CHRR - ECOLI - GREMLIN Contacts

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CHRR - Chromate reductase

UniProt:	P0AGE6	Sequences: MSEKLQVVTLLGSLRKGSFNGMVARTLPKIAPASMEVNALPSIADIPLYDADVQQEEGFPATVEALAEQIRQADGVVIVTPEYNYSVPGGLKNAIDWLSRLPDQPLAGKPVLIQTSSMGVIGGARCQYHLRQILVFLDAMVMNKPEFMGGVIQNKVDPQTGEVIDQGTLDHLTGQLTAFGEFIQRVKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11723
Length:	188 (170)
Sequences:	6277 (4243)
Seq/√Len:	325.4

ECOLI - CHRR SSUE
BACSU - AZR
HALSA - Q9HPI9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_N	69_Q	4.224	1.00
6_Q	36_E	3.155	1.00
8_V	73_A	2.867	1.00
86_S	129_H	2.794	1.00
87_V	133_I	2.754	1.00
115_T	123_G	2.678	1.00
61_A	65_A	2.657	1.00
157_D	162_E	2.570	1.00
68_E	72_Q	2.515	1.00
111_V	139_A	2.495	1.00
157_D	160_T	2.466	1.00
30_I	173_T	2.402	1.00
134_L	139_A	2.307	1.00
11_L	21_G	2.098	1.00
21_G	25_R	2.087	1.00
113_I	127_Q	2.080	1.00
9_T	24_A	1.985	1.00
112_L	175_Q	1.902	1.00
64_E	68_E	1.873	1.00
86_S	133_I	1.834	1.00
129_H	132_Q	1.830	1.00
66_L	94_A	1.797	1.00
6_Q	72_Q	1.795	1.00
92_K	96_D	1.773	1.00
24_A	79_V	1.761	1.00
6_Q	38_N	1.715	1.00
65_A	69_Q	1.715	1.00
166_Q	170_D	1.708	1.00
169_L	173_T	1.707	1.00
7_V	75_G	1.655	1.00
70_I	98_L	1.541	1.00
78_I	111_V	1.539	1.00
107_A	138_D	1.504	1.00
8_V	40_L	1.458	1.00
20_N	116_S	1.455	1.00
42_S	45_D	1.447	1.00
25_R	28_P	1.438	1.00
151_V	154_N	1.426	1.00
29_K	162_E	1.420	1.00
168_T	171_H	1.407	1.00
11_L	24_A	1.400	1.00
28_P	39_A	1.391	1.00
9_T	28_P	1.366	1.00
82_E	125_R	1.365	1.00
115_T	127_Q	1.351	1.00
75_G	179_F	1.349	1.00
95_I	137_L	1.349	1.00
83_Y	89_G	1.333	1.00
85_Y	125_R	1.311	1.00
7_V	35_M	1.303	1.00
35_M	180_G	1.290	1.00
62_T	65_A	1.269	1.00
27_L	77_V	1.268	1.00
66_L	98_L	1.255	1.00
80_T	130_L	1.245	1.00
144_K	178_A	1.243	1.00
48_L	90_G	1.228	1.00
78_I	134_L	1.222	1.00
112_L	179_F	1.211	1.00
111_V	134_L	1.210	1.00
76_V	106_L	1.208	1.00
87_V	129_H	1.200	1.00
27_L	114_Q	1.195	1.00
68_E	71_R	1.191	1.00
147_F	175_Q	1.169	1.00
80_T	126_C	1.169	1.00
38_N	73_A	1.163	1.00
89_G	96_D	1.143	1.00
166_Q	169_L	1.139	1.00
80_T	115_T	1.137	1.00
63_V	97_W	1.135	1.00
9_T	37_V	1.131	1.00
21_G	42_S	1.124	1.00
5_L	183_I	1.116	1.00
61_A	64_E	1.104	1.00
121_I	124_A	1.086	1.00
20_N	79_V	1.076	1.00
70_I	76_V	1.068	1.00
28_P	32_P	1.064	1.00
155_K	165_D	1.031	1.00
170_D	174_G	1.018	1.00
135_V	141_V	1.017	1.00
30_I	169_L	1.002	1.00
31_A	37_V	1.001	1.00
17_G	22_M	0.997	1.00
67_A	98_L	0.989	1.00
142_M	182_F	0.988	1.00
25_R	39_A	0.962	1.00
10_L	78_I	0.953	1.00
67_A	105_P	0.951	1.00
19_F	152_I	0.950	1.00
140_M	182_F	0.944	1.00
9_T	39_A	0.941	1.00
170_D	173_T	0.941	1.00
27_L	172_L	0.939	1.00
26_T	29_K	0.938	1.00
30_I	33_A	0.936	1.00
23_V	116_S	0.934	1.00
142_M	179_F	0.933	1.00
65_A	68_E	0.929	1.00
9_T	79_V	0.914	1.00
30_I	176_L	0.913	1.00
48_L	89_G	0.910	1.00
89_G	92_K	0.899	1.00
157_D	164_I	0.898	1.00
173_T	177_T	0.894	1.00
11_L	20_N	0.893	1.00
75_G	183_I	0.892	1.00
77_V	112_L	0.883	1.00
16_K	44_A	0.871	1.00
44_A	50_D	0.868	1.00
40_L	69_Q	0.864	1.00
149_G	168_T	0.861	1.00
78_I	95_I	0.857	1.00
138_D	178_A	0.853	1.00
70_I	94_A	0.851	1.00
92_K	133_I	0.847	1.00
69_Q	73_A	0.832	1.00
50_D	53_V	0.831	1.00
51_A	54_Q	0.830	1.00
167_G	170_D	0.826	1.00
177_T	181_E	0.821	1.00
46_I	49_Y	0.817	1.00
113_I	134_L	0.815	1.00
127_Q	145_P	0.813	1.00
54_Q	58_G	0.812	1.00
31_A	176_L	0.811	1.00
85_Y	136_F	0.807	1.00
134_L	141_V	0.807	1.00
155_K	168_T	0.800	1.00
129_H	133_I	0.798	1.00
128_Y	132_Q	0.798	1.00
179_F	183_I	0.796	1.00
51_A	55_Q	0.792	1.00
23_V	149_G	0.792	1.00
46_I	94_A	0.792	1.00
43_I	94_A	0.788	1.00
175_Q	179_F	0.783	1.00
95_I	130_L	0.779	1.00
45_D	65_A	0.779	1.00
14_L	90_G	0.779	1.00
118_M	153_Q	0.778	1.00
48_L	93_N	0.777	1.00
49_Y	54_Q	0.776	1.00
69_Q	72_Q	0.772	1.00
167_G	171_H	0.766	1.00
25_R	29_K	0.765	1.00
71_R	105_P	0.758	0.99
86_S	92_K	0.755	0.99
21_G	39_A	0.754	0.99
29_K	33_A	0.754	0.99
78_I	91_L	0.742	0.99
80_T	88_P	0.739	0.99
79_V	114_Q	0.732	0.99
108_G	140_M	0.730	0.99
106_L	139_A	0.723	0.99
156_V	163_V	0.723	0.99
119_G	122_G	0.721	0.99
177_T	180_G	0.719	0.99
26_T	169_L	0.719	0.99
28_P	37_V	0.715	0.99
14_L	89_G	0.714	0.99
8_V	69_Q	0.711	0.99
125_R	128_Y	0.710	0.99
174_G	178_A	0.708	0.99
127_Q	148_M	0.703	0.99
84_N	100_R	0.701	0.99
22_M	25_R	0.701	0.99
176_L	180_G	0.694	0.99
86_S	96_D	0.688	0.99
27_L	79_V	0.684	0.99
84_N	99_S	0.681	0.99
140_M	143_N	0.680	0.99
165_D	168_T	0.666	0.99
60_P	97_W	0.666	0.99
87_V	92_K	0.665	0.99
34_S	180_G	0.662	0.99
120_V	151_V	0.659	0.99
95_I	134_L	0.657	0.99
98_L	106_L	0.656	0.99
55_Q	58_G	0.654	0.98
124_A	128_Y	0.654	0.98
61_A	68_E	0.653	0.98
131_R	135_V	0.652	0.98
87_V	130_L	0.652	0.98
75_G	110_P	0.649	0.98
18_S	21_G	0.649	0.98
136_F	143_N	0.646	0.98
76_V	109_K	0.643	0.98
111_V	141_V	0.640	0.98
152_I	156_V	0.639	0.98
142_M	178_A	0.639	0.98
95_I	133_I	0.634	0.98
39_A	42_S	0.626	0.98
29_K	32_P	0.626	0.98
125_R	132_Q	0.625	0.98
78_I	130_L	0.622	0.98
33_A	173_T	0.617	0.98
7_V	183_I	0.617	0.98
77_V	114_Q	0.615	0.98
46_I	50_D	0.613	0.98
11_L	39_A	0.610	0.98
27_L	176_L	0.609	0.98
85_Y	132_Q	0.603	0.97
18_S	42_S	0.601	0.97
8_V	76_V	0.600	0.97
31_A	180_G	0.598	0.97
108_G	181_E	0.592	0.97
15_R	51_A	0.591	0.97
76_V	111_V	0.589	0.97
7_V	31_A	0.588	0.97
22_M	156_V	0.587	0.97
81_P	88_P	0.580	0.97
108_G	138_D	0.579	0.97
60_P	63_V	0.576	0.97
12_G	80_T	0.575	0.97
49_Y	53_V	0.572	0.97
99_S	105_P	0.569	0.96
149_G	172_L	0.564	0.96
93_N	97_W	0.563	0.96
5_L	35_M	0.562	0.96
155_K	164_I	0.560	0.96
47_P	52_D	0.560	0.96
123_G	127_Q	0.558	0.96
10_L	66_L	0.558	0.96
38_N	72_Q	0.557	0.96
162_E	169_L	0.556	0.96
76_V	139_A	0.553	0.96
43_I	90_G	0.552	0.96
59_F	63_V	0.547	0.96
50_D	54_Q	0.547	0.96
49_Y	52_D	0.547	0.96
54_Q	100_R	0.540	0.95
45_D	62_T	0.534	0.95
19_F	22_M	0.534	0.95
149_G	155_K	0.534	0.95
94_A	98_L	0.533	0.95
174_G	177_T	0.532	0.95
164_I	167_G	0.532	0.95
8_V	70_I	0.528	0.95
40_L	66_L	0.528	0.95
121_I	125_R	0.524	0.94
16_K	52_D	0.524	0.94
47_P	62_T	0.521	0.94
120_V	150_G	0.517	0.94
178_A	181_E	0.515	0.94
85_Y	135_V	0.511	0.94
117_S	148_M	0.511	0.94
25_R	162_E	0.509	0.93
82_E	85_Y	0.506	0.93
138_D	144_K	0.506	0.93
32_P	36_E	0.502	0.93
135_V	145_P	0.502	0.93
106_L	137_L	0.501	0.93
88_P	91_L	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3svlA	4	0.9574	100	0.341	Contact Map
2fzvA	5	0.9628	100	0.357	Contact Map
3u7rA	4	0.9628	100	0.369	Contact Map
1rttA	1	0.9255	100	0.375	Contact Map
2q62A	4	0.9574	100	0.385	Contact Map
4hs4A	6	0.9734	100	0.387	Contact Map
3fvwA	1	0.9255	100	0.417	Contact Map
4c76A	1	0.9362	100	0.45	Contact Map
3gfsA	5	0.8883	100	0.452	Contact Map
4ptzC	4	0.9149	100	0.455	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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