GREMLIN Database
TDCB - L-threonine dehydratase catabolic TdcB
UniProt: P0AGF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10990
Length: 329 (294)
Sequences: 21504 (11453)
Seq/√Len: 668.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_C101_G3.9941.00
43_E305_K3.5281.00
137_K140_E3.3781.00
32_R43_E3.1591.00
169_I307_V2.8181.00
111_K115_A2.7991.00
178_N206_I2.7101.00
68_S72_A2.7011.00
265_E294_S2.6611.00
104_V141_I2.5791.00
272_A276_R2.5551.00
211_E262_S2.4781.00
68_S157_K2.4621.00
27_K171_E2.4491.00
100_D123_E2.4311.00
77_G102_K2.3811.00
102_K123_E2.3621.00
204_R257_D2.3241.00
70_T99_I2.3231.00
140_E144_M2.2621.00
107_K128_G2.1831.00
102_K125_V2.1261.00
45_F305_K2.1041.00
27_K172_D2.0721.00
288_A308_S2.0681.00
193_A254_L2.0401.00
212_N263_E2.0341.00
262_S265_E2.0131.00
67_S97_L2.0061.00
167_L195_A1.9921.00
193_A205_V1.9741.00
154_D248_Y1.9661.00
30_M307_V1.9551.00
70_T73_E1.9361.00
162_Q198_S1.8931.00
141_I145_E1.8531.00
208_V291_A1.8431.00
200_N203_I1.8261.00
179_V196_I1.7921.00
183_I207_G1.7911.00
206_I257_D1.7821.00
151_P154_D1.7751.00
273_L281_T1.7431.00
162_Q194_V1.7241.00
139_S143_E1.7181.00
45_F173_L1.6881.00
176_V307_V1.6761.00
54_T92_L1.6751.00
32_R45_F1.6611.00
177_D305_K1.6551.00
272_A293_L1.6471.00
177_D304_R1.6381.00
301_I304_R1.6371.00
179_V192_I1.6341.00
269_S290_A1.6181.00
273_L289_C1.6061.00
197_K256_D1.5961.00
32_R37_S1.5901.00
63_F67_S1.5441.00
46_L310_I1.5291.00
114_V126_L1.5291.00
166_G192_I1.5181.00
178_N304_R1.5161.00
115_A118_C1.5141.00
238_C287_L1.5041.00
70_T97_L1.4811.00
178_N301_I1.4701.00
222_S226_T1.4701.00
39_R272_A1.4401.00
82_S87_A1.4401.00
269_S293_L1.4341.00
114_V118_C1.4181.00
166_G196_I1.4031.00
65_K155_D1.3551.00
217_A260_L1.3521.00
189_I255_V1.3491.00
125_V137_K1.3371.00
180_I208_V1.3291.00
290_A294_S1.3281.00
180_I295_G1.3261.00
77_G100_D1.3211.00
178_N204_R1.3181.00
111_K114_V1.3151.00
166_G195_A1.3121.00
142_V149_F1.3121.00
67_S71_D1.3091.00
135_I139_S1.3081.00
39_R276_R1.2931.00
173_L176_V1.2891.00
281_T310_I1.2891.00
33_S46_L1.2871.00
265_E290_A1.2851.00
194_V251_V1.2561.00
211_E260_L1.2471.00
68_S71_D1.2431.00
132_N136_A1.2331.00
64_N163_G1.2301.00
107_K129_D1.2191.00
19_Q23_G1.2161.00
117_T122_A1.2111.00
105_M117_T1.2101.00
170_M199_I1.2051.00
31_P48_F1.2041.00
114_V124_V1.2011.00
195_A199_I1.1961.00
269_S289_C1.1911.00
130_N133_D1.1821.00
170_M195_A1.1821.00
268_N272_A1.1791.00
285_G310_I1.1771.00
189_I205_V1.1741.00
196_I203_I1.1671.00
35_Y277_N1.1641.00
87_A117_T1.1641.00
72_A157_K1.1481.00
214_H260_L1.1471.00
235_A266_I1.1451.00
259_V291_A1.1431.00
30_M173_L1.1301.00
104_V137_K1.1261.00
167_L171_E1.1221.00
175_D305_K1.1211.00
137_K141_I1.1211.00
20_R23_G1.1211.00
29_G51_M1.1171.00
222_S225_I1.1011.00
30_M169_I1.0981.00
261_V290_A1.0941.00
189_I207_G1.0931.00
207_G258_I1.0891.00
265_E268_N1.0891.00
178_N306_T1.0861.00
170_M200_N1.0841.00
108_G129_D1.0821.00
206_I259_V1.0781.00
136_A139_S1.0671.00
294_S298_D1.0661.00
300_Y304_R1.0651.00
138_V142_V1.0641.00
64_N160_A1.0571.00
173_L307_V1.0511.00
105_M126_L1.0431.00
20_R64_N1.0421.00
62_A89_G1.0411.00
264_D268_N1.0391.00
41_K302_Q1.0321.00
192_I309_I1.0301.00
136_A140_E1.0291.00
139_S142_V1.0191.00
44_I292_L1.0151.00
274_I280_V1.0141.00
66_L97_L1.0131.00
234_L267_R1.0121.00
34_N38_E1.0071.00
64_N68_S1.0041.00
133_D136_A1.0041.00
271_I275_Q0.9991.00
65_K150_I0.9911.00
233_T239_D0.9891.00
118_C123_E0.9871.00
95_A101_G0.9801.00
90_V101_G0.9791.00
64_N67_S0.9771.00
66_L93_S0.9761.00
204_R256_D0.9741.00
270_M286_A0.9731.00
217_A258_I0.9711.00
35_Y276_R0.9701.00
292_L308_S0.9691.00
79_V147_R0.9671.00
169_I176_V0.9661.00
35_Y38_E0.9641.00
92_L120_Y0.9611.00
163_G167_L0.9541.00
259_V294_S0.9531.00
89_G93_S0.9501.00
79_V138_V0.9411.00
141_I144_M0.9311.00
161_G165_I0.9301.00
154_D245_N0.9181.00
195_A198_S0.9161.00
281_T285_G0.9111.00
79_V141_I0.9101.00
78_V94_C0.9071.00
91_S122_A0.9041.00
180_I292_L0.8991.00
80_A103_V0.8891.00
162_Q195_A0.8861.00
112_S318_S0.8821.00
249_E253_E0.8801.00
234_L263_E0.8791.00
246_L249_E0.8781.00
285_G311_S0.8731.00
102_K145_E0.8721.00
214_H217_A0.8711.00
66_L78_V0.8641.00
183_I189_I0.8631.00
190_A249_E0.8541.00
19_Q32_R0.8541.00
140_E143_E0.8501.00
280_V313_G0.8481.00
216_M243_P0.8471.00
24_R63_F0.8461.00
180_I206_I0.8421.00
69_L73_E0.8381.00
289_C310_I0.8381.00
165_I309_I0.8361.00
28_T52_Q0.8361.00
223_G252_R0.8311.00
181_V192_I0.8291.00
167_L199_I0.8261.00
102_K141_I0.8251.00
115_A119_D0.8241.00
76_K100_D0.8201.00
48_F310_I0.8171.00
288_A311_S0.8151.00
269_S272_A0.8151.00
79_V142_V0.8141.00
76_K146_G0.8101.00
33_S289_C0.8071.00
194_V198_S0.8051.00
189_I251_V0.8031.00
216_M251_V0.8011.00
142_V145_E0.8011.00
19_Q22_A0.8001.00
118_C126_L0.7941.00
170_M174_Y0.7911.00
64_N157_K0.7911.00
173_L305_K0.7901.00
74_K99_I0.7901.00
160_A163_G0.7891.00
77_G145_E0.7891.00
178_N295_G0.7871.00
204_R304_R0.7861.00
151_P155_D0.7861.00
142_V147_R0.7841.00
216_M258_I0.7801.00
37_S40_C0.7801.00
270_M315_I0.7771.00
295_G299_Q0.7771.00
92_L96_M0.7731.00
180_I291_A0.7721.00
95_A120_Y0.7671.00
170_M196_I0.7671.00
238_C284_A0.7661.00
77_G147_R0.7651.00
33_S277_N0.7651.00
165_I192_I0.7641.00
257_D300_Y0.7621.00
42_G304_R0.7621.00
112_S317_L0.7601.00
48_F51_M0.7561.00
81_C149_F0.7531.00
176_V203_I0.7521.00
165_I188_L0.7511.00
65_K158_V0.7501.00
215_G241_S0.7501.00
43_E303_N0.7491.00
88_Q117_T0.7461.00
182_P311_S0.7461.00
289_C308_S0.7431.00
102_K147_R0.7391.00
69_L148_I0.7371.00
46_L308_S0.7351.00
75_R146_G0.7351.00
165_I169_I0.7311.00
38_E41_K0.7311.00
183_I258_I0.7241.00
257_D298_D0.7211.00
111_K118_C0.7171.00
62_A93_S0.7171.00
270_M320_V0.7171.00
281_T286_A0.7161.00
107_K126_L0.7141.00
183_I216_M0.7131.00
210_S238_C0.7111.00
101_G122_A0.7101.00
131_F134_T0.7091.00
192_I196_I0.7061.00
266_I287_L0.7061.00
103_V117_T0.7051.00
88_Q116_A0.7031.00
223_G226_T0.7021.00
138_V149_F0.6991.00
159_I194_V0.6941.00
104_V125_V0.6931.00
179_V309_I0.6921.00
25_I59_I0.6921.00
36_F293_L0.6921.00
247_T250_I0.6901.00
252_R255_V0.6901.00
170_M173_L0.6841.00
127_H137_K0.6831.00
81_C131_F0.6831.00
40_C293_L0.6811.00
149_F190_A0.6791.00
169_I192_I0.6761.00
57_F188_L0.6751.00
40_C272_A0.6751.00
25_I52_Q0.6741.00
176_V305_K0.6721.00
129_D133_D0.6691.00
251_V255_V0.6691.00
46_L289_C0.6661.00
245_N249_E0.6641.00
34_N37_S0.6631.00
113_K236_D0.6621.00
123_E145_E0.6621.00
291_A295_G0.6591.00
267_R283_G0.6571.00
171_E199_I0.6571.00
26_Y53_R0.6551.00
100_D147_R0.6551.00
42_G306_T0.6541.00
61_G65_K0.6511.00
295_G300_Y0.6501.00
65_K157_K0.6491.00
109_A114_V0.6471.00
33_S36_F0.6461.00
78_V99_I0.6441.00
70_T74_K0.6411.00
47_K168_E0.6391.00
21_L24_R0.6391.00
206_I295_G0.6381.00
133_D137_K0.6381.00
257_D295_G0.6361.00
273_L310_I0.6341.00
71_D74_K0.6341.00
84_G87_A0.6341.00
87_A103_V0.6331.00
156_P159_I0.6321.00
37_S43_E0.6301.00
225_I245_N0.6301.00
249_E252_R0.6281.00
30_M45_F0.6281.00
36_F269_S0.6271.00
42_G303_N0.6231.00
42_G302_Q0.6211.00
208_V259_V0.6211.00
36_F289_C0.6201.00
159_I249_E0.6191.00
251_V254_L0.6181.00
42_G296_K0.6181.00
109_A236_D0.6131.00
78_V101_G0.6121.00
104_V127_H0.6101.00
179_V203_I0.6081.00
273_L279_V0.6071.00
237_G284_A0.6061.00
197_K253_E0.6051.00
180_I306_T0.6051.00
48_F279_V0.6041.00
156_P246_L0.6011.00
91_S117_T0.6011.00
160_A194_V0.5961.00
182_P288_A0.5931.00
181_V189_I0.5921.00
26_Y52_Q0.5921.00
295_G301_I0.5921.00
37_S44_I0.5901.00
273_L277_N0.5901.00
42_G301_I0.5891.00
105_M114_V0.5891.00
208_V287_L0.5881.00
78_V150_I0.5861.00
175_D200_N0.5831.00
59_I92_L0.5821.00
19_Q34_N0.5801.00
274_I320_V0.5801.00
212_N231_T0.5761.00
135_I138_V0.5731.00
82_S103_V0.5731.00
105_M109_A0.5721.00
295_G298_D0.5721.00
39_R293_L0.5711.00
46_L273_L0.5711.00
54_T120_Y0.5701.00
169_I309_I0.5641.00
209_Q215_G0.5641.00
157_K160_A0.5601.00
197_K254_L0.5601.00
263_E267_R0.5591.00
289_C293_L0.5591.00
75_R100_D0.5581.00
159_I250_I0.5571.00
116_A119_D0.5561.00
179_V205_V0.5531.00
61_G86_H0.5531.00
81_C138_V0.5521.00
134_T138_V0.5521.00
36_F272_A0.5501.00
20_R67_S0.5501.00
190_A247_T0.5491.00
235_A238_C0.5481.00
36_F40_C0.5481.00
90_V103_V0.5471.00
190_A194_V0.5461.00
79_V104_V0.5451.00
100_D145_E0.5441.00
217_A222_S0.5441.00
141_I147_R0.5431.00
53_R59_I0.5411.00
270_M283_G0.5401.00
73_E76_K0.5401.00
131_F152_P0.5401.00
30_M172_D0.5391.00
125_V141_I0.5391.00
25_I63_F0.5381.00
176_V200_N0.5371.00
91_S101_G0.5371.00
160_A164_T0.5331.00
77_G123_E0.5321.00
65_K148_I0.5311.00
66_L77_G0.5311.00
139_S149_F0.5301.00
261_V287_L0.5281.00
81_C150_I0.5281.00
150_I158_V0.5271.00
137_K144_M0.5260.99
206_I256_D0.5260.99
207_G255_V0.5260.99
50_N279_V0.5260.99
81_C135_I0.5240.99
159_I246_L0.5240.99
192_I205_V0.5220.99
263_E266_I0.5210.99
178_N300_Y0.5160.99
83_A237_G0.5110.99
33_S37_S0.5100.99
161_G164_T0.5080.99
76_K141_I0.5080.99
150_I155_D0.5060.99
148_I155_D0.5050.99
36_F276_R0.5050.99
267_R271_I0.5050.99
268_N271_I0.5040.99
53_R92_L0.5030.99
169_I179_V0.5030.99
24_R51_M0.5030.99
192_I195_A0.5020.99
104_V138_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gn0A 2 0.9878 100 0.145 Contact Map
1tdjA 2 0.9939 100 0.166 Contact Map
1v71A 2 0.9666 100 0.171 Contact Map
3l6bA 2 0.9696 100 0.192 Contact Map
1ve5A 3 0.921 100 0.205 Contact Map
3ss7X 1 0.997 100 0.214 Contact Map
2rkbA 2 0.9362 100 0.218 Contact Map
3iauA 1 0.997 100 0.218 Contact Map
4h27A 1 0.9331 100 0.22 Contact Map
4d9iA 2 0.9848 100 0.224 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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