SECY - ECOLI - GREMLIN Contacts

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SECY - Protein translocase subunit SecY

UniProt:	P0AGA2	Sequences: MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERGQRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10766
Length:	443 (415)
Sequences:	3203 (1707)
Seq/√Len:	83.8

ECOLI - SECY
BACSU - SECY
HALSA - SECY
SULSO - SECY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
322_A	382_T	5.676	1.00
36_G	78_F	5.609	1.00
360_E	364_K	5.277	1.00
29_A	174_L	5.189	1.00
92_I	116_I	4.399	1.00
24_L	28_G	4.145	1.00
343_A	363_A	4.060	1.00
330_F	375_L	4.032	1.00
305_T	309_Y	3.883	1.00
102_L	116_I	3.589	1.00
25_F	29_A	3.434	1.00
367_D	371_T	3.301	1.00
140_P	157_Y	3.232	1.00
110_E	113_R	3.211	1.00
154_F	158_F	3.163	1.00
326_I	382_T	3.144	1.00
65_N	73_S	3.063	1.00
125_L	169_M	3.023	1.00
105_I	119_Y	2.970	1.00
170_F	174_L	2.942	1.00
32_V	170_F	2.768	1.00
101_T	104_E	2.725	1.00
92_I	123_G	2.637	1.00
246_V	265_L	2.633	1.00
132_S	165_V	2.605	1.00
344_D	348_K	2.558	1.00
103_A	107_K	2.536	1.00
322_A	326_I	2.520	1.00
248_Y	351_A	2.504	1.00
129_I	165_V	2.450	1.00
17_G	21_R	2.368	1.00
341_E	345_N	2.366	1.00
92_I	102_L	2.360	1.00
267_L	370_M	2.356	1.00
30_L	189_I	2.333	1.00
277_A	385_C	2.305	1.00
23_L	27_I	2.242	1.00
39_I	77_I	2.242	1.00
240_G	269_V	2.192	1.00
302_W	306_I	2.185	1.00
169_M	172_M	2.163	1.00
155_A	159_T	2.114	1.00
329_C	381_I	2.114	1.00
26_V	189_I	2.065	1.00
315_P	319_L	2.052	1.00
30_L	193_A	2.034	1.00
33_F	194_G	1.985	1.00
41_I	160_A	1.975	1.00
115_K	118_Q	1.974	1.00
368_K	372_R	1.960	1.00
208_E	211_R	1.939	1.00
323_S	327_F	1.931	1.00
304_T	308_L	1.924	1.00
309_Y	316_L	1.906	1.00
244_I	353_V	1.864	1.00
329_C	378_A	1.855	1.00
233_F	383_F	1.846	1.00
32_V	174_L	1.819	1.00
238_E	268_K	1.806	1.00
129_I	161_V	1.805	1.00
344_D	347_K	1.782	1.00
22_R	423_L	1.757	1.00
104_E	108_E	1.735	1.00
340_R	363_A	1.729	1.00
149_V	152_P	1.721	1.00
283_I	324_A	1.712	1.00
379_L	383_F	1.698	1.00
316_L	319_L	1.664	1.00
306_I	310_L	1.652	1.00
101_T	105_I	1.651	1.00
250_K	259_A	1.627	1.00
121_R	176_E	1.603	1.00
238_E	380_Y	1.589	1.00
244_I	369_V	1.578	1.00
149_V	153_G	1.571	1.00
393_D	396_K	1.570	1.00
45_D	48_V	1.558	1.00
271_M	370_M	1.558	1.00
302_W	305_T	1.526	1.00
126_V	130_F	1.522	1.00
330_F	371_T	1.520	1.00
337_F	342_T	1.516	0.99
205_H	208_E	1.510	0.99
221_L	225_V	1.505	0.99
128_A	165_V	1.502	0.99
294_F	297_G	1.489	0.99
129_I	132_S	1.476	0.99
154_F	157_Y	1.471	0.99
342_T	366_I	1.467	0.99
172_M	187_I	1.447	0.99
339_P	367_D	1.445	0.99
226_L	230_V	1.444	0.99
128_A	168_T	1.440	0.99
48_V	51_K	1.435	0.99
124_T	172_M	1.432	0.99
58_G	62_E	1.425	0.99
239_R	414_M	1.421	0.99
29_A	170_F	1.421	0.99
286_F	290_I	1.419	0.99
366_I	370_M	1.413	0.99
359_G	362_T	1.399	0.99
326_I	378_A	1.396	0.99
96_T	106_K	1.381	0.99
288_A	291_A	1.375	0.99
147_G	150_I	1.372	0.99
92_I	119_Y	1.355	0.99
318_V	386_L	1.353	0.99
31_I	35_I	1.340	0.99
334_A	367_D	1.336	0.99
37_S	71_A	1.315	0.99
132_S	161_V	1.314	0.99
361_Q	364_K	1.311	0.99
18_E	21_R	1.308	0.98
127_L	432_A	1.304	0.98
96_T	116_I	1.304	0.98
405_S	409_V	1.303	0.98
28_G	31_I	1.292	0.98
147_G	153_G	1.277	0.98
26_V	182_G	1.274	0.98
183_I	420_V	1.269	0.98
380_Y	407_L	1.268	0.98
291_A	306_I	1.266	0.98
316_L	320_L	1.255	0.98
65_N	198_G	1.248	0.98
274_V	402_G	1.234	0.98
83_M	87_S	1.232	0.98
124_T	168_T	1.228	0.98
82_I	187_I	1.227	0.98
310_L	320_L	1.217	0.98
203_I	207_I	1.217	0.98
136_A	160_A	1.215	0.98
121_R	172_M	1.214	0.98
288_A	292_S	1.208	0.97
21_R	24_L	1.199	0.97
25_F	181_R	1.192	0.97
156_F	160_A	1.190	0.97
133_I	161_V	1.189	0.97
289_T	293_W	1.186	0.97
168_T	171_L	1.182	0.97
230_V	234_V	1.178	0.97
11_S	15_G	1.176	0.97
255_R	260_A	1.171	0.97
254_G	258_Y	1.168	0.97
152_P	156_F	1.166	0.97
337_F	366_I	1.166	0.97
358_P	362_T	1.165	0.97
217_F	221_L	1.162	0.97
237_V	240_G	1.160	0.97
88_A	123_G	1.157	0.97
236_F	240_G	1.156	0.97
157_Y	161_V	1.153	0.97
244_I	366_I	1.152	0.97
415_D	419_Q	1.149	0.97
291_A	294_F	1.148	0.97
198_G	201_P	1.140	0.96
192_F	413_I	1.139	0.96
315_P	318_V	1.130	0.96
156_F	159_T	1.129	0.96
65_N	68_S	1.123	0.96
33_F	37_S	1.122	0.96
243_R	264_H	1.115	0.96
224_A	228_F	1.114	0.96
148_L	151_N	1.114	0.96
265_L	428_Q	1.105	0.96
48_V	148_L	1.105	0.96
303_L	306_I	1.103	0.96
109_G	112_G	1.101	0.96
78_F	171_L	1.096	0.95
253_Q	258_Y	1.085	0.95
338_N	341_E	1.079	0.95
22_R	269_V	1.079	0.95
190_I	289_T	1.073	0.95
421_Q	427_S	1.070	0.95
253_Q	256_R	1.061	0.95
239_R	418_A	1.050	0.94
20_K	24_L	1.050	0.94
326_I	379_L	1.045	0.94
256_R	260_A	1.041	0.94
199_L	203_I	1.032	0.94
44_I	48_V	1.031	0.94
12_A	16_L	1.031	0.94
274_V	404_T	1.030	0.94
252_Q	428_Q	1.028	0.94
277_A	403_G	1.025	0.94
46_A	50_A	1.024	0.93
312_P	389_E	1.010	0.93
188_S	412_V	1.009	0.93
183_I	416_F	1.006	0.93
252_Q	257_V	1.005	0.93
210_A	220_L	1.002	0.93
171_L	190_I	0.999	0.93
235_V	380_Y	0.995	0.92
267_L	373_L	0.993	0.92
47_A	51_K	0.986	0.92
13_K	23_L	0.983	0.92
254_G	260_A	0.982	0.92
390_F	394_A	0.981	0.92
99_H	103_A	0.980	0.92
110_E	114_R	0.980	0.92
218_L	222_L	0.970	0.92
303_L	307_S	0.969	0.91
233_F	237_V	0.961	0.91
256_R	259_A	0.957	0.91
77_I	395_M	0.953	0.91
237_V	265_L	0.952	0.91
202_A	206_T	0.940	0.90
153_G	228_F	0.938	0.90
208_E	212_Q	0.923	0.89
265_L	366_I	0.921	0.89
176_E	250_K	0.916	0.89
33_F	174_L	0.915	0.89
41_I	136_A	0.913	0.89
193_A	196_V	0.911	0.89
416_F	419_Q	0.907	0.89
416_F	420_V	0.905	0.88
81_G	123_G	0.903	0.88
312_P	317_Y	0.902	0.88
174_L	314_Q	0.902	0.88
237_V	380_Y	0.901	0.88
378_A	382_T	0.899	0.88
129_I	158_F	0.893	0.88
191_I	278_I	0.888	0.87
13_K	420_V	0.884	0.87
322_A	386_L	0.882	0.87
37_S	76_S	0.879	0.87
211_R	214_D	0.878	0.87
95_L	98_V	0.878	0.87
12_A	428_Q	0.877	0.87
47_A	50_A	0.876	0.87
216_H	219_V	0.876	0.87
140_P	154_F	0.875	0.87
130_F	170_F	0.873	0.87
284_I	386_L	0.872	0.86
116_I	283_I	0.872	0.86
158_F	162_V	0.870	0.86
277_A	381_I	0.870	0.86
382_T	386_L	0.865	0.86
356_I	365_Y	0.865	0.86
202_A	400_Y	0.865	0.86
319_L	323_S	0.859	0.86
175_G	187_I	0.858	0.86
415_D	418_A	0.858	0.86
16_L	424_M	0.856	0.85
41_I	75_A	0.855	0.85
127_L	282_S	0.851	0.85
275_I	335_L	0.850	0.85
108_E	111_S	0.848	0.85
80_L	87_S	0.847	0.85
421_Q	432_A	0.846	0.85
230_V	387_I	0.846	0.85
237_V	376_V	0.846	0.85
118_Q	122_Y	0.844	0.85
229_A	398_P	0.841	0.84
177_Q	398_P	0.840	0.84
83_M	333_T	0.839	0.84
123_G	187_I	0.836	0.84
137_T	140_P	0.836	0.84
73_S	76_S	0.835	0.84
229_A	232_F	0.832	0.84
117_S	176_E	0.831	0.84
151_N	154_F	0.829	0.84
310_L	316_L	0.828	0.84
22_R	292_S	0.827	0.83
318_V	389_E	0.825	0.83
281_S	321_Y	0.824	0.83
153_G	156_F	0.821	0.83
274_V	403_G	0.820	0.83
352_F	358_P	0.819	0.83
80_L	168_T	0.819	0.83
133_I	164_L	0.814	0.82
345_N	349_S	0.812	0.82
80_L	342_T	0.809	0.82
165_V	370_M	0.808	0.82
254_G	259_A	0.805	0.82
253_Q	260_A	0.799	0.81
165_V	169_M	0.798	0.81
91_I	127_L	0.798	0.81
391_M	395_M	0.796	0.81
201_P	205_H	0.792	0.81
247_N	422_T	0.791	0.81
218_L	295_G	0.791	0.81
195_I	274_V	0.788	0.80
82_I	169_M	0.784	0.80
322_A	379_L	0.784	0.80
257_V	261_Q	0.783	0.80
297_G	319_L	0.783	0.80
89_S	404_T	0.781	0.80
228_F	232_F	0.780	0.80
137_T	157_Y	0.779	0.80
273_G	407_L	0.779	0.80
225_V	229_A	0.777	0.79
251_R	254_G	0.776	0.79
102_L	119_Y	0.776	0.79
62_E	65_N	0.775	0.79
342_T	380_Y	0.773	0.79
203_I	206_T	0.773	0.79
13_K	16_L	0.768	0.79
75_A	164_L	0.765	0.78
223_V	227_V	0.764	0.78
119_Y	123_G	0.761	0.78
297_G	302_W	0.758	0.78
347_K	350_G	0.756	0.78
304_T	307_S	0.754	0.77
285_L	289_T	0.752	0.77
407_L	410_V	0.750	0.77
49_L	132_S	0.747	0.77
17_G	427_S	0.746	0.77
161_V	165_V	0.746	0.77
209_Q	214_D	0.745	0.77
242_R	287_P	0.744	0.76
246_V	433_L	0.743	0.76
339_P	343_A	0.743	0.76
102_L	105_I	0.742	0.76
283_I	327_F	0.741	0.76
38_F	65_N	0.739	0.76
22_R	33_F	0.738	0.76
136_A	161_V	0.737	0.76
149_V	156_F	0.736	0.76
33_F	193_A	0.736	0.76
424_M	427_S	0.732	0.75
204_A	208_E	0.732	0.75
103_A	106_K	0.731	0.75
130_F	322_A	0.729	0.75
10_Q	58_G	0.728	0.75
45_D	49_L	0.726	0.75
18_E	423_L	0.726	0.75
97_V	335_L	0.724	0.74
296_G	304_T	0.720	0.74
87_S	91_I	0.720	0.74
204_A	207_I	0.718	0.74
307_S	311_Q	0.713	0.73
305_T	308_L	0.712	0.73
274_V	278_I	0.712	0.73
106_K	238_E	0.711	0.73
222_L	225_V	0.708	0.73
43_G	156_F	0.707	0.73
198_G	286_F	0.707	0.73
33_F	104_E	0.706	0.73
26_V	29_A	0.705	0.73
252_Q	426_S	0.705	0.73
346_L	351_A	0.703	0.72
309_Y	320_L	0.702	0.72
82_I	241_Q	0.701	0.72
25_F	177_Q	0.701	0.72
86_I	408_I	0.699	0.72
57_R	204_A	0.698	0.72
82_I	171_L	0.697	0.72
183_I	189_I	0.696	0.72
210_A	213_G	0.695	0.71
421_Q	431_S	0.695	0.71
193_A	229_A	0.694	0.71
223_V	338_N	0.692	0.71
86_I	328_F	0.691	0.71
75_A	275_I	0.690	0.71
342_T	429_Y	0.686	0.70
77_I	222_L	0.686	0.70
244_I	265_L	0.685	0.70
321_Y	385_C	0.683	0.70
323_S	326_I	0.683	0.70
11_S	391_M	0.681	0.70
199_L	406_L	0.680	0.70
16_L	20_K	0.676	0.69
366_I	373_L	0.675	0.69
371_T	375_L	0.674	0.69
117_S	169_M	0.674	0.69
10_Q	14_G	0.672	0.69
93_Q	190_I	0.671	0.69
206_T	209_Q	0.670	0.69
94_L	331_F	0.670	0.69
237_V	384_I	0.669	0.69
360_E	363_A	0.669	0.69
92_I	275_I	0.668	0.68
294_F	303_L	0.668	0.68
253_Q	257_V	0.666	0.68
214_D	218_L	0.666	0.68
334_A	378_A	0.665	0.68
339_P	366_I	0.664	0.68
296_G	305_T	0.663	0.68
192_F	196_V	0.661	0.68
411_V	415_D	0.660	0.68
71_A	268_K	0.659	0.67
194_G	197_A	0.659	0.67
373_L	378_A	0.658	0.67
280_A	321_Y	0.658	0.67
408_I	412_V	0.655	0.67
101_T	171_L	0.654	0.67
196_V	243_R	0.653	0.67
105_I	109_G	0.652	0.67
79_A	116_I	0.652	0.67
92_I	323_S	0.652	0.67
28_G	32_V	0.650	0.66
312_P	315_P	0.650	0.66
64_F	148_L	0.646	0.66
40_P	199_L	0.645	0.66
258_Y	261_Q	0.640	0.65
19_L	133_I	0.637	0.65
352_F	422_T	0.637	0.65
347_K	369_V	0.636	0.65
38_F	53_L	0.636	0.65
331_F	335_L	0.636	0.65
77_I	170_F	0.636	0.65
33_F	71_A	0.635	0.65
33_F	39_I	0.635	0.65
234_V	244_I	0.634	0.64
375_L	390_F	0.634	0.64
87_S	322_A	0.634	0.64
106_K	113_R	0.633	0.64
272_A	333_T	0.633	0.64
51_K	304_T	0.633	0.64
231_T	396_K	0.632	0.64
223_V	395_M	0.631	0.64
219_V	395_M	0.631	0.64
189_I	193_A	0.631	0.64
98_V	119_Y	0.631	0.64
85_Y	279_F	0.630	0.64
133_I	137_T	0.629	0.64
365_Y	369_V	0.628	0.64
225_V	297_G	0.628	0.64
317_Y	334_A	0.628	0.64
132_S	136_A	0.628	0.64
245_V	249_A	0.627	0.64
76_S	432_A	0.626	0.63
293_W	346_L	0.626	0.63
114_R	250_K	0.624	0.63
295_G	303_L	0.624	0.63
414_M	418_A	0.623	0.63
25_F	268_K	0.622	0.63
238_E	241_Q	0.621	0.63
87_S	277_A	0.621	0.63
64_F	366_I	0.620	0.63
253_Q	259_A	0.620	0.63
422_T	426_S	0.620	0.63
89_S	278_I	0.619	0.63
246_V	346_L	0.618	0.62
327_F	330_F	0.618	0.62
119_Y	272_A	0.618	0.62
21_R	28_G	0.617	0.62
100_P	103_A	0.617	0.62
159_T	162_V	0.616	0.62
242_R	369_V	0.615	0.62
297_G	305_T	0.614	0.62
19_L	183_I	0.613	0.62
220_L	224_A	0.613	0.62
284_I	288_A	0.610	0.61
76_S	125_L	0.610	0.61
352_F	411_V	0.609	0.61
61_I	378_A	0.608	0.61
29_A	171_L	0.607	0.61
150_I	153_G	0.606	0.61
30_L	199_L	0.605	0.61
268_K	273_G	0.605	0.61
229_A	298_T	0.605	0.61
141_N	152_P	0.603	0.61
117_S	392_R	0.603	0.61
25_F	270_N	0.603	0.61
189_I	231_T	0.603	0.61
334_A	371_T	0.601	0.60
33_F	81_G	0.601	0.60
196_V	199_L	0.601	0.60
278_I	403_G	0.601	0.60
121_R	274_V	0.601	0.60
346_L	349_S	0.599	0.60
227_V	231_T	0.598	0.60
135_I	302_W	0.597	0.60
19_L	420_V	0.595	0.60
189_I	416_F	0.594	0.59
225_V	231_T	0.594	0.59
189_I	384_I	0.594	0.59
395_M	398_P	0.594	0.59
278_I	328_F	0.593	0.59
44_I	47_A	0.592	0.59
97_V	246_V	0.592	0.59
19_L	321_Y	0.591	0.59
272_A	387_I	0.591	0.59
136_A	157_Y	0.589	0.59
124_T	230_V	0.589	0.59
274_V	279_F	0.584	0.58
210_A	231_T	0.583	0.58
16_L	19_L	0.583	0.58
101_T	119_Y	0.583	0.58
49_L	267_L	0.583	0.58
248_Y	328_F	0.582	0.58
65_N	71_A	0.582	0.58
16_L	421_Q	0.582	0.58
11_S	342_T	0.581	0.58
129_I	148_L	0.580	0.58
188_S	408_I	0.580	0.58
198_G	387_I	0.578	0.57
13_K	19_L	0.576	0.57
16_L	426_S	0.574	0.57
59_T	312_P	0.574	0.57
339_P	370_M	0.573	0.57
332_Y	351_A	0.572	0.57
34_R	197_A	0.571	0.56
176_E	335_L	0.570	0.56
250_K	264_H	0.569	0.56
26_V	183_I	0.568	0.56
73_S	228_F	0.567	0.56
73_S	353_V	0.567	0.56
271_M	374_T	0.566	0.56
43_G	164_L	0.565	0.56
207_I	319_L	0.563	0.55
150_I	221_L	0.563	0.55
181_R	402_G	0.563	0.55
188_S	328_F	0.562	0.55
192_F	332_Y	0.562	0.55
282_S	285_L	0.561	0.55
133_I	231_T	0.560	0.55
340_R	360_E	0.560	0.55
232_F	236_F	0.559	0.55
49_L	52_L	0.559	0.55
66_M	87_S	0.559	0.55
321_Y	348_K	0.557	0.55
82_I	172_M	0.556	0.54
35_I	39_I	0.555	0.54
259_A	351_A	0.554	0.54
128_A	169_M	0.553	0.54
199_L	202_A	0.553	0.54
33_F	190_I	0.551	0.54
82_I	89_S	0.550	0.54
101_T	244_I	0.550	0.54
304_T	406_L	0.550	0.54
88_A	239_R	0.550	0.54
96_T	102_L	0.549	0.54
269_V	272_A	0.547	0.53
86_I	274_V	0.546	0.53
268_K	336_V	0.546	0.53
244_I	356_I	0.546	0.53
278_I	415_D	0.545	0.53
171_L	272_A	0.544	0.53
320_L	327_F	0.543	0.53
254_G	257_V	0.543	0.53
331_F	412_V	0.542	0.53
169_M	423_L	0.542	0.53
311_Q	320_L	0.542	0.53
277_A	346_L	0.542	0.53
383_F	387_I	0.541	0.52
166_T	170_F	0.541	0.52
62_E	168_T	0.540	0.52
41_I	81_G	0.539	0.52
361_Q	383_F	0.539	0.52
218_L	394_A	0.539	0.52
314_Q	318_V	0.538	0.52
321_Y	386_L	0.537	0.52
277_A	411_V	0.537	0.52
289_T	342_T	0.537	0.52
263_T	338_N	0.536	0.52
225_V	228_F	0.536	0.52
200_P	242_R	0.536	0.52
37_S	338_N	0.536	0.52
65_N	70_G	0.534	0.52
24_L	27_I	0.533	0.51
151_N	157_Y	0.532	0.51
321_Y	384_I	0.531	0.51
29_A	32_V	0.531	0.51
205_H	296_G	0.530	0.51
277_A	281_S	0.528	0.51
307_S	310_L	0.528	0.51
77_I	110_E	0.528	0.51
15_G	261_Q	0.526	0.50
235_V	312_P	0.526	0.50
38_F	76_S	0.525	0.50
74_R	78_F	0.525	0.50
208_E	214_D	0.523	0.50
309_Y	314_Q	0.523	0.50
89_S	171_L	0.522	0.50
13_K	373_L	0.522	0.50
48_V	76_S	0.521	0.50
59_T	65_N	0.521	0.50
48_V	146_Q	0.520	0.50
10_Q	13_K	0.520	0.50
198_G	202_A	0.520	0.50
352_F	426_S	0.519	0.50
304_T	316_L	0.519	0.50
27_I	51_K	0.519	0.50
297_G	344_D	0.518	0.49
72_L	79_A	0.518	0.49
87_S	192_F	0.518	0.49
252_Q	258_Y	0.517	0.49
52_L	146_Q	0.517	0.49
313_G	318_V	0.517	0.49
56_Q	60_I	0.517	0.49
227_V	230_V	0.517	0.49
175_G	333_T	0.517	0.49
33_F	76_S	0.517	0.49
77_I	333_T	0.517	0.49
17_G	20_K	0.516	0.49
140_P	149_V	0.515	0.49
284_I	396_K	0.514	0.49
423_L	426_S	0.513	0.49
308_L	383_F	0.513	0.49
238_E	277_A	0.513	0.49
235_V	239_R	0.512	0.49
51_K	158_F	0.512	0.49
86_I	188_S	0.512	0.49
37_S	425_M	0.511	0.49
66_M	232_F	0.511	0.49
205_H	292_S	0.511	0.49
344_D	392_R	0.511	0.49
76_S	348_K	0.511	0.49
26_V	416_F	0.510	0.48
129_I	162_V	0.510	0.48
59_T	75_A	0.510	0.48
72_L	97_V	0.509	0.48
112_G	278_I	0.509	0.48
191_I	194_G	0.509	0.48
375_L	379_L	0.509	0.48
308_L	311_Q	0.508	0.48
312_P	318_V	0.508	0.48
49_L	113_R	0.508	0.48
217_F	323_S	0.506	0.48
213_G	216_H	0.505	0.48
291_A	433_L	0.505	0.48
252_Q	255_R	0.504	0.48
246_V	351_A	0.504	0.48
76_S	198_G	0.503	0.47
50_A	59_T	0.503	0.47
274_V	328_F	0.502	0.47
24_L	245_V	0.501	0.47
242_R	354_P	0.501	0.47
106_K	399_F	0.501	0.47
86_I	383_F	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dinC	1	0.8916	100	0.073	Contact Map
2zjsY	2	0.93	100	0.075	Contact Map
3j01A	1	0.9819	100	0.082	Contact Map
3dl8G	1	0.9097	100	0.085	Contact Map
3mp7A	1	0.7472	100	0.167	Contact Map
1rh5A	1	0.8533	100	0.167	Contact Map
2ww9A	1	0.93	100	0.195	Contact Map
4w251	1	0.7878	100	0.239	Contact Map
4humA	1	0.8984	4.6	0.981	Contact Map
4j05A	3	0.4853	4.6	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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