GREMLIN Database
UGPB - sn-glycerol-3-phosphate-binding periplasmic protein UgpB
UniProt: P0AG80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11047
Length: 438 (392)
Sequences: 28979 (22835)
Seq/√Len: 1153.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_T58_V3.7531.00
413_T416_Q3.5281.00
102_K321_Y3.3521.00
153_D284_N3.2601.00
231_V415_Q3.2211.00
238_E242_K3.2151.00
26_T56_K2.8791.00
152_K286_G2.8021.00
235_A239_E2.7501.00
103_P135_H2.7481.00
28_P58_V2.6611.00
52_N326_K2.6451.00
152_K156_K2.5031.00
177_A243_K2.4981.00
42_D46_Q2.4971.00
173_A239_E2.4781.00
150_Y286_G2.3941.00
168_T171_D2.3711.00
415_Q419_D2.3691.00
55_Y323_G2.3621.00
239_E243_K2.3511.00
47_R50_A2.3241.00
48_F326_K2.2481.00
67_Q70_S2.2351.00
419_D423_E2.1871.00
155_F266_M2.1641.00
49_N56_K2.1631.00
326_K329_D2.1511.00
129_S136_L2.1171.00
228_P232_K2.1131.00
226_N419_D2.1061.00
422_V426_N2.1001.00
174_D178_K2.0871.00
320_T323_G2.0731.00
122_P126_G2.0421.00
105_Y135_H2.0361.00
333_K336_N2.0321.00
24_V56_K2.0041.00
177_A181_A1.9991.00
28_P60_T1.9701.00
412_K420_T1.9681.00
160_L175_Y1.9681.00
10_A13_L1.9611.00
46_Q50_A1.9451.00
30_W75_A1.9361.00
370_D374_R1.9311.00
119_Q352_A1.9291.00
47_R330_F1.9141.00
153_D157_K1.8951.00
171_D174_D1.8831.00
43_S46_Q1.8601.00
406_S411_K1.8281.00
83_A320_T1.8271.00
235_A414_P1.8051.00
232_K235_A1.7791.00
101_I311_W1.7641.00
47_R51_E1.7581.00
178_K182_S1.7381.00
251_R254_E1.7321.00
423_E427_Q1.7321.00
11_L14_G1.7221.00
126_G129_S1.7001.00
174_D177_A1.6941.00
107_V325_A1.6781.00
85_L313_M1.6741.00
406_S412_K1.6651.00
416_Q420_T1.6621.00
322_T326_K1.6581.00
407_V417_A1.6341.00
338_A342_Q1.6311.00
235_A415_Q1.6041.00
138_S309_S1.5911.00
231_V414_P1.5841.00
316_K320_T1.5831.00
170_Q173_A1.5761.00
46_Q49_N1.5621.00
45_A49_N1.5591.00
189_A264_C1.5451.00
148_L288_G1.5371.00
420_T424_R1.5351.00
25_T323_G1.5341.00
47_R339_E1.5211.00
128_Y309_S1.5161.00
150_Y288_G1.4961.00
45_A327_F1.4891.00
49_N53_P1.4781.00
398_V402_E1.4761.00
419_D422_V1.4751.00
416_Q419_D1.4731.00
231_V235_A1.4671.00
76_F81_A1.4601.00
173_A177_A1.4491.00
166_P171_D1.4401.00
173_A240_M1.4371.00
399_I424_R1.4371.00
152_K284_N1.4351.00
170_Q174_D1.4281.00
316_K321_Y1.4171.00
103_P106_D1.4131.00
154_A179_L1.3981.00
238_E407_V1.3971.00
312_V328_L1.3871.00
154_A265_A1.3801.00
420_T423_E1.3711.00
48_F55_Y1.3701.00
226_N422_V1.3681.00
38_G42_D1.3651.00
374_R377_L1.3591.00
179_L265_A1.3561.00
102_K314_Q1.3511.00
258_K263_D1.3451.00
167_K171_D1.3451.00
24_V54_D1.3421.00
236_M240_M1.3421.00
173_A243_K1.3271.00
259_F285_Y1.3271.00
403_E412_K1.3251.00
71_A75_A1.3241.00
407_V414_P1.3221.00
334_P338_A1.3191.00
43_S47_R1.3141.00
336_N339_E1.3091.00
48_F330_F1.3061.00
96_M137_L1.2991.00
403_E420_T1.2841.00
25_T320_T1.2841.00
211_S222_V1.2811.00
180_K187_G1.2791.00
31_H59_P1.2771.00
176_A266_M1.2761.00
84_I328_L1.2711.00
158_A179_L1.2691.00
236_M239_E1.2571.00
45_A59_P1.2451.00
55_Y326_K1.2341.00
7_T13_L1.2301.00
229_E232_K1.2291.00
87_V311_W1.2191.00
148_L266_M1.2181.00
211_S220_D1.2171.00
128_Y136_L1.2151.00
48_F327_F1.2071.00
48_F52_N1.2001.00
39_K42_D1.1921.00
423_E426_N1.1911.00
412_K417_A1.1911.00
111_A329_D1.1881.00
147_V287_V1.1811.00
83_A316_K1.1791.00
202_S207_L1.1771.00
99_K314_Q1.1701.00
316_K324_V1.1701.00
173_A236_M1.1661.00
63_G67_Q1.1651.00
403_E406_S1.1631.00
170_Q294_A1.1551.00
330_F336_N1.1511.00
160_L178_K1.1471.00
424_R427_Q1.1451.00
49_N52_N1.1411.00
239_E242_K1.1391.00
371_T374_R1.1351.00
180_K245_D1.1331.00
323_G326_K1.1331.00
7_T10_A1.1311.00
8_A12_A1.1301.00
175_Y178_K1.1271.00
102_K316_K1.1251.00
155_F160_L1.1231.00
211_S219_T1.1221.00
177_A245_D1.1151.00
6_Y10_A1.1091.00
161_D165_P1.1071.00
106_D109_K1.0991.00
154_A158_A1.0981.00
403_E421_A1.0921.00
96_M132_K1.0891.00
339_E343_K1.0831.00
327_F331_L1.0801.00
151_N283_F1.0791.00
7_T11_L1.0761.00
257_E261_N1.0741.00
84_I324_V1.0741.00
312_V325_A1.0601.00
327_F330_F1.0561.00
402_E424_R1.0541.00
325_A329_D1.0531.00
396_I425_G1.0511.00
39_K43_S1.0501.00
172_L176_A1.0491.00
374_R378_N1.0491.00
153_D283_F1.0471.00
314_Q321_Y1.0371.00
156_K161_D1.0331.00
81_A313_M1.0301.00
48_F323_G1.0301.00
406_S420_T1.0301.00
29_F310_L1.0281.00
27_I327_F1.0271.00
109_K117_E1.0261.00
155_F175_Y1.0261.00
151_N154_A1.0251.00
312_V324_V1.0201.00
313_M316_K1.0171.00
231_V418_L1.0141.00
8_A14_G1.0121.00
72_G85_L1.0061.00
160_L179_L1.0051.00
57_I327_F1.0041.00
125_S129_S1.0041.00
184_M187_G1.0031.00
6_Y13_L1.0001.00
9_S12_A1.0001.00
399_I402_E0.9961.00
352_A355_D0.9901.00
12_A15_L0.9881.00
412_K416_Q0.9881.00
293_D296_A0.9851.00
11_L15_L0.9811.00
76_F100_A0.9801.00
339_E342_Q0.9791.00
223_L426_N0.9761.00
254_E257_E0.9751.00
238_E414_P0.9721.00
154_A157_K0.9711.00
211_S221_A0.9641.00
85_L311_W0.9621.00
172_L266_M0.9591.00
276_N279_E0.9571.00
179_L184_M0.9531.00
45_A57_I0.9491.00
138_S311_W0.9481.00
14_G17_L0.9471.00
321_Y325_A0.9441.00
84_I327_F0.9411.00
334_P352_A0.9401.00
350_T353_A0.9391.00
6_Y12_A0.9331.00
292_Y295_D0.9321.00
178_K181_A0.9321.00
205_N232_K0.9301.00
232_K236_M0.9291.00
175_Y266_M0.9281.00
158_A182_S0.9221.00
395_Q398_V0.9221.00
125_S136_L0.9151.00
30_W82_P0.9151.00
79_G315_G0.9101.00
373_T377_L0.9101.00
235_A238_E0.9091.00
179_L183_G0.9071.00
258_K264_C0.9041.00
228_P231_V0.9031.00
44_L47_R0.9021.00
225_F230_Q0.9011.00
234_I407_V0.8991.00
172_L188_Y0.8981.00
147_V372_A0.8951.00
15_L18_M0.8951.00
417_A421_A0.8921.00
122_P351_K0.8911.00
119_Q350_T0.8891.00
10_A14_G0.8871.00
117_E125_S0.8831.00
25_T54_D0.8811.00
402_E406_S0.8801.00
269_A273_S0.8761.00
366_N370_D0.8731.00
71_A74_A0.8731.00
335_E338_A0.8671.00
69_L91_G0.8671.00
413_T417_A0.8661.00
418_L422_V0.8621.00
105_Y109_K0.8611.00
403_E424_R0.8591.00
243_K246_F0.8571.00
27_I323_G0.8561.00
47_R335_E0.8551.00
49_N54_D0.8531.00
102_K313_M0.8531.00
18_M22_Q0.8521.00
158_A178_K0.8521.00
312_V316_K0.8501.00
74_A78_T0.8481.00
185_K263_D0.8471.00
184_M263_D0.8471.00
7_T14_G0.8451.00
30_W62_K0.8451.00
153_D156_K0.8441.00
8_A11_L0.8431.00
96_M101_I0.8411.00
399_I403_E0.8371.00
40_E43_S0.8361.00
367_P370_D0.8341.00
43_S339_E0.8291.00
107_V322_T0.8291.00
120_F332_A0.8271.00
43_S343_K0.8271.00
9_S14_G0.8251.00
29_F84_I0.8231.00
186_C248_Y0.8221.00
176_A245_D0.8221.00
51_E335_E0.8211.00
399_I421_A0.8211.00
156_K284_N0.8171.00
85_L101_I0.8141.00
105_Y136_L0.8111.00
223_L422_V0.8111.00
247_S250_G0.8101.00
27_I320_T0.8071.00
9_S13_L0.8061.00
108_F136_L0.8061.00
335_E339_E0.8051.00
155_F179_L0.8041.00
105_Y129_S0.8021.00
160_L166_P0.7981.00
165_P288_G0.7961.00
51_E333_K0.7951.00
141_F310_L0.7951.00
324_V328_L0.7931.00
101_I137_L0.7911.00
338_A353_A0.7891.00
202_S230_Q0.7891.00
403_E417_A0.7881.00
75_A80_N0.7871.00
6_Y9_S0.7871.00
106_D325_A0.7831.00
62_K71_A0.7821.00
117_E129_S0.7821.00
121_V351_K0.7811.00
149_Y269_A0.7781.00
102_K312_V0.7761.00
180_K183_G0.7751.00
154_A184_M0.7711.00
54_D326_K0.7701.00
240_M245_D0.7681.00
224_E227_K0.7681.00
418_L421_A0.7611.00
49_N57_I0.7591.00
338_A356_L0.7581.00
102_K106_D0.7571.00
161_D167_K0.7551.00
102_K107_V0.7551.00
234_I417_A0.7521.00
20_N23_A0.7511.00
212_K220_D0.7491.00
353_A356_L0.7481.00
244_G248_Y0.7431.00
176_A187_G0.7401.00
398_V401_D0.7361.00
370_D373_T0.7351.00
176_A180_K0.7341.00
179_L185_K0.7321.00
165_P175_Y0.7311.00
227_K230_Q0.7261.00
158_A183_G0.7261.00
44_L330_F0.7261.00
18_M21_A0.7261.00
246_F249_V0.7261.00
150_Y165_P0.7251.00
27_I324_V0.7241.00
257_E260_Y0.7221.00
51_E330_F0.7221.00
103_P137_L0.7201.00
47_R336_N0.7201.00
111_A325_A0.7191.00
158_A175_Y0.7181.00
393_M397_R0.7161.00
400_V421_A0.7121.00
253_D256_T0.7121.00
161_D175_Y0.7111.00
322_T325_A0.7111.00
208_P212_K0.7101.00
234_I418_L0.7071.00
173_A245_D0.7061.00
402_E405_E0.7001.00
84_I310_L0.6991.00
321_Y324_V0.6991.00
107_V111_A0.6991.00
129_S134_G0.6931.00
180_K244_G0.6911.00
70_S74_A0.6871.00
203_A208_P0.6861.00
122_P125_S0.6861.00
173_A176_A0.6851.00
198_L202_S0.6851.00
292_Y296_A0.6811.00
165_P171_D0.6801.00
25_T55_Y0.6761.00
207_L230_Q0.6761.00
279_E282_K0.6751.00
206_G210_A0.6741.00
76_F313_M0.6711.00
157_K182_S0.6651.00
169_W236_M0.6641.00
294_A297_K0.6631.00
351_K355_D0.6631.00
227_K231_V0.6601.00
158_A265_A0.6581.00
179_L266_M0.6581.00
392_N395_Q0.6561.00
44_L336_N0.6541.00
149_Y287_V0.6521.00
167_K292_Y0.6501.00
157_K185_K0.6501.00
205_N236_M0.6491.00
123_T126_G0.6491.00
120_F125_S0.6461.00
150_Y155_F0.6461.00
225_F425_G0.6461.00
407_V412_K0.6461.00
52_N55_Y0.6441.00
23_A54_D0.6441.00
222_V426_N0.6411.00
49_N55_Y0.6411.00
92_T138_S0.6401.00
44_L331_L0.6401.00
8_A13_L0.6391.00
255_S267_T0.6381.00
414_P418_L0.6381.00
107_V321_Y0.6351.00
151_N284_N0.6351.00
81_A315_G0.6331.00
27_I316_K0.6331.00
242_K245_D0.6311.00
253_D257_E0.6311.00
94_T98_S0.6311.00
247_S258_K0.6301.00
5_H12_A0.6261.00
13_L16_A0.6251.00
397_R401_D0.6241.00
157_K183_G0.6231.00
169_W173_A0.6231.00
106_D110_E0.6211.00
30_W60_T0.6211.00
415_Q418_L0.6211.00
102_K325_A0.6201.00
44_L339_E0.6161.00
334_P350_T0.6151.00
203_A380_P0.6141.00
95_M101_I0.6121.00
175_Y179_L0.6101.00
106_D135_H0.6081.00
118_S121_V0.6081.00
238_E241_N0.6051.00
93_A97_A0.6051.00
177_A180_K0.6041.00
102_K315_G0.6011.00
274_L278_R0.6011.00
417_A420_T0.5981.00
275_A279_E0.5951.00
121_V354_Y0.5941.00
367_P371_T0.5921.00
180_K186_C0.5921.00
48_F57_I0.5921.00
316_K319_E0.5911.00
380_P383_P0.5911.00
202_S233_H0.5901.00
128_Y138_S0.5891.00
87_V95_M0.5861.00
229_E233_H0.5851.00
227_K422_V0.5851.00
258_K261_N0.5831.00
405_E409_T0.5831.00
68_N72_G0.5831.00
92_T96_M0.5821.00
394_P398_V0.5811.00
119_Q334_P0.5801.00
179_L182_S0.5781.00
83_A319_E0.5771.00
189_A255_S0.5761.00
29_F45_A0.5731.00
240_M246_F0.5711.00
414_P417_A0.5711.00
310_L328_L0.5691.00
28_P75_A0.5691.00
180_K185_K0.5681.00
232_K293_D0.5681.00
151_N262_G0.5681.00
181_A184_M0.5661.00
105_Y325_A0.5661.00
260_Y280_Y0.5651.00
27_I83_A0.5651.00
29_F59_P0.5651.00
5_H8_A0.5641.00
155_F265_A0.5631.00
60_T75_A0.5621.00
69_L94_T0.5621.00
107_V110_E0.5591.00
208_P211_S0.5561.00
144_S308_A0.5561.00
11_L17_L0.5541.00
91_G94_T0.5531.00
110_E322_T0.5521.00
205_N233_H0.5521.00
226_N415_Q0.5521.00
148_L268_T0.5521.00
67_Q71_A0.5491.00
403_E407_V0.5481.00
278_R282_K0.5481.00
259_F283_F0.5471.00
96_M99_K0.5471.00
368_G372_A0.5471.00
200_N203_A0.5461.00
28_P83_A0.5461.00
371_T375_Q0.5441.00
376_M379_K0.5391.00
244_G247_S0.5381.00
354_Y357_T0.5381.00
22_Q25_T0.5381.00
286_G371_T0.5371.00
238_E413_T0.5371.00
176_A240_M0.5361.00
310_L331_L0.5351.00
5_H11_L0.5351.00
99_K102_K0.5351.00
100_A103_P0.5351.00
75_A82_P0.5341.00
224_E422_V0.5331.00
42_D59_P0.5321.00
70_S73_I0.5321.00
166_P175_Y0.5311.00
276_N280_Y0.5301.00
180_K184_M0.5291.00
108_F111_A0.5291.00
92_T101_I0.5291.00
255_S264_C0.5291.00
211_S224_E0.5281.00
219_T222_V0.5271.00
73_I94_T0.5261.00
12_A16_A0.5261.00
24_V53_P0.5241.00
35_G38_G0.5241.00
237_L241_N0.5241.00
392_N396_I0.5241.00
256_T269_A0.5231.00
320_T324_V0.5231.00
203_A206_G0.5231.00
104_V328_L0.5221.00
325_A328_L0.5211.00
108_F325_A0.5211.00
189_A258_K0.5201.00
186_C247_S0.5191.00
121_V124_V0.5181.00
6_Y11_L0.5171.00
278_R285_Y0.5171.00
149_Y274_L0.5171.00
161_D166_P0.5161.00
395_Q399_I0.5161.00
233_H237_L0.5161.00
152_K283_F0.5151.00
88_Y91_G0.5151.00
60_T71_A0.5141.00
203_A207_L0.5141.00
35_G39_K0.5141.00
259_F267_T0.5131.00
245_D248_Y0.5131.00
156_K159_G0.5131.00
156_K286_G0.5121.00
226_N231_V0.5111.00
231_V419_D0.5111.00
337_A349_I0.5101.00
29_F327_F0.5091.00
230_Q422_V0.5081.00
149_Y285_Y0.5071.00
161_D171_D0.5071.00
154_A183_G0.5071.00
129_S132_K0.5061.00
406_S417_A0.5061.00
329_D333_K0.5061.00
104_V325_A0.5051.00
49_N327_F0.5051.00
65_Y69_L0.5051.00
421_A425_G0.5041.00
144_S307_G0.5041.00
52_N323_G0.5031.00
246_F250_G0.5031.00
41_V44_L0.5031.00
167_K172_L0.5021.00
154_A185_K0.5021.00
36_E39_K0.5021.00
56_K59_P0.5021.00
24_V55_Y0.5011.00
21_A24_V0.5011.00
13_L17_L0.5001.00
62_K68_N0.5001.00
160_L265_A0.5001.00
171_D175_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.8813 100 0.164 Contact Map
4mfiA 1 0.8973 100 0.165 Contact Map
4r6kA 1 0.8904 100 0.173 Contact Map
4r9fA 1 0.8584 100 0.182 Contact Map
4r2fA 1 0.8516 100 0.197 Contact Map
4aq4A 1 0.9521 100 0.207 Contact Map
4ovjA 1 0.8676 100 0.22 Contact Map
3k01A 1 0.8699 100 0.223 Contact Map
3vxbA 1 0.8607 100 0.229 Contact Map
4gqoA 1 0.8744 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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