GREMLIN Database
MLTF - Membrane-bound lytic murein transglycosylase F
UniProt: P0AGC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11373
Length: 518 (436)
Sequences: 854 (622)
Seq/√Len: 29.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_S102_A4.8521.00
292_K296_E4.3011.00
74_F244_A4.2431.00
44_E83_K3.9171.00
51_H55_T3.8161.00
50_I55_T3.6051.00
50_I53_P3.4171.00
233_S245_L3.3981.00
112_N159_V3.3831.00
52_T55_T3.3011.00
23_W26_I3.2971.00
395_R406_D3.2481.00
73_Q248_F3.2401.00
121_P232_F3.2031.00
307_L357_V2.9841.00
398_T403_G2.9391.00
370_S406_D2.8821.00
51_H57_N2.8191.00
192_V200_T2.7641.00
370_S392_L2.7491.00
298_Y350_E2.7001.00
47_V71_A2.6941.00
401_T414_R2.5600.99
374_N377_I2.4990.99
298_Y354_S2.4710.99
122_G249_F2.4700.99
398_T414_R2.4280.99
119_Y232_F2.3140.99
122_G246_L2.2970.99
433_R436_E2.2940.99
430_G434_G2.2700.99
53_P57_N2.2560.99
404_N407_S2.2490.99
112_N121_P2.2440.99
111_Y230_T2.1850.98
373_E377_I2.1850.98
153_T197_L2.1820.98
424_Y434_G2.1810.98
421_K424_Y2.0890.98
430_G433_R2.0760.98
233_S242_S2.0630.98
46_R85_T2.0590.97
21_A26_I2.0570.97
42_R103_D2.0490.97
52_T57_N2.0370.97
44_E81_K2.0330.97
121_P230_T2.0320.97
305_R448_Q2.0300.97
110_V115_R1.9990.97
123_P246_L1.9740.97
130_Q163_D1.9610.97
115_R159_V1.9540.97
403_G414_R1.9430.96
424_Y430_G1.9140.96
120_Q242_S1.8330.95
191_D196_K1.8160.95
154_V164_L1.8030.95
396_A400_K1.7830.94
59_I62_K1.7690.94
98_D119_Y1.7650.94
134_Y199_Y1.7590.94
420_Q424_Y1.7570.94
379_F391_M1.7390.93
110_V203_D1.7290.93
131_Q134_Y1.7280.93
160_V203_D1.7280.93
110_V159_V1.7200.93
367_V391_M1.7190.93
390_H394_A1.6860.92
368_P395_R1.6750.92
205_V266_L1.6660.92
50_I57_N1.6650.92
124_T249_F1.6540.92
115_R121_P1.6520.91
77_Y251_E1.6500.91
242_S246_L1.6500.91
434_G441_V1.6490.91
419_S424_Y1.6410.91
330_M349_A1.6310.91
418_L430_G1.6280.91
98_D118_N1.6030.90
386_M437_A1.5850.90
143_T146_N1.5770.89
69_E265_Y1.5710.89
295_F311_A1.5680.89
364_M380_A1.5590.89
112_N203_D1.5400.88
22_L26_I1.5380.88
112_N115_R1.5340.88
367_V371_V1.5330.88
21_A25_S1.5310.88
440_Y444_I1.5280.88
48_S93_L1.5250.88
123_P249_F1.5220.88
310_I360_L1.5190.88
400_K426_K1.5090.87
135_K195_G1.5060.87
353_I356_G1.5040.87
188_L197_L1.5040.87
311_A330_M1.5030.87
295_F353_I1.4810.86
133_V192_V1.4650.86
55_T58_E1.4650.86
100_G103_D1.4640.86
131_Q219_V1.4520.85
47_V402_K1.4420.85
252_M258_L1.4360.84
85_T102_A1.4280.84
122_G245_L1.4270.84
151_Q198_D1.4170.84
172_F177_W1.4120.83
173_P177_W1.4110.83
418_L424_Y1.4100.83
115_R203_D1.4100.83
372_P375_E1.3910.82
207_I219_V1.3890.82
71_A82_L1.3820.82
390_H393_D1.3760.82
130_Q134_Y1.3760.82
131_Q222_D1.3760.82
48_S87_R1.3750.82
392_L396_A1.3540.81
66_L266_L1.3390.80
134_Y248_F1.3270.79
434_G444_I1.3250.79
361_Q365_S1.3250.79
105_L375_E1.3240.79
193_I216_E1.3120.78
202_A207_I1.3050.78
69_E261_I1.3030.78
421_K434_G1.3010.78
150_E199_Y1.2840.77
246_L249_F1.2840.77
68_Y82_L1.2820.77
328_R347_T1.2820.77
171_K174_E1.2810.77
420_Q434_G1.2780.77
68_Y72_K1.2780.77
325_T334_T1.2720.76
190_E194_E1.2660.76
50_I54_L1.2660.76
307_L311_A1.2640.76
275_V278_R1.2610.76
424_Y433_R1.2610.76
159_V203_D1.2590.76
419_S435_H1.2470.75
354_S358_R1.2460.75
54_L121_P1.2440.75
185_S206_A1.2420.74
47_V343_I1.2270.74
294_L350_E1.2140.73
434_G440_Y1.2120.73
363_M383_A1.2060.72
180_D183_K1.2050.72
434_G437_A1.2050.72
48_S97_L1.1880.71
72_K76_D1.1820.71
113_S116_V1.1770.70
430_G436_E1.1700.70
415_L432_A1.1680.70
252_M257_T1.1670.70
333_L355_G1.1660.70
39_I80_V1.1650.70
46_R83_K1.1590.69
67_D106_A1.1450.68
94_F97_L1.1400.68
34_N42_R1.1380.68
73_Q252_M1.1350.68
424_Y427_L1.1340.67
364_M373_E1.1310.67
69_E264_K1.1290.67
412_K442_E1.1280.67
311_A360_L1.1210.67
327_V335_K1.1180.66
328_R352_S1.1140.66
327_V346_R1.1140.66
424_Y441_V1.1050.65
130_Q227_Q1.1040.65
128_V134_Y1.1030.65
367_V406_D1.1000.65
430_G441_V1.0970.65
428_T434_G1.0950.65
343_I346_R1.0920.65
45_L104_L1.0920.65
392_L395_R1.0910.64
418_L433_R1.0900.64
67_D125_Y1.0900.64
20_V23_W1.0810.64
390_H397_L1.0690.63
420_Q430_G1.0670.63
193_I202_A1.0580.62
215_P418_L1.0570.62
51_H58_E1.0500.61
91_S157_G1.0430.61
299_A302_I1.0420.61
104_L245_L1.0410.61
421_K430_G1.0410.61
411_V414_R1.0390.61
37_A40_Q1.0330.60
361_Q364_M1.0320.60
419_S434_G1.0320.60
317_W332_M1.0300.60
51_H56_Y1.0300.60
276_D316_H1.0270.60
113_S166_T1.0220.59
131_Q207_I1.0030.58
18_L22_L0.9980.57
302_I364_M0.9940.57
87_R96_D0.9930.57
330_M353_I0.9920.57
161_V165_Q0.9890.57
333_L348_D0.9880.57
37_A240_T0.9810.56
421_K440_Y0.9800.56
323_S333_L0.9790.56
14_L24_P0.9780.56
313_Q356_G0.9760.56
327_V334_T0.9720.55
298_Y301_E0.9640.55
50_I56_Y0.9620.55
419_S427_L0.9590.54
379_F383_A0.9570.54
135_K198_D0.9570.54
49_T107_A0.9560.54
109_L333_L0.9530.54
32_A35_R0.9500.54
93_L105_L0.9500.54
447_Y451_L0.9450.53
330_M342_G0.9420.53
430_G437_A0.9410.53
14_L21_A0.9410.53
272_F275_V0.9350.53
187_E202_A0.9310.52
54_L67_D0.9300.52
88_Q92_Q0.9300.52
131_Q419_S0.9240.52
201_I223_I0.9220.51
50_I58_E0.9190.51
349_A390_H0.9180.51
302_I360_L0.9180.51
325_T333_L0.9160.51
111_Y121_P0.9130.51
317_W346_R0.9130.51
338_A346_R0.9130.51
120_Q239_N0.9080.50
52_T202_A0.9080.50
128_V131_Q0.9040.50
423_Y427_L0.9040.50
111_Y116_V0.9010.50
424_Y437_A0.8970.49
229_V266_L0.8960.49
325_T338_A0.8910.49
78_L359_Y0.8890.49
349_A394_A0.8890.49
210_F213_V0.8790.48
427_L434_G0.8790.48
437_A440_Y0.8780.48
111_Y232_F0.8770.48
154_V158_H0.8760.48
97_L121_P0.8750.48
370_S399_A0.8670.47
272_F322_T0.8660.47
186_A206_A0.8640.47
172_F175_L0.8640.47
288_L304_W0.8630.47
17_L25_S0.8630.47
21_A24_P0.8610.47
46_R86_V0.8610.47
129_S134_Y0.8600.47
132_L223_I0.8590.46
52_T56_Y0.8580.46
112_N160_V0.8570.46
112_N162_N0.8570.46
48_S105_L0.8540.46
323_S356_G0.8540.46
340_S362_D0.8520.46
441_V444_I0.8480.46
399_A405_P0.8470.46
252_M255_D0.8440.45
446_K449_I0.8440.45
325_T346_R0.8410.45
245_L287_V0.8410.45
47_V92_Q0.8380.45
83_K404_N0.8330.44
421_K444_I0.8330.44
327_V332_M0.8320.44
283_A352_S0.8310.44
318_D404_N0.8290.44
334_T338_A0.8290.44
430_G444_I0.8260.44
16_L76_D0.8260.44
297_K391_M0.8240.44
427_L432_A0.8230.44
370_S396_A0.8220.44
92_Q204_S0.8190.43
73_Q257_T0.8170.43
16_L236_D0.8160.43
143_T426_K0.8160.43
430_G440_Y0.8150.43
102_A355_G0.8150.43
348_D351_Q0.8140.43
147_L197_L0.8120.43
269_G404_N0.8110.43
424_Y444_I0.8100.43
97_L105_L0.8080.43
41_A118_N0.8080.43
235_L297_K0.8070.42
125_Y153_T0.8060.42
367_V383_A0.8040.42
418_L434_G0.7990.42
283_A287_V0.7990.42
339_Q356_G0.7900.41
153_T383_A0.7900.41
39_I43_G0.7900.41
94_F115_R0.7880.41
141_P220_A0.7860.41
397_L401_T0.7850.41
94_F119_Y0.7850.41
104_L410_D0.7790.40
418_L421_K0.7780.40
206_A423_Y0.7780.40
120_Q268_H0.7770.40
64_F210_F0.7770.40
317_W327_V0.7760.40
424_Y440_Y0.7760.40
313_Q380_A0.7760.40
71_A249_F0.7760.40
411_V415_L0.7750.40
71_A84_V0.7700.40
85_T142_R0.7690.40
37_A144_L0.7670.39
386_M438_Y0.7640.39
229_V356_G0.7600.39
289_P334_T0.7580.39
333_L351_Q0.7560.39
51_H184_G0.7540.38
392_L399_A0.7530.38
433_R441_V0.7500.38
349_A365_S0.7480.38
96_D101_N0.7470.38
283_A311_A0.7460.38
13_I17_L0.7450.38
337_T341_L0.7420.37
332_M346_R0.7420.37
87_R209_L0.7410.37
124_T246_L0.7410.37
213_V291_L0.7400.37
333_L343_I0.7390.37
244_A247_D0.7390.37
258_L267_G0.7380.37
266_L270_D0.7380.37
214_H296_E0.7380.37
148_T343_I0.7360.37
169_E176_S0.7350.37
134_Y220_A0.7350.37
77_Y247_D0.7340.37
129_S133_V0.7330.37
42_R348_D0.7320.37
152_L177_W0.7310.37
429_Y433_R0.7300.37
150_E198_D0.7280.36
393_D397_L0.7270.36
246_L250_N0.7260.36
189_M395_R0.7250.36
355_G359_Y0.7240.36
15_A22_L0.7240.36
304_W390_H0.7200.36
125_Y204_S0.7200.36
319_A330_M0.7150.36
16_L20_V0.7140.35
70_L390_H0.7110.35
141_P221_L0.7110.35
127_S228_P0.7110.35
394_A397_L0.7110.35
115_R356_G0.7090.35
364_M377_I0.7090.35
130_Q200_T0.7070.35
199_Y248_F0.7070.35
424_Y432_A0.7040.35
155_A158_H0.7040.35
171_K175_L0.7020.35
83_K86_V0.7010.35
35_R100_G0.7010.35
336_N339_Q0.7000.34
321_A333_L0.6990.34
154_V161_V0.6990.34
419_S430_G0.6970.34
299_A399_A0.6970.34
400_K423_Y0.6960.34
187_E191_D0.6950.34
389_A396_A0.6940.34
317_W334_T0.6940.34
261_I348_D0.6940.34
93_L298_Y0.6910.34
340_S363_M0.6910.34
289_P292_K0.6900.34
12_G26_I0.6890.34
36_I80_V0.6880.34
48_S359_Y0.6870.34
263_E267_G0.6860.33
128_V211_Q0.6860.33
48_S88_Q0.6850.33
327_V416_P0.6840.33
346_R352_S0.6840.33
349_A397_L0.6810.33
419_S436_E0.6800.33
136_V218_A0.6790.33
115_R200_T0.6790.33
346_R351_Q0.6780.33
412_K415_L0.6770.33
367_V388_Y0.6760.33
280_F386_M0.6740.33
157_G318_D0.6710.32
305_R449_I0.6710.32
424_Y436_E0.6710.32
379_F403_G0.6710.32
247_D250_N0.6710.32
259_A262_E0.6700.32
43_G81_K0.6690.32
35_R234_P0.6670.32
248_F397_L0.6670.32
15_A23_W0.6650.32
125_Y131_Q0.6640.32
188_L308_A0.6640.32
105_L389_A0.6630.32
18_L21_A0.6600.32
110_V160_V0.6600.32
423_Y426_K0.6590.32
341_L362_D0.6590.32
264_K269_G0.6590.32
320_Q347_T0.6580.31
107_A115_R0.6530.31
75_A394_A0.6530.31
129_S222_D0.6520.31
275_V279_T0.6500.31
53_P58_E0.6500.31
271_D355_G0.6500.31
381_L436_E0.6490.31
174_E177_W0.6480.31
19_A22_L0.6470.31
19_A26_I0.6460.31
265_Y295_F0.6450.31
40_Q99_N0.6450.31
132_L146_N0.6440.31
160_V206_A0.6440.31
432_A437_A0.6420.30
108_G185_S0.6410.30
212_R270_D0.6410.30
248_F378_W0.6400.30
404_N410_D0.6400.30
39_I136_V0.6400.30
39_I45_L0.6370.30
223_I407_S0.6370.30
214_H227_Q0.6350.30
305_R378_W0.6340.30
35_R335_K0.6320.30
73_Q76_D0.6320.30
192_V441_V0.6320.30
147_L150_E0.6320.30
168_K187_E0.6320.30
115_R160_V0.6320.30
13_I19_A0.6290.30
15_A251_E0.6280.29
17_L23_W0.6280.29
295_F308_A0.6260.29
289_P317_W0.6260.29
212_R273_D0.6240.29
257_T263_E0.6220.29
346_R416_P0.6210.29
145_G174_E0.6210.29
190_E235_L0.6200.29
268_H303_D0.6200.29
349_A362_D0.6200.29
418_L436_E0.6200.29
327_V412_K0.6190.29
53_P186_A0.6180.29
86_V330_M0.6180.29
133_V207_I0.6180.29
51_H54_L0.6170.29
17_L350_E0.6160.29
193_I386_M0.6160.29
163_D167_L0.6150.29
295_F331_M0.6150.29
144_L221_L0.6140.29
12_G22_L0.6140.29
335_K386_M0.6120.28
41_A201_I0.6110.28
331_M338_A0.6100.28
327_V447_Y0.6080.28
418_L429_Y0.6060.28
340_S366_K0.6050.28
310_I363_M0.6040.28
54_L57_N0.6030.28
316_H327_V0.6030.28
110_V121_P0.6030.28
154_V160_V0.6020.28
366_K389_A0.6020.28
366_K440_Y0.6010.28
254_E310_I0.6010.28
418_L422_P0.6000.28
269_G273_D0.5990.28
422_P436_E0.5970.27
19_A23_W0.5970.27
311_A317_W0.5960.27
66_L144_L0.5960.27
364_M383_A0.5940.27
349_A389_A0.5940.27
325_T418_L0.5930.27
45_L128_V0.5920.27
38_A229_V0.5910.27
176_S180_D0.5890.27
310_I381_L0.5880.27
30_G201_I0.5880.27
152_L176_S0.5870.27
199_Y305_R0.5870.27
127_S253_N0.5860.27
59_I295_F0.5850.27
175_L399_A0.5840.27
437_A444_I0.5830.27
140_R220_A0.5830.27
91_S162_N0.5820.27
332_M359_Y0.5820.27
141_P204_S0.5820.27
59_I64_F0.5820.27
126_Y264_K0.5810.26
59_I63_P0.5810.26
376_R380_A0.5790.26
433_R437_A0.5770.26
132_L403_G0.5760.26
146_N154_V0.5750.26
337_T383_A0.5720.26
313_Q331_M0.5720.26
108_G427_L0.5720.26
144_L167_L0.5720.26
294_L297_K0.5710.26
316_H325_T0.5700.26
156_P180_D0.5690.26
139_Y358_R0.5690.26
211_Q376_R0.5670.26
403_G413_Q0.5660.26
165_Q217_L0.5650.26
69_E72_K0.5650.26
335_K413_Q0.5640.25
419_S433_R0.5640.25
304_W393_D0.5640.25
52_T58_E0.5640.25
103_D132_L0.5630.25
418_L427_L0.5630.25
69_E326_G0.5630.25
175_L225_D0.5630.25
23_W175_L0.5620.25
15_A20_V0.5620.25
288_L334_T0.5620.25
248_F303_D0.5620.25
63_P152_L0.5610.25
368_P388_Y0.5600.25
397_L400_K0.5600.25
186_A213_V0.5600.25
382_A391_M0.5590.25
108_G268_H0.5590.25
16_L19_A0.5580.25
367_V395_R0.5580.25
105_L345_D0.5580.25
94_F105_L0.5580.25
363_M389_A0.5570.25
317_W416_P0.5570.25
125_Y249_F0.5560.25
197_L391_M0.5560.25
107_A159_V0.5550.25
336_N340_S0.5540.25
325_T328_R0.5530.25
194_E361_Q0.5530.25
291_L349_A0.5520.25
415_L434_G0.5520.25
83_K200_T0.5510.25
343_I352_S0.5510.25
188_L400_K0.5490.25
154_V203_D0.5490.25
53_P59_I0.5470.24
145_G251_E0.5470.24
111_Y122_G0.5460.24
289_P327_V0.5460.24
85_T91_S0.5450.24
415_L433_R0.5450.24
292_K334_T0.5440.24
298_Y379_F0.5420.24
208_S269_G0.5420.24
12_G16_L0.5420.24
18_L24_P0.5410.24
334_T341_L0.5410.24
434_G438_Y0.5410.24
291_L302_I0.5400.24
363_M376_R0.5400.24
370_S391_M0.5400.24
432_A447_Y0.5400.24
108_G146_N0.5400.24
93_L248_F0.5390.24
67_D266_L0.5390.24
17_L20_V0.5390.24
94_F122_G0.5390.24
427_L430_G0.5380.24
109_L115_R0.5380.24
130_Q373_E0.5370.24
133_V152_L0.5340.24
108_G159_V0.5340.24
167_L185_S0.5330.24
47_V149_A0.5330.24
313_Q433_R0.5320.24
133_V197_L0.5300.23
213_V442_E0.5300.23
298_Y450_S0.5280.23
48_S96_D0.5270.23
68_Y264_K0.5250.23
159_V162_N0.5250.23
416_P433_R0.5250.23
436_E444_I0.5240.23
152_L413_Q0.5230.23
236_D400_K0.5220.23
334_T386_M0.5220.23
229_V259_A0.5210.23
390_H433_R0.5210.23
90_I203_D0.5180.23
15_A99_N0.5180.23
155_A245_L0.5180.23
411_V427_L0.5150.23
313_Q323_S0.5130.23
143_T166_T0.5120.22
13_I21_A0.5120.22
245_L296_E0.5120.22
371_V395_R0.5120.22
93_L194_E0.5110.22
371_V437_A0.5110.22
109_L323_S0.5100.22
152_L278_R0.5090.22
142_R300_E0.5090.22
58_E156_P0.5080.22
349_A393_D0.5080.22
15_A19_A0.5070.22
112_N201_I0.5070.22
375_E445_R0.5070.22
47_V106_A0.5060.22
14_L20_V0.5060.22
335_K345_D0.5050.22
111_Y291_L0.5050.22
12_G15_A0.5030.22
295_F322_T0.5030.22
391_M443_N0.5020.22
154_V197_L0.5010.22
49_T84_V0.5010.22
16_L149_A0.5010.22
322_T339_Q0.5010.22
233_S342_G0.5010.22
142_R218_A0.5010.22
393_D440_Y0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p0gA 1 0.8224 100 0.497 Contact Map
4cfpA 1 0.5888 100 0.737 Contact Map
2yjpA 1 0.4653 100 0.801 Contact Map
4hjzA 1 0.3127 100 0.801 Contact Map
1xt8A 1 0.473 100 0.804 Contact Map
2ylnA 1 0.4498 100 0.807 Contact Map
1pb7A 1 0.4923 100 0.81 Contact Map
2ieeA 1 0.4672 100 0.811 Contact Map
3kbrA 4 0.4324 100 0.812 Contact Map
4ohnA 1 0.4595 100 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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