GREMLIN Database
RL6 - 50S ribosomal protein L6
UniProt: P0AG55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10869
Length: 177 (176)
Sequences: 3819 (2091)
Seq/√Len: 157.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_I81_E3.1621.00
73_N77_I2.9901.00
117_L123_A2.6751.00
27_K32_E2.6281.00
44_K53_G2.5061.00
124_E134_K2.4571.00
84_T134_K2.3821.00
102_V116_Q2.2741.00
102_V114_D2.1901.00
16_D27_K2.1391.00
86_K165_A2.1141.00
107_L151_Y2.0861.00
143_Q147_D2.0711.00
163_R169_V2.0331.00
56_D61_G2.0101.00
52_F72_L2.0061.00
133_L141_I1.9231.00
35_R139_Q1.8981.00
25_T32_E1.8911.00
127_T130_E1.8851.00
90_V163_R1.8771.00
115_H144_V1.8081.00
40_A61_G1.7681.00
135_G141_I1.7621.00
98_V125_C1.7431.00
23_V34_T1.7421.00
122_T134_K1.7361.00
115_H151_Y1.7191.00
86_K132_V1.6771.00
35_R75_M1.6231.00
137_D140_V1.6041.00
54_P65_A1.5981.00
23_V36_T1.5741.00
19_I24_I1.5541.00
88_Q166_D1.5471.00
25_T34_T1.5321.00
99_K104_N1.5301.00
86_K130_E1.5181.00
98_V117_L1.5081.00
101_N119_A1.4901.00
28_G31_G1.4751.00
104_N114_D1.4631.00
42_E53_G1.4531.00
173_E176_K1.4441.00
10_V49_T1.4291.00
120_G140_V1.3901.00
107_L162_V1.3851.00
42_E55_R1.3661.00
11_V17_V1.3611.00
67_T71_L1.3371.00
113_V151_Y1.3301.00
115_H147_D1.3301.00
45_H50_L1.3181.00
126_P132_V1.3091.00
11_V45_H1.3081.00
24_I72_L1.3011.00
81_E84_T1.2971.00
35_R71_L1.2741.00
130_E165_A1.2621.00
19_I45_H1.2611.00
30_N136_A1.2571.00
99_K102_V1.2421.00
123_A144_V1.2241.00
54_P62_W1.2171.00
121_I144_V1.2121.00
64_Q68_A1.2081.00
109_F113_V1.2001.00
37_L43_V1.1941.00
149_R154_P1.1841.00
5_A65_A1.1691.00
101_N116_Q1.1541.00
88_Q165_A1.1401.00
26_I75_M1.1381.00
60_D63_A1.1211.00
44_K51_T1.0950.99
96_A105_L1.0930.99
105_L151_Y1.0890.99
96_A131_I1.0860.99
10_V48_N1.0850.99
144_V148_L1.0850.99
30_N134_K1.0750.99
67_T70_A1.0570.99
139_Q143_Q1.0560.99
69_R73_N1.0510.99
18_K25_T1.0480.99
123_A133_L1.0450.99
150_A153_R1.0440.99
149_R167_E1.0410.99
50_L72_L1.0360.99
41_V55_R1.0340.99
58_Y61_G1.0320.99
22_Q36_T1.0290.99
16_D32_E1.0270.99
103_I123_A1.0250.99
117_L144_V1.0250.99
124_E132_V1.0160.99
21_G36_T1.0120.99
104_N112_P1.0010.99
154_P160_K1.0000.99
55_R61_G0.9980.99
163_R171_T0.9970.99
31_G79_V0.9850.99
20_N23_V0.9830.99
90_V169_V0.9740.99
84_T132_V0.9720.99
140_V144_V0.9710.99
99_K114_D0.9640.99
38_N64_Q0.9590.99
88_Q130_E0.9470.98
103_I148_L0.9410.98
117_L133_L0.9350.98
126_P130_E0.9300.98
102_V117_L0.9290.98
97_A104_N0.9270.98
133_L148_L0.9250.98
109_F151_Y0.9240.98
41_V61_G0.9230.98
89_L96_A0.9210.98
155_E169_V0.9150.98
35_R68_A0.9090.98
156_P171_T0.9070.98
17_V50_L0.9050.98
106_S112_P0.9050.98
115_H123_A0.9020.98
88_Q163_R0.9010.98
40_A56_D0.8830.98
101_N122_T0.8820.98
143_Q150_A0.8770.98
54_P57_G0.8710.97
63_A70_A0.8700.97
121_I135_G0.8700.97
30_N82_G0.8650.97
119_A140_V0.8640.97
28_G79_V0.8610.97
33_L75_M0.8600.97
97_A106_S0.8590.97
13_A48_N0.8560.97
98_V123_A0.8370.97
60_D64_Q0.8310.97
40_A55_R0.8260.96
94_Y152_R0.8210.96
46_A49_T0.8190.96
85_K166_D0.8040.96
7_A69_R0.8040.96
118_P140_V0.8020.96
109_F152_R0.7990.96
62_W65_A0.7830.95
107_L111_H0.7820.95
26_I80_T0.7820.95
37_L72_L0.7780.95
41_V52_F0.7750.95
30_N122_T0.7700.95
120_G135_G0.7690.95
163_R166_D0.7680.95
95_R128_Q0.7660.95
41_V64_Q0.7640.94
65_A176_K0.7630.94
18_K27_K0.7620.94
149_R164_Y0.7590.94
46_A51_T0.7510.94
145_A164_Y0.7460.94
63_A67_T0.7390.93
40_A60_D0.7350.93
15_V80_T0.7340.93
11_V50_L0.7340.93
12_P15_V0.7330.93
38_N60_D0.7270.93
38_N41_V0.7240.93
38_N68_A0.7240.93
33_L136_A0.7230.93
31_G136_A0.7230.93
90_V166_D0.7190.93
4_V70_A0.7090.92
103_I131_I0.7070.92
144_V147_D0.7040.92
87_L131_I0.7000.92
52_F68_A0.6920.91
121_I133_L0.6910.91
79_V136_A0.6910.91
140_V147_D0.6900.91
9_V76_V0.6890.91
89_L107_L0.6880.91
20_N25_T0.6830.90
8_P51_T0.6810.90
155_E171_T0.6710.90
155_E158_K0.6700.90
43_V52_F0.6670.89
14_G29_K0.6530.88
98_V124_E0.6530.88
95_R106_S0.6510.88
15_V79_V0.6460.88
17_V26_I0.6440.88
87_L133_L0.6430.88
8_P69_R0.6430.88
8_P49_T0.6300.87
19_I50_L0.6240.86
159_G171_T0.6210.86
59_A63_A0.6210.86
9_V73_N0.6180.86
86_K126_P0.6160.85
87_L145_A0.6150.85
164_Y167_E0.6140.85
69_R76_V0.6110.85
147_D151_Y0.6100.85
109_F153_R0.6100.85
6_K53_G0.6100.85
113_V162_V0.6060.84
70_A74_S0.6050.84
5_A174_A0.6040.84
26_I35_R0.6020.84
11_V14_G0.6000.84
64_Q67_T0.5950.83
154_P169_V0.5940.83
85_K164_Y0.5870.83
155_E173_E0.5850.82
22_Q42_E0.5850.82
144_V151_Y0.5840.82
57_G60_D0.5830.82
9_V69_R0.5810.82
152_R162_V0.5810.82
2_S5_A0.5790.82
98_V104_N0.5790.82
103_I125_C0.5780.82
67_T176_K0.5740.81
33_L137_D0.5690.81
18_K45_H0.5620.80
91_G161_G0.5570.79
36_T75_M0.5540.79
11_V76_V0.5520.79
57_G65_A0.5510.78
26_I33_L0.5500.78
16_D45_H0.5490.78
33_L79_V0.5470.78
70_A73_N0.5440.78
84_T165_A0.5430.77
37_L68_A0.5390.77
121_I140_V0.5380.77
90_V129_T0.5360.77
102_V123_A0.5350.76
83_F141_I0.5320.76
171_T174_A0.5320.76
141_I145_A0.5310.76
29_K80_T0.5280.75
6_K62_W0.5280.75
4_V69_R0.5280.75
117_L121_I0.5280.75
73_N81_E0.5270.75
155_E159_G0.5270.75
163_R168_V0.5210.75
85_K168_V0.5210.75
143_Q146_A0.5210.75
138_K142_G0.5210.75
105_L131_I0.5190.74
147_D150_A0.5190.74
10_V13_A0.5170.74
117_L141_I0.5160.74
133_L145_A0.5140.74
87_L164_Y0.5140.74
9_V52_F0.5130.73
41_V54_P0.5120.73
125_C131_I0.5110.73
24_I45_H0.5100.73
90_V153_R0.5050.72
149_R153_R0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zjrE 1 0.9661 100 0.006 Contact Map
1nkwE 1 0.9774 100 0.007 Contact Map
4rb6H 1 0.9831 100 0.007 Contact Map
3bboI 1 1 100 0.008 Contact Map
4tp9G 1 0.9944 100 0.026 Contact Map
1rl6A 1 0.9266 100 0.032 Contact Map
1vw4F 1 0.9492 100 0.035 Contact Map
3j21F 1 0.9887 100 0.175 Contact Map
1vq8E 1 0.9435 100 0.182 Contact Map
1vx7H 1 0.9661 100 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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