SPOT - ECOLI - GREMLIN Contacts

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SPOT - Bifunctional (p)ppGpp synthase/hydrolase SpoT

UniProt:	P0AG24	Sequences: MYLFESLNQLIQTYLPEDQIKRLRQAYLVARDAHEGQTRSSGEPYITHPVAVACILAEMKLDYETLMAALLHDVIEDTPATYQDMEQLFGKSVAELVEGVSKLDKLKFRDKKEAQAENFRKMIMAMVQDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHIKTELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILSEIEGRLQEAGIPCRVSGREKHLYSIYCKMVLKEQRFHSIMDIYAFRVIVNDSDTCYRVLGQMHSLYKPRPGRVKDYIAIPKANGYQSLHTSMIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEHGETSTTAQIRAQRWMQSLLELQQSAGSSFEFIESVKSDLFPDEIYVFTPEGRIVELPAGATPVDFAYAVHTDIGHACVGARVDRQPYPLSQPLTSGQTVEIITAPGARPNAAWLNFVVSSKARAKIRQLLKNLKRDDSVSLGRRLLNHALGGSRKLNEIPQENIQRELDRMKLATLDDLLAEIGLGNAMSVVVAKNLQHGDASIPPATQSHGHLPIKGADGVLITFAKCCRPIPGDPIIAHVSPGKGLVIHHESCRNIRGYQKEPEKFMAVEWDKETAQEFITEIKVEMFNHQGALANLTAAINTTTSNIQSLNTEEKDGRVYSAFIRLTARDRVHLANIMRKIRVMPDVIKVTRNRN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10966
Length:	702 (685)
Sequences:	3412 (1933)
Seq/√Len:	73.8

ECOLI - SPOT RELA
BACSU - RELA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
86_E	91_K	7.087	1.00
411_Y	419_H	5.407	1.00
490_L	527_I	5.179	1.00
427_D	441_Q	4.909	1.00
426_V	431_Y	4.689	1.00
685_M	697_V	4.445	1.00
407_V	460_F	4.345	1.00
25_Q	88_L	4.234	1.00
61_L	134_L	4.186	1.00
75_I	82_Y	4.069	1.00
230_P	268_N	4.039	1.00
269_D	272_T	3.826	1.00
145_R	181_E	3.655	1.00
268_N	325_E	3.578	1.00
461_V	470_I	3.571	1.00
22_R	67_M	3.537	1.00
266_I	325_E	3.529	1.00
232_R	325_E	3.504	1.00
223_R	226_E	3.445	1.00
64_E	92_S	3.409	1.00
636_H	642_N	3.155	1.00
23_L	66_L	3.150	1.00
220_I	280_M	3.032	1.00
517_L	526_E	2.987	1.00
152_P	155_R	2.958	1.00
147_L	189_A	2.869	1.00
234_S	328_D	2.827	1.00
417_I	447_T	2.814	1.00
160_R	164_E	2.796	1.00
198_I	240_L	2.729	1.00
215_K	314_H	2.720	1.00
426_V	435_Q	2.717	1.00
11_I	23_L	2.682	1.00
483_V	525_A	2.679	1.00
252_Q	257_I	2.679	1.00
191_Y	194_R	2.668	1.00
32_D	35_E	2.610	1.00
29_V	80_A	2.561	1.00
197_V	201_V	2.541	1.00
631_V	688_I	2.527	1.00
581_P	597_E	2.494	1.00
201_V	254_F	2.480	1.00
392_T	398_V	2.424	1.00
436_P	462_V	2.424	1.00
152_P	156_R	2.373	1.00
56_L	65_T	2.361	1.00
24_R	28_L	2.342	1.00
82_Y	98_E	2.327	1.00
75_I	85_M	2.324	1.00
628_E	672_R	2.314	1.00
594_I	615_V	2.277	1.00
657_L	671_I	2.276	1.00
221_E	225_Q	2.272	1.00
463_S	466_A	2.263	1.00
487_R	524_L	2.262	1.00
633_M	639_A	2.252	1.00
437_L	443_V	2.207	1.00
268_N	272_T	2.204	1.00
96_L	135_I	2.200	1.00
483_V	521_D	2.196	1.00
276_V	279_Q	2.167	1.00
155_R	189_A	2.105	1.00
425_R	444_E	2.096	1.00
629_I	685_M	2.084	1.00
212_M	312_G	2.068	1.00
53_A	66_L	2.067	1.00
84_D	87_Q	2.063	1.00
95_E	128_Q	2.056	1.00
222_G	226_E	2.027	1.00
150_L	158_I	2.010	1.00
519_T	522_D	1.980	1.00
512_L	520_L	1.974	1.00
213_I	235_G	1.962	1.00
673_L	684_I	1.962	1.00
211_E	215_K	1.958	1.00
205_A	208_N	1.948	1.00
216_I	318_V	1.944	1.00
587_S	593_V	1.925	1.00
583_I	602_I	1.904	1.00
217_L	221_E	1.897	1.00
61_L	65_T	1.896	1.00
22_R	25_Q	1.891	1.00
271_D	275_R	1.885	1.00
40_S	150_L	1.869	1.00
144_M	182_L	1.855	1.00
435_Q	438_T	1.846	1.00
404_A	463_S	1.829	1.00
28_L	31_R	1.821	1.00
267_V	276_V	1.801	1.00
652_S	680_H	1.799	1.00
22_R	64_E	1.798	1.00
517_L	523_L	1.791	1.00
63_Y	67_M	1.780	1.00
325_E	329_Q	1.773	1.00
194_R	197_V	1.769	1.00
147_L	158_I	1.766	1.00
212_M	313_P	1.754	1.00
390_V	437_L	1.747	1.00
56_L	69_A	1.737	1.00
265_V	276_V	1.731	1.00
360_Q	363_L	1.729	1.00
406_P	424_A	1.728	1.00
82_Y	86_E	1.725	1.00
73_D	77_D	1.717	1.00
448_A	451_A	1.716	1.00
30_A	46_I	1.706	1.00
206_R	237_E	1.705	1.00
202_V	240_L	1.701	1.00
478_K	481_D	1.700	1.00
86_E	94_A	1.700	1.00
561_K	614_A	1.692	1.00
67_M	93_V	1.685	1.00
631_V	671_I	1.682	1.00
223_R	283_L	1.672	1.00
68_A	96_L	1.668	1.00
403_G	436_P	1.661	1.00
83_Q	86_E	1.658	1.00
82_Y	94_A	1.652	1.00
159_A	186_G	1.638	1.00
218_S	222_G	1.629	1.00
272_T	275_R	1.624	1.00
14_Y	60_K	1.621	1.00
83_Q	87_Q	1.619	0.99
218_S	221_E	1.596	0.99
415_T	419_H	1.596	0.99
290_R	309_S	1.594	0.99
147_L	159_A	1.592	0.99
435_Q	441_Q	1.588	0.99
525_A	528_G	1.580	0.99
180_T	239_H	1.572	0.99
163_L	241_Y	1.570	0.99
180_T	206_R	1.563	0.99
21_K	25_Q	1.558	0.99
520_L	524_L	1.557	0.99
210_K	214_Q	1.557	0.99
196_R	199_K	1.547	0.99
10_L	58_E	1.531	0.99
75_I	98_E	1.529	0.99
75_I	94_A	1.512	0.99
204_A	316_V	1.495	0.99
77_D	101_S	1.493	0.99
635_N	667_Y	1.490	0.99
479_R	522_D	1.485	0.99
490_L	524_L	1.483	0.99
142_H	146_T	1.481	0.99
22_R	93_V	1.475	0.99
11_I	15_L	1.475	0.99
143_N	146_T	1.475	0.99
82_Y	95_E	1.474	0.99
187_F	240_L	1.473	0.99
636_H	639_A	1.473	0.99
387_E	399_E	1.469	0.99
187_F	191_Y	1.467	0.99
640_L	657_L	1.455	0.99
241_Y	245_C	1.447	0.99
647_I	671_I	1.436	0.99
75_I	101_S	1.430	0.99
84_D	88_L	1.408	0.99
77_D	143_N	1.406	0.99
406_P	426_V	1.405	0.99
214_Q	217_L	1.397	0.98
687_K	690_V	1.392	0.98
73_D	76_E	1.387	0.98
224_L	276_V	1.386	0.98
407_V	461_V	1.380	0.98
55_I	145_R	1.363	0.98
200_E	204_A	1.347	0.98
76_E	101_S	1.341	0.98
29_V	88_L	1.341	0.98
646_A	684_I	1.340	0.98
650_T	687_K	1.338	0.98
224_L	231_C	1.335	0.98
304_Q	330_M	1.331	0.98
81_T	84_D	1.330	0.98
225_Q	231_C	1.325	0.98
77_D	102_K	1.323	0.98
338_H	341_Y	1.322	0.98
281_H	308_T	1.317	0.98
199_K	240_L	1.317	0.98
144_M	185_L	1.314	0.98
219_E	284_Y	1.302	0.98
76_E	143_N	1.301	0.98
424_A	431_Y	1.301	0.98
472_Q	476_N	1.299	0.98
412_A	465_K	1.294	0.98
214_Q	218_S	1.294	0.98
455_A	474_L	1.292	0.97
206_R	210_K	1.284	0.97
353_I	360_Q	1.280	0.97
216_I	263_F	1.279	0.97
56_L	66_L	1.277	0.97
431_Y	435_Q	1.277	0.97
479_R	483_V	1.276	0.97
29_V	33_A	1.276	0.97
647_I	654_I	1.266	0.97
647_I	652_S	1.266	0.97
182_L	186_G	1.262	0.97
574_C	599_C	1.261	0.97
280_M	310_M	1.259	0.97
27_Y	31_R	1.257	0.97
28_L	32_D	1.254	0.97
31_R	35_E	1.251	0.97
39_R	143_N	1.247	0.97
630_K	670_F	1.245	0.97
647_I	673_L	1.243	0.97
584_A	613_M	1.237	0.97
595_H	599_C	1.235	0.97
135_I	171_H	1.225	0.97
406_P	431_Y	1.222	0.96
180_T	237_E	1.220	0.96
187_F	194_R	1.217	0.96
574_C	595_H	1.216	0.96
34_H	73_D	1.215	0.96
151_R	154_K	1.214	0.96
556_G	560_I	1.212	0.96
33_A	80_A	1.208	0.96
633_M	667_Y	1.208	0.96
678_R	682_A	1.205	0.96
56_L	100_V	1.202	0.96
21_K	24_R	1.201	0.96
33_A	84_D	1.198	0.96
153_D	157_R	1.193	0.96
217_L	233_V	1.191	0.96
583_I	612_F	1.185	0.96
46_I	49_P	1.183	0.96
80_A	88_L	1.181	0.96
39_R	77_D	1.178	0.96
557_H	560_I	1.177	0.96
388_I	439_S	1.175	0.96
632_E	696_K	1.170	0.95
39_R	73_D	1.165	0.95
585_H	611_K	1.164	0.95
139_D	143_N	1.158	0.95
80_A	84_D	1.155	0.95
338_H	342_K	1.153	0.95
636_H	693_D	1.153	0.95
365_L	369_A	1.152	0.95
508_I	520_L	1.147	0.95
336_A	342_K	1.146	0.95
602_I	612_F	1.145	0.95
286_P	296_A	1.145	0.95
571_A	593_V	1.143	0.95
643_L	669_A	1.140	0.95
49_P	143_N	1.139	0.95
404_A	462_V	1.138	0.95
34_H	77_D	1.138	0.95
267_V	272_T	1.133	0.95
73_D	143_N	1.132	0.95
12_Q	20_I	1.131	0.95
659_T	669_A	1.129	0.94
423_G	446_I	1.125	0.94
221_E	232_R	1.123	0.94
35_E	38_T	1.123	0.94
405_T	460_F	1.121	0.94
39_R	42_G	1.114	0.94
510_R	513_D	1.113	0.94
509_Q	513_D	1.111	0.94
653_N	674_T	1.111	0.94
7_L	12_Q	1.109	0.94
48_H	142_H	1.109	0.94
629_I	671_I	1.108	0.94
639_A	667_Y	1.108	0.94
573_C	595_H	1.106	0.94
246_K	341_Y	1.105	0.94
144_M	147_L	1.105	0.94
464_S	468_A	1.102	0.94
39_R	142_H	1.102	0.94
11_I	57_A	1.096	0.94
280_M	320_V	1.095	0.94
212_M	216_I	1.095	0.94
188_E	199_K	1.094	0.94
217_L	263_F	1.091	0.93
72_H	162_T	1.090	0.93
101_S	143_N	1.090	0.93
51_A	54_C	1.086	0.93
39_R	45_Y	1.085	0.93
150_L	154_K	1.084	0.93
201_V	255_H	1.084	0.93
388_I	435_Q	1.084	0.93
227_A	279_Q	1.082	0.93
272_T	276_V	1.079	0.93
638_G	653_N	1.078	0.93
77_D	142_H	1.077	0.93
196_R	200_E	1.075	0.93
246_K	342_K	1.075	0.93
195_Y	199_K	1.072	0.93
102_K	143_N	1.071	0.93
91_K	95_E	1.070	0.93
34_H	76_E	1.067	0.93
278_G	281_H	1.066	0.93
473_L	477_L	1.065	0.93
646_A	650_T	1.063	0.93
71_L	93_V	1.060	0.92
389_Y	399_E	1.060	0.92
19_Q	63_Y	1.060	0.92
202_V	260_I	1.060	0.92
262_A	338_H	1.051	0.92
34_H	143_N	1.048	0.92
34_H	45_Y	1.047	0.92
628_E	670_F	1.045	0.92
274_Y	278_G	1.043	0.92
639_A	691_M	1.042	0.92
72_H	143_N	1.042	0.92
144_M	162_T	1.041	0.92
685_M	689_R	1.037	0.92
110_D	113_E	1.034	0.91
626_I	672_R	1.032	0.91
223_R	227_A	1.029	0.91
630_K	698_T	1.025	0.91
573_C	599_C	1.022	0.91
77_D	146_T	1.018	0.91
33_A	79_P	1.018	0.91
328_D	332_E	1.018	0.91
73_D	101_S	1.017	0.91
311_I	315_G	1.017	0.91
632_E	668_S	1.014	0.91
236_R	342_K	1.012	0.91
416_D	419_H	1.012	0.91
49_P	72_H	1.012	0.91
11_I	14_Y	1.011	0.91
629_I	673_L	1.010	0.90
624_E	674_T	1.004	0.90
102_K	139_D	1.003	0.90
264_R	321_Q	1.003	0.90
10_L	54_C	0.999	0.90
73_D	78_T	0.998	0.90
452_R	473_L	0.996	0.90
587_S	601_N	0.996	0.90
126_M	130_I	0.992	0.90
406_P	437_L	0.988	0.89
156_R	190_L	0.987	0.89
660_E	670_F	0.983	0.89
45_Y	73_D	0.982	0.89
650_T	683_N	0.982	0.89
246_K	338_H	0.978	0.89
577_I	627_T	0.978	0.89
639_A	642_N	0.972	0.89
34_H	39_R	0.967	0.88
526_E	532_A	0.967	0.88
56_L	61_L	0.967	0.88
581_P	596_H	0.965	0.88
34_H	49_P	0.962	0.88
202_V	254_F	0.962	0.88
277_L	322_I	0.962	0.88
68_A	135_I	0.959	0.88
352_Q	356_Q	0.959	0.88
49_P	142_H	0.957	0.88
420_A	451_A	0.956	0.88
220_I	320_V	0.955	0.88
69_A	135_I	0.954	0.88
99_G	121_K	0.952	0.88
357_R	360_Q	0.949	0.88
637_Q	651_T	0.949	0.88
39_R	49_P	0.947	0.87
642_N	691_M	0.947	0.87
39_R	72_H	0.946	0.87
76_E	142_H	0.946	0.87
421_C	433_L	0.944	0.87
633_M	694_V	0.943	0.87
635_N	661_E	0.942	0.87
53_A	69_A	0.941	0.87
72_H	76_E	0.940	0.87
37_Q	76_E	0.938	0.87
641_A	648_N	0.938	0.87
377_E	380_K	0.938	0.87
392_T	413_V	0.935	0.87
154_K	157_R	0.934	0.87
76_E	146_T	0.933	0.87
274_Y	281_H	0.931	0.86
37_Q	77_D	0.931	0.86
54_C	58_E	0.929	0.86
274_Y	277_L	0.928	0.86
225_Q	230_P	0.928	0.86
49_P	76_E	0.928	0.86
45_Y	77_D	0.925	0.86
398_V	412_A	0.923	0.86
238_K	246_K	0.922	0.86
626_I	674_T	0.921	0.86
76_E	139_D	0.921	0.86
656_S	672_R	0.919	0.86
120_R	313_P	0.919	0.86
125_A	388_I	0.918	0.86
691_M	694_V	0.915	0.86
639_A	693_D	0.912	0.85
72_H	142_H	0.911	0.85
136_K	143_N	0.909	0.85
523_L	532_A	0.909	0.85
66_L	69_A	0.909	0.85
49_P	77_D	0.909	0.85
45_Y	143_N	0.908	0.85
39_R	146_T	0.906	0.85
329_Q	333_M	0.905	0.85
244_Y	248_V	0.905	0.85
522_D	525_A	0.904	0.85
223_R	279_Q	0.903	0.85
515_M	532_A	0.902	0.85
141_T	178_I	0.901	0.85
677_D	680_H	0.898	0.84
32_D	36_G	0.897	0.84
216_I	284_Y	0.897	0.84
409_F	413_V	0.896	0.84
13_T	404_A	0.895	0.84
231_C	276_V	0.892	0.84
34_H	101_S	0.892	0.84
52_V	139_D	0.892	0.84
45_Y	142_H	0.891	0.84
85_M	94_A	0.889	0.84
34_H	72_H	0.889	0.84
73_D	162_T	0.888	0.84
48_H	52_V	0.887	0.84
64_E	67_M	0.887	0.84
23_L	63_Y	0.885	0.84
101_S	146_T	0.882	0.83
133_I	169_L	0.881	0.83
220_I	263_F	0.879	0.83
49_P	73_D	0.878	0.83
9_Q	13_T	0.878	0.83
461_V	466_A	0.877	0.83
246_K	262_A	0.874	0.83
34_H	37_Q	0.870	0.83
236_R	341_Y	0.869	0.82
15_L	63_Y	0.865	0.82
238_K	338_H	0.863	0.82
116_A	466_A	0.861	0.82
18_D	21_K	0.859	0.82
494_L	538_A	0.859	0.82
262_A	342_K	0.858	0.82
559_P	616_E	0.857	0.82
281_H	291_V	0.856	0.82
48_H	72_H	0.856	0.82
15_L	18_D	0.855	0.81
652_S	684_I	0.854	0.81
78_T	143_N	0.853	0.81
247_M	254_F	0.851	0.81
39_R	76_E	0.850	0.81
419_H	473_L	0.850	0.81
34_H	146_T	0.850	0.81
264_R	338_H	0.848	0.81
246_K	319_E	0.847	0.81
34_H	142_H	0.844	0.81
336_A	341_Y	0.840	0.80
292_K	309_S	0.840	0.80
219_E	223_R	0.840	0.80
72_H	139_D	0.838	0.80
150_L	157_R	0.838	0.80
407_V	421_C	0.836	0.80
572_K	575_R	0.836	0.80
406_P	436_P	0.836	0.80
262_A	341_Y	0.835	0.80
238_K	321_Q	0.833	0.80
101_S	142_H	0.832	0.80
48_H	139_D	0.831	0.80
39_R	48_H	0.830	0.79
34_H	48_H	0.829	0.79
319_E	341_Y	0.829	0.79
424_A	445_I	0.829	0.79
41_S	149_S	0.827	0.79
326_D	329_Q	0.827	0.79
245_C	249_L	0.827	0.79
238_K	319_E	0.826	0.79
219_E	283_L	0.826	0.79
304_Q	601_N	0.824	0.79
657_L	661_E	0.823	0.79
570_F	577_I	0.822	0.79
55_I	181_E	0.820	0.79
56_L	602_I	0.818	0.78
415_T	469_K	0.817	0.78
48_H	143_N	0.816	0.78
72_H	77_D	0.815	0.78
25_Q	67_M	0.815	0.78
37_Q	78_T	0.815	0.78
645_A	649_T	0.814	0.78
45_Y	49_P	0.814	0.78
637_Q	653_N	0.811	0.78
38_T	44_P	0.811	0.78
270_S	282_S	0.808	0.78
413_V	470_I	0.808	0.78
188_E	196_R	0.806	0.77
11_I	16_P	0.804	0.77
246_K	264_R	0.802	0.77
148_G	188_E	0.801	0.77
677_D	681_L	0.801	0.77
420_A	450_G	0.800	0.77
86_E	90_G	0.800	0.77
118_N	391_F	0.799	0.77
72_H	101_S	0.797	0.77
425_R	446_I	0.795	0.76
630_K	668_S	0.794	0.76
375_F	380_K	0.792	0.76
638_G	644_T	0.792	0.76
509_Q	520_L	0.791	0.76
224_L	229_I	0.790	0.76
605_Y	612_F	0.789	0.76
45_Y	48_H	0.789	0.76
78_T	146_T	0.788	0.76
236_R	262_A	0.787	0.76
277_L	281_H	0.784	0.75
313_P	640_L	0.784	0.75
356_Q	360_Q	0.784	0.75
363_L	366_Q	0.782	0.75
119_F	284_Y	0.782	0.75
15_L	471_R	0.782	0.75
49_P	78_T	0.782	0.75
636_H	691_M	0.781	0.75
124_M	171_H	0.781	0.75
563_A	566_V	0.780	0.75
208_N	211_E	0.778	0.75
139_D	142_H	0.777	0.75
154_K	158_I	0.777	0.75
45_Y	78_T	0.776	0.75
246_K	336_A	0.776	0.75
7_L	10_L	0.775	0.75
319_E	338_H	0.775	0.75
560_I	582_I	0.774	0.75
39_R	101_S	0.773	0.74
636_H	643_L	0.773	0.74
55_I	138_A	0.772	0.74
39_R	78_T	0.772	0.74
122_M	126_M	0.771	0.74
681_L	685_M	0.770	0.74
73_D	142_H	0.770	0.74
425_R	430_P	0.770	0.74
644_T	693_D	0.768	0.74
592_L	615_V	0.768	0.74
646_A	687_K	0.767	0.74
72_H	146_T	0.765	0.74
236_R	338_H	0.765	0.74
45_Y	72_H	0.765	0.74
518_A	522_D	0.765	0.74
48_H	73_D	0.765	0.74
246_K	321_Q	0.764	0.74
82_Y	85_M	0.763	0.73
416_D	420_A	0.760	0.73
78_T	101_S	0.760	0.73
102_K	146_T	0.756	0.73
143_N	154_K	0.756	0.73
188_E	206_R	0.755	0.73
287_R	317_P	0.754	0.73
238_K	342_K	0.754	0.73
48_H	102_K	0.753	0.73
351_A	354_R	0.753	0.73
73_D	102_K	0.751	0.72
388_I	403_G	0.751	0.72
99_G	132_V	0.751	0.72
476_N	480_D	0.749	0.72
655_Q	674_T	0.745	0.72
49_P	52_V	0.744	0.72
558_L	582_I	0.743	0.71
102_K	142_H	0.740	0.71
41_S	77_D	0.739	0.71
164_E	380_K	0.739	0.71
635_N	638_G	0.738	0.71
48_H	146_T	0.738	0.71
48_H	77_D	0.738	0.71
150_L	155_R	0.737	0.71
641_A	645_A	0.736	0.71
455_A	478_K	0.735	0.71
489_L	527_I	0.735	0.71
305_S	323_R	0.733	0.70
39_R	139_D	0.733	0.70
602_I	606_Q	0.732	0.70
264_R	341_Y	0.731	0.70
413_V	416_D	0.731	0.70
646_A	691_M	0.730	0.70
156_R	320_V	0.730	0.70
629_I	697_V	0.730	0.70
130_I	289_G	0.729	0.70
247_M	358_W	0.728	0.70
205_A	209_R	0.727	0.70
215_K	219_E	0.726	0.70
39_R	102_K	0.726	0.70
238_K	341_Y	0.724	0.70
228_G	463_S	0.724	0.70
494_L	524_L	0.723	0.69
406_P	435_Q	0.721	0.69
238_K	262_A	0.721	0.69
134_L	175_I	0.720	0.69
319_E	336_A	0.720	0.69
49_P	146_T	0.719	0.69
497_S	538_A	0.719	0.69
45_Y	146_T	0.718	0.69
215_K	218_S	0.714	0.68
278_G	282_S	0.713	0.68
507_N	510_R	0.713	0.68
20_I	24_R	0.713	0.68
76_E	99_G	0.713	0.68
468_A	472_Q	0.712	0.68
202_V	314_H	0.711	0.68
98_E	121_K	0.711	0.68
45_Y	76_E	0.711	0.68
583_I	597_E	0.709	0.68
124_M	384_F	0.708	0.68
9_Q	12_Q	0.707	0.68
29_V	85_M	0.706	0.68
73_D	97_V	0.705	0.67
37_Q	45_Y	0.705	0.67
19_Q	22_R	0.704	0.67
57_A	187_F	0.703	0.67
212_M	314_H	0.702	0.67
47_T	51_A	0.702	0.67
64_E	93_V	0.702	0.67
76_E	102_K	0.701	0.67
576_P	595_H	0.698	0.67
116_A	383_L	0.698	0.67
321_Q	338_H	0.697	0.67
34_H	78_T	0.697	0.67
77_D	154_K	0.697	0.67
626_I	655_Q	0.697	0.67
494_L	541_L	0.696	0.66
77_D	139_D	0.694	0.66
194_R	244_Y	0.694	0.66
319_E	342_K	0.694	0.66
661_E	667_Y	0.693	0.66
78_T	142_H	0.692	0.66
391_F	396_R	0.692	0.66
625_F	675_A	0.691	0.66
78_T	102_K	0.691	0.66
643_L	647_I	0.691	0.66
490_L	537_V	0.690	0.66
220_I	421_C	0.688	0.66
100_V	103_L	0.687	0.65
140_R	161_E	0.687	0.65
475_K	529_L	0.685	0.65
52_V	72_H	0.685	0.65
633_M	669_A	0.683	0.65
209_R	237_E	0.682	0.65
210_K	237_E	0.682	0.65
215_K	435_Q	0.681	0.65
419_H	474_L	0.681	0.65
246_K	259_D	0.681	0.65
76_E	100_V	0.681	0.65
45_Y	101_S	0.679	0.65
359_M	365_L	0.679	0.65
238_K	264_R	0.679	0.65
200_E	203_K	0.679	0.65
534_S	538_A	0.678	0.64
249_L	252_Q	0.678	0.64
139_D	146_T	0.678	0.64
73_D	146_T	0.677	0.64
43_E	48_H	0.677	0.64
87_Q	91_K	0.675	0.64
393_P	414_H	0.674	0.64
42_G	48_H	0.674	0.64
59_M	178_I	0.673	0.64
238_K	336_A	0.673	0.64
143_N	162_T	0.672	0.64
560_I	615_V	0.671	0.64
48_H	101_S	0.669	0.63
162_T	182_L	0.669	0.63
558_L	611_K	0.669	0.63
482_S	528_G	0.669	0.63
493_A	496_G	0.668	0.63
16_P	19_Q	0.668	0.63
359_M	362_L	0.667	0.63
42_G	101_S	0.667	0.63
209_R	296_A	0.667	0.63
180_T	183_E	0.666	0.63
242_S	342_K	0.664	0.63
359_M	363_L	0.663	0.63
247_M	294_Y	0.661	0.63
139_D	162_T	0.660	0.62
49_P	101_S	0.660	0.62
39_R	154_K	0.660	0.62
486_G	528_G	0.659	0.62
339_W	342_K	0.658	0.62
622_A	631_V	0.658	0.62
68_A	97_V	0.658	0.62
75_I	84_D	0.656	0.62
121_K	132_V	0.656	0.62
34_H	41_S	0.655	0.62
236_R	246_K	0.654	0.62
596_H	639_A	0.654	0.62
198_I	201_V	0.653	0.62
86_E	95_E	0.653	0.62
426_V	443_V	0.653	0.62
104_D	158_I	0.653	0.62
8_N	24_R	0.653	0.62
48_H	74_V	0.651	0.61
15_L	19_Q	0.650	0.61
100_V	278_G	0.649	0.61
587_S	591_G	0.648	0.61
576_P	599_C	0.648	0.61
606_Q	612_F	0.648	0.61
108_F	265_V	0.648	0.61
8_N	20_I	0.648	0.61
36_G	44_P	0.647	0.61
264_R	319_E	0.645	0.61
624_E	676_R	0.644	0.60
136_K	140_R	0.643	0.60
415_T	634_F	0.643	0.60
78_T	81_T	0.643	0.60
135_I	186_G	0.643	0.60
15_L	66_L	0.643	0.60
575_R	628_E	0.642	0.60
415_T	473_L	0.641	0.60
55_I	66_L	0.641	0.60
372_S	689_R	0.640	0.60
259_D	338_H	0.639	0.60
115_Q	134_L	0.638	0.60
37_Q	73_D	0.638	0.60
561_K	616_E	0.638	0.60
484_S	488_R	0.634	0.59
361_S	386_D	0.634	0.59
640_L	653_N	0.633	0.59
312_G	316_V	0.633	0.59
274_Y	296_A	0.633	0.59
585_H	605_Y	0.632	0.59
265_V	685_M	0.632	0.59
156_R	160_R	0.632	0.59
146_T	154_K	0.632	0.59
155_R	425_R	0.630	0.59
526_E	531_N	0.630	0.59
49_P	102_K	0.629	0.59
105_K	114_A	0.627	0.58
10_L	13_T	0.627	0.58
34_H	42_G	0.626	0.58
569_T	590_K	0.626	0.58
640_L	659_T	0.624	0.58
178_I	629_I	0.624	0.58
217_L	234_S	0.623	0.58
120_R	453_P	0.622	0.58
647_I	684_I	0.622	0.58
431_Y	688_I	0.622	0.58
264_R	336_A	0.621	0.58
62_D	65_T	0.620	0.58
420_A	448_A	0.620	0.58
411_Y	453_P	0.620	0.58
76_E	154_K	0.619	0.57
511_E	537_V	0.619	0.57
587_S	611_K	0.619	0.57
123_I	127_V	0.618	0.57
191_Y	344_H	0.618	0.57
102_K	136_K	0.617	0.57
487_R	521_D	0.616	0.57
636_H	667_Y	0.615	0.57
48_H	76_E	0.615	0.57
229_I	276_V	0.615	0.57
236_R	319_E	0.615	0.57
193_N	196_R	0.615	0.57
39_R	136_K	0.614	0.57
147_L	155_R	0.614	0.57
42_G	143_N	0.613	0.57
388_I	464_S	0.613	0.57
264_R	342_K	0.613	0.57
15_L	93_V	0.613	0.57
7_L	54_C	0.612	0.57
339_W	573_C	0.612	0.57
225_Q	541_L	0.612	0.57
8_N	11_I	0.611	0.57
73_D	154_K	0.610	0.56
34_H	97_V	0.610	0.56
165_I	364_E	0.610	0.56
249_L	254_F	0.609	0.56
147_L	150_L	0.608	0.56
73_D	139_D	0.608	0.56
321_Q	341_Y	0.608	0.56
353_I	356_Q	0.607	0.56
27_Y	50_V	0.607	0.56
223_R	282_S	0.607	0.56
100_V	136_K	0.606	0.56
577_I	699_R	0.605	0.56
492_H	495_G	0.605	0.56
561_K	618_D	0.604	0.56
37_Q	143_N	0.604	0.56
409_F	445_I	0.603	0.56
160_R	190_L	0.602	0.55
584_A	615_V	0.602	0.55
41_S	45_Y	0.601	0.55
75_I	81_T	0.601	0.55
516_K	531_N	0.600	0.55
460_F	465_K	0.600	0.55
426_V	430_P	0.600	0.55
184_E	188_E	0.599	0.55
676_R	680_H	0.599	0.55
204_A	359_M	0.599	0.55
177_H	594_I	0.598	0.55
648_N	654_I	0.598	0.55
22_R	28_L	0.597	0.55
259_D	341_Y	0.596	0.55
259_D	319_E	0.596	0.55
58_E	594_I	0.592	0.54
275_R	279_Q	0.592	0.54
97_V	140_R	0.591	0.54
644_T	648_N	0.591	0.54
344_H	348_S	0.591	0.54
515_M	523_L	0.590	0.54
643_L	646_A	0.590	0.54
635_N	639_A	0.590	0.54
302_G	330_M	0.589	0.54
212_M	316_V	0.588	0.54
242_S	336_A	0.588	0.54
71_L	75_I	0.587	0.54
12_Q	18_D	0.587	0.54
302_G	325_E	0.587	0.54
567_L	592_L	0.587	0.54
41_S	48_H	0.587	0.54
557_H	562_G	0.586	0.53
573_C	576_P	0.585	0.53
439_S	680_H	0.584	0.53
213_I	432_P	0.583	0.53
482_S	525_A	0.583	0.53
117_E	578_P	0.581	0.53
394_E	445_I	0.581	0.53
634_F	695_I	0.581	0.53
454_N	474_L	0.580	0.53
30_A	459_N	0.580	0.53
657_L	669_A	0.579	0.53
493_A	497_S	0.578	0.52
202_V	243_I	0.578	0.52
98_E	465_K	0.577	0.52
224_L	233_V	0.576	0.52
288_P	441_Q	0.576	0.52
358_W	365_L	0.574	0.52
101_S	139_D	0.573	0.52
682_A	686_R	0.573	0.52
484_S	487_R	0.572	0.52
350_T	353_I	0.572	0.52
17_E	21_K	0.572	0.52
94_A	98_E	0.572	0.52
61_L	175_I	0.572	0.52
52_V	69_A	0.571	0.52
9_Q	19_Q	0.570	0.51
627_T	653_N	0.570	0.51
254_F	451_A	0.570	0.51
208_N	260_I	0.569	0.51
204_A	261_Y	0.569	0.51
127_V	286_P	0.568	0.51
186_G	403_G	0.568	0.51
140_R	158_I	0.568	0.51
402_A	436_P	0.567	0.51
7_L	27_Y	0.567	0.51
130_I	134_L	0.567	0.51
241_Y	244_Y	0.567	0.51
61_L	444_E	0.566	0.51
105_K	407_V	0.566	0.51
318_V	396_R	0.566	0.51
384_F	439_S	0.566	0.51
16_P	20_I	0.566	0.51
19_Q	25_Q	0.566	0.51
71_L	85_M	0.566	0.51
69_A	149_S	0.566	0.51
109_R	320_V	0.565	0.51
594_I	652_S	0.565	0.51
454_N	459_N	0.564	0.51
686_R	689_R	0.564	0.51
144_M	194_R	0.564	0.51
252_Q	256_S	0.563	0.51
285_K	391_F	0.563	0.51
580_D	596_H	0.562	0.50
122_M	365_L	0.561	0.50
262_A	319_E	0.560	0.50
193_N	197_V	0.559	0.50
491_N	524_L	0.559	0.50
284_Y	512_L	0.559	0.50
559_P	618_D	0.559	0.50
85_M	158_I	0.559	0.50
11_I	20_I	0.559	0.50
66_L	96_L	0.558	0.50
41_S	102_K	0.558	0.50
262_A	320_V	0.558	0.50
23_L	35_E	0.557	0.50
100_V	104_D	0.557	0.50
220_I	233_V	0.555	0.50
41_S	76_E	0.554	0.49
78_T	97_V	0.554	0.49
356_Q	363_L	0.554	0.49
242_S	321_Q	0.554	0.49
647_I	685_M	0.552	0.49
142_H	154_K	0.552	0.49
328_D	333_M	0.552	0.49
274_Y	308_T	0.551	0.49
261_Y	316_V	0.550	0.49
639_A	694_V	0.550	0.49
39_R	43_E	0.550	0.49
292_K	305_S	0.550	0.49
527_I	533_M	0.550	0.49
34_H	154_K	0.550	0.49
560_I	613_M	0.549	0.49
313_P	318_V	0.549	0.49
463_S	469_K	0.549	0.49
506_E	509_Q	0.548	0.49
27_Y	476_N	0.548	0.49
490_L	523_L	0.548	0.49
31_R	36_G	0.548	0.49
430_P	446_I	0.548	0.49
357_R	361_S	0.547	0.49
72_H	97_V	0.547	0.49
34_H	102_K	0.546	0.48
130_I	301_N	0.546	0.48
365_L	368_S	0.546	0.48
41_S	143_N	0.546	0.48
478_K	531_N	0.545	0.48
355_A	385_P	0.545	0.48
301_N	308_T	0.545	0.48
385_P	494_L	0.545	0.48
144_M	155_R	0.545	0.48
644_T	657_L	0.544	0.48
72_H	78_T	0.544	0.48
150_L	153_D	0.544	0.48
512_L	524_L	0.544	0.48
321_Q	336_A	0.544	0.48
236_R	336_A	0.543	0.48
302_G	329_Q	0.543	0.48
646_A	673_L	0.543	0.48
136_K	139_D	0.543	0.48
405_T	644_T	0.543	0.48
57_A	278_G	0.542	0.48
242_S	319_E	0.541	0.48
629_I	654_I	0.541	0.48
553_Q	594_I	0.541	0.48
495_G	560_I	0.540	0.48
421_C	644_T	0.540	0.48
259_D	321_Q	0.539	0.48
38_T	47_T	0.539	0.48
487_R	491_N	0.539	0.48
406_P	430_P	0.539	0.48
278_G	291_V	0.539	0.48
209_R	235_G	0.538	0.47
522_D	647_I	0.538	0.47
216_I	261_Y	0.538	0.47
108_F	528_G	0.537	0.47
276_V	380_K	0.537	0.47
115_Q	118_N	0.537	0.47
119_F	201_V	0.537	0.47
657_L	667_Y	0.536	0.47
9_Q	17_E	0.536	0.47
7_L	70_L	0.535	0.47
422_V	451_A	0.535	0.47
396_R	416_D	0.534	0.47
339_W	574_C	0.534	0.47
307_H	323_R	0.534	0.47
420_A	447_T	0.534	0.47
167_S	186_G	0.534	0.47
641_A	644_T	0.534	0.47
264_R	323_R	0.534	0.47
559_P	570_F	0.534	0.47
292_K	477_L	0.533	0.47
43_E	142_H	0.533	0.47
236_R	242_S	0.533	0.47
304_Q	326_D	0.532	0.47
557_H	618_D	0.532	0.47
119_F	357_R	0.531	0.47
631_V	643_L	0.530	0.46
49_P	139_D	0.530	0.46
361_S	365_L	0.530	0.46
51_A	142_H	0.530	0.46
159_A	190_L	0.529	0.46
381_S	387_E	0.529	0.46
45_Y	52_V	0.528	0.46
167_S	239_H	0.528	0.46
41_S	52_V	0.528	0.46
239_H	328_D	0.527	0.46
490_L	503_I	0.526	0.46
163_L	186_G	0.526	0.46
483_V	627_T	0.526	0.46
40_S	158_I	0.526	0.46
384_F	475_K	0.526	0.46
211_E	214_Q	0.526	0.46
42_G	52_V	0.524	0.46
188_E	280_M	0.524	0.46
413_V	568_I	0.524	0.46
355_A	365_L	0.523	0.46
505_Q	509_Q	0.522	0.45
65_T	96_L	0.521	0.45
220_I	616_E	0.521	0.45
34_H	139_D	0.521	0.45
189_A	427_D	0.520	0.45
135_I	615_V	0.520	0.45
182_L	390_V	0.519	0.45
139_D	147_L	0.519	0.45
44_P	48_H	0.519	0.45
679_V	683_N	0.519	0.45
29_V	84_D	0.518	0.45
160_R	191_Y	0.517	0.45
424_A	469_K	0.517	0.45
99_G	125_A	0.517	0.45
198_I	533_M	0.515	0.45
381_S	389_Y	0.515	0.45
489_L	534_S	0.515	0.45
187_F	250_K	0.515	0.45
406_P	433_L	0.514	0.44
186_G	461_V	0.514	0.44
123_I	465_K	0.514	0.44
21_K	28_L	0.514	0.44
332_E	413_V	0.514	0.44
285_K	297_I	0.514	0.44
344_H	347_T	0.514	0.44
340_A	360_Q	0.513	0.44
229_I	267_V	0.512	0.44
99_G	358_W	0.512	0.44
404_A	695_I	0.512	0.44
609_P	612_F	0.511	0.44
316_V	421_C	0.510	0.44
73_D	147_L	0.510	0.44
407_V	528_G	0.510	0.44
517_L	532_A	0.509	0.44
77_D	136_K	0.509	0.44
78_T	139_D	0.509	0.44
179_K	183_E	0.508	0.44
351_A	467_R	0.508	0.44
179_K	262_A	0.508	0.44
115_Q	122_M	0.508	0.44
81_T	673_L	0.507	0.44
635_N	640_L	0.506	0.44
317_P	474_L	0.506	0.44
644_T	669_A	0.506	0.44
136_K	146_T	0.506	0.44
192_P	196_R	0.506	0.44
176_H	568_I	0.506	0.44
39_R	44_P	0.506	0.44
39_R	52_V	0.506	0.44
52_V	102_K	0.506	0.44
389_Y	564_D	0.506	0.44
600_R	629_I	0.506	0.44
28_L	35_E	0.506	0.44
206_R	240_L	0.505	0.43
396_R	625_F	0.505	0.43
528_G	649_T	0.505	0.43
630_K	700_N	0.504	0.43
212_M	318_V	0.504	0.43
602_I	664_G	0.503	0.43
105_K	306_L	0.502	0.43
22_R	92_S	0.502	0.43
505_Q	600_R	0.502	0.43
61_L	213_I	0.500	0.43
237_E	318_V	0.500	0.43
97_V	101_S	0.500	0.43
187_F	281_H	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vj7A	1	0.4758	100	0.507	Contact Map
3l9dA	1	0.265	100	0.765	Contact Map
4yf1A	2	0.2194	100	0.822	Contact Map
3nr1A	2	0.2479	100	0.83	Contact Map
2be3A	2	0.2735	100	0.834	Contact Map
3nqwA	2	0.2436	100	0.836	Contact Map
2ekiA	1	0.1197	99.9	0.922	Contact Map
3hvzA	2	0.0912	99.7	0.935	Contact Map
3j7y7	1	0.3533	99.4	0.945	Contact Map
1wxqA	1	0.3048	99.4	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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