GREMLIN Database
SODC - Superoxide dismutase [Cu-Zn]
UniProt: P0AGD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13419
Length: 173 (141)
Sequences: 2330 (1543)
Seq/√Len: 129.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_N123_K3.0521.00
54_P126_D2.9981.00
148_V165_E2.9701.00
63_E117_V2.9111.00
55_D125_T2.8761.00
43_I144_L2.6661.00
41_V54_P2.4341.00
60_P167_Y2.2961.00
135_S138_E2.2901.00
98_T107_A2.2821.00
63_E150_G2.2071.00
51_E127_A2.1541.00
50_L134_K2.1381.00
62_G118_V2.0451.00
154_S157_P1.8591.00
139_I142_K1.8561.00
155_D160_L1.8111.00
89_A143_A1.7611.00
156_Q162_G1.7521.00
67_H92_H1.6951.00
43_I52_F1.6901.00
64_H118_V1.6851.00
115_A153_M1.6621.00
72_G171_V1.6491.00
41_V144_L1.6311.00
138_E142_K1.5921.00
51_E129_I1.5731.00
43_I139_I1.5681.00
73_S88_S1.5621.00
92_H109_H1.5411.00
57_K123_K1.5271.00
154_S162_G1.5191.00
44_T53_S1.5091.00
102_E153_M1.4641.00
74_C143_A1.4601.00
53_S127_A1.4521.00
75_Q88_S1.4071.00
113_L130_A1.4061.00
54_P127_A1.4011.00
68_I172_I1.3811.00
118_V124_A1.3461.00
93_L110_L1.3431.00
74_C169_C1.2911.00
65_G163_G1.2631.00
108_G130_A1.2631.00
68_I144_L1.2521.00
99_G107_A1.2451.00
56_L116_L1.2321.00
70_A91_G1.2241.00
59_L124_A1.2090.99
50_L133_L1.1910.99
76_P87_E1.1870.99
95_P110_L1.1830.99
86_A169_C1.1540.99
61_P122_G1.1490.99
45_E50_L1.1450.99
60_P64_H1.1370.99
52_F128_V1.1340.99
24_V28_L1.1320.99
49_G129_I1.1290.99
94_D98_T1.0910.99
89_A166_R1.0900.99
65_G116_L1.0840.99
61_P120_N1.0840.99
101_H105_E1.0840.99
68_I133_L1.0760.99
69_H92_H1.0760.99
54_P66_F1.0630.99
41_V52_F1.0540.99
43_I172_I1.0460.98
160_L163_G1.0440.98
100_K109_H1.0400.98
93_L142_K1.0320.98
93_L135_S1.0260.98
54_P124_A1.0230.98
38_I58_A0.9950.98
56_L124_A0.9940.98
152_N155_D0.9910.98
38_I168_A0.9840.98
41_V126_D0.9660.97
102_E105_E0.9570.97
130_A133_L0.9510.97
59_L146_V0.9490.97
72_G143_A0.9440.97
67_H147_H0.9400.97
46_T51_E0.9360.97
77_A87_E0.9320.97
101_H108_G0.9310.97
26_M170_G0.9140.96
115_A152_N0.9130.96
26_M30_T0.9040.96
93_L138_E0.9030.96
151_D161_G0.9000.96
69_H147_H0.8940.96
32_Q38_I0.8940.96
113_L133_L0.8890.96
96_Q110_L0.8880.96
100_K103_G0.8860.96
40_S55_D0.8750.95
152_N161_G0.8690.95
161_G164_G0.8680.95
149_G162_G0.8660.95
152_N162_G0.8530.95
86_A157_P0.8480.95
101_H104_P0.8420.94
74_C89_A0.8370.94
149_G167_Y0.8230.94
96_Q148_V0.8200.94
147_H166_R0.8190.94
77_A88_S0.8140.93
39_G56_L0.8080.93
71_K90_G0.7900.92
71_K143_A0.7880.92
116_L124_A0.7760.92
166_R169_C0.7730.91
160_L165_E0.7720.91
155_D163_G0.7710.91
94_D97_N0.7710.91
109_H151_D0.7700.91
86_A145_M0.7690.91
147_H163_G0.7640.91
89_A145_M0.7540.90
25_E29_V0.7510.90
71_K142_K0.7400.90
26_M32_Q0.7380.89
114_P153_M0.7380.89
153_M156_Q0.7340.89
53_S125_T0.7340.89
110_L132_R0.7260.89
151_D164_G0.7170.88
76_P86_A0.7160.88
148_V167_Y0.7120.88
70_A97_N0.7110.88
92_H147_H0.7010.87
58_A122_G0.6910.86
45_E48_K0.6900.86
69_H166_R0.6880.86
66_F116_L0.6870.86
134_K138_E0.6850.86
67_H166_R0.6840.86
100_K104_P0.6760.85
60_P118_V0.6640.84
100_K105_E0.6610.84
100_K152_N0.6580.83
126_D153_M0.6510.83
38_I57_K0.6450.82
62_G117_V0.6410.82
135_S139_I0.6350.81
70_A143_A0.6290.81
33_G36_Q0.6270.80
66_F124_A0.6260.80
157_P161_G0.6250.80
30_T33_G0.6250.80
93_L137_D0.6240.80
100_K161_G0.6240.80
72_G141_D0.6240.80
152_N156_Q0.6210.80
67_H109_H0.6190.80
152_N164_G0.6170.79
68_I130_A0.6140.79
56_L146_V0.6140.79
94_D100_K0.6120.79
30_T56_L0.6110.79
48_K120_N0.6080.78
42_T123_K0.6070.78
59_L62_G0.6020.78
28_L170_G0.5980.77
44_T51_E0.5980.77
64_H167_Y0.5940.77
63_E153_M0.5930.77
113_L116_L0.5900.76
108_G132_R0.5870.76
137_D142_K0.5800.75
29_V34_V0.5790.75
96_Q137_D0.5770.75
135_S140_K0.5720.74
61_P121_D0.5720.74
46_T129_I0.5650.73
54_P128_V0.5640.73
109_H114_P0.5630.73
74_C157_P0.5610.73
24_V27_N0.5600.72
94_D101_H0.5580.72
26_M51_E0.5560.72
101_H161_G0.5500.71
109_H161_G0.5490.71
70_A156_Q0.5430.70
119_N125_T0.5420.70
61_P118_V0.5420.70
53_S126_D0.5380.69
28_L34_V0.5370.69
110_L130_A0.5350.69
53_S57_K0.5340.69
50_L135_S0.5330.69
109_H164_G0.5330.69
104_P107_A0.5290.68
74_C171_V0.5240.67
23_K123_K0.5220.67
144_L170_G0.5210.67
28_L31_S0.5190.67
95_P98_T0.5190.67
76_P88_S0.5180.67
47_D129_I0.5180.67
64_H150_G0.5150.66
30_T168_A0.5120.66
66_F147_H0.5110.66
30_T34_V0.5090.65
95_P109_H0.5080.65
27_N30_T0.5060.65
94_D99_G0.5060.65
109_H160_L0.5050.65
91_G147_H0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z9nA 2 0.8902 100 0.143 Contact Map
4l05A 1 0.8844 100 0.187 Contact Map
2aqpA 3 0.8902 100 0.189 Contact Map
1eqwA 2 0.8902 100 0.193 Contact Map
1esoA 1 0.8844 100 0.197 Contact Map
1oalA 1 0.8671 100 0.201 Contact Map
3pu7A 2 0.8266 100 0.234 Contact Map
3f7lA 2 0.8208 100 0.234 Contact Map
2e47A 2 0.8439 100 0.235 Contact Map
2q2lA 1 0.8092 100 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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