GREMLIN Database
SPOT - Bifunctional (p)ppGpp synthase/hydrolase SpoT
UniProt: P0AG24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10966
Length: 702 (685)
Sequences: 3412 (1933)
Seq/√Len: 73.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_E91_K7.0871.00
411_Y419_H5.4071.00
490_L527_I5.1791.00
427_D441_Q4.9091.00
426_V431_Y4.6891.00
685_M697_V4.4451.00
407_V460_F4.3451.00
25_Q88_L4.2341.00
61_L134_L4.1861.00
75_I82_Y4.0691.00
230_P268_N4.0391.00
269_D272_T3.8261.00
145_R181_E3.6551.00
268_N325_E3.5781.00
461_V470_I3.5711.00
22_R67_M3.5371.00
266_I325_E3.5291.00
232_R325_E3.5041.00
223_R226_E3.4451.00
64_E92_S3.4091.00
636_H642_N3.1551.00
23_L66_L3.1501.00
220_I280_M3.0321.00
517_L526_E2.9871.00
152_P155_R2.9581.00
147_L189_A2.8691.00
234_S328_D2.8271.00
417_I447_T2.8141.00
160_R164_E2.7961.00
198_I240_L2.7291.00
215_K314_H2.7201.00
426_V435_Q2.7171.00
11_I23_L2.6821.00
483_V525_A2.6791.00
252_Q257_I2.6791.00
191_Y194_R2.6681.00
32_D35_E2.6101.00
29_V80_A2.5611.00
197_V201_V2.5411.00
631_V688_I2.5271.00
581_P597_E2.4941.00
201_V254_F2.4801.00
392_T398_V2.4241.00
436_P462_V2.4241.00
152_P156_R2.3731.00
56_L65_T2.3611.00
24_R28_L2.3421.00
82_Y98_E2.3271.00
75_I85_M2.3241.00
628_E672_R2.3141.00
594_I615_V2.2771.00
657_L671_I2.2761.00
221_E225_Q2.2721.00
463_S466_A2.2631.00
487_R524_L2.2621.00
633_M639_A2.2521.00
437_L443_V2.2071.00
268_N272_T2.2041.00
96_L135_I2.2001.00
483_V521_D2.1961.00
276_V279_Q2.1671.00
155_R189_A2.1051.00
425_R444_E2.0961.00
629_I685_M2.0841.00
212_M312_G2.0681.00
53_A66_L2.0671.00
84_D87_Q2.0631.00
95_E128_Q2.0561.00
222_G226_E2.0271.00
150_L158_I2.0101.00
519_T522_D1.9801.00
512_L520_L1.9741.00
213_I235_G1.9621.00
673_L684_I1.9621.00
211_E215_K1.9581.00
205_A208_N1.9481.00
216_I318_V1.9441.00
587_S593_V1.9251.00
583_I602_I1.9041.00
217_L221_E1.8971.00
61_L65_T1.8961.00
22_R25_Q1.8911.00
271_D275_R1.8851.00
40_S150_L1.8691.00
144_M182_L1.8551.00
435_Q438_T1.8461.00
404_A463_S1.8291.00
28_L31_R1.8211.00
267_V276_V1.8011.00
652_S680_H1.7991.00
22_R64_E1.7981.00
517_L523_L1.7911.00
63_Y67_M1.7801.00
325_E329_Q1.7731.00
194_R197_V1.7691.00
147_L158_I1.7661.00
212_M313_P1.7541.00
390_V437_L1.7471.00
56_L69_A1.7371.00
265_V276_V1.7311.00
360_Q363_L1.7291.00
406_P424_A1.7281.00
82_Y86_E1.7251.00
73_D77_D1.7171.00
448_A451_A1.7161.00
30_A46_I1.7061.00
206_R237_E1.7051.00
202_V240_L1.7011.00
478_K481_D1.7001.00
86_E94_A1.7001.00
561_K614_A1.6921.00
67_M93_V1.6851.00
631_V671_I1.6821.00
223_R283_L1.6721.00
68_A96_L1.6681.00
403_G436_P1.6611.00
83_Q86_E1.6581.00
82_Y94_A1.6521.00
159_A186_G1.6381.00
218_S222_G1.6291.00
272_T275_R1.6241.00
14_Y60_K1.6211.00
83_Q87_Q1.6190.99
218_S221_E1.5960.99
415_T419_H1.5960.99
290_R309_S1.5940.99
147_L159_A1.5920.99
435_Q441_Q1.5880.99
525_A528_G1.5800.99
180_T239_H1.5720.99
163_L241_Y1.5700.99
180_T206_R1.5630.99
21_K25_Q1.5580.99
520_L524_L1.5570.99
210_K214_Q1.5570.99
196_R199_K1.5470.99
10_L58_E1.5310.99
75_I98_E1.5290.99
75_I94_A1.5120.99
204_A316_V1.4950.99
77_D101_S1.4930.99
635_N667_Y1.4900.99
479_R522_D1.4850.99
490_L524_L1.4830.99
142_H146_T1.4810.99
22_R93_V1.4750.99
11_I15_L1.4750.99
143_N146_T1.4750.99
82_Y95_E1.4740.99
187_F240_L1.4730.99
636_H639_A1.4730.99
387_E399_E1.4690.99
187_F191_Y1.4670.99
640_L657_L1.4550.99
241_Y245_C1.4470.99
647_I671_I1.4360.99
75_I101_S1.4300.99
84_D88_L1.4080.99
77_D143_N1.4060.99
406_P426_V1.4050.99
214_Q217_L1.3970.98
687_K690_V1.3920.98
73_D76_E1.3870.98
224_L276_V1.3860.98
407_V461_V1.3800.98
55_I145_R1.3630.98
200_E204_A1.3470.98
76_E101_S1.3410.98
29_V88_L1.3410.98
646_A684_I1.3400.98
650_T687_K1.3380.98
224_L231_C1.3350.98
304_Q330_M1.3310.98
81_T84_D1.3300.98
225_Q231_C1.3250.98
77_D102_K1.3230.98
338_H341_Y1.3220.98
281_H308_T1.3170.98
199_K240_L1.3170.98
144_M185_L1.3140.98
219_E284_Y1.3020.98
76_E143_N1.3010.98
424_A431_Y1.3010.98
472_Q476_N1.2990.98
412_A465_K1.2940.98
214_Q218_S1.2940.98
455_A474_L1.2920.97
206_R210_K1.2840.97
353_I360_Q1.2800.97
216_I263_F1.2790.97
56_L66_L1.2770.97
431_Y435_Q1.2770.97
479_R483_V1.2760.97
29_V33_A1.2760.97
647_I654_I1.2660.97
647_I652_S1.2660.97
182_L186_G1.2620.97
574_C599_C1.2610.97
280_M310_M1.2590.97
27_Y31_R1.2570.97
28_L32_D1.2540.97
31_R35_E1.2510.97
39_R143_N1.2470.97
630_K670_F1.2450.97
647_I673_L1.2430.97
584_A613_M1.2370.97
595_H599_C1.2350.97
135_I171_H1.2250.97
406_P431_Y1.2220.96
180_T237_E1.2200.96
187_F194_R1.2170.96
574_C595_H1.2160.96
34_H73_D1.2150.96
151_R154_K1.2140.96
556_G560_I1.2120.96
33_A80_A1.2080.96
633_M667_Y1.2080.96
678_R682_A1.2050.96
56_L100_V1.2020.96
21_K24_R1.2010.96
33_A84_D1.1980.96
153_D157_R1.1930.96
217_L233_V1.1910.96
583_I612_F1.1850.96
46_I49_P1.1830.96
80_A88_L1.1810.96
39_R77_D1.1780.96
557_H560_I1.1770.96
388_I439_S1.1750.96
632_E696_K1.1700.95
39_R73_D1.1650.95
585_H611_K1.1640.95
139_D143_N1.1580.95
80_A84_D1.1550.95
338_H342_K1.1530.95
636_H693_D1.1530.95
365_L369_A1.1520.95
508_I520_L1.1470.95
336_A342_K1.1460.95
602_I612_F1.1450.95
286_P296_A1.1450.95
571_A593_V1.1430.95
643_L669_A1.1400.95
49_P143_N1.1390.95
404_A462_V1.1380.95
34_H77_D1.1380.95
267_V272_T1.1330.95
73_D143_N1.1320.95
12_Q20_I1.1310.95
659_T669_A1.1290.94
423_G446_I1.1250.94
221_E232_R1.1230.94
35_E38_T1.1230.94
405_T460_F1.1210.94
39_R42_G1.1140.94
510_R513_D1.1130.94
509_Q513_D1.1110.94
653_N674_T1.1110.94
7_L12_Q1.1090.94
48_H142_H1.1090.94
629_I671_I1.1080.94
639_A667_Y1.1080.94
573_C595_H1.1060.94
246_K341_Y1.1050.94
144_M147_L1.1050.94
464_S468_A1.1020.94
39_R142_H1.1020.94
11_I57_A1.0960.94
280_M320_V1.0950.94
212_M216_I1.0950.94
188_E199_K1.0940.94
217_L263_F1.0910.93
72_H162_T1.0900.93
101_S143_N1.0900.93
51_A54_C1.0860.93
39_R45_Y1.0850.93
150_L154_K1.0840.93
201_V255_H1.0840.93
388_I435_Q1.0840.93
227_A279_Q1.0820.93
272_T276_V1.0790.93
638_G653_N1.0780.93
77_D142_H1.0770.93
196_R200_E1.0750.93
246_K342_K1.0750.93
195_Y199_K1.0720.93
102_K143_N1.0710.93
91_K95_E1.0700.93
34_H76_E1.0670.93
278_G281_H1.0660.93
473_L477_L1.0650.93
646_A650_T1.0630.93
71_L93_V1.0600.92
389_Y399_E1.0600.92
19_Q63_Y1.0600.92
202_V260_I1.0600.92
262_A338_H1.0510.92
34_H143_N1.0480.92
34_H45_Y1.0470.92
628_E670_F1.0450.92
274_Y278_G1.0430.92
639_A691_M1.0420.92
72_H143_N1.0420.92
144_M162_T1.0410.92
685_M689_R1.0370.92
110_D113_E1.0340.91
626_I672_R1.0320.91
223_R227_A1.0290.91
630_K698_T1.0250.91
573_C599_C1.0220.91
77_D146_T1.0180.91
33_A79_P1.0180.91
328_D332_E1.0180.91
73_D101_S1.0170.91
311_I315_G1.0170.91
632_E668_S1.0140.91
236_R342_K1.0120.91
416_D419_H1.0120.91
49_P72_H1.0120.91
11_I14_Y1.0110.91
629_I673_L1.0100.90
624_E674_T1.0040.90
102_K139_D1.0030.90
264_R321_Q1.0030.90
10_L54_C0.9990.90
73_D78_T0.9980.90
452_R473_L0.9960.90
587_S601_N0.9960.90
126_M130_I0.9920.90
406_P437_L0.9880.89
156_R190_L0.9870.89
660_E670_F0.9830.89
45_Y73_D0.9820.89
650_T683_N0.9820.89
246_K338_H0.9780.89
577_I627_T0.9780.89
639_A642_N0.9720.89
34_H39_R0.9670.88
526_E532_A0.9670.88
56_L61_L0.9670.88
581_P596_H0.9650.88
34_H49_P0.9620.88
202_V254_F0.9620.88
277_L322_I0.9620.88
68_A135_I0.9590.88
352_Q356_Q0.9590.88
49_P142_H0.9570.88
420_A451_A0.9560.88
220_I320_V0.9550.88
69_A135_I0.9540.88
99_G121_K0.9520.88
357_R360_Q0.9490.88
637_Q651_T0.9490.88
39_R49_P0.9470.87
642_N691_M0.9470.87
39_R72_H0.9460.87
76_E142_H0.9460.87
421_C433_L0.9440.87
633_M694_V0.9430.87
635_N661_E0.9420.87
53_A69_A0.9410.87
72_H76_E0.9400.87
37_Q76_E0.9380.87
641_A648_N0.9380.87
377_E380_K0.9380.87
392_T413_V0.9350.87
154_K157_R0.9340.87
76_E146_T0.9330.87
274_Y281_H0.9310.86
37_Q77_D0.9310.86
54_C58_E0.9290.86
274_Y277_L0.9280.86
225_Q230_P0.9280.86
49_P76_E0.9280.86
45_Y77_D0.9250.86
398_V412_A0.9230.86
238_K246_K0.9220.86
626_I674_T0.9210.86
76_E139_D0.9210.86
656_S672_R0.9190.86
120_R313_P0.9190.86
125_A388_I0.9180.86
691_M694_V0.9150.86
639_A693_D0.9120.85
72_H142_H0.9110.85
136_K143_N0.9090.85
523_L532_A0.9090.85
66_L69_A0.9090.85
49_P77_D0.9090.85
45_Y143_N0.9080.85
39_R146_T0.9060.85
329_Q333_M0.9050.85
244_Y248_V0.9050.85
522_D525_A0.9040.85
223_R279_Q0.9030.85
515_M532_A0.9020.85
141_T178_I0.9010.85
677_D680_H0.8980.84
32_D36_G0.8970.84
216_I284_Y0.8970.84
409_F413_V0.8960.84
13_T404_A0.8950.84
231_C276_V0.8920.84
34_H101_S0.8920.84
52_V139_D0.8920.84
45_Y142_H0.8910.84
85_M94_A0.8890.84
34_H72_H0.8890.84
73_D162_T0.8880.84
48_H52_V0.8870.84
64_E67_M0.8870.84
23_L63_Y0.8850.84
101_S146_T0.8820.83
133_I169_L0.8810.83
220_I263_F0.8790.83
49_P73_D0.8780.83
9_Q13_T0.8780.83
461_V466_A0.8770.83
246_K262_A0.8740.83
34_H37_Q0.8700.83
236_R341_Y0.8690.82
15_L63_Y0.8650.82
238_K338_H0.8630.82
116_A466_A0.8610.82
18_D21_K0.8590.82
494_L538_A0.8590.82
262_A342_K0.8580.82
559_P616_E0.8570.82
281_H291_V0.8560.82
48_H72_H0.8560.82
15_L18_D0.8550.81
652_S684_I0.8540.81
78_T143_N0.8530.81
247_M254_F0.8510.81
39_R76_E0.8500.81
419_H473_L0.8500.81
34_H146_T0.8500.81
264_R338_H0.8480.81
246_K319_E0.8470.81
34_H142_H0.8440.81
336_A341_Y0.8400.80
292_K309_S0.8400.80
219_E223_R0.8400.80
72_H139_D0.8380.80
150_L157_R0.8380.80
407_V421_C0.8360.80
572_K575_R0.8360.80
406_P436_P0.8360.80
262_A341_Y0.8350.80
238_K321_Q0.8330.80
101_S142_H0.8320.80
48_H139_D0.8310.80
39_R48_H0.8300.79
34_H48_H0.8290.79
319_E341_Y0.8290.79
424_A445_I0.8290.79
41_S149_S0.8270.79
326_D329_Q0.8270.79
245_C249_L0.8270.79
238_K319_E0.8260.79
219_E283_L0.8260.79
304_Q601_N0.8240.79
657_L661_E0.8230.79
570_F577_I0.8220.79
55_I181_E0.8200.79
56_L602_I0.8180.78
415_T469_K0.8170.78
48_H143_N0.8160.78
72_H77_D0.8150.78
25_Q67_M0.8150.78
37_Q78_T0.8150.78
645_A649_T0.8140.78
45_Y49_P0.8140.78
637_Q653_N0.8110.78
38_T44_P0.8110.78
270_S282_S0.8080.78
413_V470_I0.8080.78
188_E196_R0.8060.77
11_I16_P0.8040.77
246_K264_R0.8020.77
148_G188_E0.8010.77
677_D681_L0.8010.77
420_A450_G0.8000.77
86_E90_G0.8000.77
118_N391_F0.7990.77
72_H101_S0.7970.77
425_R446_I0.7950.76
630_K668_S0.7940.76
375_F380_K0.7920.76
638_G644_T0.7920.76
509_Q520_L0.7910.76
224_L229_I0.7900.76
605_Y612_F0.7890.76
45_Y48_H0.7890.76
78_T146_T0.7880.76
236_R262_A0.7870.76
277_L281_H0.7840.75
313_P640_L0.7840.75
356_Q360_Q0.7840.75
363_L366_Q0.7820.75
119_F284_Y0.7820.75
15_L471_R0.7820.75
49_P78_T0.7820.75
636_H691_M0.7810.75
124_M171_H0.7810.75
563_A566_V0.7800.75
208_N211_E0.7780.75
139_D142_H0.7770.75
154_K158_I0.7770.75
45_Y78_T0.7760.75
246_K336_A0.7760.75
7_L10_L0.7750.75
319_E338_H0.7750.75
560_I582_I0.7740.75
39_R101_S0.7730.74
636_H643_L0.7730.74
55_I138_A0.7720.74
39_R78_T0.7720.74
122_M126_M0.7710.74
681_L685_M0.7700.74
73_D142_H0.7700.74
425_R430_P0.7700.74
644_T693_D0.7680.74
592_L615_V0.7680.74
646_A687_K0.7670.74
72_H146_T0.7650.74
236_R338_H0.7650.74
45_Y72_H0.7650.74
518_A522_D0.7650.74
48_H73_D0.7650.74
246_K321_Q0.7640.74
82_Y85_M0.7630.73
416_D420_A0.7600.73
78_T101_S0.7600.73
102_K146_T0.7560.73
143_N154_K0.7560.73
188_E206_R0.7550.73
287_R317_P0.7540.73
238_K342_K0.7540.73
48_H102_K0.7530.73
351_A354_R0.7530.73
73_D102_K0.7510.72
388_I403_G0.7510.72
99_G132_V0.7510.72
476_N480_D0.7490.72
655_Q674_T0.7450.72
49_P52_V0.7440.72
558_L582_I0.7430.71
102_K142_H0.7400.71
41_S77_D0.7390.71
164_E380_K0.7390.71
635_N638_G0.7380.71
48_H146_T0.7380.71
48_H77_D0.7380.71
150_L155_R0.7370.71
641_A645_A0.7360.71
455_A478_K0.7350.71
489_L527_I0.7350.71
305_S323_R0.7330.70
39_R139_D0.7330.70
602_I606_Q0.7320.70
264_R341_Y0.7310.70
413_V416_D0.7310.70
646_A691_M0.7300.70
156_R320_V0.7300.70
629_I697_V0.7300.70
130_I289_G0.7290.70
247_M358_W0.7280.70
205_A209_R0.7270.70
215_K219_E0.7260.70
39_R102_K0.7260.70
238_K341_Y0.7240.70
228_G463_S0.7240.70
494_L524_L0.7230.69
406_P435_Q0.7210.69
238_K262_A0.7210.69
134_L175_I0.7200.69
319_E336_A0.7200.69
49_P146_T0.7190.69
497_S538_A0.7190.69
45_Y146_T0.7180.69
215_K218_S0.7140.68
278_G282_S0.7130.68
507_N510_R0.7130.68
20_I24_R0.7130.68
76_E99_G0.7130.68
468_A472_Q0.7120.68
202_V314_H0.7110.68
98_E121_K0.7110.68
45_Y76_E0.7110.68
583_I597_E0.7090.68
124_M384_F0.7080.68
9_Q12_Q0.7070.68
29_V85_M0.7060.68
73_D97_V0.7050.67
37_Q45_Y0.7050.67
19_Q22_R0.7040.67
57_A187_F0.7030.67
212_M314_H0.7020.67
47_T51_A0.7020.67
64_E93_V0.7020.67
76_E102_K0.7010.67
576_P595_H0.6980.67
116_A383_L0.6980.67
321_Q338_H0.6970.67
34_H78_T0.6970.67
77_D154_K0.6970.67
626_I655_Q0.6970.67
494_L541_L0.6960.66
77_D139_D0.6940.66
194_R244_Y0.6940.66
319_E342_K0.6940.66
661_E667_Y0.6930.66
78_T142_H0.6920.66
391_F396_R0.6920.66
625_F675_A0.6910.66
78_T102_K0.6910.66
643_L647_I0.6910.66
490_L537_V0.6900.66
220_I421_C0.6880.66
100_V103_L0.6870.65
140_R161_E0.6870.65
475_K529_L0.6850.65
52_V72_H0.6850.65
633_M669_A0.6830.65
209_R237_E0.6820.65
210_K237_E0.6820.65
215_K435_Q0.6810.65
419_H474_L0.6810.65
246_K259_D0.6810.65
76_E100_V0.6810.65
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359_M365_L0.6790.65
238_K264_R0.6790.65
200_E203_K0.6790.65
534_S538_A0.6780.64
249_L252_Q0.6780.64
139_D146_T0.6780.64
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43_E48_H0.6770.64
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42_G48_H0.6740.64
59_M178_I0.6730.64
238_K336_A0.6730.64
143_N162_T0.6720.64
560_I615_V0.6710.64
48_H101_S0.6690.63
162_T182_L0.6690.63
558_L611_K0.6690.63
482_S528_G0.6690.63
493_A496_G0.6680.63
16_P19_Q0.6680.63
359_M362_L0.6670.63
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180_T183_E0.6660.63
242_S342_K0.6640.63
359_M363_L0.6630.63
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49_P101_S0.6600.62
39_R154_K0.6600.62
486_G528_G0.6590.62
339_W342_K0.6580.62
622_A631_V0.6580.62
68_A97_V0.6580.62
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121_K132_V0.6560.62
34_H41_S0.6550.62
236_R246_K0.6540.62
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136_K140_R0.6430.60
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78_T81_T0.6430.60
135_I186_G0.6430.60
15_L66_L0.6430.60
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259_D338_H0.6390.60
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37_Q73_D0.6380.60
561_K616_E0.6380.60
484_S488_R0.6340.59
361_S386_D0.6340.59
640_L653_N0.6330.59
312_G316_V0.6330.59
274_Y296_A0.6330.59
585_H605_Y0.6320.59
265_V685_M0.6320.59
156_R160_R0.6320.59
146_T154_K0.6320.59
155_R425_R0.6300.59
526_E531_N0.6300.59
49_P102_K0.6290.59
105_K114_A0.6270.58
10_L13_T0.6270.58
34_H42_G0.6260.58
569_T590_K0.6260.58
640_L659_T0.6240.58
178_I629_I0.6240.58
217_L234_S0.6230.58
120_R453_P0.6220.58
647_I684_I0.6220.58
431_Y688_I0.6220.58
264_R336_A0.6210.58
62_D65_T0.6200.58
420_A448_A0.6200.58
411_Y453_P0.6200.58
76_E154_K0.6190.57
511_E537_V0.6190.57
587_S611_K0.6190.57
123_I127_V0.6180.57
191_Y344_H0.6180.57
102_K136_K0.6170.57
487_R521_D0.6160.57
636_H667_Y0.6150.57
48_H76_E0.6150.57
229_I276_V0.6150.57
236_R319_E0.6150.57
193_N196_R0.6150.57
39_R136_K0.6140.57
147_L155_R0.6140.57
42_G143_N0.6130.57
388_I464_S0.6130.57
264_R342_K0.6130.57
15_L93_V0.6130.57
7_L54_C0.6120.57
339_W573_C0.6120.57
225_Q541_L0.6120.57
8_N11_I0.6110.57
73_D154_K0.6100.56
34_H97_V0.6100.56
165_I364_E0.6100.56
249_L254_F0.6090.56
147_L150_L0.6080.56
73_D139_D0.6080.56
321_Q341_Y0.6080.56
353_I356_Q0.6070.56
27_Y50_V0.6070.56
223_R282_S0.6070.56
100_V136_K0.6060.56
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492_H495_G0.6050.56
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37_Q143_N0.6040.56
409_F445_I0.6030.56
160_R190_L0.6020.55
584_A615_V0.6020.55
41_S45_Y0.6010.55
75_I81_T0.6010.55
516_K531_N0.6000.55
460_F465_K0.6000.55
426_V430_P0.6000.55
184_E188_E0.5990.55
676_R680_H0.5990.55
204_A359_M0.5990.55
177_H594_I0.5980.55
648_N654_I0.5980.55
22_R28_L0.5970.55
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275_R279_Q0.5920.54
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515_M523_L0.5900.54
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288_P441_Q0.5760.52
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484_S487_R0.5720.52
350_T353_I0.5720.52
17_E21_K0.5720.52
94_A98_E0.5720.52
61_L175_I0.5720.52
52_V69_A0.5710.52
9_Q19_Q0.5700.51
627_T653_N0.5700.51
254_F451_A0.5700.51
208_N260_I0.5690.51
204_A261_Y0.5690.51
127_V286_P0.5680.51
186_G403_G0.5680.51
140_R158_I0.5680.51
402_A436_P0.5670.51
7_L27_Y0.5670.51
130_I134_L0.5670.51
241_Y244_Y0.5670.51
61_L444_E0.5660.51
105_K407_V0.5660.51
318_V396_R0.5660.51
384_F439_S0.5660.51
16_P20_I0.5660.51
19_Q25_Q0.5660.51
71_L85_M0.5660.51
69_A149_S0.5660.51
109_R320_V0.5650.51
594_I652_S0.5650.51
454_N459_N0.5640.51
686_R689_R0.5640.51
144_M194_R0.5640.51
252_Q256_S0.5630.51
285_K391_F0.5630.51
580_D596_H0.5620.50
122_M365_L0.5610.50
262_A319_E0.5600.50
193_N197_V0.5590.50
491_N524_L0.5590.50
284_Y512_L0.5590.50
559_P618_D0.5590.50
85_M158_I0.5590.50
11_I20_I0.5590.50
66_L96_L0.5580.50
41_S102_K0.5580.50
262_A320_V0.5580.50
23_L35_E0.5570.50
100_V104_D0.5570.50
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78_T97_V0.5540.49
356_Q363_L0.5540.49
242_S321_Q0.5540.49
647_I685_M0.5520.49
142_H154_K0.5520.49
328_D333_M0.5520.49
274_Y308_T0.5510.49
261_Y316_V0.5500.49
639_A694_V0.5500.49
39_R43_E0.5500.49
292_K305_S0.5500.49
527_I533_M0.5500.49
34_H154_K0.5500.49
560_I613_M0.5490.49
313_P318_V0.5490.49
463_S469_K0.5490.49
506_E509_Q0.5480.49
27_Y476_N0.5480.49
490_L523_L0.5480.49
31_R36_G0.5480.49
430_P446_I0.5480.49
357_R361_S0.5470.49
72_H97_V0.5470.49
34_H102_K0.5460.48
130_I301_N0.5460.48
365_L368_S0.5460.48
41_S143_N0.5460.48
478_K531_N0.5450.48
355_A385_P0.5450.48
301_N308_T0.5450.48
385_P494_L0.5450.48
144_M155_R0.5450.48
644_T657_L0.5440.48
72_H78_T0.5440.48
150_L153_D0.5440.48
512_L524_L0.5440.48
321_Q336_A0.5440.48
236_R336_A0.5430.48
302_G329_Q0.5430.48
646_A673_L0.5430.48
136_K139_D0.5430.48
405_T644_T0.5430.48
57_A278_G0.5420.48
242_S319_E0.5410.48
629_I654_I0.5410.48
553_Q594_I0.5410.48
495_G560_I0.5400.48
421_C644_T0.5400.48
259_D321_Q0.5390.48
38_T47_T0.5390.48
487_R491_N0.5390.48
406_P430_P0.5390.48
278_G291_V0.5390.48
209_R235_G0.5380.47
522_D647_I0.5380.47
216_I261_Y0.5380.47
108_F528_G0.5370.47
276_V380_K0.5370.47
115_Q118_N0.5370.47
119_F201_V0.5370.47
657_L667_Y0.5360.47
9_Q17_E0.5360.47
7_L70_L0.5350.47
422_V451_A0.5350.47
396_R416_D0.5340.47
339_W574_C0.5340.47
307_H323_R0.5340.47
420_A447_T0.5340.47
167_S186_G0.5340.47
641_A644_T0.5340.47
264_R323_R0.5340.47
559_P570_F0.5340.47
292_K477_L0.5330.47
43_E142_H0.5330.47
236_R242_S0.5330.47
304_Q326_D0.5320.47
557_H618_D0.5320.47
119_F357_R0.5310.47
631_V643_L0.5300.46
49_P139_D0.5300.46
361_S365_L0.5300.46
51_A142_H0.5300.46
159_A190_L0.5290.46
381_S387_E0.5290.46
45_Y52_V0.5280.46
167_S239_H0.5280.46
41_S52_V0.5280.46
239_H328_D0.5270.46
490_L503_I0.5260.46
163_L186_G0.5260.46
483_V627_T0.5260.46
40_S158_I0.5260.46
384_F475_K0.5260.46
211_E214_Q0.5260.46
42_G52_V0.5240.46
188_E280_M0.5240.46
413_V568_I0.5240.46
355_A365_L0.5230.46
505_Q509_Q0.5220.45
65_T96_L0.5210.45
220_I616_E0.5210.45
34_H139_D0.5210.45
189_A427_D0.5200.45
135_I615_V0.5200.45
182_L390_V0.5190.45
139_D147_L0.5190.45
44_P48_H0.5190.45
679_V683_N0.5190.45
29_V84_D0.5180.45
160_R191_Y0.5170.45
424_A469_K0.5170.45
99_G125_A0.5170.45
198_I533_M0.5150.45
381_S389_Y0.5150.45
489_L534_S0.5150.45
187_F250_K0.5150.45
406_P433_L0.5140.44
186_G461_V0.5140.44
123_I465_K0.5140.44
21_K28_L0.5140.44
332_E413_V0.5140.44
285_K297_I0.5140.44
344_H347_T0.5140.44
340_A360_Q0.5130.44
229_I267_V0.5120.44
99_G358_W0.5120.44
404_A695_I0.5120.44
609_P612_F0.5110.44
316_V421_C0.5100.44
73_D147_L0.5100.44
407_V528_G0.5100.44
517_L532_A0.5090.44
77_D136_K0.5090.44
78_T139_D0.5090.44
179_K183_E0.5080.44
351_A467_R0.5080.44
179_K262_A0.5080.44
115_Q122_M0.5080.44
81_T673_L0.5070.44
635_N640_L0.5060.44
317_P474_L0.5060.44
644_T669_A0.5060.44
136_K146_T0.5060.44
192_P196_R0.5060.44
176_H568_I0.5060.44
39_R44_P0.5060.44
39_R52_V0.5060.44
52_V102_K0.5060.44
389_Y564_D0.5060.44
600_R629_I0.5060.44
28_L35_E0.5060.44
206_R240_L0.5050.43
396_R625_F0.5050.43
528_G649_T0.5050.43
630_K700_N0.5040.43
212_M318_V0.5040.43
602_I664_G0.5030.43
105_K306_L0.5020.43
22_R92_S0.5020.43
505_Q600_R0.5020.43
61_L213_I0.5000.43
237_E318_V0.5000.43
97_V101_S0.5000.43
187_F281_H0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vj7A 1 0.4758 100 0.507 Contact Map
3l9dA 1 0.265 100 0.765 Contact Map
4yf1A 2 0.2194 100 0.822 Contact Map
3nr1A 2 0.2479 100 0.83 Contact Map
2be3A 2 0.2735 100 0.834 Contact Map
3nqwA 2 0.2436 100 0.836 Contact Map
2ekiA 1 0.1197 99.9 0.922 Contact Map
3hvzA 2 0.0912 99.7 0.935 Contact Map
3j7y7 1 0.3533 99.4 0.945 Contact Map
1wxqA 1 0.3048 99.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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