GREMLIN Database
SECF - Protein translocase subunit SecF
UniProt: P0AG93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10940
Length: 323 (288)
Sequences: 48943 (35088)
Seq/√Len: 2067.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_T235_E4.3631.00
17_Y238_N3.5751.00
187_I279_I3.2641.00
115_L119_N2.9611.00
117_V120_E2.7751.00
224_N239_V2.6971.00
224_N227_K2.5911.00
229_R239_V2.5761.00
22_W25_W2.5401.00
15_K290_Y2.5071.00
224_N229_R2.4311.00
111_G115_L2.4291.00
234_Y297_L2.3211.00
113_Q116_K2.2771.00
169_L222_R2.2651.00
222_R226_R2.2551.00
21_R234_Y2.2101.00
220_R224_N2.1961.00
183_I283_I2.1301.00
206_V280_G2.0991.00
256_L282_S2.0861.00
224_N243_Q2.0661.00
252_S285_T2.0631.00
213_D252_S2.0521.00
72_R76_Q2.0471.00
112_S116_K2.0381.00
38_I42_G2.0251.00
235_E239_V1.9751.00
158_L170_A1.9721.00
237_F297_L1.9501.00
39_V43_V1.9481.00
113_Q117_V1.9111.00
256_L278_L1.8991.00
39_V42_G1.8931.00
67_E70_V1.8711.00
27_F298_K1.8651.00
60_I63_E1.8621.00
151_M155_L1.8571.00
229_R232_T1.8291.00
234_Y238_N1.7961.00
18_D21_R1.7811.00
18_D22_W1.7271.00
116_K120_E1.7261.00
14_R17_Y1.7181.00
74_A78_A1.6941.00
23_D297_L1.6921.00
147_A151_M1.6881.00
220_R223_E1.6721.00
69_D73_D1.6671.00
66_A71_M1.6361.00
239_V242_T1.6171.00
210_S284_G1.5861.00
112_S115_L1.5841.00
43_V189_S1.5801.00
220_R243_Q1.5771.00
191_F275_L1.5701.00
62_L65_P1.5571.00
223_E227_K1.5531.00
188_L276_T1.5391.00
213_D251_T1.5361.00
162_G170_A1.5221.00
17_Y21_R1.5141.00
19_F26_A1.5071.00
69_D72_R1.4961.00
148_M152_A1.4891.00
263_Y278_L1.4661.00
284_G288_S1.4601.00
285_T289_I1.4131.00
32_L36_A1.4111.00
225_F300_G1.4081.00
25_W28_G1.3971.00
116_K119_N1.3921.00
60_I65_P1.3871.00
221_I240_S1.3731.00
70_V74_A1.3681.00
105_T108_Q1.3661.00
59_E62_L1.3651.00
144_Q147_A1.3631.00
66_A70_V1.3621.00
228_I239_V1.3591.00
80_F85_L1.3511.00
140_A144_Q1.3401.00
144_Q148_M1.3351.00
158_L174_V1.3301.00
23_D298_K1.3291.00
24_Y298_K1.3291.00
221_I296_A1.3281.00
70_V73_D1.3131.00
225_F233_P1.3131.00
228_I236_I1.3121.00
73_D76_Q1.3081.00
217_V241_L1.3071.00
30_S291_V1.3061.00
35_I39_V1.2881.00
249_L285_T1.2871.00
61_T64_K1.2861.00
263_Y275_L1.2771.00
58_I61_T1.2691.00
224_N228_I1.2681.00
68_I71_M1.2641.00
24_Y28_G1.2561.00
16_V20_M1.2501.00
73_D77_K1.2481.00
112_S140_A1.2471.00
148_M151_M1.2471.00
130_R133_F1.2431.00
233_P237_F1.2421.00
260_L278_L1.2421.00
27_F31_G1.2341.00
14_R18_D1.2261.00
229_R235_E1.2151.00
49_G54_G1.2151.00
238_N242_T1.2131.00
155_L159_V1.1961.00
110_L113_Q1.1851.00
74_A77_K1.1831.00
71_M78_A1.1831.00
71_M74_A1.1821.00
196_D199_I1.1791.00
225_F296_A1.1761.00
59_E63_E1.1631.00
239_V243_Q1.1551.00
302_K305_H1.1551.00
188_L199_I1.1501.00
68_I72_R1.1461.00
80_F83_P1.1321.00
157_I211_L1.1301.00
104_E108_Q1.1291.00
101_A105_T1.1231.00
101_A104_E1.1201.00
104_E107_G1.1171.00
193_I275_L1.0971.00
20_M297_L1.0551.00
221_I237_F1.0551.00
294_A297_L1.0371.00
188_L193_I1.0351.00
268_P271_E1.0351.00
21_R24_Y1.0311.00
20_M238_N1.0311.00
225_F236_I1.0191.00
179_H287_S1.0171.00
40_I186_G1.0141.00
225_F228_I1.0051.00
36_A40_I1.0041.00
98_M101_A1.0021.00
110_L114_V0.9971.00
100_P104_E0.9971.00
34_L183_I0.9961.00
40_I190_L0.9961.00
103_G106_G0.9951.00
58_I63_E0.9951.00
28_G32_L0.9951.00
87_N92_H0.9941.00
186_G189_S0.9881.00
79_G82_E0.9811.00
71_M76_Q0.9811.00
31_G35_I0.9801.00
170_A173_V0.9781.00
235_E238_N0.9761.00
85_L89_G0.9721.00
40_I189_S0.9721.00
59_E64_K0.9611.00
86_Q89_G0.9601.00
158_L162_G0.9591.00
249_L253_G0.9571.00
172_G295_L0.9551.00
66_A72_R0.9551.00
228_I232_T0.9541.00
255_T281_V0.9531.00
252_S281_V0.9461.00
68_I76_Q0.9431.00
34_L38_I0.9421.00
108_Q112_S0.9401.00
58_I62_L0.9381.00
171_A175_I0.9371.00
83_P87_N0.9351.00
47_N194_E0.9341.00
36_A39_V0.9321.00
80_F89_G0.9271.00
61_T65_P0.9261.00
57_V60_I0.9241.00
184_T280_G0.9241.00
100_P103_G0.9231.00
30_S179_H0.9221.00
191_F279_I0.9151.00
145_T148_M0.9091.00
28_G35_I0.8991.00
233_P301_M0.8901.00
100_P105_T0.8881.00
100_P106_G0.8841.00
176_A287_S0.8811.00
125_N130_R0.8781.00
40_I43_V0.8781.00
50_L53_T0.8781.00
217_V248_T0.8771.00
34_L182_I0.8741.00
75_L78_A0.8731.00
284_G289_I0.8671.00
172_G299_L0.8631.00
85_L92_H0.8601.00
102_E106_G0.8521.00
300_G303_R0.8511.00
67_E74_A0.8501.00
108_Q113_Q0.8461.00
196_D272_G0.8401.00
221_I233_P0.8331.00
67_E71_M0.8201.00
20_M294_A0.8191.00
15_K18_D0.8181.00
30_S290_Y0.8161.00
100_P107_G0.8121.00
172_G292_A0.8081.00
153_A157_I0.8071.00
168_R302_K0.8051.00
68_I75_L0.8011.00
214_S292_A0.7981.00
209_Y213_D0.7981.00
98_M105_T0.7971.00
88_F92_H0.7931.00
68_I78_A0.7931.00
20_M234_Y0.7881.00
72_R75_L0.7871.00
29_I36_A0.7821.00
278_L282_S0.7821.00
18_D26_A0.7791.00
212_N254_T0.7761.00
232_T236_I0.7761.00
26_A29_I0.7751.00
166_E169_L0.7701.00
294_A298_K0.7691.00
275_L279_I0.7691.00
88_F93_D0.7631.00
122_T126_A0.7611.00
57_V61_T0.7611.00
59_E65_P0.7591.00
29_I33_L0.7571.00
86_Q90_S0.7561.00
245_L249_L0.7541.00
233_P297_L0.7531.00
32_L35_I0.7521.00
34_L179_H0.7501.00
19_F294_A0.7491.00
223_E226_R0.7491.00
233_P236_I0.7491.00
183_I287_S0.7461.00
82_E85_L0.7451.00
57_V64_K0.7401.00
202_S277_M0.7391.00
37_A40_I0.7391.00
50_L57_V0.7381.00
115_L130_R0.7371.00
184_T188_L0.7371.00
83_P89_G0.7361.00
187_I275_L0.7351.00
225_F229_R0.7331.00
66_A78_A0.7331.00
233_P300_G0.7331.00
177_L210_S0.7321.00
67_E72_R0.7301.00
66_A74_A0.7281.00
103_G107_G0.7241.00
154_L207_I0.7241.00
133_F137_S0.7231.00
152_A156_S0.7231.00
92_H100_P0.7221.00
202_S276_T0.7211.00
98_M107_G0.7181.00
245_L289_I0.7121.00
173_V211_L0.7111.00
263_Y271_E0.7111.00
26_A30_S0.7061.00
118_I128_V0.7061.00
271_E275_L0.7051.00
98_M104_E0.7031.00
49_G53_T0.6991.00
24_Y27_F0.6981.00
70_V78_A0.6971.00
15_K19_F0.6951.00
237_F241_L0.6951.00
296_A300_G0.6951.00
83_P88_F0.6921.00
114_V130_R0.6911.00
49_G55_G0.6881.00
68_I74_A0.6861.00
115_L140_A0.6851.00
229_R236_I0.6801.00
53_T56_T0.6781.00
81_E88_F0.6771.00
57_V63_E0.6771.00
213_D216_V0.6751.00
137_S140_A0.6741.00
102_E105_T0.6721.00
251_T285_T0.6691.00
57_V62_L0.6681.00
217_V240_S0.6671.00
24_Y35_I0.6671.00
222_R225_F0.6671.00
179_H291_V0.6651.00
21_R25_W0.6641.00
122_T128_V0.6621.00
115_L133_F0.6611.00
259_I277_M0.6581.00
172_G214_S0.6581.00
208_G212_N0.6531.00
71_M77_K0.6521.00
98_M102_E0.6511.00
25_W29_I0.6471.00
72_R78_A0.6471.00
301_M305_H0.6431.00
212_N255_T0.6431.00
187_I283_I0.6421.00
91_S95_M0.6411.00
41_M46_F0.6391.00
217_V288_S0.6391.00
38_I182_I0.6391.00
209_Y255_T0.6351.00
44_R48_W0.6331.00
23_D27_F0.6331.00
110_L115_L0.6321.00
35_I38_I0.6291.00
187_I191_F0.6261.00
173_V218_S0.6261.00
82_E86_Q0.6261.00
176_A214_S0.6231.00
100_P110_L0.6221.00
52_F55_G0.6211.00
72_R77_K0.6201.00
193_I272_G0.6191.00
197_L200_V0.6181.00
97_R100_P0.6181.00
92_H98_M0.6171.00
83_P86_Q0.6171.00
140_A143_A0.6141.00
69_D74_A0.6141.00
282_S286_A0.6141.00
97_R102_E0.6131.00
60_I64_K0.6121.00
49_G52_F0.6071.00
79_G83_P0.6061.00
180_D184_T0.6061.00
87_N90_S0.6041.00
199_I272_G0.6031.00
48_W52_F0.6001.00
167_W171_A0.5971.00
70_V76_Q0.5971.00
16_V241_L0.5971.00
198_T269_V0.5961.00
80_F87_N0.5951.00
128_V133_F0.5931.00
68_I77_K0.5931.00
34_L37_A0.5931.00
18_D25_W0.5911.00
251_T255_T0.5911.00
98_M110_L0.5901.00
92_H95_M0.5901.00
37_A186_G0.5901.00
121_S124_Q0.5881.00
58_I65_P0.5871.00
53_T57_V0.5861.00
101_A107_G0.5861.00
17_Y235_E0.5851.00
67_E76_Q0.5831.00
259_I278_L0.5831.00
182_I186_G0.5821.00
173_V214_S0.5801.00
236_I240_S0.5781.00
23_D234_Y0.5761.00
291_V295_L0.5761.00
216_V247_R0.5741.00
186_G190_L0.5721.00
286_A290_Y0.5721.00
241_L245_L0.5711.00
195_I199_I0.5701.00
159_V163_F0.5681.00
165_F215_I0.5681.00
292_A296_A0.5681.00
169_L300_G0.5681.00
16_V242_T0.5671.00
131_I135_G0.5661.00
98_M106_G0.5661.00
114_V117_V0.5621.00
162_G167_W0.5621.00
18_D23_D0.5591.00
165_F208_G0.5591.00
84_M88_F0.5551.00
46_F50_L0.5551.00
53_T59_E0.5541.00
81_E86_Q0.5531.00
252_S256_L0.5521.00
191_F194_E0.5511.00
213_D284_G0.5491.00
149_A153_A0.5481.00
167_W170_A0.5461.00
111_G118_I0.5451.00
84_M87_N0.5441.00
80_F88_F0.5441.00
176_A292_A0.5441.00
225_F232_T0.5421.00
152_A155_L0.5411.00
69_D76_Q0.5381.00
216_V248_T0.5351.00
82_E87_N0.5351.00
300_G304_E0.5351.00
221_I225_F0.5341.00
220_R240_S0.5341.00
122_T125_N0.5331.00
248_T285_T0.5321.00
115_L118_I0.5311.00
45_G48_W0.5311.00
263_Y274_S0.5301.00
124_Q130_R0.5291.00
297_L301_M0.5291.00
42_G45_G0.5271.00
70_V77_K0.5261.00
50_L59_E0.5261.00
54_G60_I0.5251.00
184_T276_T0.5231.00
16_V238_N0.5231.00
141_D144_Q0.5211.00
244_T247_R0.5201.00
67_E75_L0.5121.00
212_N216_V0.5121.00
260_L264_L0.5111.00
206_V277_M0.5101.00
47_N50_L0.5081.00
193_I271_E0.5041.00
48_W55_G0.5041.00
79_G89_G0.5021.00
142_L197_L0.5011.00
234_Y237_F0.5011.00
279_I283_I0.5011.00
85_L88_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.8947 100 0.363 Contact Map
3w9iA 3 0.9257 100 0.384 Contact Map
4dx5A 3 0.9536 100 0.389 Contact Map
4mt1A 3 0.904 100 0.39 Contact Map
4k0jA 3 0.8916 100 0.4 Contact Map
3ne5A 3 0.9102 100 0.401 Contact Map
4j72A 2 0.1238 48.9 0.929 Contact Map
4ea3A 2 0.7399 17.6 0.944 Contact Map
2kncA 1 0.1672 13.3 0.947 Contact Map
2m20A 2 0.1548 9.8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.