GREMLIN Database
CHRR - Chromate reductase
UniProt: P0AGE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11723
Length: 188 (170)
Sequences: 6277 (4243)
Seq/√Len: 325.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_N69_Q4.2241.00
6_Q36_E3.1551.00
8_V73_A2.8671.00
86_S129_H2.7941.00
87_V133_I2.7541.00
115_T123_G2.6781.00
61_A65_A2.6571.00
157_D162_E2.5701.00
68_E72_Q2.5151.00
111_V139_A2.4951.00
157_D160_T2.4661.00
30_I173_T2.4021.00
134_L139_A2.3071.00
11_L21_G2.0981.00
21_G25_R2.0871.00
113_I127_Q2.0801.00
9_T24_A1.9851.00
112_L175_Q1.9021.00
64_E68_E1.8731.00
86_S133_I1.8341.00
129_H132_Q1.8301.00
66_L94_A1.7971.00
6_Q72_Q1.7951.00
92_K96_D1.7731.00
24_A79_V1.7611.00
6_Q38_N1.7151.00
65_A69_Q1.7151.00
166_Q170_D1.7081.00
169_L173_T1.7071.00
7_V75_G1.6551.00
70_I98_L1.5411.00
78_I111_V1.5391.00
107_A138_D1.5041.00
8_V40_L1.4581.00
20_N116_S1.4551.00
42_S45_D1.4471.00
25_R28_P1.4381.00
151_V154_N1.4261.00
29_K162_E1.4201.00
168_T171_H1.4071.00
11_L24_A1.4001.00
28_P39_A1.3911.00
9_T28_P1.3661.00
82_E125_R1.3651.00
115_T127_Q1.3511.00
75_G179_F1.3491.00
95_I137_L1.3491.00
83_Y89_G1.3331.00
85_Y125_R1.3111.00
7_V35_M1.3031.00
35_M180_G1.2901.00
62_T65_A1.2691.00
27_L77_V1.2681.00
66_L98_L1.2551.00
80_T130_L1.2451.00
144_K178_A1.2431.00
48_L90_G1.2281.00
78_I134_L1.2221.00
112_L179_F1.2111.00
111_V134_L1.2101.00
76_V106_L1.2081.00
87_V129_H1.2001.00
27_L114_Q1.1951.00
68_E71_R1.1911.00
147_F175_Q1.1691.00
80_T126_C1.1691.00
38_N73_A1.1631.00
89_G96_D1.1431.00
166_Q169_L1.1391.00
80_T115_T1.1371.00
63_V97_W1.1351.00
9_T37_V1.1311.00
21_G42_S1.1241.00
5_L183_I1.1161.00
61_A64_E1.1041.00
121_I124_A1.0861.00
20_N79_V1.0761.00
70_I76_V1.0681.00
28_P32_P1.0641.00
155_K165_D1.0311.00
170_D174_G1.0181.00
135_V141_V1.0171.00
30_I169_L1.0021.00
31_A37_V1.0011.00
17_G22_M0.9971.00
67_A98_L0.9891.00
142_M182_F0.9881.00
25_R39_A0.9621.00
10_L78_I0.9531.00
67_A105_P0.9511.00
19_F152_I0.9501.00
140_M182_F0.9441.00
9_T39_A0.9411.00
170_D173_T0.9411.00
27_L172_L0.9391.00
26_T29_K0.9381.00
30_I33_A0.9361.00
23_V116_S0.9341.00
142_M179_F0.9331.00
65_A68_E0.9291.00
9_T79_V0.9141.00
30_I176_L0.9131.00
48_L89_G0.9101.00
89_G92_K0.8991.00
157_D164_I0.8981.00
173_T177_T0.8941.00
11_L20_N0.8931.00
75_G183_I0.8921.00
77_V112_L0.8831.00
16_K44_A0.8711.00
44_A50_D0.8681.00
40_L69_Q0.8641.00
149_G168_T0.8611.00
78_I95_I0.8571.00
138_D178_A0.8531.00
70_I94_A0.8511.00
92_K133_I0.8471.00
69_Q73_A0.8321.00
50_D53_V0.8311.00
51_A54_Q0.8301.00
167_G170_D0.8261.00
177_T181_E0.8211.00
46_I49_Y0.8171.00
113_I134_L0.8151.00
127_Q145_P0.8131.00
54_Q58_G0.8121.00
31_A176_L0.8111.00
85_Y136_F0.8071.00
134_L141_V0.8071.00
155_K168_T0.8001.00
129_H133_I0.7981.00
128_Y132_Q0.7981.00
179_F183_I0.7961.00
51_A55_Q0.7921.00
23_V149_G0.7921.00
46_I94_A0.7921.00
43_I94_A0.7881.00
175_Q179_F0.7831.00
95_I130_L0.7791.00
45_D65_A0.7791.00
14_L90_G0.7791.00
118_M153_Q0.7781.00
48_L93_N0.7771.00
49_Y54_Q0.7761.00
69_Q72_Q0.7721.00
167_G171_H0.7661.00
25_R29_K0.7651.00
71_R105_P0.7580.99
86_S92_K0.7550.99
21_G39_A0.7540.99
29_K33_A0.7540.99
78_I91_L0.7420.99
80_T88_P0.7390.99
79_V114_Q0.7320.99
108_G140_M0.7300.99
106_L139_A0.7230.99
156_V163_V0.7230.99
119_G122_G0.7210.99
177_T180_G0.7190.99
26_T169_L0.7190.99
28_P37_V0.7150.99
14_L89_G0.7140.99
8_V69_Q0.7110.99
125_R128_Y0.7100.99
174_G178_A0.7080.99
127_Q148_M0.7030.99
84_N100_R0.7010.99
22_M25_R0.7010.99
176_L180_G0.6940.99
86_S96_D0.6880.99
27_L79_V0.6840.99
84_N99_S0.6810.99
140_M143_N0.6800.99
165_D168_T0.6660.99
60_P97_W0.6660.99
87_V92_K0.6650.99
34_S180_G0.6620.99
120_V151_V0.6590.99
95_I134_L0.6570.99
98_L106_L0.6560.99
55_Q58_G0.6540.98
124_A128_Y0.6540.98
61_A68_E0.6530.98
131_R135_V0.6520.98
87_V130_L0.6520.98
75_G110_P0.6490.98
18_S21_G0.6490.98
136_F143_N0.6460.98
76_V109_K0.6430.98
111_V141_V0.6400.98
152_I156_V0.6390.98
142_M178_A0.6390.98
95_I133_I0.6340.98
39_A42_S0.6260.98
29_K32_P0.6260.98
125_R132_Q0.6250.98
78_I130_L0.6220.98
33_A173_T0.6170.98
7_V183_I0.6170.98
77_V114_Q0.6150.98
46_I50_D0.6130.98
11_L39_A0.6100.98
27_L176_L0.6090.98
85_Y132_Q0.6030.97
18_S42_S0.6010.97
8_V76_V0.6000.97
31_A180_G0.5980.97
108_G181_E0.5920.97
15_R51_A0.5910.97
76_V111_V0.5890.97
7_V31_A0.5880.97
22_M156_V0.5870.97
81_P88_P0.5800.97
108_G138_D0.5790.97
60_P63_V0.5760.97
12_G80_T0.5750.97
49_Y53_V0.5720.97
99_S105_P0.5690.96
149_G172_L0.5640.96
93_N97_W0.5630.96
5_L35_M0.5620.96
155_K164_I0.5600.96
47_P52_D0.5600.96
123_G127_Q0.5580.96
10_L66_L0.5580.96
38_N72_Q0.5570.96
162_E169_L0.5560.96
76_V139_A0.5530.96
43_I90_G0.5520.96
59_F63_V0.5470.96
50_D54_Q0.5470.96
49_Y52_D0.5470.96
54_Q100_R0.5400.95
45_D62_T0.5340.95
19_F22_M0.5340.95
149_G155_K0.5340.95
94_A98_L0.5330.95
174_G177_T0.5320.95
164_I167_G0.5320.95
8_V70_I0.5280.95
40_L66_L0.5280.95
121_I125_R0.5240.94
16_K52_D0.5240.94
47_P62_T0.5210.94
120_V150_G0.5170.94
178_A181_E0.5150.94
85_Y135_V0.5110.94
117_S148_M0.5110.94
25_R162_E0.5090.93
82_E85_Y0.5060.93
138_D144_K0.5060.93
32_P36_E0.5020.93
135_V145_P0.5020.93
106_L137_L0.5010.93
88_P91_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3svlA 4 0.9574 100 0.341 Contact Map
2fzvA 5 0.9628 100 0.357 Contact Map
3u7rA 4 0.9628 100 0.369 Contact Map
1rttA 1 0.9255 100 0.375 Contact Map
2q62A 4 0.9574 100 0.385 Contact Map
4hs4A 6 0.9734 100 0.387 Contact Map
3fvwA 1 0.9255 100 0.417 Contact Map
4c76A 1 0.9362 100 0.45 Contact Map
3gfsA 5 0.8883 100 0.452 Contact Map
4ptzC 4 0.9149 100 0.455 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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