GREMLIN Database
THIL - Thiamine-monophosphate kinase
UniProt: P0AGG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20227
Length: 325 (277)
Sequences: 15087 (9527)
Seq/√Len: 572.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_W292_C3.4871.00
233_R297_T2.9741.00
233_R295_Q2.9651.00
271_V279_L2.6931.00
275_N278_A2.6261.00
151_P298_A2.5971.00
153_D208_N2.5171.00
235_D238_L2.4161.00
154_W295_Q2.4031.00
154_W276_R2.3621.00
62_A109_D2.3571.00
156_Y292_C2.2861.00
62_A102_S2.2651.00
155_I270_T2.2321.00
225_V232_A2.2041.00
102_S105_D2.2021.00
230_C296_M2.2001.00
208_N272_P2.1941.00
156_Y280_D2.1671.00
108_F112_N2.0821.00
276_R292_C2.0561.00
43_A81_A2.0441.00
231_G297_T2.0011.00
221_L232_A1.9981.00
154_W273_E1.9931.00
156_Y290_F1.9301.00
272_P275_N1.9301.00
35_N140_M1.9121.00
62_A105_D1.8891.00
221_L234_I1.8881.00
280_D290_F1.8851.00
156_Y271_V1.8551.00
276_R280_D1.8531.00
61_P128_L1.8141.00
72_N134_I1.8041.00
66_Y110_L1.7961.00
273_E295_Q1.7761.00
76_L81_A1.7611.00
208_N270_T1.7511.00
151_P230_C1.7391.00
156_Y276_R1.7271.00
231_G299_D1.7211.00
224_I270_T1.7141.00
155_I232_A1.6721.00
84_A137_F1.6701.00
277_G281_V1.6671.00
39_K140_M1.6421.00
18_S112_N1.6361.00
45_S134_I1.6141.00
109_D112_N1.5831.00
205_D282_A1.5661.00
44_I87_T1.5431.00
278_A281_V1.5241.00
232_A296_M1.5111.00
198_L201_Q1.5091.00
292_C295_Q1.5071.00
283_L290_F1.4981.00
149_A209_S1.4971.00
150_K272_P1.4861.00
153_D272_P1.4861.00
210_A269_F1.4711.00
105_D109_D1.4671.00
88_L107_L1.4611.00
109_D113_Y1.4591.00
149_A296_M1.4531.00
163_D242_S1.4261.00
221_L268_C1.4241.00
209_S224_I1.4141.00
281_V285_H1.4051.00
33_L43_A1.4021.00
153_D296_M1.3931.00
150_K208_N1.3921.00
149_A270_T1.3761.00
24_E41_T1.3751.00
87_T120_G1.3741.00
163_D171_L1.3651.00
46_T89_A1.3611.00
231_G302_G1.3531.00
299_D303_L1.3501.00
196_R266_E1.3481.00
110_L113_Y1.3431.00
270_T296_M1.3351.00
277_G280_D1.3351.00
142_R204_R1.3341.00
144_L210_A1.3311.00
156_Y279_L1.3301.00
138_V143_A1.3301.00
63_D106_S1.3241.00
31_C79_M1.3241.00
63_D66_Y1.3241.00
76_L134_I1.3071.00
90_L100_L1.2951.00
213_L268_C1.2771.00
61_P99_W1.2631.00
278_A282_A1.2551.00
280_D284_G1.2481.00
39_K141_G1.2461.00
200_G203_L1.2401.00
85_W119_I1.2361.00
41_T140_M1.2351.00
82_D204_R1.2311.00
44_I135_H1.2261.00
69_L107_L1.2231.00
210_A267_L1.2171.00
37_P137_F1.2141.00
32_A119_I1.2141.00
280_D292_C1.2131.00
231_G300_I1.2091.00
190_H194_S1.2081.00
91_T126_G1.2071.00
186_L190_H1.2031.00
68_A130_M1.1991.00
46_T133_G1.1881.00
78_A210_A1.1801.00
213_L220_D1.1681.00
199_Q203_L1.1631.00
59_I187_I1.1601.00
63_D192_R1.1561.00
48_T131_T1.1541.00
66_Y113_Y1.1441.00
155_I268_C1.1391.00
235_D295_Q1.1331.00
282_A286_L1.1331.00
96_D99_W1.1261.00
44_I133_G1.1221.00
281_V284_G1.1151.00
199_Q202_A1.0931.00
154_W271_V1.0911.00
160_T163_D1.0901.00
86_L134_I1.0901.00
187_I191_L1.0891.00
111_L118_L1.0771.00
271_V276_R1.0761.00
189_R192_R1.0751.00
87_T133_G1.0691.00
209_S270_T1.0651.00
70_A110_L1.0651.00
73_L134_I1.0641.00
206_L282_A1.0581.00
15_R105_D1.0561.00
139_P204_R1.0551.00
282_A285_H1.0471.00
188_K191_L1.0451.00
236_L254_A1.0411.00
69_L86_L1.0411.00
145_T148_G1.0301.00
33_L143_A1.0261.00
279_L282_A1.0251.00
37_P40_Q1.0051.00
31_C43_A1.0041.00
201_Q205_D1.0001.00
60_D63_D0.9991.00
40_Q139_P0.9921.00
92_L100_L0.9851.00
211_I223_H0.9841.00
153_D270_T0.9831.00
148_G208_N0.9811.00
187_I190_H0.9811.00
269_F279_L0.9771.00
48_T89_A0.9701.00
139_P142_R0.9681.00
73_L116_M0.9671.00
114_Y196_R0.9651.00
169_A172_Q0.9631.00
192_R195_P0.9531.00
184_D192_R0.9391.00
36_I137_F0.9381.00
253_Q256_R0.9331.00
165_A261_G0.9321.00
85_W117_Q0.9301.00
151_P154_W0.9301.00
158_T269_F0.9271.00
149_A224_I0.9251.00
29_D79_M0.9241.00
69_L111_L0.9241.00
23_V26_G0.9231.00
158_T199_Q0.9221.00
299_D302_G0.9211.00
107_L132_L0.9191.00
69_L73_L0.9171.00
66_Y109_D0.9151.00
217_L268_C0.9151.00
190_H193_P0.9131.00
151_P297_T0.9081.00
240_P291_T0.9071.00
67_K263_E0.9071.00
168_L171_L0.9031.00
98_A102_S0.9031.00
60_D188_K0.8991.00
45_S76_L0.8971.00
168_L172_Q0.8951.00
279_L283_L0.8941.00
85_W135_H0.8921.00
186_L189_R0.8921.00
145_T149_A0.8911.00
65_A106_S0.8881.00
86_L132_L0.8841.00
211_I268_C0.8831.00
40_Q137_F0.8761.00
158_T283_L0.8761.00
82_D201_Q0.8731.00
111_L116_M0.8691.00
92_L103_F0.8661.00
199_Q283_L0.8641.00
184_D189_R0.8631.00
184_D188_K0.8621.00
65_A103_F0.8551.00
198_L202_A0.8541.00
189_R193_P0.8541.00
66_Y70_A0.8521.00
152_G295_Q0.8501.00
73_L110_L0.8451.00
23_V117_Q0.8431.00
233_R236_L0.8421.00
89_A131_T0.8411.00
24_E35_N0.8401.00
41_T143_A0.8391.00
221_L225_V0.8391.00
185_Y188_K0.8371.00
126_G129_S0.8331.00
258_A263_E0.8311.00
25_L145_T0.8281.00
171_L176_Q0.8251.00
236_L258_A0.8211.00
158_T267_L0.8191.00
41_T138_V0.8181.00
155_I159_G0.8171.00
68_A132_L0.8151.00
99_W103_F0.8091.00
155_I296_M0.8061.00
35_N39_K0.8031.00
65_A107_L0.7901.00
82_D115_D0.7871.00
220_D268_C0.7851.00
213_L266_E0.7801.00
202_A206_L0.7791.00
82_D137_F0.7781.00
150_K153_D0.7781.00
69_L110_L0.7761.00
33_L79_M0.7751.00
30_D211_I0.7721.00
97_E101_E0.7681.00
43_A76_L0.7631.00
90_L130_M0.7631.00
188_K194_S0.7631.00
86_L107_L0.7581.00
149_A228_S0.7561.00
144_L207_A0.7561.00
182_D189_R0.7511.00
49_L71_V0.7491.00
23_V27_I0.7491.00
202_A205_D0.7481.00
200_G204_R0.7451.00
233_R303_L0.7451.00
43_A138_V0.7451.00
86_L111_L0.7451.00
48_T91_T0.7441.00
231_G301_E0.7441.00
148_G155_I0.7441.00
201_Q204_R0.7351.00
217_L221_L0.7351.00
188_K192_R0.7291.00
205_D278_A0.7281.00
189_R194_S0.7241.00
23_V119_I0.7211.00
15_R101_E0.7201.00
62_A106_S0.7201.00
225_V296_M0.7201.00
180_A183_A0.7171.00
213_L217_L0.7151.00
103_F130_M0.7121.00
284_G289_P0.7121.00
46_T131_T0.7081.00
273_E276_R0.7081.00
185_Y189_R0.7081.00
165_A257_W0.7031.00
101_E105_D0.7001.00
229_D299_D0.6941.00
78_A267_L0.6921.00
58_D176_Q0.6901.00
81_A138_V0.6891.00
16_V19_S0.6871.00
191_L195_P0.6851.00
219_S223_H0.6821.00
191_L194_S0.6821.00
56_L59_I0.6801.00
206_L278_A0.6721.00
200_G206_L0.6711.00
15_R18_S0.6691.00
91_T124_T0.6681.00
29_D146_R0.6661.00
103_F107_L0.6631.00
72_N132_L0.6621.00
164_S190_H0.6601.00
156_Y269_F0.6581.00
34_L85_W0.6581.00
49_L68_A0.6551.00
202_A282_A0.6551.00
154_W274_L0.6441.00
87_T119_I0.6441.00
35_N38_E0.6441.00
99_W102_S0.6401.00
254_A258_A0.6391.00
73_L114_Y0.6381.00
95_V100_L0.6371.00
91_T129_S0.6371.00
186_L194_S0.6371.00
163_D168_L0.6351.00
88_L104_S0.6321.00
157_V240_P0.6321.00
257_W261_G0.6301.00
238_L291_T0.6271.00
60_D102_S0.6241.00
39_K139_P0.6181.00
113_Y194_S0.6181.00
185_Y194_S0.6171.00
211_I224_I0.6121.00
146_R227_A0.6101.00
261_G264_D0.6071.00
195_P288_V0.6061.00
95_V99_W0.6051.00
183_A186_L0.6051.00
45_S72_N0.6041.00
40_Q140_M0.6021.00
181_K184_D0.5961.00
25_L28_G0.5881.00
161_P164_S0.5881.00
160_T289_P0.5861.00
159_G289_P0.5841.00
163_D189_R0.5811.00
206_L279_L0.5801.00
231_G303_L0.5791.00
44_I85_W0.5791.00
170_I177_V0.5771.00
142_R205_D0.5771.00
149_A208_N0.5771.00
256_R260_S0.5761.00
212_D223_H0.5751.00
277_G292_C0.5731.00
75_D212_D0.5721.00
25_L33_L0.5721.00
197_I201_Q0.5721.00
106_S110_L0.5711.00
105_D108_F0.5700.99
159_G291_T0.5700.99
182_D188_K0.5690.99
157_V161_P0.5690.99
252_E257_W0.5680.99
14_D17_R0.5680.99
172_Q175_L0.5680.99
182_D185_Y0.5670.99
174_R252_E0.5670.99
251_P254_A0.5660.99
201_Q286_L0.5640.99
86_L118_L0.5620.99
64_L103_F0.5610.99
208_N275_N0.5590.99
63_D102_S0.5590.99
289_P292_C0.5590.99
181_K185_Y0.5580.99
147_S227_A0.5560.99
218_I255_L0.5530.99
48_T129_S0.5530.99
30_D212_D0.5530.99
92_L99_W0.5520.99
107_L130_M0.5520.99
155_I224_I0.5520.99
279_L290_F0.5490.99
167_G170_I0.5480.99
277_G284_G0.5480.99
107_L110_L0.5480.99
161_P266_E0.5470.99
225_V228_S0.5430.99
235_D292_C0.5430.99
164_S263_E0.5410.99
203_L279_L0.5390.99
206_L275_N0.5380.99
54_H58_D0.5350.99
185_Y192_R0.5350.99
35_N41_T0.5350.99
297_T300_I0.5310.99
70_A114_Y0.5310.99
180_A186_L0.5310.99
222_G226_K0.5290.99
160_T242_S0.5290.99
152_G273_E0.5290.99
186_L191_L0.5280.99
87_T91_T0.5280.99
149_A230_C0.5270.99
164_S262_G0.5250.99
230_C298_A0.5250.99
220_D223_H0.5240.99
186_L193_P0.5240.99
41_T141_G0.5240.99
46_T87_T0.5240.99
111_L132_L0.5230.99
169_A173_N0.5210.99
238_L292_C0.5210.99
47_D75_D0.5200.99
50_V53_N0.5200.99
34_L44_I0.5180.99
53_N103_F0.5160.99
31_C78_A0.5160.99
107_L118_L0.5150.99
187_I194_S0.5140.99
61_P102_S0.5110.99
153_D273_E0.5090.99
241_F258_A0.5080.99
165_A169_A0.5060.99
154_W159_G0.5030.99
34_L119_I0.5030.99
258_A261_G0.5030.99
150_K230_C0.5010.99
252_E256_R0.5010.99
259_L266_E0.5000.99
225_V302_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcqA 2 0.9292 100 0.151 Contact Map
2yxzA 2 0.9169 100 0.228 Contact Map
3c9uA 2 0.92 100 0.232 Contact Map
2z01A 2 0.8954 100 0.289 Contact Map
3m84A 2 0.9354 100 0.299 Contact Map
2btuA 2 0.9231 100 0.304 Contact Map
2zodA 2 0.8831 100 0.311 Contact Map
3p4eA 2 0.92 100 0.311 Contact Map
3vtiC 2 0.8923 100 0.334 Contact Map
3u0oA 2 0.92 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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