GREMLIN Database
SERB - Phosphoserine phosphatase
UniProt: P0AGB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10945
Length: 322 (279)
Sequences: 1276 (766)
Seq/√Len: 45.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_T245_D5.3571.00
146_R160_S5.1521.00
229_E238_N5.0951.00
194_E221_T4.2741.00
247_Q251_K4.1361.00
277_L295_V3.8881.00
174_Q178_E3.7641.00
229_E240_I3.4841.00
145_E149_R3.2581.00
166_K238_N2.9301.00
287_I311_V2.8751.00
187_T217_K2.8741.00
246_A278_P2.8591.00
254_T282_A2.8501.00
143_V164_T2.8251.00
201_A256_L2.8071.00
169_D234_K2.7851.00
132_K137_G2.7821.00
152_L156_A2.6581.00
177_R213_Y2.5441.00
296_N304_R2.5141.00
142_E146_R2.5121.00
224_V255_R2.5061.00
123_Q183_M2.5021.00
122_I126_C2.4421.00
211_A223_V2.3411.00
168_A172_I2.3211.00
212_E215_R2.3071.00
115_M270_I2.3001.00
173_L209_F2.2491.00
124_I181_P2.1821.00
183_M289_Y2.1661.00
170_A174_Q2.1591.00
199_K222_A2.1361.00
215_R223_V2.1271.00
145_E289_Y2.0861.00
248_Y252_T2.0701.00
224_V252_T2.0630.99
170_A230_I1.9990.99
253_L269_A1.9440.99
229_E236_T1.9240.99
255_R259_E1.8920.99
146_R149_R1.8450.99
193_L315_L1.8430.99
156_A160_S1.8350.99
175_Q179_N1.7850.99
155_T159_R1.7630.98
194_E219_R1.7580.98
159_R241_G1.7320.98
257_A267_T1.7300.98
212_E223_V1.7080.98
155_T243_I1.7060.98
146_R151_E1.6850.98
131_A140_V1.6600.98
136_T164_T1.6590.98
99_A314_I1.6510.97
153_D156_A1.6430.97
71_V74_Y1.6120.97
123_Q184_P1.6060.97
190_V200_V1.5970.97
139_M143_V1.5580.96
159_R238_N1.5240.96
269_A279_M1.5220.96
295_V298_K1.5180.96
121_A186_L1.5110.96
306_A310_G1.5000.96
133_L175_Q1.4970.96
139_M142_E1.4630.95
288_A291_A1.4560.95
224_V248_Y1.4350.94
170_A233_G1.4340.94
194_E200_V1.4190.94
152_L160_S1.4100.94
257_A264_L1.4050.94
128_D137_G1.4040.94
294_K298_K1.3600.93
231_M238_N1.3270.92
113_L193_L1.3190.91
166_K234_K1.3170.91
133_L179_N1.2950.91
158_L235_F1.2790.90
270_I311_V1.2790.90
193_L198_W1.2550.89
257_A262_I1.2500.89
139_M164_T1.2360.88
41_L101_L1.2330.88
112_L267_T1.2220.88
136_T139_M1.2000.87
70_C76_V1.1970.87
213_Y217_K1.1790.86
285_L301_V1.1720.86
281_K298_K1.1680.85
59_L66_V1.1600.85
280_I286_G1.1500.84
48_D51_R1.1470.84
130_I168_A1.1470.84
202_I220_L1.1110.82
263_P266_Q1.1090.82
253_L267_T1.1020.82
174_Q209_F1.0860.81
222_A259_E1.0750.80
242_D251_K1.0660.80
201_A222_A1.0660.80
121_A218_L1.0510.79
187_T214_L1.0490.79
70_C73_D1.0400.78
112_L194_E1.0360.78
60_G65_I1.0250.77
149_R293_P1.0250.77
210_F290_H1.0230.77
124_I129_E1.0190.76
277_L298_K1.0170.76
280_I295_V1.0160.76
134_A137_G1.0110.76
296_N302_T1.0110.76
124_I180_L1.0110.76
182_L217_K1.0110.76
153_D245_D1.0020.75
290_H306_A0.9970.75
129_E132_K0.9970.75
132_K138_E0.9910.74
231_M240_I0.9880.74
173_L235_F0.9760.73
159_R243_I0.9730.73
82_S86_R0.9700.73
170_A209_F0.9640.72
186_L308_L0.9580.72
255_R258_Q0.9570.72
84_T88_T0.9520.71
208_T227_E0.9520.71
144_T154_F0.9460.71
264_L282_A0.9430.71
79_L82_S0.9420.71
86_R89_R0.9420.71
227_E240_I0.9340.70
191_L218_L0.9340.70
182_L214_L0.9240.69
158_L202_I0.9200.69
252_T256_L0.9160.68
125_E144_T0.9150.68
71_V76_V0.9120.68
67_A70_C0.9100.68
125_E148_M0.9070.68
264_L267_T0.9020.67
144_T148_M0.8840.66
199_K221_T0.8840.66
218_L250_A0.8730.65
303_I310_G0.8720.65
118_D126_C0.8670.64
199_K260_Y0.8650.64
55_Y227_E0.8610.64
257_A260_Y0.8590.63
110_P198_W0.8590.63
229_E241_G0.8490.63
169_D172_I0.8460.62
125_E207_F0.8400.62
124_I246_A0.8390.62
222_A256_L0.8380.62
250_A278_P0.8370.61
52_L58_K0.8210.60
197_G284_G0.8210.60
152_L196_L0.8130.59
119_S144_T0.8070.59
68_A71_V0.8060.58
59_L62_A0.8050.58
158_L162_V0.8000.58
127_I225_A0.7960.58
142_E182_L0.7910.57
268_V309_M0.7890.57
145_E290_H0.7870.57
126_C129_E0.7840.56
149_R289_Y0.7820.56
250_A254_T0.7820.56
139_M160_S0.7760.56
307_D310_G0.7750.56
198_W303_I0.7740.55
57_S61_A0.7730.55
136_T140_V0.7720.55
216_D259_E0.7710.55
154_F204_S0.7670.55
313_C316_S0.7660.55
125_E205_G0.7650.55
173_L177_R0.7650.55
156_A244_V0.7630.54
73_D77_I0.7600.54
256_L267_T0.7560.54
148_M205_G0.7550.54
262_I267_T0.7550.54
126_C210_F0.7530.53
121_A309_M0.7500.53
163_A238_N0.7480.53
130_I173_L0.7480.53
250_A282_A0.7450.53
274_A279_M0.7420.52
247_Q250_A0.7420.52
125_E161_R0.7420.52
149_R218_L0.7400.52
148_M207_F0.7400.52
85_A139_M0.7400.52
177_R209_F0.7380.52
254_T258_Q0.7350.52
117_M307_D0.7310.51
111_G266_Q0.7300.51
144_T207_F0.7290.51
121_A126_C0.7290.51
147_A207_F0.7270.51
125_E147_A0.7270.51
171_N234_K0.7260.51
289_Y312_F0.7190.50
128_D290_H0.7190.50
150_G274_A0.7170.50
54_Q61_A0.7120.49
247_Q278_P0.7110.49
41_L71_V0.7100.49
209_F213_Y0.7080.49
235_F294_K0.7070.49
117_M210_F0.7050.49
288_A304_R0.7030.48
125_E154_F0.7020.48
99_A301_V0.7020.48
270_I287_I0.7010.48
244_V248_Y0.7010.48
97_D310_G0.7000.48
256_L259_E0.6970.48
144_T161_R0.6960.48
208_T211_A0.6910.47
131_A204_S0.6910.47
127_I269_A0.6900.47
170_A231_M0.6890.47
107_L111_G0.6890.47
288_A299_A0.6880.47
119_S207_F0.6830.46
250_A281_K0.6830.46
212_E227_E0.6810.46
222_A260_Y0.6760.46
277_L293_P0.6760.46
119_S125_E0.6750.46
49_K53_T0.6750.46
112_L262_I0.6730.46
156_A241_G0.6720.45
225_A266_Q0.6720.45
176_V211_A0.6720.45
123_Q290_H0.6720.45
121_A127_I0.6710.45
127_I140_V0.6700.45
202_I223_V0.6700.45
220_L223_V0.6690.45
233_G236_T0.6660.45
198_W315_L0.6600.44
144_T292_K0.6520.43
115_M121_A0.6480.43
70_C314_I0.6430.43
114_V196_L0.6420.43
288_A292_K0.6420.43
260_Y264_L0.6410.42
173_L218_L0.6410.42
273_G292_K0.6400.42
169_D175_Q0.6390.42
127_I228_L0.6370.42
115_M189_L0.6350.42
74_Y77_I0.6340.42
52_L62_A0.6340.42
144_T205_G0.6330.42
148_M206_G0.6320.42
295_V300_E0.6250.41
224_V256_L0.6240.41
125_E273_G0.6190.40
144_T147_A0.6190.40
41_L44_G0.6180.40
191_L194_E0.6160.40
117_M128_D0.6120.40
269_A280_I0.6110.40
148_M161_R0.6110.40
89_R94_A0.6110.40
67_A76_V0.6110.40
280_I299_A0.6090.39
133_L176_V0.6080.39
123_Q181_P0.6080.39
148_M154_F0.6080.39
87_A100_P0.6070.39
117_M211_A0.6070.39
175_Q178_E0.6010.39
131_A239_V0.6000.39
53_T287_I0.5990.38
117_M290_H0.5990.38
66_V287_I0.5990.38
158_L203_A0.5990.38
267_T311_V0.5980.38
56_Q59_L0.5980.38
125_E206_G0.5980.38
193_L286_G0.5970.38
58_K65_I0.5940.38
201_A210_F0.5940.38
200_V203_A0.5910.38
131_A154_F0.5910.38
306_A309_M0.5900.38
267_T278_P0.5900.38
117_M129_E0.5900.38
161_R206_G0.5890.38
89_R93_E0.5890.38
242_D312_F0.5880.37
117_M246_A0.5880.37
71_V197_G0.5870.37
108_R312_F0.5870.37
68_A77_I0.5850.37
245_D248_Y0.5850.37
121_A157_S0.5840.37
70_C75_Q0.5830.37
203_A248_Y0.5820.37
146_R152_L0.5800.37
85_A174_Q0.5800.37
151_E293_P0.5780.37
119_S154_F0.5770.36
256_L260_Y0.5770.36
70_C74_Y0.5770.36
254_T264_L0.5760.36
54_Q212_E0.5760.36
72_E77_I0.5750.36
140_V228_L0.5730.36
152_L274_A0.5720.36
41_L55_Y0.5720.36
283_A311_V0.5710.36
230_I233_G0.5690.36
144_T273_G0.5690.36
90_L94_A0.5680.36
296_N310_G0.5670.36
157_S293_P0.5670.36
125_E275_N0.5660.35
98_V250_A0.5640.35
130_I280_I0.5640.35
101_L313_C0.5610.35
229_E232_D0.5610.35
101_L115_M0.5580.35
138_E142_E0.5570.35
246_A251_K0.5570.35
189_L308_L0.5560.35
161_R207_F0.5540.34
277_L294_K0.5530.34
138_E172_I0.5520.34
234_K238_N0.5520.34
58_K62_A0.5510.34
275_N292_K0.5500.34
188_Q309_M0.5500.34
139_M163_A0.5490.34
183_M290_H0.5480.34
111_G260_Y0.5480.34
244_V252_T0.5480.34
138_E164_T0.5470.34
223_V244_V0.5450.34
147_A205_G0.5440.33
154_F225_A0.5430.33
46_G50_Q0.5430.33
136_T203_A0.5420.33
290_H307_D0.5420.33
47_L298_K0.5410.33
119_S292_K0.5410.33
125_E274_A0.5410.33
40_W43_Y0.5410.33
82_S89_R0.5390.33
71_V189_L0.5390.33
121_A220_L0.5370.33
218_L233_G0.5370.33
296_N309_M0.5370.33
45_R73_D0.5360.33
109_T196_L0.5350.33
242_D248_Y0.5340.33
123_Q137_G0.5330.33
180_L200_V0.5320.32
156_A159_R0.5320.32
45_R184_P0.5320.32
303_I306_A0.5320.32
148_M273_G0.5320.32
151_E291_A0.5310.32
157_S309_M0.5310.32
257_A269_A0.5300.32
47_L56_Q0.5300.32
163_A166_K0.5280.32
119_S131_A0.5280.32
119_S148_M0.5280.32
173_L210_F0.5260.32
218_L314_I0.5260.32
114_V223_V0.5250.32
86_R93_E0.5240.32
44_G139_M0.5240.32
125_E292_K0.5230.32
144_T157_S0.5230.32
203_A252_T0.5210.32
155_T247_Q0.5200.31
129_E210_F0.5200.31
57_S60_G0.5190.31
55_Y73_D0.5180.31
164_T221_T0.5180.31
40_W52_L0.5150.31
203_A244_V0.5130.31
60_G69_W0.5130.31
128_D141_A0.5130.31
134_A303_I0.5110.31
143_V211_A0.5110.31
178_E191_L0.5110.31
257_A282_A0.5100.31
190_V307_D0.5090.30
150_G161_R0.5070.30
154_F207_F0.5070.30
206_G226_N0.5070.30
131_A144_T0.5070.30
226_N271_G0.5060.30
176_V229_E0.5060.30
177_R309_M0.5060.30
133_L181_P0.5040.30
206_G273_G0.5040.30
125_E150_G0.5040.30
79_L259_E0.5030.30
90_L95_Q0.5020.30
235_F290_H0.5020.30
150_G279_M0.5010.30
62_A86_R0.5000.30
61_A179_N0.5000.30
121_A202_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ezeA 1 0.8602 100 0.539 Contact Map
3p96A 2 1 100 0.574 Contact Map
3m1yA 2 0.6491 100 0.63 Contact Map
1l7mA 1 0.6522 100 0.646 Contact Map
3n28A 1 0.9503 100 0.662 Contact Map
3fvvA 2 0.6304 100 0.701 Contact Map
1rkuA 2 0.6211 100 0.704 Contact Map
4gxtA 1 0.764 100 0.71 Contact Map
4as2A 4 0.7267 100 0.712 Contact Map
1y8aA 1 0.6429 100 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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