GREMLIN Database
RHTC - Threonine efflux protein
UniProt: P0AG38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11468
Length: 206 (197)
Sequences: 12850 (9141)
Seq/√Len: 651.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_C115_F5.2361.00
86_G196_A3.5911.00
87_Y91_R3.4451.00
186_W189_G2.9201.00
72_T75_M2.7641.00
83_C199_G2.6271.00
112_G116_L2.5351.00
40_M111_S2.3891.00
185_K189_G2.3441.00
51_V119_L2.2921.00
76_V80_L2.2241.00
84_W88_Q2.1811.00
90_L189_G2.1441.00
90_L192_G2.0611.00
30_A38_A2.0511.00
25_F41_G2.0221.00
193_A197_G1.9601.00
79_G203_I1.9581.00
88_Q91_R1.8941.00
11_V135_V1.8841.00
9_A159_E1.8301.00
48_G123_L1.8301.00
86_G192_G1.8181.00
29_T33_R1.7451.00
93_A189_G1.7391.00
79_G199_G1.7351.00
37_E114_S1.7281.00
69_W72_T1.7241.00
23_F167_V1.7071.00
22_D45_I1.7051.00
83_C196_A1.7051.00
71_H75_M1.6451.00
38_A168_A1.6441.00
16_L159_E1.5761.00
116_L120_L1.5741.00
149_R153_F1.5521.00
72_T76_V1.5431.00
17_M163_W1.5181.00
50_M157_I1.4771.00
94_L189_G1.4711.00
83_C87_Y1.4591.00
62_L66_K1.4531.00
43_L115_F1.4491.00
29_T41_G1.4271.00
30_A168_A1.4021.00
160_T164_F1.4021.00
186_W190_F1.3991.00
42_V168_A1.3861.00
38_A42_V1.3751.00
115_F119_L1.3621.00
41_G118_G1.3611.00
27_S171_F1.3611.00
69_W73_L1.3571.00
132_F156_I1.3171.00
39_M169_S1.3141.00
119_L123_L1.3011.00
173_L176_M1.2981.00
175_Q179_G1.2891.00
73_L77_G1.2771.00
110_K113_R1.2721.00
76_V79_G1.2511.00
146_T149_R1.2301.00
35_R169_S1.2301.00
81_Y85_M1.2031.00
182_R186_W1.1991.00
180_Y183_L1.1981.00
6_L10_M1.1971.00
183_L186_W1.1791.00
54_G58_L1.1791.00
113_R116_L1.1781.00
33_R37_E1.1721.00
196_A200_I1.1631.00
192_G196_A1.1591.00
29_T117_K1.1541.00
163_W167_V1.1431.00
76_V203_I1.1321.00
22_D122_N1.1311.00
25_F29_T1.1311.00
35_R172_A1.1281.00
4_L7_T1.1271.00
36_K40_M1.1251.00
25_F121_T1.1241.00
46_T161_L1.1001.00
46_T157_I1.0941.00
8_V12_H1.0931.00
7_T10_M1.0881.00
92_G188_D1.0821.00
51_V123_L1.0811.00
166_V170_L1.0801.00
91_R94_L1.0771.00
86_G199_G1.0661.00
147_T150_W1.0661.00
12_H156_I1.0611.00
22_D121_T1.0561.00
39_M165_T1.0501.00
16_L160_T1.0501.00
26_V164_F1.0471.00
113_R117_K1.0471.00
44_G115_F1.0441.00
141_G149_R1.0371.00
7_T11_V1.0321.00
189_G193_A1.0291.00
32_S36_K1.0291.00
26_V30_A1.0171.00
141_G144_V1.0161.00
31_V171_F1.0141.00
197_G201_H1.0111.00
175_Q178_R1.0111.00
28_Q32_S1.0111.00
59_G64_I1.0091.00
173_L177_R1.0081.00
49_V128_A0.9991.00
48_G119_L0.9991.00
81_Y84_W0.9911.00
149_R152_I0.9891.00
22_D160_T0.9831.00
23_F164_F0.9651.00
145_G148_A0.9611.00
49_V122_N0.9471.00
182_R185_K0.9451.00
9_A13_I0.9271.00
13_I159_E0.9221.00
190_F193_A0.9201.00
26_V168_A0.9111.00
150_W153_F0.9081.00
109_A113_R0.9071.00
120_L124_A0.9061.00
52_W129_I0.8981.00
35_R165_T0.8951.00
52_W123_L0.8911.00
36_K111_S0.8791.00
22_D49_V0.8721.00
49_V52_W0.8561.00
47_C119_L0.8521.00
59_G66_K0.8471.00
24_F191_A0.8441.00
11_V14_V0.8431.00
88_Q92_G0.8371.00
44_G119_L0.8341.00
146_T150_W0.8311.00
94_L97_E0.8291.00
64_I67_M0.8291.00
5_F9_A0.8291.00
5_F158_V0.8251.00
165_T169_S0.8221.00
10_M14_V0.8221.00
179_G183_L0.8201.00
161_L165_T0.8171.00
177_R183_L0.8081.00
80_L83_C0.8021.00
108_L112_G0.8021.00
134_S138_L0.8011.00
24_F28_Q0.7981.00
35_R168_A0.7961.00
196_A199_G0.7891.00
77_G80_L0.7891.00
184_A188_D0.7831.00
53_A132_F0.7811.00
114_S117_K0.7801.00
91_R95_K0.7771.00
84_W87_Y0.7731.00
90_L196_A0.7731.00
61_H65_E0.7721.00
23_F27_S0.7671.00
39_M168_A0.7671.00
52_W128_A0.7641.00
170_L173_L0.7591.00
12_H16_L0.7561.00
89_M192_G0.7531.00
124_A133_G0.7491.00
6_L9_A0.7471.00
46_T160_T0.7461.00
23_F163_W0.7441.00
58_L62_L0.7431.00
22_D164_F0.7431.00
37_E40_M0.7421.00
42_V165_T0.7401.00
87_Y196_A0.7391.00
47_C51_V0.7371.00
52_W56_A0.7301.00
67_M70_L0.7301.00
70_L73_L0.7261.00
144_V148_A0.7261.00
67_M71_H0.7231.00
40_M114_S0.7201.00
14_V18_S0.7181.00
187_I191_A0.7161.00
42_V46_T0.7141.00
16_L23_F0.7141.00
16_L163_W0.7121.00
190_F194_L0.7081.00
79_G83_C0.7081.00
151_G154_A0.7081.00
94_L185_K0.7051.00
164_F167_V0.7031.00
53_A164_F0.7031.00
57_L154_A0.7021.00
26_V41_G0.6981.00
26_V45_I0.6961.00
52_W122_N0.6961.00
45_I49_V0.6941.00
33_R114_S0.6931.00
147_T151_G0.6921.00
144_V149_R0.6871.00
27_S167_V0.6851.00
176_M179_G0.6851.00
52_W133_G0.6831.00
171_F174_P0.6821.00
68_A72_T0.6811.00
62_L65_E0.6781.00
151_G155_L0.6761.00
177_R180_Y0.6751.00
178_R183_L0.6751.00
49_V160_T0.6721.00
48_G122_N0.6711.00
30_A171_F0.6691.00
77_G124_A0.6681.00
169_S173_L0.6661.00
49_V157_I0.6621.00
39_M42_V0.6581.00
80_L84_W0.6571.00
78_G130_I0.6571.00
200_I204_I0.6561.00
45_I122_N0.6531.00
11_V15_A0.6451.00
183_L187_I0.6381.00
23_F121_T0.6371.00
73_L76_V0.6361.00
41_G114_S0.6361.00
51_V54_G0.6351.00
49_V132_F0.6351.00
37_E111_S0.6331.00
16_L164_F0.6331.00
162_A166_V0.6301.00
34_S37_E0.6301.00
93_A96_K0.6291.00
56_A129_I0.6131.00
49_V156_I0.6071.00
157_I161_L0.6071.00
19_P127_K0.6061.00
13_I17_M0.6061.00
177_R181_Q0.6031.00
29_T32_S0.6031.00
33_R109_A0.6011.00
111_S115_F0.5991.00
56_A61_H0.5991.00
102_P105_Q0.5981.00
112_G115_F0.5951.00
144_V147_T0.5931.00
74_I78_G0.5901.00
122_N128_A0.5871.00
86_G90_L0.5851.00
18_S23_F0.5831.00
28_Q188_D0.5811.00
56_A132_F0.5781.00
16_L49_V0.5731.00
170_L174_P0.5731.00
83_C203_I0.5711.00
53_A154_A0.5681.00
201_H204_I0.5671.00
129_I133_G0.5621.00
176_M180_Y0.5611.00
37_E110_K0.5611.00
26_V42_V0.5611.00
128_A160_T0.5511.00
67_M72_T0.5511.00
132_F160_T0.5501.00
52_W61_H0.5501.00
43_L46_T0.5481.00
122_N164_F0.5481.00
66_K69_W0.5461.00
163_W166_V0.5411.00
197_G200_I0.5391.00
21_P125_N0.5361.00
158_V162_A0.5330.99
117_K121_T0.5330.99
88_Q117_K0.5320.99
164_F168_A0.5310.99
22_D128_A0.5300.99
21_P89_M0.5240.99
90_L193_A0.5230.99
128_A164_F0.5210.99
41_G121_T0.5210.99
9_A12_H0.5200.99
42_V161_L0.5200.99
46_T164_F0.5170.99
39_M43_L0.5160.99
148_A152_I0.5160.99
131_Y135_V0.5140.99
38_A41_G0.5140.99
16_L128_A0.5110.99
15_A135_V0.5090.99
18_S188_D0.5090.99
193_A196_A0.5060.99
42_V164_F0.5030.99
135_V156_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.932 17 0.933 Contact Map
4ikvA 1 0.5437 11.9 0.937 Contact Map
1pw4A 1 0.8981 11.3 0.938 Contact Map
2cfqA 1 0.8883 11.1 0.938 Contact Map
4c7rA 3 0.3204 9.1 0.94 Contact Map
4w6vA 1 0.5049 8.2 0.942 Contact Map
2gfpA 2 0.9272 8 0.942 Contact Map
3giaA 1 0.466 6.8 0.943 Contact Map
4m64A 1 0.9126 6.1 0.945 Contact Map
3wdoA 1 0.8835 5.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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