GREMLIN Database
SODF - Superoxide dismutase [Fe]
UniProt: P0AGD3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10954
Length: 193 (189)
Sequences: 4168 (2333)
Seq/√Len: 169.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q37_T4.0311.00
170_A173_G2.8911.00
106_D109_A2.5291.00
94_A98_A2.5141.00
186_F189_K2.4941.00
129_N135_A2.4181.00
22_E168_R2.3641.00
115_A124_T2.3341.00
38_N41_N2.3191.00
21_A25_E2.3181.00
93_V188_A2.2691.00
186_F190_N2.2301.00
156_V175_L2.1801.00
18_H180_A2.0771.00
109_A113_D2.0481.00
95_E98_A2.0051.00
81_L178_F1.9241.00
118_N138_S1.9111.00
100_S133_K1.9081.00
112_T176_E1.8671.00
106_D110_Q1.8571.00
20_S166_D1.8491.00
12_K29_G1.8441.00
79_N186_F1.8291.00
19_I77_Y1.8231.00
173_G176_E1.8141.00
96_A99_A1.7891.00
115_A156_V1.7771.00
36_V71_V1.7611.00
96_A191_L1.7021.00
115_A175_L1.6771.00
113_D117_K1.6681.00
154_L187_V1.6671.00
4_E7_A1.6231.00
110_Q113_D1.6141.00
127_V137_V1.6111.00
13_D21_A1.6061.00
41_N44_K1.5801.00
39_L68_A1.5741.00
37_T41_N1.5311.00
96_A100_S1.5281.00
6_P75_T1.5241.00
107_F111_F1.4961.00
51_K59_S1.4801.00
165_I168_R1.4431.00
80_C187_V1.4131.00
71_V75_T1.3941.00
32_H78_W1.3891.00
112_T116_I1.3861.00
156_V178_F1.3771.00
116_I172_P1.3741.00
116_I175_L1.3601.00
167_Y177_H1.3341.00
128_K191_L1.3311.00
82_A85_A1.3301.00
24_I77_Y1.3071.00
45_G49_E1.3071.00
22_E25_E1.3021.00
92_K95_E1.2901.00
43_I46_T1.2801.00
125_W139_T1.2731.00
127_V135_A1.2651.00
52_S55_E1.2631.00
112_T175_L1.2591.00
124_T138_S1.2561.00
11_A14_A1.2421.00
25_E29_G1.2331.00
88_E105_A1.2151.00
182_V187_V1.2111.00
26_Y168_R1.2071.00
112_T179_W1.2021.00
80_C186_F1.2021.00
38_N67_N1.1921.00
5_L28_Y1.1911.00
129_N150_A1.1811.00
79_N190_N1.1791.00
39_L64_V1.1771.00
118_N124_T1.1731.00
135_A150_A1.1681.00
12_K25_E1.1461.00
185_E188_A1.1391.00
153_L187_V1.1371.00
114_A136_I1.1191.00
111_F156_V1.1171.00
72_W76_F1.1161.00
179_W182_V1.1111.00
158_V171_R1.0951.00
104_F107_F1.0891.00
114_A124_T1.0881.00
12_K28_Y1.0781.00
3_F39_L1.0761.00
69_A142_A1.0741.00
72_W144_T1.0721.00
183_N186_F1.0691.00
9_P79_N1.0570.99
109_A176_E1.0570.99
90_T188_A1.0550.99
77_Y174_Y1.0530.99
34_T38_N1.0520.99
163_Y171_R1.0500.99
46_T49_E1.0480.99
75_T79_N1.0460.99
103_S106_D1.0400.99
31_H164_Y1.0320.99
97_I107_F1.0220.99
80_C190_N1.0210.99
3_F43_I1.0200.99
95_E99_A1.0160.99
65_F143_G0.9910.99
178_F182_V0.9800.99
107_F136_I0.9740.99
20_S23_T0.9670.99
92_K188_A0.9640.99
76_F186_F0.9630.99
111_F178_F0.9620.99
177_H180_A0.9480.99
32_H75_T0.9450.99
113_D116_I0.9420.99
127_V150_A0.9350.99
23_T166_D0.9340.99
82_A86_G0.9340.99
105_A108_K0.9280.99
154_L182_V0.9260.99
114_A138_S0.9200.99
185_E189_K0.9070.98
137_V150_A0.9060.98
173_G177_H0.8890.98
47_A51_K0.8850.98
36_V40_N0.8840.98
88_E98_A0.8800.98
22_E166_D0.8780.98
70_Q142_A0.8720.98
97_I104_F0.8710.98
88_E94_A0.8670.98
66_N119_F0.8620.98
48_F51_K0.8570.98
12_K21_A0.8530.98
81_L181_L0.8520.98
93_V191_L0.8510.98
77_Y156_V0.8480.98
104_F108_K0.8440.97
110_Q114_A0.8410.97
91_G95_E0.8340.97
13_D16_A0.8100.97
100_S134_L0.8080.97
72_W146_L0.8080.97
53_L72_W0.8080.97
118_N140_S0.8040.97
10_Y81_L0.8030.97
128_K132_G0.8030.97
129_N133_K0.8030.97
3_F56_I0.8030.97
96_A128_K0.7980.96
93_V97_I0.7950.96
93_V187_V0.7880.96
30_K170_A0.7870.96
29_G33_Q0.7860.96
22_E26_Y0.7850.96
34_T37_T0.7820.96
6_P32_H0.7790.96
82_A185_E0.7670.96
71_V78_W0.7660.96
44_K49_E0.7610.95
51_K55_E0.7530.95
124_T156_V0.7510.95
89_P104_F0.7460.95
12_K24_I0.7430.95
30_K33_Q0.7290.94
128_K153_L0.7280.94
99_A133_K0.7250.94
128_K151_T0.7250.94
16_A21_A0.7140.94
74_H157_D0.7120.93
89_P94_A0.7110.93
82_A183_N0.7070.93
32_H71_V0.7070.93
108_K176_E0.6910.92
108_K112_T0.6910.92
108_K180_A0.6890.92
62_G65_F0.6870.92
18_H177_H0.6830.92
88_E108_K0.6820.92
101_F110_Q0.6810.92
105_A109_A0.6780.92
82_A87_G0.6770.92
19_I24_I0.6770.92
73_N125_W0.6770.92
48_F53_L0.6760.92
184_W187_V0.6750.92
27_H74_H0.6740.92
5_L32_H0.6740.92
7_A11_A0.6690.91
33_Q36_V0.6680.91
125_W155_T0.6660.91
41_N45_G0.6640.91
34_T116_I0.6500.90
155_T174_Y0.6500.90
39_L53_L0.6490.90
24_I174_Y0.6450.90
94_A104_F0.6440.90
19_I174_Y0.6440.90
108_K179_W0.6410.89
76_F190_N0.6400.89
121_S141_N0.6400.89
137_V148_T0.6390.89
98_A103_S0.6360.89
90_T185_E0.6280.88
38_N63_G0.6270.88
90_T94_A0.6260.88
137_V147_T0.6260.88
30_K169_N0.6250.88
142_A155_T0.6230.88
91_G94_A0.6220.88
48_F61_E0.6210.88
45_G56_I0.6210.88
167_Y173_G0.6200.88
84_N87_G0.6140.87
27_H157_D0.6130.87
55_E59_S0.6120.87
35_Y70_Q0.6110.87
126_L134_L0.6070.87
118_N136_I0.6050.86
18_H181_L0.6030.86
5_L33_Q0.6030.86
55_E58_R0.5990.86
60_S147_T0.5990.86
36_V75_T0.5970.86
19_I81_L0.5960.86
144_T147_T0.5960.86
9_P183_N0.5960.86
65_F142_A0.5950.86
101_F134_L0.5900.85
74_H161_H0.5890.85
157_D161_H0.5870.85
143_G148_T0.5860.85
110_Q136_I0.5840.85
31_H169_N0.5840.85
175_L179_W0.5840.85
124_T158_V0.5840.85
122_G158_V0.5780.84
56_I59_S0.5760.84
54_E72_W0.5750.84
117_K138_S0.5720.83
92_K191_L0.5720.83
53_L60_S0.5690.83
114_A118_N0.5680.83
164_Y169_N0.5680.83
18_H178_F0.5670.83
69_A73_N0.5630.82
39_L43_I0.5620.82
147_T150_A0.5620.82
26_Y29_G0.5620.82
65_F70_Q0.5610.82
172_P176_E0.5610.82
115_A158_V0.5610.82
73_N142_A0.5580.82
90_T104_F0.5510.81
18_H166_D0.5490.81
80_C153_L0.5490.81
7_A29_G0.5480.81
16_A22_E0.5470.81
91_G188_A0.5470.81
20_S26_Y0.5450.80
27_H161_H0.5440.80
111_F136_I0.5400.80
42_L64_V0.5380.79
90_T93_V0.5370.79
104_F179_W0.5300.78
100_S135_A0.5290.78
26_Y165_I0.5280.78
118_N141_N0.5270.78
91_G104_F0.5270.78
89_P188_A0.5260.78
166_D181_L0.5210.77
71_V77_Y0.5210.77
100_S191_L0.5180.77
157_D160_E0.5160.77
26_Y30_K0.5160.77
5_L36_V0.5150.76
60_S65_F0.5090.76
19_I23_T0.5060.75
22_E165_I0.5040.75
128_K133_K0.5020.75
54_E58_R0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqjA 2 0.9948 100 -0.012 Contact Map
1mngA 3 0.9741 100 -0.012 Contact Map
1gv3A 2 1 100 -0.01 Contact Map
1uerA 2 0.9896 100 -0.01 Contact Map
2awpA 2 1 100 -0.01 Contact Map
4yetA 2 1 100 -0.01 Contact Map
2cw2A 2 0.9948 100 -0.008 Contact Map
2rcvA 2 0.9896 100 -0.007 Contact Map
5a9gA 2 1 100 -0.006 Contact Map
2nybA 2 0.9948 100 -0.003 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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