GREMLIN Database
SECY - Protein translocase subunit SecY
UniProt: P0AGA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10766
Length: 443 (415)
Sequences: 3203 (1707)
Seq/√Len: 83.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_A382_T5.6761.00
36_G78_F5.6091.00
360_E364_K5.2771.00
29_A174_L5.1891.00
92_I116_I4.3991.00
24_L28_G4.1451.00
343_A363_A4.0601.00
330_F375_L4.0321.00
305_T309_Y3.8831.00
102_L116_I3.5891.00
25_F29_A3.4341.00
367_D371_T3.3011.00
140_P157_Y3.2321.00
110_E113_R3.2111.00
154_F158_F3.1631.00
326_I382_T3.1441.00
65_N73_S3.0631.00
125_L169_M3.0231.00
105_I119_Y2.9701.00
170_F174_L2.9421.00
32_V170_F2.7681.00
101_T104_E2.7251.00
92_I123_G2.6371.00
246_V265_L2.6331.00
132_S165_V2.6051.00
344_D348_K2.5581.00
103_A107_K2.5361.00
322_A326_I2.5201.00
248_Y351_A2.5041.00
129_I165_V2.4501.00
17_G21_R2.3681.00
341_E345_N2.3661.00
92_I102_L2.3601.00
267_L370_M2.3561.00
30_L189_I2.3331.00
277_A385_C2.3051.00
23_L27_I2.2421.00
39_I77_I2.2421.00
240_G269_V2.1921.00
302_W306_I2.1851.00
169_M172_M2.1631.00
155_A159_T2.1141.00
329_C381_I2.1141.00
26_V189_I2.0651.00
315_P319_L2.0521.00
30_L193_A2.0341.00
33_F194_G1.9851.00
41_I160_A1.9751.00
115_K118_Q1.9741.00
368_K372_R1.9601.00
208_E211_R1.9391.00
323_S327_F1.9311.00
304_T308_L1.9241.00
309_Y316_L1.9061.00
244_I353_V1.8641.00
329_C378_A1.8551.00
233_F383_F1.8461.00
32_V174_L1.8191.00
238_E268_K1.8061.00
129_I161_V1.8051.00
344_D347_K1.7821.00
22_R423_L1.7571.00
104_E108_E1.7351.00
340_R363_A1.7291.00
149_V152_P1.7211.00
283_I324_A1.7121.00
379_L383_F1.6981.00
316_L319_L1.6641.00
306_I310_L1.6521.00
101_T105_I1.6511.00
250_K259_A1.6271.00
121_R176_E1.6031.00
238_E380_Y1.5891.00
244_I369_V1.5781.00
149_V153_G1.5711.00
393_D396_K1.5701.00
45_D48_V1.5581.00
271_M370_M1.5581.00
302_W305_T1.5261.00
126_V130_F1.5221.00
330_F371_T1.5201.00
337_F342_T1.5160.99
205_H208_E1.5100.99
221_L225_V1.5050.99
128_A165_V1.5020.99
294_F297_G1.4890.99
129_I132_S1.4760.99
154_F157_Y1.4710.99
342_T366_I1.4670.99
172_M187_I1.4470.99
339_P367_D1.4450.99
226_L230_V1.4440.99
128_A168_T1.4400.99
48_V51_K1.4350.99
124_T172_M1.4320.99
58_G62_E1.4250.99
239_R414_M1.4210.99
29_A170_F1.4210.99
286_F290_I1.4190.99
366_I370_M1.4130.99
359_G362_T1.3990.99
326_I378_A1.3960.99
96_T106_K1.3810.99
288_A291_A1.3750.99
147_G150_I1.3720.99
92_I119_Y1.3550.99
318_V386_L1.3530.99
31_I35_I1.3400.99
334_A367_D1.3360.99
37_S71_A1.3150.99
132_S161_V1.3140.99
361_Q364_K1.3110.99
18_E21_R1.3080.98
127_L432_A1.3040.98
96_T116_I1.3040.98
405_S409_V1.3030.98
28_G31_I1.2920.98
147_G153_G1.2770.98
26_V182_G1.2740.98
183_I420_V1.2690.98
380_Y407_L1.2680.98
291_A306_I1.2660.98
316_L320_L1.2550.98
65_N198_G1.2480.98
274_V402_G1.2340.98
83_M87_S1.2320.98
124_T168_T1.2280.98
82_I187_I1.2270.98
310_L320_L1.2170.98
203_I207_I1.2170.98
136_A160_A1.2150.98
121_R172_M1.2140.98
288_A292_S1.2080.97
21_R24_L1.1990.97
25_F181_R1.1920.97
156_F160_A1.1900.97
133_I161_V1.1890.97
289_T293_W1.1860.97
168_T171_L1.1820.97
230_V234_V1.1780.97
11_S15_G1.1760.97
255_R260_A1.1710.97
254_G258_Y1.1680.97
152_P156_F1.1660.97
337_F366_I1.1660.97
358_P362_T1.1650.97
217_F221_L1.1620.97
237_V240_G1.1600.97
88_A123_G1.1570.97
236_F240_G1.1560.97
157_Y161_V1.1530.97
244_I366_I1.1520.97
415_D419_Q1.1490.97
291_A294_F1.1480.97
198_G201_P1.1400.96
192_F413_I1.1390.96
315_P318_V1.1300.96
156_F159_T1.1290.96
65_N68_S1.1230.96
33_F37_S1.1220.96
243_R264_H1.1150.96
224_A228_F1.1140.96
148_L151_N1.1140.96
265_L428_Q1.1050.96
48_V148_L1.1050.96
303_L306_I1.1030.96
109_G112_G1.1010.96
78_F171_L1.0960.95
253_Q258_Y1.0850.95
338_N341_E1.0790.95
22_R269_V1.0790.95
190_I289_T1.0730.95
421_Q427_S1.0700.95
253_Q256_R1.0610.95
239_R418_A1.0500.94
20_K24_L1.0500.94
326_I379_L1.0450.94
256_R260_A1.0410.94
199_L203_I1.0320.94
44_I48_V1.0310.94
12_A16_L1.0310.94
274_V404_T1.0300.94
252_Q428_Q1.0280.94
277_A403_G1.0250.94
46_A50_A1.0240.93
312_P389_E1.0100.93
188_S412_V1.0090.93
183_I416_F1.0060.93
252_Q257_V1.0050.93
210_A220_L1.0020.93
171_L190_I0.9990.93
235_V380_Y0.9950.92
267_L373_L0.9930.92
47_A51_K0.9860.92
13_K23_L0.9830.92
254_G260_A0.9820.92
390_F394_A0.9810.92
99_H103_A0.9800.92
110_E114_R0.9800.92
218_L222_L0.9700.92
303_L307_S0.9690.91
233_F237_V0.9610.91
256_R259_A0.9570.91
77_I395_M0.9530.91
237_V265_L0.9520.91
202_A206_T0.9400.90
153_G228_F0.9380.90
208_E212_Q0.9230.89
265_L366_I0.9210.89
176_E250_K0.9160.89
33_F174_L0.9150.89
41_I136_A0.9130.89
193_A196_V0.9110.89
416_F419_Q0.9070.89
416_F420_V0.9050.88
81_G123_G0.9030.88
312_P317_Y0.9020.88
174_L314_Q0.9020.88
237_V380_Y0.9010.88
378_A382_T0.8990.88
129_I158_F0.8930.88
191_I278_I0.8880.87
13_K420_V0.8840.87
322_A386_L0.8820.87
37_S76_S0.8790.87
211_R214_D0.8780.87
95_L98_V0.8780.87
12_A428_Q0.8770.87
47_A50_A0.8760.87
216_H219_V0.8760.87
140_P154_F0.8750.87
130_F170_F0.8730.87
284_I386_L0.8720.86
116_I283_I0.8720.86
158_F162_V0.8700.86
277_A381_I0.8700.86
382_T386_L0.8650.86
356_I365_Y0.8650.86
202_A400_Y0.8650.86
319_L323_S0.8590.86
175_G187_I0.8580.86
415_D418_A0.8580.86
16_L424_M0.8560.85
41_I75_A0.8550.85
127_L282_S0.8510.85
275_I335_L0.8500.85
108_E111_S0.8480.85
80_L87_S0.8470.85
421_Q432_A0.8460.85
230_V387_I0.8460.85
237_V376_V0.8460.85
118_Q122_Y0.8440.85
229_A398_P0.8410.84
177_Q398_P0.8400.84
83_M333_T0.8390.84
123_G187_I0.8360.84
137_T140_P0.8360.84
73_S76_S0.8350.84
229_A232_F0.8320.84
117_S176_E0.8310.84
151_N154_F0.8290.84
310_L316_L0.8280.84
22_R292_S0.8270.83
318_V389_E0.8250.83
281_S321_Y0.8240.83
153_G156_F0.8210.83
274_V403_G0.8200.83
352_F358_P0.8190.83
80_L168_T0.8190.83
133_I164_L0.8140.82
345_N349_S0.8120.82
80_L342_T0.8090.82
165_V370_M0.8080.82
254_G259_A0.8050.82
253_Q260_A0.7990.81
165_V169_M0.7980.81
91_I127_L0.7980.81
391_M395_M0.7960.81
201_P205_H0.7920.81
247_N422_T0.7910.81
218_L295_G0.7910.81
195_I274_V0.7880.80
82_I169_M0.7840.80
322_A379_L0.7840.80
257_V261_Q0.7830.80
297_G319_L0.7830.80
89_S404_T0.7810.80
228_F232_F0.7800.80
137_T157_Y0.7790.80
273_G407_L0.7790.80
225_V229_A0.7770.79
251_R254_G0.7760.79
102_L119_Y0.7760.79
62_E65_N0.7750.79
342_T380_Y0.7730.79
203_I206_T0.7730.79
13_K16_L0.7680.79
75_A164_L0.7650.78
223_V227_V0.7640.78
119_Y123_G0.7610.78
297_G302_W0.7580.78
347_K350_G0.7560.78
304_T307_S0.7540.77
285_L289_T0.7520.77
407_L410_V0.7500.77
49_L132_S0.7470.77
17_G427_S0.7460.77
161_V165_V0.7460.77
209_Q214_D0.7450.77
242_R287_P0.7440.76
246_V433_L0.7430.76
339_P343_A0.7430.76
102_L105_I0.7420.76
283_I327_F0.7410.76
38_F65_N0.7390.76
22_R33_F0.7380.76
136_A161_V0.7370.76
149_V156_F0.7360.76
33_F193_A0.7360.76
424_M427_S0.7320.75
204_A208_E0.7320.75
103_A106_K0.7310.75
130_F322_A0.7290.75
10_Q58_G0.7280.75
45_D49_L0.7260.75
18_E423_L0.7260.75
97_V335_L0.7240.74
296_G304_T0.7200.74
87_S91_I0.7200.74
204_A207_I0.7180.74
307_S311_Q0.7130.73
305_T308_L0.7120.73
274_V278_I0.7120.73
106_K238_E0.7110.73
222_L225_V0.7080.73
43_G156_F0.7070.73
198_G286_F0.7070.73
33_F104_E0.7060.73
26_V29_A0.7050.73
252_Q426_S0.7050.73
346_L351_A0.7030.72
309_Y320_L0.7020.72
82_I241_Q0.7010.72
25_F177_Q0.7010.72
86_I408_I0.6990.72
57_R204_A0.6980.72
82_I171_L0.6970.72
183_I189_I0.6960.72
210_A213_G0.6950.71
421_Q431_S0.6950.71
193_A229_A0.6940.71
223_V338_N0.6920.71
86_I328_F0.6910.71
75_A275_I0.6900.71
342_T429_Y0.6860.70
77_I222_L0.6860.70
244_I265_L0.6850.70
321_Y385_C0.6830.70
323_S326_I0.6830.70
11_S391_M0.6810.70
199_L406_L0.6800.70
16_L20_K0.6760.69
366_I373_L0.6750.69
371_T375_L0.6740.69
117_S169_M0.6740.69
10_Q14_G0.6720.69
93_Q190_I0.6710.69
206_T209_Q0.6700.69
94_L331_F0.6700.69
237_V384_I0.6690.69
360_E363_A0.6690.69
92_I275_I0.6680.68
294_F303_L0.6680.68
253_Q257_V0.6660.68
214_D218_L0.6660.68
334_A378_A0.6650.68
339_P366_I0.6640.68
296_G305_T0.6630.68
192_F196_V0.6610.68
411_V415_D0.6600.68
71_A268_K0.6590.67
194_G197_A0.6590.67
373_L378_A0.6580.67
280_A321_Y0.6580.67
408_I412_V0.6550.67
101_T171_L0.6540.67
196_V243_R0.6530.67
105_I109_G0.6520.67
79_A116_I0.6520.67
92_I323_S0.6520.67
28_G32_V0.6500.66
312_P315_P0.6500.66
64_F148_L0.6460.66
40_P199_L0.6450.66
258_Y261_Q0.6400.65
19_L133_I0.6370.65
352_F422_T0.6370.65
347_K369_V0.6360.65
38_F53_L0.6360.65
331_F335_L0.6360.65
77_I170_F0.6360.65
33_F71_A0.6350.65
33_F39_I0.6350.65
234_V244_I0.6340.64
375_L390_F0.6340.64
87_S322_A0.6340.64
106_K113_R0.6330.64
272_A333_T0.6330.64
51_K304_T0.6330.64
231_T396_K0.6320.64
223_V395_M0.6310.64
219_V395_M0.6310.64
189_I193_A0.6310.64
98_V119_Y0.6310.64
85_Y279_F0.6300.64
133_I137_T0.6290.64
365_Y369_V0.6280.64
225_V297_G0.6280.64
317_Y334_A0.6280.64
132_S136_A0.6280.64
245_V249_A0.6270.64
76_S432_A0.6260.63
293_W346_L0.6260.63
114_R250_K0.6240.63
295_G303_L0.6240.63
414_M418_A0.6230.63
25_F268_K0.6220.63
238_E241_Q0.6210.63
87_S277_A0.6210.63
64_F366_I0.6200.63
253_Q259_A0.6200.63
422_T426_S0.6200.63
89_S278_I0.6190.63
246_V346_L0.6180.62
327_F330_F0.6180.62
119_Y272_A0.6180.62
21_R28_G0.6170.62
100_P103_A0.6170.62
159_T162_V0.6160.62
242_R369_V0.6150.62
297_G305_T0.6140.62
19_L183_I0.6130.62
220_L224_A0.6130.62
284_I288_A0.6100.61
76_S125_L0.6100.61
352_F411_V0.6090.61
61_I378_A0.6080.61
29_A171_L0.6070.61
150_I153_G0.6060.61
30_L199_L0.6050.61
268_K273_G0.6050.61
229_A298_T0.6050.61
141_N152_P0.6030.61
117_S392_R0.6030.61
25_F270_N0.6030.61
189_I231_T0.6030.61
334_A371_T0.6010.60
33_F81_G0.6010.60
196_V199_L0.6010.60
278_I403_G0.6010.60
121_R274_V0.6010.60
346_L349_S0.5990.60
227_V231_T0.5980.60
135_I302_W0.5970.60
19_L420_V0.5950.60
189_I416_F0.5940.59
225_V231_T0.5940.59
189_I384_I0.5940.59
395_M398_P0.5940.59
278_I328_F0.5930.59
44_I47_A0.5920.59
97_V246_V0.5920.59
19_L321_Y0.5910.59
272_A387_I0.5910.59
136_A157_Y0.5890.59
124_T230_V0.5890.59
274_V279_F0.5840.58
210_A231_T0.5830.58
16_L19_L0.5830.58
101_T119_Y0.5830.58
49_L267_L0.5830.58
248_Y328_F0.5820.58
65_N71_A0.5820.58
16_L421_Q0.5820.58
11_S342_T0.5810.58
129_I148_L0.5800.58
188_S408_I0.5800.58
198_G387_I0.5780.57
13_K19_L0.5760.57
16_L426_S0.5740.57
59_T312_P0.5740.57
339_P370_M0.5730.57
332_Y351_A0.5720.57
34_R197_A0.5710.56
176_E335_L0.5700.56
250_K264_H0.5690.56
26_V183_I0.5680.56
73_S228_F0.5670.56
73_S353_V0.5670.56
271_M374_T0.5660.56
43_G164_L0.5650.56
207_I319_L0.5630.55
150_I221_L0.5630.55
181_R402_G0.5630.55
188_S328_F0.5620.55
192_F332_Y0.5620.55
282_S285_L0.5610.55
133_I231_T0.5600.55
340_R360_E0.5600.55
232_F236_F0.5590.55
49_L52_L0.5590.55
66_M87_S0.5590.55
321_Y348_K0.5570.55
82_I172_M0.5560.54
35_I39_I0.5550.54
259_A351_A0.5540.54
128_A169_M0.5530.54
199_L202_A0.5530.54
33_F190_I0.5510.54
82_I89_S0.5500.54
101_T244_I0.5500.54
304_T406_L0.5500.54
88_A239_R0.5500.54
96_T102_L0.5490.54
269_V272_A0.5470.53
86_I274_V0.5460.53
268_K336_V0.5460.53
244_I356_I0.5460.53
278_I415_D0.5450.53
171_L272_A0.5440.53
320_L327_F0.5430.53
254_G257_V0.5430.53
331_F412_V0.5420.53
169_M423_L0.5420.53
311_Q320_L0.5420.53
277_A346_L0.5420.53
383_F387_I0.5410.52
166_T170_F0.5410.52
62_E168_T0.5400.52
41_I81_G0.5390.52
361_Q383_F0.5390.52
218_L394_A0.5390.52
314_Q318_V0.5380.52
321_Y386_L0.5370.52
277_A411_V0.5370.52
289_T342_T0.5370.52
263_T338_N0.5360.52
225_V228_F0.5360.52
200_P242_R0.5360.52
37_S338_N0.5360.52
65_N70_G0.5340.52
24_L27_I0.5330.51
151_N157_Y0.5320.51
321_Y384_I0.5310.51
29_A32_V0.5310.51
205_H296_G0.5300.51
277_A281_S0.5280.51
307_S310_L0.5280.51
77_I110_E0.5280.51
15_G261_Q0.5260.50
235_V312_P0.5260.50
38_F76_S0.5250.50
74_R78_F0.5250.50
208_E214_D0.5230.50
309_Y314_Q0.5230.50
89_S171_L0.5220.50
13_K373_L0.5220.50
48_V76_S0.5210.50
59_T65_N0.5210.50
48_V146_Q0.5200.50
10_Q13_K0.5200.50
198_G202_A0.5200.50
352_F426_S0.5190.50
304_T316_L0.5190.50
27_I51_K0.5190.50
297_G344_D0.5180.49
72_L79_A0.5180.49
87_S192_F0.5180.49
252_Q258_Y0.5170.49
52_L146_Q0.5170.49
313_G318_V0.5170.49
56_Q60_I0.5170.49
227_V230_V0.5170.49
175_G333_T0.5170.49
33_F76_S0.5170.49
77_I333_T0.5170.49
17_G20_K0.5160.49
140_P149_V0.5150.49
284_I396_K0.5140.49
423_L426_S0.5130.49
308_L383_F0.5130.49
238_E277_A0.5130.49
235_V239_R0.5120.49
51_K158_F0.5120.49
86_I188_S0.5120.49
37_S425_M0.5110.49
66_M232_F0.5110.49
205_H292_S0.5110.49
344_D392_R0.5110.49
76_S348_K0.5110.49
26_V416_F0.5100.48
129_I162_V0.5100.48
59_T75_A0.5100.48
72_L97_V0.5090.48
112_G278_I0.5090.48
191_I194_G0.5090.48
375_L379_L0.5090.48
308_L311_Q0.5080.48
312_P318_V0.5080.48
49_L113_R0.5080.48
217_F323_S0.5060.48
213_G216_H0.5050.48
291_A433_L0.5050.48
252_Q255_R0.5040.48
246_V351_A0.5040.48
76_S198_G0.5030.47
50_A59_T0.5030.47
274_V328_F0.5020.47
24_L245_V0.5010.47
242_R354_P0.5010.47
106_K399_F0.5010.47
86_I383_F0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dinC 1 0.8916 100 0.073 Contact Map
2zjsY 2 0.93 100 0.075 Contact Map
3j01A 1 0.9819 100 0.082 Contact Map
3dl8G 1 0.9097 100 0.085 Contact Map
3mp7A 1 0.7472 100 0.167 Contact Map
1rh5A 1 0.8533 100 0.167 Contact Map
2ww9A 1 0.93 100 0.195 Contact Map
4w251 1 0.7878 100 0.239 Contact Map
4humA 1 0.8984 4.6 0.981 Contact Map
4j05A 3 0.4853 4.6 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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