GREMLIN Database
SUCD - Succinyl-CoA ligase [ADP-forming] subunit alpha
UniProt: P0AGE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10982
Length: 289 (273)
Sequences: 4788 (2811)
Seq/√Len: 170.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K202_E5.1611.00
56_T59_E3.3871.00
255_G273_T3.2021.00
55_N59_E3.1021.00
118_R185_G2.9161.00
63_A66_A2.9051.00
86_I115_A2.7801.00
83_L111_K2.6711.00
263_F273_T2.6081.00
58_R84_E2.4911.00
93_I117_V2.4351.00
60_A66_A2.4291.00
149_G173_S2.4281.00
47_T50_G2.3401.00
262_K266_L2.3171.00
266_L271_V2.3161.00
83_L107_T2.3111.00
173_S201_T2.2811.00
82_I93_I2.2721.00
101_P105_M2.2631.00
274_V283_A2.2221.00
73_V81_S2.1711.00
58_R87_D2.1151.00
232_G266_L2.0861.00
186_S191_I2.0321.00
69_S85_A1.9501.00
158_T175_C1.9491.00
79_K107_T1.9461.00
85_A90_I1.9071.00
73_V77_F1.9061.00
38_G62_A1.8991.00
204_I226_V1.8921.00
19_S22_T1.8911.00
198_D201_T1.8791.00
176_V191_I1.8151.00
80_D84_E1.7991.00
149_G201_T1.7691.00
95_T108_V1.7651.00
196_E227_T1.7641.00
163_K167_D1.7521.00
112_L119_M1.7481.00
83_L87_D1.7361.00
106_L110_V1.7341.00
205_V280_I1.7251.00
86_I117_V1.6961.00
221_Y271_V1.6941.00
42_G60_A1.6871.00
232_G271_V1.6831.00
148_V203_A1.6771.00
205_V284_L1.6291.00
83_L114_E1.6111.00
203_A284_L1.6061.00
14_Q69_S1.5941.00
206_M232_G1.5581.00
168_Y285_K1.5511.00
192_L204_I1.5231.00
129_T132_E1.5171.00
63_A88_A1.5151.00
220_A224_E1.5151.00
57_V85_A1.5061.00
86_I111_K1.5021.00
103_L107_T1.4841.00
204_I224_E1.4821.00
71_I81_S1.4691.00
78_C100_I1.4531.00
69_S90_I1.4331.00
110_V114_E1.4271.00
67_T91_K1.4181.00
221_Y230_V1.3941.00
124_C177_G1.3831.00
146_G171_G1.3761.00
7_K132_E1.3731.00
148_V284_L1.3591.00
149_G195_F1.3581.00
40_T54_F1.3531.00
26_E30_A1.3421.00
78_C95_T1.3321.00
41_P51_L1.3041.00
237_V275_R1.2941.00
11_V134_K1.2891.00
16_F25_S1.2881.00
188_F208_G1.2851.00
80_D83_L1.2831.00
82_I111_K1.2821.00
95_T119_M1.2781.00
12_I37_G1.2711.00
150_I172_Q1.2571.00
25_S49_L1.2571.00
265_A269_A1.2561.00
13_C35_M1.2491.00
109_K113_D1.2451.00
196_E224_E1.2381.00
48_H53_V1.2351.00
151_V191_I1.2281.00
120_I127_V1.2281.00
213_S217_E1.2231.00
213_S216_E1.2121.00
120_I191_I1.2081.00
231_V274_V1.2061.00
118_R186_S1.1951.00
44_G55_N1.1951.00
54_F61_V1.1911.00
264_A268_A1.1841.00
68_A135_I1.1801.00
13_C28_A1.1781.00
103_L106_L1.1741.00
57_V88_A1.1651.00
27_Q96_I1.1581.00
46_T55_N1.1551.00
196_E226_V1.1541.00
16_F48_H1.1491.00
29_I32_G1.1461.00
210_I250_A1.1321.00
174_T195_F1.1181.00
109_K182_P1.1021.00
176_V195_F1.0951.00
46_T53_V1.0921.00
56_T84_E1.0911.00
193_E223_K1.0891.00
109_K112_L1.0881.00
60_A63_A1.0861.00
22_T25_S1.0841.00
157_L277_L1.0811.00
111_K115_A1.0791.00
174_T201_T1.0751.00
193_E197_K1.0711.00
28_A51_L1.0631.00
25_S29_I1.0460.99
82_I108_V1.0440.99
75_A97_T1.0390.99
129_T174_T1.0220.99
189_I220_A1.0190.99
275_R279_D1.0190.99
218_A265_A1.0120.99
255_G263_F1.0060.99
29_I49_L1.0040.99
272_K283_A1.0030.99
94_I127_V1.0010.99
181_D212_G0.9980.99
196_E223_K0.9970.99
193_E216_E0.9890.99
145_P200_Q0.9830.99
263_F267_E0.9820.99
14_Q57_V0.9720.99
107_T110_V0.9690.99
82_I117_V0.9690.99
61_V66_A0.9620.99
276_S279_D0.9610.99
18_G47_T0.9580.99
217_E221_Y0.9570.99
81_S84_E0.9480.99
209_E247_H0.9450.99
42_G55_N0.9440.99
74_P77_F0.9430.99
79_K108_V0.9420.99
27_Q30_A0.9420.99
110_V113_D0.9400.99
10_K38_G0.9400.99
18_G49_L0.9400.99
105_M180_G0.9370.99
68_A94_I0.9340.99
211_G262_K0.9320.99
12_I66_A0.9270.99
40_T62_A0.9230.99
151_V178_I0.9160.99
11_V33_T0.9120.98
83_L115_A0.9030.98
151_V195_F0.9000.98
230_V271_V0.8980.98
130_P173_S0.8970.98
181_D188_F0.8930.98
99_G102_T0.8930.98
197_K223_K0.8920.98
162_V175_C0.8920.98
40_T60_A0.8910.98
61_V88_A0.8860.98
208_G232_G0.8850.98
172_Q175_C0.8820.98
104_D108_V0.8820.98
134_K137_I0.8730.98
16_F22_T0.8700.98
31_Y39_V0.8670.98
152_S158_T0.8660.98
267_E275_R0.8600.98
92_L118_R0.8600.98
131_G200_Q0.8590.98
71_I78_C0.8520.98
60_A88_A0.8510.98
192_L196_E0.8490.98
86_I108_V0.8470.98
125_P159_Y0.8440.98
41_P54_F0.8420.97
40_T44_G0.8420.97
133_C137_I0.8410.97
7_K131_G0.8400.97
131_G145_P0.8380.97
231_V283_A0.8330.97
22_T48_H0.8300.97
14_Q81_S0.8250.97
28_A41_P0.8220.97
95_T112_L0.8210.97
165_T172_Q0.8210.97
89_G115_A0.8190.97
37_G51_L0.8180.97
150_I165_T0.8170.97
205_V231_V0.8110.97
47_T51_L0.8100.97
5_I92_L0.8050.97
125_P156_T0.8020.97
151_V206_M0.7990.97
92_L120_I0.7980.97
187_N190_D0.7970.96
190_D216_E0.7960.96
77_F81_S0.7960.96
23_F138_Q0.7910.96
83_L86_I0.7890.96
93_I112_L0.7870.96
19_S25_S0.7840.96
68_A92_L0.7830.96
149_G174_T0.7820.96
79_K86_I0.7780.96
112_L116_G0.7770.96
86_I93_I0.7750.96
79_K104_D0.7750.96
244_R248_A0.7750.96
68_A136_G0.7750.96
87_D115_A0.7710.96
237_V263_F0.7710.96
192_L206_M0.7710.96
222_I271_V0.7690.96
10_K67_T0.7630.96
28_A70_V0.7610.95
6_D132_E0.7610.95
12_I41_P0.7590.95
6_D176_V0.7590.95
120_I186_S0.7580.95
62_A88_A0.7530.95
155_G249_G0.7500.95
246_G250_A0.7500.95
58_R88_A0.7490.95
279_D282_E0.7430.95
143_H162_V0.7420.95
84_E87_D0.7420.95
144_K166_T0.7370.95
164_Q281_G0.7370.95
186_S194_M0.7310.94
98_E248_A0.7300.94
11_V31_Y0.7280.94
188_F206_M0.7250.94
100_I180_G0.7240.94
203_A231_V0.7220.94
174_T194_M0.7190.94
14_Q85_A0.7130.94
264_A267_E0.7120.94
107_T111_K0.7120.94
79_K83_L0.7120.94
66_A90_I0.7100.93
196_E220_A0.7070.93
27_Q70_V0.7020.93
41_P53_V0.7010.93
247_H250_A0.7000.93
123_N180_G0.6990.93
39_V51_L0.6990.93
72_Y96_I0.6990.93
18_G48_H0.6990.93
11_V35_M0.6990.93
41_P52_P0.6990.93
192_L220_A0.6970.93
247_H251_I0.6890.92
135_I138_Q0.6890.92
193_E220_A0.6880.92
165_T281_G0.6840.92
79_K111_K0.6800.92
47_T52_P0.6790.92
89_G117_V0.6780.92
219_A222_I0.6770.92
86_I112_L0.6760.92
244_R250_A0.6730.92
86_I114_E0.6720.91
168_Y282_E0.6690.91
98_E156_T0.6690.91
86_I89_G0.6680.91
105_M182_P0.6650.91
62_A66_A0.6650.91
244_R247_H0.6610.91
191_I195_F0.6580.91
189_I216_E0.6580.91
16_F51_L0.6580.91
150_I162_V0.6550.90
35_M38_G0.6550.90
75_A100_I0.6540.90
261_E265_A0.6520.90
246_G251_I0.6510.90
274_V280_I0.6500.90
152_S207_I0.6450.90
100_I104_D0.6440.90
102_T180_G0.6410.89
256_K261_E0.6400.89
13_C25_S0.6380.89
234_I273_T0.6350.89
40_T55_N0.6300.89
9_T68_A0.6270.88
97_T124_C0.6270.88
13_C41_P0.6260.88
16_F24_H0.6250.88
112_L115_A0.6240.88
75_A99_G0.6230.88
155_G209_E0.6200.88
57_V69_S0.6160.87
253_A256_K0.6140.87
46_T52_P0.6120.87
58_R62_A0.6110.87
108_V112_L0.6090.87
241_K244_R0.6090.87
16_F41_P0.6080.87
40_T61_V0.6060.87
114_E117_V0.6050.87
211_G217_E0.6050.87
178_I181_D0.6050.87
75_A79_K0.6000.86
102_T105_M0.5990.86
118_R194_M0.5980.86
11_V67_T0.5970.86
28_A39_V0.5960.86
134_K138_Q0.5950.86
123_N247_H0.5950.86
74_P155_G0.5940.86
28_A35_M0.5940.86
48_H51_L0.5930.85
105_M109_K0.5920.85
121_G179_G0.5910.85
133_C136_G0.5910.85
196_E225_H0.5870.85
91_K117_V0.5860.85
193_E196_E0.5840.85
136_G139_P0.5830.84
221_Y226_V0.5800.84
89_G116_G0.5770.84
77_F80_D0.5760.84
215_E219_A0.5740.84
84_E88_A0.5740.84
187_N213_S0.5730.83
223_K226_V0.5710.83
178_I191_I0.5670.83
124_C152_S0.5670.83
69_S93_I0.5670.83
29_I51_L0.5670.83
111_K114_E0.5630.82
263_F275_R0.5610.82
195_F204_I0.5580.82
100_I105_M0.5580.82
150_I161_A0.5570.82
262_K273_T0.5540.81
13_C31_Y0.5530.81
166_T172_Q0.5510.81
40_T66_A0.5510.81
66_A89_G0.5510.81
5_I133_C0.5490.81
223_K268_A0.5470.81
127_V134_K0.5460.80
173_S228_K0.5440.80
193_E226_V0.5440.80
220_A268_A0.5430.80
239_A242_G0.5420.80
206_M230_V0.5410.80
210_I249_G0.5410.80
133_C138_Q0.5390.80
17_T24_H0.5390.80
44_G59_E0.5370.79
220_A223_K0.5360.79
210_I253_A0.5360.79
82_I112_L0.5350.79
7_K129_T0.5330.79
7_K194_M0.5320.79
23_F72_Y0.5320.79
207_I235_A0.5310.79
149_G229_P0.5310.79
113_D185_G0.5280.78
12_I42_G0.5280.78
10_K40_T0.5270.78
16_F49_L0.5250.78
5_I127_V0.5240.78
178_I188_F0.5240.78
101_P249_G0.5200.77
196_E221_Y0.5200.77
218_A222_I0.5190.77
128_I137_I0.5190.77
195_F201_T0.5190.77
130_P149_G0.5190.77
165_T284_L0.5190.77
82_I119_M0.5170.77
155_G247_H0.5160.77
132_E145_P0.5160.77
158_T177_G0.5160.77
12_I69_S0.5160.77
76_P104_D0.5150.77
252_I256_K0.5150.77
244_R252_I0.5140.76
78_C97_T0.5140.76
91_K118_R0.5100.76
113_D116_G0.5090.76
6_D174_T0.5080.76
187_N216_E0.5080.76
21_G26_E0.5050.75
135_I139_P0.5030.75
38_G52_P0.5020.75
90_I117_V0.5020.75
130_P174_T0.5010.75
74_P97_T0.5010.75
246_G249_G0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.91 100 0.199 Contact Map
3pffA 2 0.9204 100 0.22 Contact Map
3mwdB 1 0.9308 100 0.264 Contact Map
2fp4A 1 0.9862 100 0.318 Contact Map
2yv1A 1 0.9031 100 0.335 Contact Map
2nu8A 1 0.9792 100 0.335 Contact Map
1oi7A 1 0.917 100 0.346 Contact Map
2yv2A 1 0.9135 100 0.361 Contact Map
3dmyA 2 0.7232 100 0.374 Contact Map
3ff4A 1 0.4152 99.9 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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