GREMLIN Database
RHO - Transcription termination factor Rho
UniProt: P0AG30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10845
Length: 419 (350)
Sequences: 7781 (2563)
Seq/√Len: 137.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_E122_D8.3851.00
170_R259_D5.7621.00
207_L246_V5.0631.00
346_S359_D4.8101.00
161_V358_I4.2531.00
70_S82_S3.1491.00
168_I316_I3.1021.00
115_K125_E3.0671.00
110_Y256_H3.0551.00
203_V258_K3.0551.00
247_I317_A2.9851.00
153_S170_R2.9521.00
102_R105_K2.7921.00
110_Y258_K2.7541.00
205_M250_A2.6341.00
349_I354_V2.6021.00
217_T221_R2.5981.00
372_T377_L2.5751.00
391_G394_D2.5001.00
382_I385_K2.4331.00
105_K136_L2.4251.00
250_A313_L2.3021.00
374_Q378_Q2.2981.00
137_T141_A2.2511.00
251_K303_A2.2321.00
111_F134_E2.2051.00
394_D398_F2.1891.00
117_N249_K2.1701.00
165_A383_L2.1531.00
327_M344_H2.1121.00
145_L202_C2.1091.00
156_D163_D2.1011.00
226_E249_K2.0841.00
203_V226_E2.0761.00
254_V307_V2.0701.00
228_V249_K2.0661.00
137_T248_E2.0331.00
179_P182_A2.0181.00
137_T252_R1.9961.00
174_G316_I1.8841.00
168_I343_L1.8731.00
162_L343_L1.8691.00
57_I72_Y1.8461.00
373_T376_E1.8311.00
353_R381_W1.8301.00
203_V253_L1.8161.00
174_G341_M1.8141.00
220_Q227_V1.8041.00
167_P368_E1.7641.00
107_G136_L1.7581.00
243_A300_F1.7561.00
252_R256_H1.7481.00
259_D312_S1.7111.00
153_S306_N1.6651.00
104_P139_L1.6541.00
244_E274_Y1.6501.00
175_L339_G1.6491.00
369_E377_L1.6411.00
332_Y344_H1.6161.00
377_L381_W1.6031.00
205_M249_K1.6001.00
222_L370_L1.5851.00
115_K123_K1.5681.00
207_L264_L1.5661.00
88_R91_L1.5601.00
155_E202_C1.5571.00
209_I242_V1.5361.00
260_V313_L1.5341.00
382_I386_I1.5341.00
319_A335_F1.5311.00
137_T255_E1.5141.00
368_E380_M1.5081.00
102_R136_L1.4881.00
133_F136_L1.4761.00
162_L191_I1.4741.00
274_Y296_R1.4321.00
352_K394_D1.4261.00
301_F338_T1.4251.00
297_P335_F1.4251.00
234_E238_R1.4221.00
110_Y252_R1.3921.00
112_A249_K1.3911.00
208_L216_V1.3871.00
144_R376_E1.3801.00
115_K128_R1.3641.00
166_S343_L1.3611.00
106_E245_M1.3541.00
247_I304_A1.3451.00
329_E332_Y1.3441.00
117_N228_V1.3311.00
115_K129_N1.3051.00
267_I335_F1.2941.00
278_V285_L1.2921.00
348_K351_E1.2881.00
111_F132_L1.2871.00
192_A263_L1.2871.00
106_E249_K1.2821.00
159_A162_L1.2821.00
157_L168_I1.2801.00
116_V220_Q1.2791.00
389_P392_E1.2771.00
359_D362_R1.2721.00
209_I264_L1.2571.00
141_A255_E1.2481.00
268_T272_R1.2471.00
381_W384_R1.2351.00
247_I313_L1.2281.00
143_S170_R1.2221.00
372_T380_M1.2221.00
221_R308_E1.2191.00
107_G133_F1.2171.00
168_I314_T1.2151.00
123_K129_N1.2131.00
351_E362_R1.2071.00
301_F335_F1.2041.00
207_L262_I1.1981.00
62_F65_L1.1941.00
321_I332_Y1.1901.00
367_K371_L1.1871.00
156_D190_N1.1720.99
162_L166_S1.1620.99
154_T371_L1.1620.99
119_V245_M1.1590.99
255_E307_V1.1550.99
362_R391_G1.1550.99
86_I238_R1.1440.99
178_A182_A1.1310.99
118_E234_E1.1270.99
368_E372_T1.1240.99
130_K133_F1.1210.99
92_R95_D1.1200.99
257_K310_G1.1150.99
113_L203_V1.1140.99
111_F133_F1.1090.99
297_P338_T1.1020.99
168_I174_G1.0990.99
247_I262_I1.0970.99
84_S88_R1.0930.99
109_R112_A1.0920.99
205_M228_V1.0900.99
198_N259_D1.0890.99
135_N252_R1.0790.99
393_I397_E1.0770.99
63_G66_R1.0750.99
244_E296_R1.0720.99
192_A225_G1.0710.99
211_E215_E1.0710.99
54_V58_L1.0700.99
306_N312_S1.0610.99
272_R322_D1.0560.99
212_R215_E1.0550.99
162_L187_L1.0530.99
213_P231_T1.0500.99
295_H298_K1.0490.99
113_L226_E1.0480.99
179_P347_R1.0480.99
159_A187_L1.0410.99
204_L225_G1.0270.99
307_V310_G1.0230.99
179_P333_E1.0190.99
272_R334_E1.0130.98
148_E308_E1.0060.98
192_A204_L1.0020.98
137_T309_E0.9970.98
111_F131_I0.9920.98
66_R95_D0.9920.98
166_S364_G0.9900.98
55_L60_D0.9870.98
53_G57_I0.9810.98
211_E269_R0.9810.98
56_E60_D0.9790.98
325_S328_D0.9750.98
192_A206_V0.9740.98
261_I316_I0.9730.98
57_I60_D0.9700.98
119_V238_R0.9620.98
209_I243_A0.9610.98
202_C261_I0.9610.98
256_H260_V0.9580.98
64_F67_S0.9540.98
157_L163_D0.9440.98
297_P334_E0.9440.98
321_I329_E0.9420.97
155_E195_I0.9310.97
304_A315_I0.9300.97
148_E309_E0.9290.97
119_V234_E0.9290.97
263_L318_T0.9280.97
205_M226_E0.9260.97
167_P372_T0.9210.97
270_L300_F0.9200.97
407_K410_D0.9190.97
198_N258_K0.9190.97
151_N370_L0.9170.97
119_V124_P0.9150.97
239_H276_T0.9140.97
240_V274_Y0.9110.97
246_V262_I0.9060.97
62_F66_R0.9050.97
67_S70_S0.9040.97
154_T167_P0.9030.97
324_G329_E0.9030.97
139_L245_M0.9000.97
164_L167_P0.8950.97
254_V260_V0.8860.96
153_S259_D0.8830.96
112_A226_E0.8820.96
145_L148_E0.8820.96
271_A331_I0.8780.96
188_L219_M0.8730.96
122_D130_K0.8670.96
348_K391_G0.8670.96
113_L116_V0.8660.96
389_P393_I0.8630.96
230_S239_H0.8570.96
252_R255_E0.8560.96
341_M366_R0.8550.96
196_A259_D0.8520.95
150_G310_G0.8490.95
284_V289_V0.8490.95
344_H362_R0.8490.95
206_V225_G0.8480.95
257_K309_E0.8460.95
81_V281_S0.8450.95
105_K138_P0.8450.95
385_K389_P0.8420.95
272_R289_V0.8410.95
167_P376_E0.8390.95
254_V313_L0.8380.95
195_I261_I0.8320.95
115_K124_P0.8320.95
267_I301_F0.8320.95
170_R312_S0.8290.95
174_G343_L0.8290.95
204_L207_L0.8280.95
104_P245_M0.8270.95
240_V277_V0.8240.95
333_E336_K0.8240.95
327_M332_Y0.8230.95
75_G81_V0.8210.94
53_G62_F0.8200.94
132_L135_N0.8160.94
112_A117_N0.8160.94
177_V332_Y0.8150.94
395_A398_F0.8110.94
110_Y253_L0.8100.94
150_G306_N0.8090.94
55_L58_L0.8090.94
270_L296_R0.8030.94
128_R131_I0.8020.94
57_I63_G0.8000.94
64_F98_S0.7950.93
180_P272_R0.7930.93
283_K292_N0.7930.93
390_M394_D0.7920.93
157_L400_I0.7900.93
126_N129_N0.7870.93
204_L263_L0.7860.93
104_P241_Q0.7830.93
266_S318_T0.7820.93
378_Q381_W0.7820.93
193_Q220_Q0.7820.93
186_M189_Q0.7810.93
157_L316_I0.7810.93
244_E270_L0.7800.93
165_A380_M0.7770.93
327_M362_R0.7770.93
169_G371_L0.7760.93
61_G64_F0.7750.93
262_I304_A0.7740.93
179_P325_S0.7740.93
188_L263_L0.7710.92
57_I62_F0.7690.92
125_E129_N0.7680.92
218_E370_L0.7670.92
180_P336_K0.7650.92
346_S362_R0.7650.92
405_M409_N0.7630.92
179_P288_G0.7560.92
212_R269_R0.7550.92
76_P81_V0.7480.91
163_D194_S0.7460.91
159_A190_N0.7460.91
205_M246_V0.7420.91
372_T376_E0.7420.91
131_I134_E0.7380.91
169_G367_K0.7370.91
359_D391_G0.7370.91
165_A360_Y0.7360.91
75_G93_T0.7340.90
116_V124_P0.7340.90
293_A296_R0.7340.90
192_A224_K0.7340.90
369_E384_R0.7320.90
240_V296_R0.7320.90
280_A284_V0.7310.90
344_H347_R0.7290.90
56_E99_G0.7280.90
216_V229_A0.7260.90
53_G58_L0.7250.90
104_P163_D0.7240.90
53_G56_E0.7240.90
180_P338_T0.7220.90
118_E124_P0.7220.90
238_R241_Q0.7190.90
395_A401_N0.7180.89
264_L300_F0.7180.89
402_K405_M0.7160.89
368_E376_E0.7160.89
59_Q62_F0.7150.89
86_I235_P0.7120.89
123_K128_R0.7110.89
113_L258_K0.7100.89
325_S347_R0.7100.89
283_K305_R0.7080.89
230_S234_E0.7050.89
115_K130_K0.7040.89
117_N131_I0.7010.88
60_D65_L0.7010.88
235_P238_R0.7000.88
203_V260_V0.7000.88
85_Q238_R0.6980.88
183_G265_D0.6960.88
103_P138_P0.6960.88
162_L168_I0.6940.88
86_I122_D0.6940.88
71_S85_Q0.6890.87
240_V270_L0.6870.87
59_Q65_L0.6840.87
247_I264_L0.6830.87
210_D239_H0.6820.87
157_L162_L0.6810.87
108_E248_E0.6800.87
348_K392_E0.6770.87
53_G60_D0.6760.86
393_I398_F0.6760.86
280_A291_A0.6760.86
58_L64_F0.6740.86
249_K253_L0.6730.86
100_K117_N0.6730.86
218_E222_L0.6700.86
278_V291_A0.6700.86
270_L274_Y0.6670.86
123_K130_K0.6670.86
367_K372_T0.6630.85
353_R385_K0.6630.85
115_K126_N0.6620.85
226_E253_L0.6610.85
163_D167_P0.6610.85
276_T291_A0.6600.85
376_E380_M0.6600.85
387_I391_G0.6540.85
286_T334_E0.6540.85
259_D306_N0.6530.85
176_I343_L0.6470.84
156_D196_A0.6470.84
278_V292_N0.6470.84
135_N256_H0.6470.84
206_V216_V0.6450.84
271_A297_P0.6440.84
378_Q382_I0.6430.84
181_K276_T0.6410.83
58_L62_F0.6410.83
401_N405_M0.6410.83
242_V246_V0.6370.83
386_I389_P0.6370.83
184_K211_E0.6340.83
177_V339_G0.6330.83
361_N387_I0.6320.83
106_E109_R0.6290.82
274_Y277_V0.6240.82
163_D195_I0.6240.82
53_G99_G0.6230.82
83_P281_S0.6220.82
400_I410_D0.6220.82
101_I104_P0.6220.82
396_M399_L0.6210.82
154_T367_K0.6170.81
245_M248_E0.6140.81
190_N194_S0.6130.81
189_Q218_E0.6120.81
85_Q120_N0.6120.81
337_G342_E0.6080.80
80_Y97_I0.6060.80
321_I328_D0.6050.80
56_E98_S0.6050.80
172_Q366_R0.6050.80
347_R351_E0.6040.80
114_L125_E0.6030.80
147_M359_D0.6030.80
184_K269_R0.6020.79
180_P337_G0.6010.79
185_T265_D0.6010.79
206_V223_V0.5990.79
56_E64_F0.5990.79
124_P234_E0.5980.79
284_V291_A0.5980.79
251_K254_V0.5960.79
110_Y134_E0.5960.79
108_E112_A0.5950.79
140_H244_E0.5950.79
184_K265_D0.5940.79
133_F252_R0.5940.79
281_S292_N0.5930.78
55_L62_F0.5930.78
286_T290_D0.5930.78
55_L59_Q0.5920.78
125_E130_K0.5920.78
369_E372_T0.5910.78
53_G61_G0.5900.78
208_L211_E0.5900.78
328_D335_F0.5890.78
144_R307_V0.5870.78
158_T187_L0.5870.78
123_K126_N0.5860.78
138_P141_A0.5850.78
100_K115_K0.5850.78
322_D328_D0.5840.77
375_E379_K0.5830.77
112_A133_F0.5820.77
148_E152_G0.5800.77
73_L281_S0.5760.76
122_D132_L0.5750.76
253_L258_K0.5740.76
247_I251_K0.5740.76
207_L210_D0.5720.76
335_F339_G0.5700.76
263_L272_R0.5690.76
153_S310_G0.5690.76
55_L61_G0.5660.75
180_P334_E0.5660.75
138_P248_E0.5600.74
125_E128_R0.5600.74
189_Q229_A0.5600.74
169_G366_R0.5600.74
243_A264_L0.5600.74
206_V219_M0.5590.74
81_V176_I0.5570.74
239_H251_K0.5570.74
74_A81_V0.5570.74
150_G307_V0.5570.74
248_E251_K0.5560.74
83_P395_A0.5560.74
379_K382_I0.5550.74
260_V276_T0.5550.74
85_Q104_P0.5540.74
334_E399_L0.5530.74
53_G63_G0.5530.74
159_A194_S0.5520.73
120_N238_R0.5500.73
58_L66_R0.5490.73
180_P401_N0.5490.73
216_V231_T0.5470.73
176_I332_Y0.5470.73
103_P165_A0.5460.73
390_M397_E0.5460.73
72_Y75_G0.5460.73
53_G64_F0.5450.72
180_P324_G0.5440.72
267_I300_F0.5430.72
63_G67_S0.5420.72
267_I317_A0.5420.72
111_F135_N0.5420.72
148_E153_S0.5410.72
289_V395_A0.5410.72
167_P364_G0.5400.72
183_G211_E0.5400.72
146_R149_R0.5390.72
294_L297_P0.5380.72
83_P277_V0.5380.72
275_N331_I0.5380.72
146_R163_D0.5380.72
398_F407_K0.5370.71
182_A347_R0.5370.71
191_I261_I0.5370.71
374_Q377_L0.5370.71
163_D241_Q0.5360.71
376_E379_K0.5360.71
71_S215_E0.5360.71
298_K313_L0.5350.71
230_S238_R0.5280.70
134_E137_T0.5280.70
272_R287_G0.5280.70
191_I194_S0.5280.70
142_N299_R0.5260.70
400_I404_A0.5220.69
159_A165_A0.5220.69
278_V290_D0.5210.69
196_A224_K0.5210.69
71_S241_Q0.5210.69
186_M190_N0.5200.69
151_N222_L0.5200.69
116_V408_T0.5200.69
286_T328_D0.5190.69
98_S118_E0.5190.69
215_E269_R0.5180.69
329_E333_E0.5160.68
78_D310_G0.5160.68
197_Y224_K0.5160.68
169_G172_Q0.5160.68
125_E158_T0.5150.68
157_L304_A0.5150.68
354_V391_G0.5140.68
337_G364_G0.5130.68
223_V229_A0.5120.68
321_I327_M0.5110.68
334_E395_A0.5100.67
152_G310_G0.5100.67
56_E61_G0.5100.67
105_K110_Y0.5100.67
179_P321_I0.5100.67
334_E337_G0.5090.67
403_L406_T0.5080.67
204_L261_I0.5080.67
384_R387_I0.5080.67
55_L63_G0.5060.67
193_Q331_I0.5050.67
192_A223_V0.5040.67
135_N150_G0.5040.67
254_V259_D0.5030.66
301_F315_I0.5020.66
215_E218_E0.5020.66
120_N399_L0.5020.66
129_N133_F0.5010.66
379_K386_I0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oaaA 2 0.9045 100 0.2 Contact Map
2qe7A 1 0.8974 100 0.202 Contact Map
1fx0A 1 0.9045 100 0.209 Contact Map
2c61A 2 0.852 100 0.21 Contact Map
3l0oA 2 0.9761 100 0.21 Contact Map
3gqbB 1 0.9069 100 0.211 Contact Map
2ck3A 1 0.9117 100 0.212 Contact Map
3vr4D 1 0.9021 100 0.212 Contact Map
3j9tA 1 0.8926 100 0.213 Contact Map
3mfyA 1 0.7327 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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