GREMLIN Database
SSTT - Serine/threonine transporter SstT
UniProt: P0AGE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12732
Length: 414 (386)
Sequences: 6245 (3763)
Seq/√Len: 191.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_D146_K4.4861.00
279_E285_R3.5851.00
103_S327_A3.2001.00
183_F186_K3.1171.00
28_L197_F3.1051.00
82_R403_E3.0801.00
135_S154_V2.9521.00
101_V225_C2.9441.00
63_L156_A2.9301.00
67_M174_V2.8771.00
44_G48_T2.8511.00
271_I292_I2.7711.00
32_L197_F2.7521.00
106_F109_T2.7361.00
21_Q190_R2.7231.00
49_L136_M2.6651.00
284_D405_D2.5541.00
63_L67_M2.5351.00
168_E171_K2.5291.00
323_D326_T2.5251.00
64_M177_M2.5191.00
167_N170_T2.4741.00
46_L198_G2.4491.00
223_V383_C2.4191.00
284_D400_C2.3711.00
159_L180_A2.3591.00
258_G390_S2.3431.00
220_V224_G2.2581.00
17_S20_K2.2511.00
239_W243_R2.2441.00
130_R134_M2.1601.00
86_F395_F2.1141.00
82_R402_A2.1061.00
138_S142_D2.0941.00
257_S277_L2.0841.00
90_L237_L2.0811.00
23_L27_V2.0781.00
31_L35_I2.0511.00
101_V228_L2.0511.00
105_A221_V1.9541.00
314_A369_V1.9411.00
25_G197_F1.9101.00
72_N175_N1.9011.00
81_I85_L1.8991.00
96_A100_V1.8951.00
226_M383_C1.8641.00
100_V104_F1.8591.00
276_A280_K1.8541.00
64_M181_V1.8451.00
102_F312_L1.8421.00
278_C393_V1.8371.00
283_L397_A1.7941.00
57_V188_V1.7861.00
107_P316_N1.7831.00
163_L180_A1.7721.00
148_N151_G1.7681.00
377_G384_E1.7631.00
238_V394_L1.7511.00
213_W217_Q1.7461.00
105_A224_G1.7291.00
165_H183_F1.7201.00
25_G29_G1.7051.00
141_I145_L1.7001.00
242_I401_Q1.6981.00
321_P325_P1.6981.00
283_L400_C1.6911.00
291_S396_T1.6871.00
253_C281_L1.6761.00
16_G20_K1.6731.00
140_P155_W1.6551.00
254_L393_V1.6351.00
78_K403_E1.6291.00
141_I144_L1.6271.00
49_L133_V1.6241.00
314_A361_I1.6231.00
274_N393_V1.6011.00
381_D385_T1.5951.00
101_V221_V1.5871.00
248_P252_L1.5861.00
102_F309_V1.5751.00
228_L232_V1.5631.00
216_A220_V1.5621.00
279_E288_Y1.5261.00
173_L176_D1.5061.00
258_G386_A1.5041.00
226_M387_L1.4871.00
318_L369_V1.4601.00
253_C280_K1.4561.00
275_M288_Y1.4561.00
127_E130_R1.4341.00
136_M154_V1.4341.00
55_K138_S1.4201.00
62_V149_Y1.4071.00
165_H187_L1.4051.00
20_K24_V1.4041.00
111_H319_G1.4021.00
225_C305_I1.3971.00
56_A155_W1.3971.00
32_L36_S1.3951.00
162_A184_M1.3941.00
63_L144_L1.3921.00
324_L328_L1.3921.00
48_T52_G1.3901.00
52_G138_S1.3721.00
116_A119_I1.3651.00
37_K205_A1.3631.00
268_A343_G1.3501.00
175_N179_N1.3481.00
68_A174_V1.3451.00
26_L200_V1.3401.00
400_C406_R1.3341.00
284_D287_T1.3241.00
247_F252_L1.3091.00
70_I157_I1.3071.00
254_L390_S1.2861.00
202_S206_T1.2801.00
287_T400_C1.2751.00
239_W245_N1.2651.00
36_S39_A1.2631.00
400_C404_D1.2601.00
16_G24_V1.2601.00
311_T330_L1.2561.00
89_L93_F1.2441.00
166_G170_T1.2431.00
321_P326_T1.2421.00
99_A327_A1.2411.00
297_T300_M1.2391.00
230_A387_L1.2321.00
221_V309_V1.2301.00
187_L191_F1.2291.00
162_A187_L1.2201.00
330_L359_F1.2181.00
274_N292_I1.2181.00
134_M148_N1.2131.00
245_N248_P1.2121.00
88_Y92_T1.2101.00
213_W216_A1.2041.00
217_Q220_V1.2031.00
83_P291_S1.2011.00
166_G176_D1.2011.00
57_V185_V1.1971.00
59_P152_I1.1871.00
270_N274_N1.1861.00
158_G184_M1.1821.00
159_L177_M1.1791.00
100_V103_S1.1701.00
44_G202_S1.1631.00
261_A385_T1.1591.00
219_L376_I1.1561.00
181_V185_V1.1551.00
75_H286_D1.1491.00
172_N176_D1.1481.00
49_L53_A1.1411.00
186_K276_A1.1401.00
169_T172_N1.1391.00
256_E280_K1.1371.00
400_C405_D1.1331.00
306_T377_G1.1271.00
210_S213_W1.1221.00
157_I161_F1.1211.00
214_G217_Q1.1181.00
244_R248_P1.1171.00
87_L291_S1.1131.00
46_L191_F1.1101.00
31_L34_W1.1101.00
92_T96_A1.1051.00
78_K82_R1.1031.00
231_L235_P1.0891.00
142_D145_L1.0841.00
85_L89_L1.0841.00
64_M68_A1.0831.00
274_N389_S1.0791.00
238_V244_R1.0791.00
271_I296_A1.0761.00
401_Q404_D1.0761.00
236_L240_W1.0761.00
191_F194_I1.0691.00
303_A348_S1.0691.00
349_L374_F1.0681.00
328_L332_V1.0661.00
32_L201_S1.0601.00
79_T287_T1.0601.00
38_P41_E1.0591.00
265_R378_V1.0521.00
21_Q25_G1.0511.00
301_A338_A1.0481.00
236_L239_W1.0461.00
278_C283_L1.0431.00
222_L309_V1.0411.00
219_L379_L1.0371.00
278_C292_I1.0341.00
249_L254_L1.0291.00
27_V31_L1.0251.00
136_M139_N1.0221.00
166_G180_A1.0211.00
28_L32_L1.0201.00
17_S21_Q1.0191.00
101_V105_A1.0151.00
252_L255_R1.0141.00
99_A103_S1.0071.00
108_S316_N1.0021.00
306_T384_E0.9971.00
39_A42_A0.9900.99
172_N175_N0.9890.99
129_M133_V0.9770.99
283_L288_Y0.9730.99
90_L301_A0.9690.99
244_R406_R0.9670.99
170_T176_D0.9640.99
47_G199_L0.9630.99
345_A381_D0.9590.99
270_N273_V0.9590.99
229_V233_V0.9580.99
163_L174_V0.9550.99
232_V235_P0.9540.99
324_L327_A0.9540.99
279_E289_S0.9530.99
96_A331_S0.9530.99
227_L231_L0.9490.99
253_C257_S0.9440.99
98_A308_T0.9440.99
183_F187_L0.9410.99
90_L94_S0.9400.99
277_L280_K0.9400.99
52_G55_K0.9390.99
66_V153_L0.9390.99
307_I352_I0.9340.99
299_N392_D0.9330.99
337_C355_A0.9320.99
253_C277_L0.9310.99
262_F382_S0.9220.99
267_S388_N0.9190.99
161_F165_H0.9170.99
222_L380_Q0.9170.99
111_H114_S0.9090.99
257_S274_N0.9060.99
223_V227_L0.9060.99
239_W246_P0.9040.99
257_S270_N0.9010.99
243_R401_Q0.9000.99
143_A155_W0.8970.99
68_A175_N0.8950.99
96_A328_L0.8950.99
79_T399_A0.8940.99
312_L327_A0.8920.99
97_L228_L0.8910.99
217_Q316_N0.8910.99
154_V158_G0.8830.99
158_G187_L0.8820.99
16_G21_Q0.8780.99
300_M392_D0.8760.99
159_L184_M0.8760.99
47_G195_G0.8710.99
229_V305_I0.8680.99
36_S43_V0.8670.99
278_C288_Y0.8660.99
260_Y270_N0.8650.99
306_T380_Q0.8640.99
249_L393_V0.8620.99
255_R259_V0.8610.99
186_K190_R0.8610.99
260_Y273_V0.8600.99
87_L91_G0.8590.99
169_T179_N0.8570.98
201_S205_A0.8560.98
43_V201_S0.8550.98
57_V184_M0.8530.98
39_A43_V0.8500.98
42_A45_L0.8490.98
156_A160_G0.8490.98
276_A279_E0.8460.98
310_L373_G0.8450.98
128_V132_L0.8370.98
224_G227_L0.8350.98
224_G228_L0.8350.98
232_V236_L0.8350.98
52_G134_M0.8340.98
218_L373_G0.8330.98
64_M174_V0.8330.98
65_L178_S0.8300.98
234_N251_L0.8270.98
32_L43_V0.8200.98
67_M163_L0.8200.98
101_V104_F0.8190.98
260_Y264_T0.8160.98
296_A392_D0.8110.98
219_L380_Q0.8090.98
322_V326_T0.8040.98
155_W159_L0.8030.98
122_P126_V0.8020.98
197_F201_S0.7990.98
353_P370_V0.7980.98
43_V198_G0.7960.98
126_V130_R0.7940.98
401_Q406_R0.7920.97
192_A195_G0.7910.97
287_T291_S0.7880.97
178_S182_T0.7840.97
349_L370_V0.7840.97
42_A46_L0.7820.97
50_F192_A0.7810.97
257_S273_V0.7790.97
127_E131_G0.7770.97
307_I349_L0.7710.97
144_L155_W0.7710.97
248_P253_C0.7690.97
67_M159_L0.7670.97
21_Q194_I0.7650.97
166_G179_N0.7600.97
173_L177_M0.7600.97
22_I192_A0.7590.97
218_L380_Q0.7520.97
238_V242_I0.7520.97
98_A309_V0.7520.97
235_P251_L0.7500.96
36_S201_S0.7500.96
87_L90_L0.7490.96
67_M156_A0.7460.96
265_R381_D0.7450.96
298_I339_C0.7450.96
219_L223_V0.7450.96
218_L309_V0.7430.96
181_V188_V0.7400.96
130_R133_V0.7370.96
71_A164_R0.7350.96
311_T355_A0.7340.96
349_L380_Q0.7330.96
221_V224_G0.7330.96
101_V224_G0.7300.96
222_L226_M0.7280.96
353_P357_N0.7270.96
85_L88_Y0.7260.96
218_L306_T0.7260.96
29_G201_S0.7240.96
318_L364_D0.7240.96
144_L151_G0.7220.96
38_P205_A0.7200.96
32_L39_A0.7180.96
249_L397_A0.7180.96
303_A307_I0.7170.95
106_F316_N0.7170.95
140_P147_G0.7160.95
341_A351_L0.7150.95
274_N392_D0.7100.95
122_P125_I0.7090.95
139_N143_A0.7080.95
261_A389_S0.7050.95
74_Q77_Q0.7030.95
78_K81_I0.7010.95
140_P145_L0.6990.95
140_P143_A0.6980.95
76_G80_N0.6980.95
303_A341_A0.6970.95
91_G94_S0.6970.95
192_A264_T0.6960.95
244_R253_C0.6950.95
124_G127_E0.6950.95
75_H405_D0.6940.95
26_L196_I0.6940.95
139_N155_W0.6930.95
91_G98_A0.6920.95
176_D179_N0.6900.94
41_E205_A0.6880.94
131_G135_S0.6870.94
215_Y218_L0.6860.94
217_Q221_V0.6860.94
67_M177_M0.6860.94
196_I345_A0.6850.94
294_L298_I0.6820.94
237_L398_A0.6820.94
39_A205_A0.6810.94
87_L92_T0.6800.94
343_G346_G0.6790.94
92_T98_A0.6790.94
163_L170_T0.6780.94
40_A205_A0.6780.94
166_G169_T0.6760.94
50_F191_F0.6740.94
218_L310_L0.6740.94
75_H80_N0.6730.94
170_T179_N0.6720.94
73_H80_N0.6710.94
24_V28_L0.6700.94
154_V191_F0.6680.93
249_L394_L0.6680.93
49_L154_V0.6670.93
307_I341_A0.6650.93
241_K398_A0.6650.93
296_A300_M0.6640.93
176_D180_A0.6630.93
225_C309_V0.6630.93
325_P328_L0.6620.93
101_V220_V0.6590.93
334_A351_L0.6590.93
325_P329_L0.6580.93
123_S126_V0.6550.93
37_K41_E0.6550.93
327_A331_S0.6540.93
231_L236_L0.6530.93
113_S116_A0.6520.93
54_L260_Y0.6510.93
194_I198_G0.6500.93
315_V320_I0.6500.93
32_L35_I0.6480.92
73_H161_F0.6460.92
179_N183_F0.6420.92
173_L180_A0.6410.92
97_L225_C0.6390.92
92_T335_S0.6380.92
285_R289_S0.6380.92
292_I396_T0.6370.92
230_A235_P0.6360.92
396_T400_C0.6350.92
329_L359_F0.6350.92
333_V358_M0.6350.92
311_T315_V0.6340.92
131_G134_M0.6340.92
103_S324_L0.6320.91
116_A120_S0.6310.91
281_L397_A0.6270.91
339_C392_D0.6270.91
87_L395_F0.6260.91
83_P399_A0.6260.91
308_T334_A0.6240.91
300_M341_A0.6220.91
331_S334_A0.6210.91
185_V262_F0.6200.91
93_F96_A0.6200.91
163_L176_D0.6190.91
270_N296_A0.6180.91
105_A217_Q0.6170.90
331_S335_S0.6160.90
215_Y219_L0.6150.90
254_L274_N0.6130.90
79_T403_E0.6120.90
213_W219_L0.6100.90
273_V276_A0.6090.90
175_N178_S0.6090.90
59_P144_L0.6090.90
29_G33_A0.6070.90
287_T405_D0.6070.90
364_D371_A0.6060.90
265_R269_A0.6050.90
87_L229_V0.6020.89
311_T314_A0.6010.89
53_A188_V0.6010.89
127_E132_L0.6010.89
30_I33_A0.6000.89
307_I311_T0.6000.89
73_H77_Q0.5980.89
252_L256_E0.5930.89
268_A296_A0.5930.89
275_M292_I0.5920.89
270_N389_S0.5900.88
18_L21_Q0.5900.88
88_Y91_G0.5890.88
35_I127_E0.5890.88
167_N171_K0.5880.88
74_Q165_H0.5880.88
223_V226_M0.5860.88
321_P324_L0.5860.88
234_N394_L0.5840.88
190_R194_I0.5830.88
76_G82_R0.5820.88
32_L40_A0.5820.88
353_P363_N0.5810.88
53_A191_F0.5810.88
326_T329_L0.5800.88
61_L153_L0.5790.87
91_G99_A0.5790.87
369_V372_V0.5790.87
301_A391_T0.5790.87
183_F190_R0.5780.87
218_L226_M0.5770.87
143_A147_G0.5760.87
341_A348_S0.5760.87
93_F97_L0.5760.87
284_D288_Y0.5750.87
166_G183_F0.5740.87
53_A136_M0.5720.87
53_A158_G0.5720.87
37_K40_A0.5710.87
303_A384_E0.5710.87
153_L318_L0.5700.87
235_P257_S0.5700.87
68_A72_N0.5680.86
329_L333_V0.5680.86
343_G347_G0.5660.86
79_T83_P0.5650.86
145_L148_N0.5650.86
330_L334_A0.5630.86
286_D405_D0.5620.86
102_F107_P0.5620.86
195_G199_L0.5610.86
376_I380_Q0.5600.86
44_G206_T0.5600.86
45_L133_V0.5600.86
317_T372_V0.5590.86
26_L382_S0.5560.85
314_A351_L0.5560.85
46_L194_I0.5550.85
48_T133_V0.5550.85
388_N392_D0.5540.85
58_A372_V0.5530.85
244_R401_Q0.5530.85
128_V131_G0.5530.85
261_A270_N0.5520.85
103_S312_L0.5510.85
306_T310_L0.5500.85
293_P300_M0.5490.85
261_A386_A0.5470.84
151_G346_G0.5450.84
348_S355_A0.5440.84
29_G200_V0.5430.84
395_F398_A0.5420.84
189_I192_A0.5410.84
318_L362_S0.5400.84
117_G120_S0.5400.84
283_L396_T0.5390.83
302_G387_L0.5370.83
87_L98_A0.5370.83
18_L24_V0.5360.83
314_A318_L0.5360.83
25_G201_S0.5360.83
98_A306_T0.5350.83
90_L298_I0.5340.83
83_P87_L0.5340.83
117_G121_P0.5340.83
91_G304_A0.5330.83
87_L392_D0.5310.83
34_W209_F0.5310.83
76_G81_I0.5310.83
310_L377_G0.5310.83
348_S352_I0.5300.82
41_E206_T0.5290.82
84_I298_I0.5290.82
304_A335_S0.5280.82
261_A381_D0.5280.82
338_A350_L0.5230.82
278_C392_D0.5210.81
197_F208_G0.5210.81
99_A331_S0.5200.81
254_L258_G0.5200.81
235_P246_P0.5190.81
48_T202_S0.5190.81
390_S394_L0.5170.81
162_A166_G0.5170.81
397_A406_R0.5170.81
225_C229_V0.5170.81
234_N391_T0.5170.81
94_S98_A0.5160.81
360_G364_D0.5160.81
109_T112_L0.5150.81
123_S127_E0.5150.81
182_T218_L0.5140.81
252_L280_K0.5140.81
49_L191_F0.5130.80
87_L94_S0.5130.80
229_V301_A0.5130.80
322_V330_L0.5120.80
231_L247_F0.5110.80
86_F91_G0.5110.80
111_H115_S0.5110.80
110_L217_Q0.5090.80
170_T180_A0.5090.80
33_A204_L0.5090.80
259_V263_F0.5090.80
212_L215_Y0.5090.80
378_V382_S0.5090.80
94_S305_I0.5060.80
303_A347_G0.5060.80
346_G350_L0.5050.79
98_A305_I0.5050.79
58_A347_G0.5040.79
102_F106_F0.5040.79
303_A381_D0.5030.79
116_A122_P0.5020.79
51_V185_V0.5010.79
326_T360_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.913 100 0.085 Contact Map
4czbA 2 0.6353 41.4 0.963 Contact Map
4cz8A 2 0.6353 27.4 0.967 Contact Map
4n7wA 2 0.3913 17.3 0.969 Contact Map
2m8rA 1 0.099 11.9 0.972 Contact Map
4bwzA 2 0.6256 11.2 0.972 Contact Map
3hd7A 1 0.087 7.5 0.974 Contact Map
3fymA 1 0 6.1 0.975 Contact Map
3zuxA 1 0.3768 5.9 0.975 Contact Map
4humA 1 0.215 4.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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