GREMLIN Database
RL21 - 50S ribosomal protein L21
UniProt: P0AG48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50001
Length: 103 (100)
Sequences: 2618 (1399)
Seq/√Len: 139.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E99_T3.3281.00
6_Q37_E3.2831.00
16_E100_G3.0531.00
68_R92_W2.7791.00
28_A31_E2.7251.00
73_K86_Q2.7231.00
15_S18_Q2.6131.00
27_I63_V2.5961.00
21_R95_D2.3061.00
61_A98_I2.2071.00
34_E58_V2.1971.00
62_E97_K2.1511.00
32_T60_K1.9041.00
35_F96_V1.8421.00
78_R83_Y1.7601.00
22_L96_V1.7111.00
40_M47_V1.6891.00
67_G93_F1.6881.00
76_K83_Y1.5941.00
19_T97_K1.5461.00
61_A96_V1.5211.00
19_T95_D1.4951.00
64_V97_K1.4871.00
10_K23_E1.4321.00
65_A95_D1.3841.00
7_S22_L1.3831.00
77_F80_R1.3761.00
74_I87_Q1.3421.00
60_K100_G1.3131.00
34_E60_K1.3121.00
32_T99_T1.2901.00
37_E53_F1.2871.00
6_Q53_F1.2861.00
27_I31_E1.2811.00
5_F35_F1.2761.00
24_K92_W1.2521.00
29_T65_A1.2281.00
75_V84_R1.2131.00
43_N46_E1.2041.00
7_S23_E1.1931.00
2_Y13_R1.1901.00
35_F61_A1.1670.99
21_R69_G1.1630.99
63_V94_T1.1400.99
40_M49_I1.1100.99
52_P56_G1.1020.99
49_I52_P1.0670.99
19_T64_V1.0470.99
60_K99_T1.0460.99
54_V57_G1.0350.99
43_N47_V1.0310.99
22_L25_L1.0260.99
21_R67_G1.0170.99
67_G95_D1.0070.98
74_I83_Y0.9970.98
8_G23_E0.9670.98
75_V86_Q0.9620.98
20_V96_V0.9560.98
2_Y47_V0.9260.97
77_F84_R0.9210.97
78_R82_H0.8780.96
41_I57_G0.8720.96
32_T62_E0.8650.96
23_E91_Q0.8650.96
14_V18_Q0.8320.95
21_R65_A0.8290.95
5_F14_V0.8260.95
7_S12_H0.8250.95
24_K66_H0.8160.95
66_H94_T0.8020.94
12_H20_V0.7990.94
41_I54_V0.7870.94
48_K54_V0.7830.93
50_G53_F0.7770.93
5_F59_I0.7660.93
12_H23_E0.7550.92
72_V87_Q0.7480.92
29_T66_H0.7420.91
7_S10_K0.7410.91
23_E93_F0.7360.91
69_G93_F0.7300.91
39_L52_P0.7290.91
23_E89_H0.7150.90
80_R83_Y0.7030.89
43_N48_K0.6950.88
67_G92_W0.6930.88
26_D66_H0.6920.88
41_I101_I0.6890.88
20_V98_I0.6880.88
65_A93_F0.6810.87
74_I82_H0.6790.87
25_L94_T0.6750.87
83_Y87_Q0.6560.85
21_R93_F0.6500.85
73_K87_Q0.6500.85
4_V8_G0.6300.83
77_F83_Y0.6300.83
33_V96_V0.6190.82
25_L33_V0.6170.82
30_G62_E0.6120.81
74_I84_R0.6100.81
50_G56_G0.6070.81
77_F82_H0.6060.81
73_K76_K0.6040.80
50_G54_V0.6040.80
51_V56_G0.6000.80
20_V61_A0.5960.80
51_V54_V0.5860.78
37_E52_P0.5840.78
48_K55_D0.5820.78
76_K85_K0.5740.77
7_S35_F0.5740.77
27_I33_V0.5740.77
51_V55_D0.5720.77
7_S25_L0.5720.77
8_G22_L0.5680.76
3_A8_G0.5660.76
78_R81_K0.5640.76
52_P57_G0.5640.76
63_V66_H0.5580.75
36_A58_V0.5490.74
2_Y82_H0.5490.74
45_E55_D0.5470.74
30_G76_K0.5430.73
73_K84_R0.5420.73
4_V95_D0.5410.73
22_L61_A0.5390.72
39_L50_G0.5390.72
69_G84_R0.5380.72
93_F96_V0.5380.72
74_I89_H0.5370.72
12_H15_S0.5290.71
73_K77_F0.5280.71
66_H92_W0.5280.71
17_G99_T0.5260.71
77_F81_K0.5220.70
67_G87_Q0.5210.70
1_M16_E0.5200.70
2_Y84_R0.5190.70
43_N57_G0.5180.69
64_V95_D0.5130.69
82_H85_K0.5100.68
52_P55_D0.5090.68
24_K67_G0.5080.68
39_L82_H0.5070.68
48_K51_V0.5070.68
24_K93_F0.5050.68
33_V61_A0.5020.67
16_E19_T0.5020.67
29_T62_E0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboT 1 1 100 0.044 Contact Map
4tp9R 1 1 100 0.059 Contact Map
3j7yS 1 1 100 0.065 Contact Map
1vw4N 1 1 100 0.067 Contact Map
4rb6V 1 0.9806 100 0.078 Contact Map
3j3wR 1 0.9903 100 0.079 Contact Map
2zjrO 1 0.9126 100 0.105 Contact Map
2xhaA 1 0.8058 63.2 0.897 Contact Map
2y4xA 1 0.5049 18.7 0.924 Contact Map
4av2M 1 0.5243 11.9 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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