GREMLIN Database
SRP54 - Signal recognition particle protein
UniProt: P0AGD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10300
Length: 453 (435)
Sequences: 2879 (1374)
Seq/√Len: 65.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_A159_F5.0371.00
105_M117_V4.0701.00
315_Q336_E3.9171.00
206_K239_A3.8401.00
234_K238_E3.6751.00
146_K149_E3.5821.00
332_N389_A3.5721.00
339_R377_E3.4701.00
178_E182_K3.3381.00
28_K56_K3.1981.00
196_H228_D3.1971.00
203_D207_Q3.0421.00
162_S174_A2.9641.00
237_N268_K2.9201.00
118_G279_T2.8941.00
400_R404_A2.8301.00
342_K377_E2.8071.00
276_G281_A2.6921.00
117_V188_L2.6861.00
335_L381_N2.6361.00
177_K181_L2.5901.00
189_V212_I2.5261.00
409_Q412_D2.4721.00
50_E264_H2.4681.00
118_G151_L2.4651.00
394_I417_L2.4351.00
68_L304_I2.4211.00
158_D184_Y2.3641.00
170_D174_A2.3421.00
172_V212_I2.3391.00
51_F55_V2.3191.00
160_F174_A2.2981.00
135_V175_A2.2761.00
81_E84_A2.2661.00
117_V134_V2.2651.00
386_K393_I2.2231.00
167_K207_Q2.2131.00
334_F420_F2.2101.00
149_E153_E2.2091.00
403_A413_V2.1591.00
167_K170_D2.1321.00
315_Q318_K2.1091.00
122_K126_E2.1081.00
435_M438_M2.0581.00
379_I413_V2.0381.00
134_V152_A2.0371.00
301_L304_I2.0241.00
169_V211_S2.0171.00
124_L186_V2.0001.00
137_A172_V1.9961.00
320_A324_K1.9901.00
84_A88_E1.9841.00
331_L417_L1.9751.00
125_R156_G1.9431.00
125_R157_V1.9271.00
58_K81_E1.8851.00
76_K80_N1.8691.00
313_R317_E1.8681.00
93_L124_L1.8621.00
19_R26_N1.8581.00
216_E271_K1.8321.00
218_L246_V1.8171.00
121_G157_V1.8101.00
58_K80_N1.7981.00
130_K186_V1.7981.00
394_I402_I1.7911.00
66_K314_A1.7791.00
377_E381_N1.7741.00
250_V273_L1.7711.00
131_K184_Y1.7501.00
134_V188_L1.7421.00
133_L178_E1.7401.00
50_E54_R1.7251.00
242_L268_K1.7040.99
53_N57_E1.7010.99
375_R412_D1.6890.99
169_V207_Q1.6860.99
386_K390_K1.6620.99
217_T240_L1.6460.99
139_V171_I1.6430.99
317_E320_A1.6400.99
203_D206_K1.6300.99
54_R84_A1.6200.99
79_R83_V1.6150.99
149_E161_P1.6110.99
123_F127_K1.6110.99
250_V290_I1.6070.99
330_D389_A1.5880.99
176_L187_L1.5880.99
332_N385_M1.5830.99
375_R408_M1.5660.99
218_L244_G1.5420.99
140_Y171_I1.5390.99
209_H241_P1.5300.99
95_L186_V1.5270.99
371_K374_V1.5220.99
58_K84_A1.5210.99
132_V184_Y1.5080.99
135_V187_L1.5020.99
27_V60_V1.4990.99
102_V189_V1.4990.99
90_N284_P1.4980.99
126_E309_S1.4880.99
120_L246_V1.4860.99
361_P364_V1.4750.98
420_F424_Q1.4720.98
208_V212_I1.4690.98
209_H217_T1.4490.98
97_A101_A1.4440.98
123_F272_F1.4430.98
151_L155_V1.4430.98
79_R292_S1.4210.98
327_D330_D1.4050.98
247_L259_A1.4040.98
16_I30_T1.3940.98
289_R305_E1.3930.98
53_N56_K1.3890.98
122_K280_E1.3850.98
399_K417_L1.3840.98
408_M412_D1.3830.98
354_L357_M1.3780.98
155_V279_T1.3770.98
132_V158_D1.3660.97
306_D353_K1.3650.97
177_K180_K1.3610.97
31_L56_K1.3560.97
314_A318_K1.3560.97
151_L279_T1.3530.97
153_E156_G1.3400.97
116_S274_G1.3390.97
54_R81_E1.3370.97
96_A99_P1.3340.97
139_V168_P1.3340.97
221_V262_I1.3290.97
235_A239_A1.3210.97
102_V176_L1.3130.97
96_A101_A1.3110.97
133_L184_Y1.2940.96
206_K210_A1.2800.96
50_E53_N1.2670.96
134_V159_F1.2650.96
14_R18_G1.2630.96
135_V172_V1.2620.96
228_D231_N1.2600.96
101_A215_V1.2540.96
369_D374_V1.2540.96
379_I416_L1.2520.96
312_D315_Q1.2400.95
349_S352_G1.2390.95
433_G438_M1.2390.95
347_M351_M1.2260.95
339_R381_N1.2260.95
196_H235_A1.2250.95
103_V188_L1.2230.95
169_V208_V1.2210.95
116_S246_V1.2190.95
275_V282_L1.2150.95
273_L290_I1.2130.95
13_L16_I1.2080.95
178_E184_Y1.2060.95
173_N211_S1.1850.94
286_H302_S1.1820.94
308_E313_R1.1810.94
396_G399_K1.1760.94
68_L301_L1.1750.94
178_E181_L1.1740.94
346_G349_S1.1720.94
175_A187_L1.1710.94
342_K374_V1.1630.94
172_V211_S1.1600.94
152_A155_V1.1460.93
165_G170_D1.1420.93
102_V187_L1.1400.93
25_D29_D1.1380.93
9_L12_T1.1360.93
152_A158_D1.1360.93
174_A177_K1.1310.93
334_F338_L1.1280.93
317_E321_S1.1260.92
31_L55_V1.1170.92
31_L52_I1.1160.92
95_L130_K1.1160.92
26_N74_F1.1150.92
122_K125_R1.1120.92
216_E243_T1.1070.92
170_D173_N1.1050.92
58_K63_E1.1050.92
104_L205_I1.0980.92
11_R15_N1.0960.91
199_E203_D1.0930.91
318_K321_S1.0900.91
133_L158_D1.0850.91
335_L377_E1.0850.91
8_R40_E1.0830.91
396_G410_V1.0800.91
392_E421_D1.0800.91
335_L339_R1.0790.91
173_N177_K1.0740.91
122_K279_T1.0700.90
15_N29_D1.0540.90
196_H232_T1.0510.90
176_L212_I1.0430.89
122_K282_L1.0370.89
360_I363_N1.0260.88
358_G362_D1.0250.88
339_R342_K1.0230.88
207_Q211_S1.0200.88
166_Q170_D1.0140.88
105_M246_V1.0050.87
122_K155_V1.0030.87
111_A117_V1.0020.87
104_L189_V1.0010.87
228_D232_T1.0000.87
136_S162_S0.9990.87
140_Y204_E0.9970.87
379_I408_M0.9960.87
116_S282_L0.9860.86
31_L74_F0.9860.86
199_E239_A0.9850.86
93_L218_L0.9830.86
259_A270_I0.9820.86
24_E60_V0.9810.86
406_C409_Q0.9790.86
288_D301_L0.9790.86
286_H289_R0.9780.86
150_T153_E0.9770.86
158_D178_E0.9720.86
385_M389_A0.9600.85
214_P217_T0.9590.85
127_K309_S0.9590.85
95_L101_A0.9530.84
371_K375_R0.9530.84
324_K431_K0.9530.84
54_R264_H0.9510.84
392_E424_Q0.9470.84
172_V176_L0.9440.84
241_P268_K0.9410.84
223_A250_V0.9330.83
331_L393_I0.9310.83
136_S145_I0.9310.83
97_A215_V0.9290.83
358_G364_V0.9290.83
372_V419_Q0.9280.83
163_D166_Q0.9280.83
103_V186_V0.9280.83
94_N215_V0.9270.83
379_I403_A0.9160.82
62_H66_K0.9150.82
32_R36_M0.9100.82
201_M205_I0.9080.81
25_D28_K0.9070.81
14_R19_R0.9030.81
346_G350_L0.9020.81
102_V215_V0.8940.80
54_R57_E0.8910.80
338_L423_M0.8880.80
169_V176_L0.8880.80
357_M360_I0.8840.80
23_T26_N0.8840.80
93_L103_V0.8840.80
422_D425_R0.8820.80
125_R155_V0.8810.79
347_M350_L0.8790.79
162_S166_Q0.8790.79
135_V189_V0.8770.79
59_A77_I0.8750.79
289_R302_S0.8740.79
90_N286_H0.8700.79
209_H242_L0.8680.78
130_K185_D0.8670.78
433_G436_A0.8650.78
232_T235_A0.8630.78
125_R153_E0.8620.78
334_F376_M0.8610.78
234_K237_N0.8520.77
30_T74_F0.8510.77
22_L74_F0.8490.77
98_Q101_A0.8470.77
145_I163_D0.8460.77
368_M374_V0.8440.77
250_V275_V0.8430.76
230_A265_I0.8360.76
140_Y168_P0.8340.76
369_D372_V0.8340.76
306_D309_S0.8320.75
291_A294_I0.8290.75
176_L180_K0.8280.75
149_E159_F0.8230.75
123_F284_P0.8230.75
399_K414_N0.8210.75
105_M116_S0.8210.75
27_V74_F0.8180.74
311_V316_A0.8170.74
80_N301_L0.8160.74
105_M274_G0.8160.74
408_M411_Q0.8100.74
22_L27_V0.8100.74
288_D292_S0.8090.73
146_K163_D0.8080.73
235_A238_E0.8080.73
245_V262_I0.8080.73
218_L271_K0.8040.73
304_I308_E0.8030.73
88_E263_R0.8020.73
21_R63_E0.8020.73
121_G155_V0.8000.73
321_S325_K0.7970.72
169_V212_I0.7950.72
348_A363_N0.7950.72
237_N242_L0.7940.72
319_L323_L0.7920.72
137_A189_V0.7920.72
87_G287_P0.7890.72
331_L420_F0.7880.71
104_L217_T0.7850.71
69_T72_Q0.7820.71
176_L211_S0.7800.71
146_K164_V0.7800.71
76_K308_E0.7790.71
136_S161_P0.7790.71
314_A317_E0.7770.70
374_V381_N0.7740.70
72_Q300_V0.7730.70
320_A323_L0.7730.70
166_Q174_A0.7720.70
372_V375_R0.7700.70
315_Q343_N0.7680.69
34_V74_F0.7680.69
118_G155_V0.7650.69
118_G154_Q0.7630.69
145_I162_S0.7620.69
34_V75_V0.7610.69
124_L128_H0.7600.69
149_E163_D0.7590.69
133_L187_L0.7550.68
207_Q210_A0.7540.68
132_V215_V0.7530.68
334_F426_M0.7510.68
342_K370_D0.7510.68
434_G437_K0.7500.68
14_R17_S0.7490.68
13_L22_L0.7460.67
390_K393_I0.7450.67
169_V172_V0.7440.67
221_V247_L0.7430.67
326_G424_Q0.7420.67
219_F245_V0.7410.67
360_I364_V0.7400.67
61_G64_V0.7400.67
210_A213_N0.7360.66
133_L182_K0.7360.66
26_N29_D0.7310.66
386_K389_A0.7300.66
11_R14_R0.7260.65
35_R48_V0.7260.65
412_D415_R0.7230.65
415_R419_Q0.7220.65
154_Q281_A0.7210.65
352_G361_P0.7210.65
270_I273_L0.7200.64
424_Q428_K0.7190.64
374_V377_E0.7190.64
359_Q362_D0.7190.64
41_A255_R0.7170.64
425_R429_K0.7160.64
380_I388_R0.7140.64
139_V204_E0.7130.64
305_E308_E0.7100.63
351_M354_L0.7080.63
31_L34_V0.7080.63
71_G75_V0.7050.63
136_S159_F0.7040.63
146_K150_T0.7040.63
421_D424_Q0.7040.63
300_V304_I0.7000.62
242_L274_G0.6980.62
72_Q297_M0.6980.62
151_L154_Q0.6940.62
111_A223_A0.6940.62
348_A367_Q0.6880.61
109_Q195_L0.6870.61
382_S405_G0.6860.61
65_N304_I0.6860.61
340_Q344_M0.6850.61
188_L282_L0.6850.61
322_K330_D0.6830.60
369_D375_R0.6820.60
27_V31_L0.6820.60
321_S324_K0.6800.60
205_I217_T0.6800.60
406_C411_Q0.6790.60
92_T128_H0.6750.60
395_K399_K0.6710.59
318_K330_D0.6710.59
221_V391_P0.6710.59
152_A157_V0.6680.59
106_A157_V0.6640.58
419_Q423_M0.6610.58
189_V208_V0.6610.58
219_F232_T0.6610.58
350_L354_L0.6600.58
161_P164_V0.6550.57
49_R53_N0.6540.57
146_K153_E0.6530.57
65_N80_N0.6520.57
136_S335_L0.6520.57
134_V158_D0.6500.57
202_M228_D0.6500.57
435_M439_M0.6490.57
132_V185_D0.6480.56
357_M362_D0.6470.56
200_A203_D0.6460.56
160_F178_E0.6450.56
13_L20_G0.6450.56
306_D310_K0.6420.56
56_K60_V0.6420.56
22_L30_T0.6410.56
139_V162_S0.6410.56
338_L373_L0.6410.56
172_V189_V0.6410.56
18_G23_T0.6390.55
85_A243_T0.6390.55
243_T268_K0.6380.55
372_V412_D0.6380.55
164_V167_K0.6370.55
101_A130_K0.6370.55
332_N381_N0.6360.55
417_L420_F0.6350.55
272_F284_P0.6340.55
80_N304_I0.6340.55
372_V423_M0.6320.55
94_N101_A0.6310.54
434_G439_M0.6290.54
419_Q422_D0.6290.54
326_G431_K0.6290.54
393_I417_L0.6280.54
286_H305_E0.6250.54
155_V159_F0.6220.53
106_A217_T0.6220.53
65_N73_E0.6220.53
116_S275_V0.6210.53
34_V86_M0.6200.53
306_D409_Q0.6200.53
275_V283_E0.6180.53
396_G400_R0.6170.53
306_D349_S0.6170.53
401_R405_G0.6160.53
75_V301_L0.6160.53
274_G400_R0.6150.53
213_N243_T0.6140.52
199_E386_K0.6140.52
32_R49_R0.6130.52
346_G354_L0.6120.52
334_F424_Q0.6120.52
134_V148_L0.6110.52
161_P166_Q0.6110.52
344_M350_L0.6100.52
8_R35_R0.6090.52
92_T127_K0.6070.52
13_L71_G0.6060.52
319_L322_K0.6050.51
322_K333_D0.6050.51
421_D425_R0.6050.51
13_L30_T0.6030.51
2_F325_K0.5990.51
202_M224_M0.5990.51
115_T274_G0.5980.51
241_P358_G0.5980.51
298_G355_P0.5970.50
26_N304_I0.5970.50
162_S171_I0.5960.50
62_H314_A0.5950.50
124_L271_K0.5940.50
275_V306_D0.5940.50
162_S170_D0.5940.50
7_D11_R0.5930.50
169_V245_V0.5910.50
27_V30_T0.5900.50
205_I235_A0.5900.50
163_D249_K0.5900.50
334_F349_S0.5870.49
308_E311_V0.5870.49
167_K175_A0.5870.49
162_S165_G0.5870.49
65_N68_L0.5860.49
36_M39_L0.5850.49
136_S215_V0.5850.49
196_H205_I0.5840.49
360_I366_S0.5820.49
4_N7_D0.5810.49
332_N335_L0.5810.49
378_A408_M0.5810.49
77_I312_D0.5810.49
139_V145_I0.5800.48
222_D249_K0.5800.48
346_G352_G0.5800.48
54_R350_L0.5790.48
145_I249_K0.5790.48
62_H77_I0.5790.48
187_L212_I0.5780.48
420_F427_M0.5780.48
149_E152_A0.5770.48
205_I232_T0.5760.48
283_E290_I0.5760.48
55_V59_A0.5750.48
433_G437_K0.5740.48
125_R154_Q0.5740.48
8_R13_L0.5730.48
224_M253_D0.5730.48
10_S359_Q0.5730.48
245_V268_K0.5720.48
55_V78_V0.5720.48
351_M357_M0.5720.48
225_T229_A0.5710.47
327_D392_E0.5690.47
140_Y201_M0.5690.47
105_M120_L0.5690.47
116_S242_L0.5680.47
45_L49_R0.5680.47
410_V414_N0.5680.47
102_V180_K0.5660.47
26_N71_G0.5660.47
136_S152_A0.5650.47
105_M188_L0.5650.47
218_L406_C0.5640.47
334_F377_E0.5630.46
331_L380_I0.5630.46
14_R26_N0.5620.46
96_A100_P0.5610.46
301_L308_E0.5610.46
104_L424_Q0.5600.46
91_Q263_R0.5600.46
12_T15_N0.5600.46
372_V376_M0.5590.46
341_M354_L0.5590.46
372_V415_R0.5580.46
255_R291_A0.5580.46
181_L238_E0.5580.46
155_V158_D0.5580.46
366_S369_D0.5570.46
15_N20_G0.5570.46
26_N34_V0.5570.46
237_N240_L0.5570.46
208_V211_S0.5570.46
122_K154_Q0.5560.46
68_L72_Q0.5540.45
337_Q341_M0.5540.45
2_F6_T0.5540.45
101_A136_S0.5530.45
348_A352_G0.5530.45
137_A381_N0.5530.45
219_F242_L0.5490.45
311_V349_S0.5480.45
368_M372_V0.5480.45
109_Q202_M0.5480.45
168_P208_V0.5470.45
37_A259_A0.5470.45
76_K225_T0.5460.44
195_L228_D0.5450.44
55_V322_K0.5450.44
69_T296_G0.5450.44
375_R424_Q0.5430.44
386_K413_V0.5430.44
281_A284_P0.5430.44
197_V202_M0.5430.44
346_G376_M0.5430.44
400_R411_Q0.5430.44
86_M290_I0.5420.44
203_D210_A0.5420.44
237_N262_I0.5420.44
136_S290_I0.5400.44
88_E91_Q0.5400.44
64_V77_I0.5390.44
68_L151_L0.5380.44
169_V173_N0.5370.43
38_L48_V0.5370.43
39_L55_V0.5360.43
49_R54_R0.5350.43
272_F406_C0.5330.43
68_L73_E0.5330.43
189_V211_S0.5310.43
145_I168_P0.5290.43
98_Q215_V0.5290.43
201_M274_G0.5290.43
98_Q180_K0.5280.42
302_S305_E0.5280.42
29_D62_H0.5280.42
369_D378_A0.5280.42
198_D202_M0.5280.42
341_M376_M0.5270.42
205_I234_K0.5270.42
123_F128_H0.5260.42
22_L26_N0.5260.42
187_L267_G0.5260.42
424_Q431_K0.5260.42
136_S166_Q0.5260.42
154_Q278_K0.5250.42
180_K348_A0.5250.42
347_M363_N0.5250.42
318_K322_K0.5250.42
263_R267_G0.5240.42
116_S266_T0.5240.42
131_K183_F0.5240.42
191_T297_M0.5230.42
410_V428_K0.5230.42
134_V212_I0.5230.42
180_K203_D0.5220.42
325_K428_K0.5210.42
331_L410_V0.5210.42
75_V304_I0.5210.42
22_L64_V0.5200.41
137_A175_A0.5200.41
67_S266_T0.5190.41
210_A385_M0.5190.41
39_L45_L0.5190.41
96_A223_A0.5190.41
34_V274_G0.5180.41
173_N406_C0.5180.41
80_N308_E0.5170.41
53_N105_M0.5170.41
357_M361_P0.5170.41
176_L208_V0.5170.41
28_K237_N0.5160.41
75_V297_M0.5150.41
223_A369_D0.5150.41
145_I161_P0.5150.41
86_M105_M0.5140.41
22_L78_V0.5140.41
91_Q94_N0.5140.41
177_K210_A0.5130.41
109_Q224_M0.5120.41
34_V55_V0.5110.40
219_F258_A0.5100.40
65_N69_T0.5100.40
154_Q279_T0.5080.40
17_S123_F0.5070.40
64_V67_S0.5070.40
205_I274_G0.5070.40
11_R63_E0.5060.40
17_S359_Q0.5050.40
54_R58_K0.5050.40
111_A343_N0.5050.40
36_M40_E0.5040.40
19_R58_K0.5040.40
256_G266_T0.5040.40
392_E395_K0.5030.40
17_S187_L0.5030.40
86_M223_A0.5030.40
311_V315_Q0.5010.39
165_G174_A0.5010.39
180_K215_V0.5000.39
4_N334_F0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ffhA 4 0.8985 100 0.388 Contact Map
2v3cC 1 0.8852 100 0.397 Contact Map
2xxaA 1 0.9095 100 0.398 Contact Map
2j37W 1 0.9691 100 0.414 Contact Map
3dm5A 4 0.9139 100 0.444 Contact Map
3kl4A 1 0.8985 100 0.45 Contact Map
4c7oA 1 0.6534 100 0.618 Contact Map
1ls1A 1 0.638 100 0.631 Contact Map
2yhsA 1 0.6446 100 0.657 Contact Map
2og2A 1 0.6203 100 0.663 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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