.7080.74
203_S265_F0.7070.74
27_E34_V0.7060.74
41_G156_R0.7050.74
52_P88_S0.7040.74
177_H250_E0.7020.74
60_F63_Y0.7010.74
245_L267_T0.6990.73
121_M124_A0.6980.73
90_R230_D0.6970.73
131_P136_I0.6960.73
77_D93_A0.6940.73
60_F104_M0.6930.73
41_G200_G0.6920.73
113_A116_E0.6890.72
134_T185_N0.6890.72
42_Q76_Y0.6870.72
111_P238_P0.6870.72
16_K20_G0.6860.72
55_R110_A0.6850.72
29_L34_V0.6830.72
158_L202_A0.6820.72
18_E23_R0.6800.71
192_L239_F0.6760.71
169_L182_I0.6740.71
74_I253_S0.6690.70
209_P249_V0.6690.70
265_F274_A0.6680.70
187_S235_F0.6660.70
47_A106_A0.6660.70
120_T284_N0.6650.70
59_S63_Y0.6650.70
31_L70_S0.6640.70
176_P210_V0.6630.69
124_A129_G0.6610.69
228_T276_T0.6610.69
124_A246_L0.6600.69
58_H279_E0.6590.69
190_D241_L0.6590.69
90_R107_S0.6580.69
40_V261_V0.6570.69
44_L200_G0.6560.69
114_G215_H0.6550.69
125_P130_L0.6540.68
63_Y107_S0.6530.68
63_Y228_T0.6510.68
78_V90_R0.6510.68
188_V198_L0.6510.68
130_L163_V0.6490.68
233_M274_A0.6470.68
106_A233_M0.6470.68
21_L98_G0.6450.67
234_W279_E0.6450.67
133_E162_P0.6440.67
23_R43_A0.6430.67
18_E98_G0.6420.67
42_Q231_H0.6410.67
115_F215_H0.6400.67
115_F284_N0.6360.66
229_I258_R0.6360.66
7_N185_N0.6330.66
76_Y112_E0.6280.65
62_S81_L0.6270.65
91_R105_T0.6270.65
175_E214_P0.6230.65
65_L103_Y0.6230.65
207_F249_V0.6220.65
79_E91_R0.6200.64
208_L211_A0.6200.64
23_R95_I0.6190.64
40_V196_Q0.6190.64
212_L226_I0.6150.64
18_E50_T0.6150.64
207_F247_Y0.6140.64
7_N54_E0.6110.63
87_F228_T0.6100.63
167_N170_K0.6080.63
231_H234_W0.6070.63
81_L253_S0.6070.63
16_K111_P0.6050.62
9_L189_P0.6050.62
178_R213_Q0.6020.62
20_G23_R0.6010.62
222_P284_N0.5980.62
66_R89_A0.5960.61
162_P213_Q0.5960.61
168_P171_G0.5950.61
209_P216_G0.5950.61
74_I101_I0.5930.61
26_S38_Q0.5910.61
58_H90_R0.5900.60
58_H258_R0.5890.60
22_F48_K0.5890.60
71_K138_Q0.5870.60
28_D71_K0.5860.60
62_S232_S0.5840.60
239_F267_T0.5830.60
215_H224_I0.5810.59
260_F277_V0.5800.59
84_G231_H0.5790.59
43_A104_M0.5780.59
28_D32_R0.5780.59
162_P179_Q0.5770.59
40_V232_S0.5770.59
87_F257_A0.5760.59
134_T138_Q0.5680.58
79_E95_I0.5680.58
242_N245_L0.5660.57
101_I231_H0.5650.57
212_L217_I0.5590.56
192_L195_H0.5570.56
230_D279_E0.5570.56
130_L268_Q0.5570.56
48_K57_V0.5560.56
44_L235_F0.5560.56
183_R242_N0.5550.56
22_F51_V0.5540.56
39_V63_Y0.5540.56
7_N25_Q0.5530.56
231_H279_E0.5530.56
87_F281_V0.5520.55
44_L197_Y0.5520.55
208_L226_I0.5510.55
168_P219_F0.5510.55
179_Q246_L0.5500.55
180_V248_S0.5500.55
239_F242_N0.5500.55
65_L100_P0.5470.55
40_V194_V0.5470.55
176_P251_S0.5470.55
63_Y101_I0.5470.55
236_H244_W0.5470.55
203_S263_G0.5470.55
134_T153_I0.5460.55
94_A98_G0.5450.55
40_V197_Y0.5450.55
42_Q61_H0.5440.54
9_L198_L0.5430.54
136_I167_N0.5420.54
140_L169_L0.5420.54
74_I255_S0.5390.54
87_F114_G0.5390.54
36_G278_Q0.5370.53
125_P163_V0.5360.53
132_S136_I0.5360.53
43_A75_I0.5360.53
36_G204_D0.5330.53
65_L82_R0.5330.53
269_D277_V0.5330.53
137_A141_A0.5330.53
129_G172_H0.5330.53
199_L245_L0.5320.53
155_D217_I0.5300.53
170_K173_V0.5290.52
204_D231_H0.5280.52
85_N111_P0.5260.52
239_F245_L0.5260.52
42_Q203_S0.5240.52
208_L261_V0.5240.52
59_S89_A0.5220.51
39_V66_R0.5200.51
39_V86_S0.5200.51
43_A62_S0.5180.51
118_Q122_P0.5160.51
11_L224_I0.5150.50
87_F112_E0.5150.50
192_L238_P0.5140.50
49_E193_R0.5140.50
261_V276_T0.5100.50
24_G87_F0.5090.50
62_S207_F0.5060.49
8_L41_G0.5060.49
39_V274_A0.5050.49
34_V101_I0.5040.49
59_S279_E0.5030.49
38_Q68_G0.5020.49
112_E281_V0.5000.48
116_E257_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c8uA 2 0.9965 100 0.211 Contact Map
3rd7A 2 0.9476 100 0.236 Contact Map
4r9zA 2 0.8671 100 0.252 Contact Map
3u0aA 4 0.8951 100 0.254 Contact Map
3rqbA 2 0.8951 100 0.35 Contact Map
3cjyA 2 0.8601 100 0.39 Contact Map
3bbjA 2 0.9196 100 0.436 Contact Map
1tbuA 3 0.3462 100 0.646 Contact Map
2gvhA 3 0.8112 98.7 0.868 Contact Map
4zv3A 3 0.8497 98.5 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.