GREMLIN Database
SMP - Protein Smp
UniProt: P0AGC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10951
Length: 214 (188)
Sequences: 220 (129)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A144_L3.8730.98
89_D93_Y3.2490.94
10_L19_C3.0060.92
168_M183_L2.3890.78
39_R185_Q2.3860.78
12_R167_L2.3390.77
89_D127_Q2.2530.74
15_I19_C2.2170.73
126_Q131_P2.0900.68
74_I100_I2.0310.66
27_M142_L1.9900.64
52_L113_L1.9650.63
29_G33_F1.9560.63
12_R177_V1.9460.62
91_G98_D1.9130.61
131_P141_Y1.9040.61
90_A179_L1.8990.60
55_Q128_I1.8940.60
169_L177_V1.8890.60
60_V77_I1.8430.58
13_A105_E1.8200.57
70_D92_V1.7720.55
11_H15_I1.7290.53
97_G140_G1.7220.53
89_D145_T1.7090.52
13_A17_L1.6980.52
44_Q52_L1.6830.51
67_D180_T1.6700.50
61_A133_A1.6680.50
110_R113_L1.6590.50
57_T174_A1.5900.47
15_I127_Q1.5840.46
81_L143_R1.5790.46
37_H64_M1.5650.46
34_S155_A1.5590.45
44_Q89_D1.5560.45
99_L102_R1.5500.45
12_R187_K1.5430.45
89_D143_R1.5160.43
25_A66_T1.4870.42
57_T61_A1.4810.42
144_L171_L1.4710.42
52_L87_I1.4670.41
124_F147_D1.4660.41
45_L144_L1.4500.41
13_A20_L1.4440.40
129_V170_L1.4430.40
38_Q116_D1.4360.40
190_R193_Q1.4260.40
14_V73_R1.4180.39
141_Y180_T1.4170.39
60_V74_I1.3990.38
174_A189_T1.3970.38
71_E98_D1.3960.38
186_G190_R1.3870.38
100_I135_K1.3720.37
90_A103_S1.3710.37
21_A24_V1.3640.37
90_A145_T1.3590.37
79_D84_E1.3430.36
20_L83_D1.3360.36
113_L116_D1.3330.36
15_I141_Y1.3320.36
177_V180_T1.3310.36
22_L49_A1.3150.35
16_V21_A1.3090.35
87_I108_E1.2900.34
83_D90_A1.2790.34
26_L172_S1.2660.33
16_V25_A1.2640.33
52_L101_A1.2510.32
108_E183_L1.2390.32
53_A57_T1.2160.31
133_A139_L1.2070.31
60_V78_L1.1870.30
117_G193_Q1.1800.30
50_R130_E1.1730.29
175_I183_L1.1720.29
100_I138_P1.1650.29
74_I144_L1.1540.29
36_N164_I1.1530.29
64_M130_E1.1480.29
120_A170_L1.1480.29
119_K141_Y1.1430.28
102_R155_A1.1360.28
72_K118_K1.1310.28
21_A92_V1.1260.28
17_L21_A1.1220.28
61_A134_G1.1090.27
25_A79_D1.1050.27
146_L181_R1.1010.27
57_T144_L1.0930.27
7_K106_S1.0820.26
132_I164_I1.0760.26
33_F38_Q1.0490.25
10_L83_D1.0400.25
192_Q195_P1.0350.25
76_A104_G1.0350.25
23_L142_L1.0340.25
127_Q131_P1.0260.24
130_E137_G1.0220.24
167_L177_V1.0220.24
146_L163_N1.0040.24
115_L164_I1.0030.24
72_K87_I1.0030.24
60_V159_D0.9920.23
13_A23_L0.9870.23
130_E169_L0.9870.23
19_C29_G0.9820.23
39_R167_L0.9700.23
188_R191_W0.9580.22
65_R83_D0.9450.22
130_E144_L0.9420.22
110_R114_A0.9410.22
52_L84_E0.9390.22
54_R57_T0.9380.22
120_A128_I0.9310.21
81_L91_G0.9280.21
49_A181_R0.9200.21
110_R115_L0.9180.21
100_I136_N0.9140.21
157_Q171_L0.9120.21
50_R155_A0.9070.21
82_T93_Y0.9070.21
59_N80_Q0.9010.20
29_G165_L0.8980.20
18_F65_R0.8970.20
36_N41_R0.8960.20
75_Q137_G0.8890.20
55_Q90_A0.8870.20
61_A181_R0.8860.20
144_L180_T0.8840.20
92_V110_R0.8700.20
66_T100_I0.8680.20
122_G141_Y0.8630.19
37_H87_I0.8570.19
54_R130_E0.8560.19
40_Q61_A0.8550.19
40_Q184_L0.8530.19
81_L85_S0.8460.19
139_L169_L0.8440.19
146_L166_R0.8400.19
39_R132_I0.8390.19
71_E100_I0.8380.19
146_L176_G0.8200.18
73_R139_L0.8150.18
92_V128_I0.8030.18
146_L177_V0.8010.18
165_L172_S0.8000.18
75_Q100_I0.8000.18
91_G99_L0.7990.18
91_G144_L0.7970.18
89_D103_S0.7960.18
49_A168_M0.7950.18
14_V85_S0.7950.18
53_A180_T0.7820.17
67_D83_D0.7820.17
73_R138_P0.7800.17
94_D98_D0.7800.17
94_D149_H0.7700.17
94_D108_E0.7690.17
35_Q99_L0.7590.17
63_L130_E0.7560.17
48_L138_P0.7550.17
26_L64_M0.7510.16
43_P180_T0.7510.16
9_R20_L0.7470.16
19_C179_L0.7460.16
61_A65_R0.7410.16
18_F22_L0.7370.16
35_Q57_T0.7370.16
50_R102_R0.7340.16
129_V153_T0.7330.16
54_R76_A0.7260.16
26_L175_I0.7260.16
29_G78_L0.7250.16
44_Q176_G0.7240.16
36_N131_P0.7190.16
16_V170_L0.7110.16
129_V132_I0.7080.15
162_T166_R0.7050.15
20_L170_L0.6950.15
54_R63_L0.6940.15
77_I92_V0.6940.15
116_D176_G0.6850.15
14_V196_F0.6850.15
33_F40_Q0.6850.15
21_A170_L0.6840.15
96_Q141_Y0.6840.15
44_Q143_R0.6790.15
19_C30_A0.6760.15
77_I139_L0.6760.15
116_D177_V0.6720.15
79_D103_S0.6710.15
41_R60_V0.6680.15
17_L92_V0.6680.15
127_Q145_T0.6670.15
158_V162_T0.6640.14
55_Q131_P0.6620.14
146_L155_A0.6610.14
93_Y166_R0.6610.14
157_Q175_I0.6600.14
19_C33_F0.6580.14
134_G179_L0.6560.14
35_Q38_Q0.6540.14
56_V147_D0.6540.14
127_Q143_R0.6530.14
127_Q166_R0.6490.14
137_G189_T0.6490.14
93_Y164_I0.6440.14
9_R190_R0.6440.14
37_H47_E0.6440.14
125_N147_D0.6340.14
126_Q130_E0.6330.14
76_A100_I0.6300.14
167_L183_L0.6260.14
23_L167_L0.6260.14
59_N148_T0.6220.14
7_K101_A0.6220.14
132_I137_G0.6200.14
132_I156_Q0.6190.13
79_D163_N0.6190.13
179_L192_Q0.6180.13
149_H164_I0.6170.13
66_T144_L0.6160.13
117_G147_D0.6160.13
39_R67_D0.6150.13
94_D141_Y0.6140.13
39_R175_I0.6130.13
104_G112_R0.6130.13
22_L172_S0.6110.13
86_R151_L0.6070.13
43_P67_D0.6050.13
94_D196_F0.6040.13
57_T71_E0.6010.13
26_L37_H0.5930.13
90_A143_R0.5930.13
71_E75_Q0.5910.13
133_A173_L0.5880.13
62_P109_V0.5870.13
44_Q165_L0.5850.13
29_G148_T0.5830.13
26_L114_A0.5790.13
62_P65_R0.5780.13
52_L153_T0.5760.13
15_I29_G0.5750.13
182_T188_R0.5720.13
54_R84_E0.5710.13
38_Q48_L0.5710.13
30_A168_M0.5700.13
171_L184_L0.5680.12
115_L155_A0.5680.12
36_N146_L0.5610.12
64_M101_A0.5610.12
25_A183_L0.5540.12
193_Q196_F0.5530.12
78_L99_L0.5510.12
56_V77_I0.5500.12
16_V64_M0.5470.12
8_F77_I0.5460.12
192_Q196_F0.5430.12
67_D72_K0.5400.12
87_I157_Q0.5390.12
111_D161_T0.5390.12
24_V87_I0.5330.12
61_A94_D0.5310.12
107_V113_L0.5310.12
65_R129_V0.5260.12
43_P103_S0.5230.12
70_D79_D0.5230.12
42_N150_T0.5220.12
34_S167_L0.5200.12
19_C75_Q0.5190.12
12_R34_S0.5140.11
73_R80_Q0.5080.11
84_E178_V0.5070.11
42_N187_K0.5070.11
128_I135_K0.5060.11
12_R45_L0.5030.11
65_R153_T0.5030.11
62_P139_L0.5000.11
79_D128_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b47A 2 0.4907 97.4 0.875 Contact Map
3b42A 2 0.5234 97.2 0.879 Contact Map
3by8A 2 0.5607 96.9 0.884 Contact Map
1p0zA 4 0.5467 96.4 0.89 Contact Map
4onxA 3 0.5327 96.3 0.892 Contact Map
3e4oA 2 0.771 96 0.894 Contact Map
3cwfA 2 0.486 94.8 0.903 Contact Map
2kseA 1 0.3178 79.7 0.928 Contact Map
4cq4A 4 0.257 79.3 0.928 Contact Map
3by9A 1 0.7944 73.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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