GREMLIN Database
PSTS - Phosphate-binding protein PstS
UniProt: P0AG82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10734
Length: 346 (282)
Sequences: 5261 (3795)
Seq/√Len: 226.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_D132_K4.0301.00
121_D124_T3.8851.00
135_K152_S3.6481.00
137_D152_S3.4441.00
153_Q214_G3.4101.00
128_I155_I3.2741.00
119_V241_P3.2121.00
233_K243_S2.9291.00
120_L232_T2.8611.00
121_D144_L2.8321.00
111_P213_P2.5801.00
135_K154_N2.5191.00
123_K127_D2.4651.00
32_A75_V2.3971.00
106_L125_L2.3821.00
124_T145_N2.3261.00
107_A209_V2.3001.00
35_T60_G2.2011.00
34_A37_P2.1861.00
145_N149_K2.1581.00
124_T127_D2.1431.00
32_A69_Q2.1341.00
48_Y300_K2.1221.00
86_D90_A2.1211.00
61_I65_G2.1121.00
95_F287_K2.0441.00
245_T248_N2.0431.00
119_V233_K2.0181.00
235_I241_P2.0131.00
323_D327_E2.0051.00
47_T304_W2.0031.00
47_T50_K2.0001.00
156_A212_L1.9721.00
169_V279_S1.9501.00
107_A219_V1.9031.00
41_Y301_F1.8911.00
124_T144_L1.8831.00
327_E331_A1.8811.00
38_A60_G1.8691.00
118_L230_A1.8631.00
63_S80_S1.8301.00
51_E308_T1.8081.00
303_D330_R1.8071.00
82_A88_K1.7701.00
108_V232_T1.7631.00
121_D235_I1.7551.00
106_L170_F1.6871.00
48_Y54_N1.6801.00
135_K153_Q1.6601.00
129_Y157_V1.6281.00
41_Y305_A1.6151.00
120_L125_L1.6141.00
76_D294_Q1.5971.00
126_G178_N1.5801.00
224_A231_Y1.5691.00
209_V217_G1.5521.00
125_L234_L1.5331.00
103_G249_F1.5141.00
31_G77_F1.4911.00
38_A42_A1.4611.00
134_K138_D1.4491.00
296_T300_K1.4231.00
153_Q213_P1.4141.00
30_T57_N1.4121.00
69_Q75_V1.4111.00
104_V279_S1.3981.00
133_I138_D1.3861.00
327_E330_R1.3791.00
283_I305_A1.3761.00
49_Q55_K1.3751.00
60_G203_D1.3741.00
80_S284_L1.3551.00
70_I78_G1.3541.00
291_K294_Q1.3481.00
329_V332_A1.3261.00
207_A211_R1.3211.00
27_A297_E1.3141.00
15_T18_M1.2941.00
127_D133_I1.2921.00
206_A219_V1.2771.00
202_N223_Y1.2581.00
37_P41_Y1.2581.00
107_A229_L1.2551.00
326_V330_R1.2501.00
328_Q331_A1.2371.00
157_V216_I1.2331.00
118_L233_K1.2291.00
98_P329_V1.2211.00
314_N320_S1.2151.00
246_E250_A1.2131.00
285_I302_F1.2111.00
307_K330_R1.2051.00
100_V281_T1.2051.00
120_L128_I1.1931.00
85_S88_K1.1891.00
41_Y283_I1.1831.00
48_Y304_W1.1771.00
44_W305_A1.1761.00
15_T19_S1.1731.00
97_F306_Y1.1711.00
28_S57_N1.1661.00
158_V208_F1.1641.00
28_S55_K1.1631.00
306_Y310_A1.1621.00
25_A54_N1.1441.00
41_Y99_T1.1431.00
289_Q295_G1.1401.00
300_K303_D1.1341.00
13_A16_L1.1321.00
67_V84_L1.1321.00
105_V224_A1.1271.00
311_K315_D1.1231.00
43_K315_D1.1231.00
135_K150_L1.1211.00
236_S239_G1.1121.00
18_M21_F1.1031.00
160_R164_S1.1011.00
246_E314_N1.1001.00
234_L277_I1.0961.00
159_R198_G1.0911.00
97_F285_I1.0861.00
32_A61_I1.0821.00
173_Y177_V1.0771.00
73_N286_H1.0761.00
47_T312_Q1.0521.00
84_L94_L1.0501.00
235_I239_G1.0481.00
303_D307_K1.0461.00
79_A283_I1.0451.00
158_V212_L1.0421.00
34_A81_D1.0421.00
306_Y329_V1.0361.00
122_G174_L1.0321.00
104_V169_V1.0311.00
12_V15_T1.0211.00
129_Y170_F1.0201.00
59_Q69_Q1.0171.00
328_Q332_A1.0131.00
67_V80_S1.0111.00
34_A41_Y1.0071.00
119_V235_I0.9871.00
36_F102_G0.9871.00
87_E90_A0.9841.00
242_V274_A0.9831.00
132_K180_E0.9831.00
21_F25_A0.9811.00
310_A326_V0.9731.00
71_I91_Q0.9661.00
41_Y79_A0.9611.00
225_K228_N0.9601.00
11_V14_A0.9521.00
75_V78_G0.9471.00
36_F281_T0.9451.00
299_L303_D0.9431.00
101_I280_T0.9381.00
43_K46_D0.9341.00
45_A56_V0.9271.00
301_F305_A0.9271.00
99_T281_T0.9271.00
324_S327_E0.9271.00
222_A318_Y0.9251.00
8_V12_V0.9221.00
199_G205_I0.9201.00
106_L275_W0.9201.00
99_T283_I0.9201.00
19_S22_S0.9201.00
158_V197_L0.9191.00
323_D326_V0.9171.00
123_K126_G0.9161.00
134_K154_N0.9140.99
40_V100_V0.9130.99
221_Y244_P0.9030.99
86_D89_L0.8990.99
18_M23_V0.8950.99
45_A301_F0.8920.99
83_P96_Q0.8860.99
84_L284_L0.8850.99
68_K72_A0.8830.99
325_V328_Q0.8810.99
45_A49_Q0.8800.99
221_Y225_K0.8730.99
156_A197_L0.8700.99
202_N219_V0.8650.99
45_A58_Y0.8640.99
234_L275_W0.8610.99
158_V215_A0.8590.99
167_S218_Y0.8580.99
18_M22_S0.8500.99
69_Q74_T0.8450.99
77_F283_I0.8440.99
98_P280_T0.8440.99
82_A168_F0.8430.99
37_P99_T0.8430.99
29_L297_E0.8420.99
122_G126_G0.8400.99
242_V248_N0.8360.99
102_G279_S0.8350.99
104_V166_T0.8330.99
145_N148_L0.8320.99
100_V313_A0.8320.99
208_F212_L0.8300.99
20_A24_F0.8300.99
64_S163_G0.8270.99
81_D281_T0.8260.99
250_A319_A0.8240.99
102_G220_E0.8200.99
159_R196_G0.8200.99
144_L148_L0.8190.99
48_Y301_F0.8180.99
108_V230_A0.8160.99
312_Q315_D0.8160.99
130_L180_E0.8130.99
304_W312_Q0.8110.99
248_N274_A0.8070.99
21_F24_F0.8050.99
306_Y330_R0.8040.99
135_K149_K0.8020.99
84_L96_Q0.7990.99
67_V78_G0.7980.99
197_L208_F0.7980.99
96_Q284_L0.7970.99
88_K91_Q0.7960.99
127_D130_L0.7920.99
98_P325_V0.7920.99
61_I69_Q0.7880.98
201_G204_G0.7880.98
205_I217_G0.7870.98
137_D145_N0.7860.98
180_E184_N0.7840.98
36_F279_S0.7840.98
70_I94_L0.7840.98
164_S202_N0.7830.98
14_A17_S0.7830.98
44_W309_G0.7760.98
32_A59_Q0.7760.98
283_I302_F0.7730.98
36_F81_D0.7730.98
62_G66_G0.7670.98
9_A14_A0.7660.98
89_L94_L0.7630.98
128_I148_L0.7630.98
126_G174_L0.7610.98
129_Y216_I0.7610.98
249_F278_T0.7570.98
120_L150_L0.7540.98
122_G173_Y0.7520.98
204_G208_F0.7480.98
43_K316_L0.7470.98
114_K230_A0.7450.98
11_V15_T0.7420.98
77_F285_I0.7410.98
67_V88_K0.7410.98
37_P283_I0.7400.98
322_P325_V0.7380.98
160_R218_Y0.7380.98
43_K47_T0.7360.98
144_L241_P0.7290.98
135_K138_D0.7270.97
137_D150_L0.7270.97
248_N273_D0.7210.97
10_T13_A0.7170.97
248_N272_E0.7160.97
243_S248_N0.7150.97
311_K314_N0.7110.97
105_V221_Y0.7100.97
39_P223_Y0.7090.97
81_D279_S0.7020.97
158_V199_G0.7020.97
102_G281_T0.7010.97
34_A165_G0.7010.97
8_V11_V0.6990.97
325_V329_V0.6980.97
113_L151_P0.6950.97
126_G130_L0.6920.97
96_Q282_F0.6910.97
137_D149_K0.6880.96
161_A200_K0.6850.96
13_A17_S0.6810.96
244_P248_N0.6780.96
231_Y244_P0.6770.96
122_G238_D0.6770.96
210_Q228_N0.6760.96
97_F329_V0.6730.96
22_S25_A0.6710.96
37_P281_T0.6700.96
286_H289_Q0.6690.96
172_S176_K0.6690.96
16_L19_S0.6660.96
219_V223_Y0.6650.96
40_V313_A0.6620.96
105_V231_Y0.6600.96
120_L234_L0.6580.95
246_E320_S0.6560.95
247_E250_A0.6550.95
17_S22_S0.6540.95
110_I214_G0.6540.95
17_S20_A0.6520.95
62_G81_D0.6520.95
47_T51_E0.6520.95
81_D102_G0.6520.95
106_L129_Y0.6490.95
171_T175_A0.6480.95
168_F172_S0.6470.95
310_A313_A0.6430.95
108_V118_L0.6420.95
199_G208_F0.6390.95
121_D241_P0.6390.95
164_S200_K0.6380.95
206_A225_K0.6370.95
12_V16_L0.6350.95
66_G165_G0.6350.95
166_T202_N0.6310.94
38_A61_I0.6290.94
138_D150_L0.6280.94
129_Y159_R0.6270.94
220_E223_Y0.6260.94
34_A99_T0.6240.94
181_W185_V0.6230.94
65_G69_Q0.6210.94
84_L89_L0.6200.94
82_A85_S0.6180.94
158_V205_I0.6180.94
105_V244_P0.6140.93
120_L124_T0.6130.93
109_N213_P0.6130.93
233_K241_P0.6130.93
105_V249_F0.6110.93
297_E300_K0.6110.93
221_Y246_E0.6080.93
325_V332_A0.6080.93
34_A283_I0.6070.93
27_A54_N0.6050.93
308_T311_K0.6050.93
54_N297_E0.6040.93
235_I238_D0.6020.93
31_G79_A0.6020.93
25_A48_Y0.6010.93
79_A305_A0.5990.93
59_Q65_G0.5980.93
35_T201_G0.5980.93
302_F306_Y0.5970.93
125_L129_Y0.5960.92
169_V173_Y0.5960.92
122_G276_P0.5940.92
30_T59_Q0.5930.92
124_T133_I0.5910.92
155_I214_G0.5900.92
164_S205_I0.5890.92
20_A23_V0.5870.92
134_K152_S0.5850.92
233_K244_P0.5810.91
180_E183_N0.5800.91
54_N300_K0.5790.91
199_G204_G0.5780.91
111_P214_G0.5770.91
99_T305_A0.5760.91
212_L215_A0.5740.91
225_K317_D0.5740.91
157_V181_W0.5730.91
62_G166_T0.5720.91
83_P282_F0.5700.91
170_F277_I0.5690.91
107_A217_G0.5670.90
156_A214_G0.5660.90
63_S66_G0.5620.90
161_A201_G0.5610.90
41_Y58_Y0.5590.90
122_G144_L0.5590.90
17_S21_F0.5580.90
57_N69_Q0.5580.90
7_T11_V0.5580.90
285_I298_V0.5550.90
302_F305_A0.5540.89
113_L230_A0.5530.89
324_S328_Q0.5520.89
13_A18_M0.5510.89
11_V17_S0.5510.89
160_R202_N0.5490.89
124_T149_K0.5470.89
123_K180_E0.5450.89
128_I144_L0.5450.89
175_A178_N0.5410.88
14_A24_F0.5400.88
207_A210_Q0.5390.88
10_T14_A0.5390.88
305_A309_G0.5380.88
89_L96_Q0.5370.88
48_Y297_E0.5340.88
18_M24_F0.5310.87
307_K326_V0.5300.87
32_A65_G0.5300.87
303_D306_Y0.5290.87
97_F302_F0.5290.87
36_F166_T0.5250.87
68_K91_Q0.5240.87
307_K310_A0.5220.87
173_Y176_K0.5210.86
295_G298_V0.5180.86
118_L232_T0.5180.86
121_D125_L0.5170.86
35_T62_G0.5160.86
62_G65_G0.5150.86
76_D298_V0.5130.86
120_L216_I0.5120.85
167_S171_T0.5120.85
71_I94_L0.5110.85
135_K214_G0.5110.85
68_K85_S0.5090.85
130_L175_A0.5090.85
118_L150_L0.5080.85
166_T279_S0.5080.85
304_W308_T0.5070.85
81_D166_T0.5060.85
209_V215_A0.5060.85
84_L88_K0.5050.85
181_W184_N0.5050.85
11_V16_L0.5040.85
130_L183_N0.5030.84
69_Q72_A0.5020.84
87_E91_Q0.5020.84
44_W47_T0.5000.84
102_G318_Y0.5000.84
221_Y249_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f1vA 1 0.8844 100 0.355 Contact Map
1ixhA 1 0.922 100 0.459 Contact Map
1pc3A 1 0.9249 100 0.499 Contact Map
4n13A 1 0.7023 100 0.512 Contact Map
4lvqA 1 0.8728 100 0.595 Contact Map
4jwoA 1 0.7803 100 0.638 Contact Map
4ombA 1 0.7803 100 0.64 Contact Map
4ecfA 1 0.7399 99.9 0.653 Contact Map
4exlA 1 0.7514 99.9 0.657 Contact Map
1twyA 5 0.7139 99.9 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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