GREMLIN Database
SSB - Single-stranded DNA-binding protein
UniProt: P0AGE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10976
Length: 178 (158)
Sequences: 3167 (2418)
Seq/√Len: 192.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_T96_D3.5651.00
77_Q114_G3.4261.00
91_D95_Q3.1571.00
23_Y29_A3.1341.00
88_K96_D2.7311.00
87_R101_E2.6231.00
17_Q34_T2.5971.00
34_T57_R2.5651.00
58_V104_V2.5511.00
6_V10_I2.4541.00
60_L68_A2.4301.00
87_R99_T2.3731.00
16_G55_W2.3591.00
21_V31_A2.3141.00
24_M30_V2.2461.00
43_D50_K2.2031.00
72_L78_V2.1981.00
33_I60_L2.1541.00
14_N77_Q2.1241.00
15_L72_L2.0811.00
42_R49_M2.0471.00
83_Q105_N2.0081.00
52_Q85_R1.9871.00
33_I58_V1.9581.00
68_A72_L1.9021.00
8_K81_E1.9021.00
28_G62_G1.8681.00
91_D97_R1.7931.00
89_W99_T1.7561.00
24_M61_F1.7461.00
24_M28_G1.7181.00
16_G34_T1.6721.00
6_V12_V1.6561.00
86_T100_T1.6221.00
11_L35_L1.6111.00
35_L80_I1.6061.00
42_R47_G1.6031.00
105_N109_T1.5941.00
85_R103_V1.5671.00
37_T56_H1.5651.00
60_L80_I1.4901.00
40_S49_M1.4811.00
59_V101_E1.4651.00
29_A66_E1.4631.00
60_L64_L1.3791.00
63_K66_E1.3771.00
12_V113_L1.3771.00
39_E52_Q1.3351.00
17_Q57_R1.3201.00
67_V112_M1.3171.00
41_W50_K1.2981.00
66_E70_E1.2741.00
32_N87_R1.2701.00
60_L104_V1.2671.00
43_D46_T1.2161.00
84_L102_V1.2091.00
30_V61_F1.2071.00
85_R105_N1.1971.00
6_V79_Y1.1841.00
68_A78_V1.1841.00
9_V84_L1.1431.00
21_V69_S1.1321.00
17_Q20_E1.1211.00
61_F103_V1.1001.00
11_L102_V1.0881.00
14_N38_S1.0791.00
86_T98_Y1.0771.00
19_P31_A1.0661.00
56_H100_T1.0601.00
167_E170_M1.0311.00
59_V87_R1.0271.00
57_R99_T1.0141.00
104_V110_M1.0051.00
25_P28_G0.9991.00
29_A69_S0.9700.99
166_N169_P0.9520.99
67_V71_Y0.9490.99
89_W95_Q0.9450.99
32_N59_V0.9300.99
39_E83_Q0.9230.99
15_L19_P0.9180.99
60_L110_M0.9170.99
54_E102_V0.9090.99
56_H102_V0.9050.99
31_A65_A0.8860.99
89_W101_E0.8840.99
31_A68_A0.8810.99
128_G131_Q0.8780.99
76_S114_G0.8690.99
23_Y66_E0.8640.99
11_L56_H0.8630.99
133_Q136_W0.8540.98
29_A65_A0.8540.98
83_Q103_V0.8520.98
41_W44_K0.8520.98
72_L112_M0.8500.98
159_S163_A0.8440.98
62_G105_N0.8430.98
88_K99_T0.8320.98
35_L78_V0.8320.98
76_S117_Q0.8260.98
158_Q162_A0.8220.98
64_L104_V0.8170.98
19_P68_A0.8110.98
38_S53_T0.8080.98
6_V111_Q0.8060.98
23_Y70_E0.7940.98
160_A163_A0.7910.97
68_A110_M0.7880.97
64_L67_V0.7810.97
72_L110_M0.7810.97
29_A70_E0.7770.97
54_E86_T0.7670.97
159_S162_A0.7650.97
54_E100_T0.7600.97
90_T95_Q0.7600.97
33_I104_V0.7590.97
18_D73_R0.7560.97
89_W92_Q0.7530.97
22_R30_V0.7520.97
168_P171_D0.7490.97
76_S112_M0.7490.97
39_E54_E0.7480.96
12_V79_Y0.7460.96
164_P167_E0.7400.96
64_L110_M0.7350.96
118_G122_P0.7340.96
73_R76_S0.7250.96
134_G137_G0.7220.96
63_K70_E0.7210.96
46_T50_K0.7200.96
38_S51_E0.7170.96
141_Q145_G0.7160.95
77_Q111_Q0.7150.95
31_A60_L0.7130.95
67_V110_M0.7110.95
166_N170_M0.7110.95
165_S168_P0.7090.95
10_I81_E0.6970.95
32_N57_R0.6930.95
12_V111_Q0.6790.94
42_R48_E0.6790.94
59_V103_V0.6720.94
77_Q113_L0.6700.94
168_P172_F0.6690.94
41_W51_E0.6660.93
60_L67_V0.6650.93
8_K79_Y0.6650.93
167_E171_D0.6610.93
143_Q146_N0.6600.93
163_A166_N0.6590.93
21_V29_A0.6580.93
160_A166_N0.6570.93
15_L78_V0.6560.93
9_V102_V0.6550.93
56_H86_T0.6550.93
169_P172_F0.6480.92
140_Q144_G0.6470.92
44_K47_G0.6460.92
122_P125_G0.6390.92
131_Q135_G0.6350.92
120_G123_A0.6320.92
161_P165_S0.6320.92
90_T99_T0.6310.91
172_F176_I0.6310.91
160_A164_P0.6180.91
37_T54_E0.6170.91
62_G66_E0.6110.90
161_P164_P0.6100.90
92_Q95_Q0.6090.90
165_S170_M0.6020.89
24_M59_V0.5940.89
170_M175_D0.5920.89
166_N171_D0.5900.89
16_G53_T0.5870.88
133_Q139_P0.5860.88
62_G77_Q0.5860.88
40_S51_E0.5810.88
115_G118_G0.5790.88
132_P136_W0.5790.88
63_K104_V0.5780.87
122_P128_G0.5770.87
16_G57_R0.5750.87
52_Q83_Q0.5740.87
60_L112_M0.5740.87
131_Q136_W0.5720.87
21_V65_A0.5710.87
71_Y114_G0.5700.87
158_Q161_P0.5700.87
136_W140_Q0.5680.87
123_A126_N0.5670.86
136_W139_P0.5650.86
126_N140_Q0.5630.86
173_D176_I0.5620.86
76_S116_R0.5600.86
129_G136_W0.5580.86
129_G138_Q0.5550.85
57_R86_T0.5530.85
159_S164_P0.5510.85
120_G124_G0.5490.85
117_Q121_A0.5490.85
137_G142_P0.5490.85
137_G141_Q0.5470.84
10_I79_Y0.5460.84
62_G65_A0.5450.84
129_G132_P0.5430.84
89_W96_D0.5410.84
67_V70_E0.5400.84
141_Q146_N0.5390.84
142_P145_G0.5370.83
91_D96_D0.5360.83
39_E105_N0.5340.83
54_E89_W0.5330.83
31_A69_S0.5330.83
162_A166_N0.5320.83
57_R98_Y0.5320.83
83_Q104_V0.5300.83
138_Q144_G0.5300.83
50_K83_Q0.5290.83
166_N172_F0.5280.82
63_K67_V0.5230.82
33_I68_A0.5220.82
28_G61_F0.5190.81
26_N32_N0.5180.81
119_G122_P0.5170.81
74_K119_G0.5170.81
12_V81_E0.5170.81
57_R100_T0.5140.81
127_I131_Q0.5140.81
162_A165_S0.5140.81
41_W49_M0.5130.81
124_G127_I0.5090.80
116_R120_G0.5060.80
128_G134_G0.5050.80
130_G146_N0.5020.79
126_N129_G0.5020.79
140_Q143_Q0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz9A 4 0.6404 100 0.179 Contact Map
3pgzA 2 0.6292 100 0.247 Contact Map
1se8A 2 0.5787 100 0.278 Contact Map
3lgjA 2 0.5393 100 0.278 Contact Map
3afpA 3 0.6404 100 0.292 Contact Map
3tqyA 4 0.618 100 0.294 Contact Map
1z9fA 4 0.5 100 0.3 Contact Map
3eivA 3 0.6629 100 0.316 Contact Map
3ulpA 4 0.6404 100 0.342 Contact Map
2fxqA 2 0.5506 100 0.347 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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