GREMLIN Database
RHTB - Homoserine/homoserine lactone efflux protein
UniProt: P0AG34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11469
Length: 206 (199)
Sequences: 12776 (9178)
Seq/√Len: 650.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T112_F5.2651.00
87_G194_M3.6041.00
88_I92_R3.4791.00
6_W153_T3.1191.00
184_A187_K2.9451.00
73_E76_K2.7791.00
84_I197_G2.6571.00
109_R113_Q2.4911.00
183_K187_K2.3631.00
41_A108_R2.3381.00
52_I116_V2.2471.00
77_W81_A2.2151.00
85_W89_Q2.2081.00
91_W187_K2.1321.00
91_W190_G2.0731.00
31_S39_A2.0381.00
80_A201_A1.9991.00
26_N42_S1.9731.00
191_S195_L1.9611.00
12_T132_L1.8891.00
89_Q92_R1.8541.00
49_G120_L1.8341.00
10_L157_V1.8311.00
87_G190_G1.8061.00
70_I73_E1.7881.00
39_A166_A1.7481.00
84_I194_M1.7391.00
80_A197_G1.7221.00
23_G46_L1.7181.00
24_A165_Y1.7011.00
38_G111_L1.6831.00
30_T34_H1.6241.00
72_F76_K1.6221.00
173_A177_K1.6061.00
94_A187_K1.5861.00
17_S157_V1.5771.00
113_Q117_F1.5601.00
18_L161_V1.5411.00
73_E77_W1.5381.00
51_A155_I1.5051.00
84_I88_I1.4621.00
10_L153_T1.4591.00
44_A112_F1.4251.00
30_T42_S1.4191.00
63_T67_R1.4121.00
43_I166_A1.4091.00
184_A188_I1.3961.00
54_I151_G1.3901.00
112_F116_V1.3801.00
39_A43_I1.3751.00
28_M169_A1.3751.00
31_S166_A1.3701.00
95_G187_K1.3591.00
70_I74_V1.3501.00
42_S115_A1.3351.00
74_V78_A1.3191.00
107_S110_H1.3121.00
181_Q184_A1.3031.00
40_V167_T1.3021.00
116_V120_L1.2931.00
180_K184_A1.2561.00
77_W80_A1.2561.00
129_L154_T1.2521.00
82_Y86_L1.2451.00
158_D162_M1.2421.00
36_Y167_T1.2341.00
110_H113_Q1.2281.00
178_G181_Q1.2281.00
9_Y150_L1.2261.00
171_R174_L1.2091.00
55_V59_V1.1891.00
5_W8_A1.1681.00
36_Y170_Q1.1501.00
194_M198_A1.1471.00
77_W201_A1.1451.00
37_R41_A1.1441.00
7_F11_L1.1401.00
47_Q159_I1.1391.00
8_A11_L1.1331.00
30_T114_R1.1221.00
34_H38_G1.1201.00
26_N118_V1.1151.00
26_N30_T1.1141.00
171_R175_W1.1101.00
164_G168_L1.1071.00
9_Y13_S1.1051.00
87_G197_G1.0961.00
47_Q155_I1.0951.00
23_G119_N1.0851.00
40_V163_I1.0811.00
138_M146_Q1.0751.00
190_G194_M1.0751.00
17_S158_D1.0701.00
13_S154_T1.0681.00
161_V165_Y1.0581.00
45_G112_F1.0581.00
187_K191_S1.0541.00
93_A186_N1.0511.00
52_I120_L1.0491.00
8_A12_T1.0381.00
33_N37_R1.0341.00
23_G118_V1.0311.00
138_M141_Q1.0281.00
195_L199_L1.0271.00
92_R95_G1.0231.00
27_T162_M1.0211.00
49_G116_V1.0181.00
82_Y85_W1.0111.00
27_T31_S1.0101.00
29_T33_N1.0091.00
95_G98_D1.0031.00
23_G158_D1.0001.00
110_H114_R0.9931.00
32_L169_A0.9921.00
24_A162_M0.9891.00
60_G65_F0.9821.00
141_Q146_Q0.9721.00
50_L119_N0.9691.00
106_Q110_H0.9631.00
50_L125_S0.9581.00
188_I191_S0.9461.00
36_Y163_I0.9361.00
14_I157_V0.9191.00
117_F121_T0.9181.00
180_K183_K0.9111.00
36_Y166_A0.9091.00
144_L147_Y0.9011.00
10_L14_I0.8981.00
177_K181_Q0.8931.00
53_H126_I0.8831.00
142_P145_M0.8771.00
23_G50_L0.8651.00
105_T109_R0.8631.00
37_R108_R0.8601.00
25_I189_F0.8591.00
48_T116_V0.8461.00
12_T15_I0.8461.00
27_T166_A0.8441.00
163_I167_T0.8381.00
6_W156_V0.8371.00
53_H120_L0.8341.00
65_F68_S0.8341.00
54_I129_L0.8341.00
50_L53_H0.8291.00
159_I163_I0.8291.00
60_G67_R0.8281.00
78_A81_A0.8231.00
194_M197_G0.8191.00
131_A135_Q0.8181.00
25_I29_T0.8181.00
182_M186_N0.8171.00
144_L148_I0.8141.00
40_V166_A0.8051.00
45_G116_V0.7951.00
175_W181_Q0.7941.00
81_A84_I0.7941.00
90_Q190_G0.7861.00
13_S17_S0.7841.00
89_Q93_A0.7781.00
85_W88_I0.7751.00
11_L15_I0.7741.00
24_A28_M0.7721.00
38_G41_A0.7701.00
68_S71_A0.7681.00
145_M148_I0.7641.00
43_I163_I0.7611.00
71_A74_V0.7581.00
168_L171_R0.7511.00
59_V63_T0.7511.00
68_S72_F0.7491.00
53_H125_S0.7471.00
7_F10_L0.7461.00
111_L114_R0.7451.00
91_W194_M0.7401.00
24_A161_V0.7401.00
97_I100_K0.7391.00
88_I194_M0.7371.00
47_Q158_D0.7341.00
80_A84_I0.7331.00
62_G66_S0.7291.00
23_G162_M0.7281.00
185_L189_F0.7271.00
92_R96_A0.7221.00
121_T130_A0.7171.00
46_L50_L0.7161.00
142_P146_Q0.7161.00
48_T52_I0.7111.00
188_I192_L0.6981.00
31_S169_A0.6981.00
54_I162_M0.6931.00
15_I19_S0.6921.00
50_L155_I0.6881.00
69_V73_E0.6871.00
27_T46_L0.6841.00
17_S24_A0.6831.00
17_S161_V0.6801.00
28_M165_Y0.6791.00
27_T42_S0.6781.00
53_H57_V0.6761.00
6_W10_L0.6751.00
41_A111_L0.6741.00
94_A97_I0.6731.00
169_A172_I0.6721.00
40_V43_I0.6721.00
53_H119_N0.6721.00
50_L158_D0.6641.00
43_I47_Q0.6631.00
167_T171_R0.6581.00
46_L119_N0.6561.00
198_A202_S0.6531.00
162_M165_Y0.6511.00
17_S162_M0.6491.00
53_H130_A0.6441.00
34_H111_L0.6431.00
95_G183_K0.6431.00
175_W178_G0.6431.00
78_A121_T0.6411.00
63_T66_S0.6331.00
24_A118_V0.6311.00
42_S111_L0.6301.00
30_T33_N0.6291.00
143_Q146_Q0.6281.00
12_T16_L0.6281.00
74_V77_W0.6251.00
173_A176_I0.6221.00
38_G108_R0.6221.00
156_V160_I0.6211.00
49_G119_N0.6211.00
57_V62_G0.6191.00
81_A85_W0.6191.00
101_S104_S0.6171.00
52_I55_V0.6131.00
4_E7_F0.6081.00
119_N125_S0.6071.00
4_E8_A0.6051.00
160_I164_G0.6021.00
50_L129_L0.6021.00
181_Q185_L0.6021.00
19_S24_A0.6011.00
108_R112_F0.5951.00
58_G151_G0.5941.00
54_I155_I0.5921.00
174_L178_G0.5911.00
119_N162_M0.5881.00
155_I159_I0.5861.00
87_G91_W0.5791.00
44_A47_Q0.5721.00
57_V126_I0.5711.00
55_V151_G0.5691.00
20_P124_K0.5691.00
109_R112_F0.5691.00
27_T43_I0.5691.00
149_V153_T0.5691.00
50_L154_T0.5671.00
79_G127_V0.5641.00
84_I201_A0.5631.00
199_L202_S0.5631.00
22_S90_Q0.5591.00
57_V129_L0.5561.00
42_S118_V0.5561.00
14_I18_L0.5551.00
129_L158_D0.5541.00
29_T186_N0.5541.00
195_L198_A0.5531.00
114_R118_V0.5521.00
17_S50_L0.5491.00
23_G125_S0.5481.00
13_S153_T0.5471.00
168_L172_I0.5411.00
126_I130_A0.5381.00
176_I179_P0.5351.00
94_A183_K0.5330.99
35_G38_G0.5320.99
19_S186_N0.5310.99
105_T108_R0.5300.99
22_S122_N0.5300.99
89_Q114_R0.5290.99
53_H62_G0.5280.99
161_V164_G0.5280.99
175_W179_P0.5270.99
125_S162_M0.5260.99
38_G107_S0.5250.99
141_Q144_L0.5250.99
36_Y171_R0.5240.99
40_V44_A0.5230.99
57_V137_I0.5230.99
132_L154_T0.5210.99
75_L79_G0.5200.99
162_M166_A0.5180.99
47_Q162_M0.5180.99
68_S73_E0.5170.99
160_I163_I0.5140.99
67_R70_I0.5110.99
39_A42_S0.5110.99
102_L105_T0.5080.99
16_L132_L0.5020.99
101_S105_T0.5010.99
65_F75_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9078 24 0.927 Contact Map
4m64A 1 0.9417 15.4 0.933 Contact Map
3o7qA 1 0.9175 13 0.935 Contact Map
4x5mA 2 0.4515 8.9 0.94 Contact Map
3j1zP 8 0.8447 8.2 0.941 Contact Map
4w6vA 1 0.5 7.3 0.942 Contact Map
3wdoA 1 0.4709 7.2 0.942 Contact Map
4xnjA 1 0.466 6.7 0.943 Contact Map
2gfpA 2 0.9126 5.9 0.945 Contact Map
4ikvA 1 0.5146 5.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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