RELA - ECOLI - GREMLIN Contacts

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RELA - GTP pyrophosphokinase

UniProt:	P0AG20	Sequences: MVAVRSAHINKAGEFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAAIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKPSAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRLHGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10835
Length:	744 (704)
Sequences:	3419 (1960)
Seq/√Len:	73.9

ECOLI - RELA SPOT
BACSU - RELA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_R	101_K	7.582	1.00
429_Y	437_H	5.445	1.00
512_L	546_I	5.246	1.00
444_I	449_V	4.799	1.00
445_G	459_D	4.662	1.00
726_L	738_A	4.521	1.00
246_K	284_E	4.373	1.00
35_L	98_S	4.344	1.00
425_L	482_Y	4.256	1.00
85_A	92_E	4.112	1.00
71_M	150_V	4.090	1.00
285_R	288_D	3.842	1.00
284_E	341_K	3.790	1.00
483_V	492_I	3.734	1.00
161_R	197_E	3.730	1.00
32_C	77_R	3.721	1.00
248_E	341_K	3.641	1.00
282_V	341_K	3.626	1.00
239_E	242_A	3.514	1.00
74_D	102_S	3.329	1.00
676_R	682_D	3.254	1.00
33_E	76_L	3.146	1.00
168_E	171_R	3.128	1.00
236_L	296_V	3.083	1.00
176_K	180_N	3.029	1.00
536_F	545_A	3.002	1.00
250_Y	344_H	2.878	1.00
231_E	330_G	2.869	1.00
42_C	45_Q	2.846	1.00
21_I	33_E	2.842	1.00
505_I	544_A	2.834	1.00
163_V	205_Y	2.815	1.00
435_V	465_T	2.773	1.00
444_I	453_Y	2.761	1.00
268_L	273_L	2.729	1.00
207_H	210_E	2.711	1.00
620_E	636_A	2.696	1.00
213_R	217_L	2.692	1.00
237_R	241_K	2.636	1.00
39_W	90_V	2.613	1.00
214_I	256_I	2.599	1.00
454_Q	484_T	2.586	1.00
671_V	729_L	2.545	1.00
217_L	270_F	2.512	1.00
34_C	38_T	2.489	1.00
168_E	172_V	2.462	1.00
633_V	655_A	2.432	1.00
410_T	416_V	2.428	1.00
85_A	95_L	2.405	1.00
92_E	108_H	2.371	1.00
668_V	713_T	2.365	1.00
509_R	543_L	2.324	1.00
669_V	726_L	2.305	1.00
94_V	97_E	2.276	1.00
697_V	712_M	2.275	1.00
284_E	288_D	2.250	1.00
485_T	488_G	2.247	1.00
455_L	461_I	2.247	1.00
63_V	76_L	2.243	1.00
66_L	75_T	2.200	1.00
673_A	679_L	2.171	1.00
166_A	174_A	2.148	1.00
531_L	539_V	2.138	1.00
227_H	231_E	2.116	1.00
238_A	242_A	2.116	1.00
106_L	151_I	2.102	1.00
32_C	35_L	2.101	1.00
105_N	144_D	2.089	1.00
505_I	540_D	2.078	1.00
292_A	295_I	2.059	1.00
443_K	462_E	2.045	1.00
221_R	224_D	2.044	1.00
538_D	541_E	2.037	1.00
626_T	632_S	2.025	1.00
622_V	641_L	2.009	1.00
171_R	205_Y	1.963	1.00
714_I	725_V	1.961	1.00
234_G	238_A	1.961	1.00
228_Y	328_G	1.951	1.00
233_V	237_R	1.937	1.00
692_V	721_V	1.934	1.00
341_K	345_E	1.919	1.00
38_T	41_Y	1.909	1.00
281_I	292_A	1.895	1.00
210_E	213_R	1.889	1.00
234_G	237_R	1.872	1.00
287_Q	291_A	1.864	1.00
50_P	166_A	1.860	1.00
163_V	175_A	1.831	1.00
232_F	334_V	1.826	1.00
160_L	198_L	1.818	1.00
453_Y	456_Q	1.813	1.00
422_S	485_T	1.796	1.00
71_M	75_T	1.794	1.00
283_A	292_A	1.791	1.00
93_D	96_R	1.788	1.00
163_V	174_A	1.781	1.00
424_P	442_A	1.778	1.00
73_I	77_R	1.771	1.00
288_D	291_A	1.769	1.00
32_C	74_D	1.757	1.00
408_V	455_L	1.743	1.00
222_R	253_P	1.741	1.00
66_L	79_A	1.733	1.00
92_E	96_R	1.729	1.00
536_F	542_L	1.724	1.00
229_I	251_G	1.709	1.00
453_Y	459_D	1.698	1.00
92_E	104_V	1.697	1.00
433_S	437_H	1.697	1.00
96_R	104_V	1.697	1.00
20_W	68_T	1.691	1.00
175_A	202_C	1.690	1.00
600_E	654_D	1.690	1.00
226_E	230_E	1.689	1.00
239_E	299_H	1.681	1.00
421_G	454_Q	1.681	1.00
32_C	103_V	1.674	1.00
212_K	215_A	1.670	1.00
500_D	503_K	1.668	1.00
83_P	87_A	1.662	1.00
539_V	543_L	1.657	1.00
671_V	712_M	1.653	1.00
675_D	708_A	1.651	1.00
218_L	256_I	1.641	1.00
77_R	103_V	1.639	1.00
369_G	372_D	1.637	1.00
196_W	255_H	1.630	1.00
78_A	106_L	1.626	1.00
85_A	108_H	1.607	0.99
93_D	97_E	1.607	0.99
24_L	70_S	1.588	0.99
512_L	543_L	1.587	0.99
40_A	56_L	1.579	0.99
220_E	332_K	1.569	0.99
92_E	105_N	1.563	0.99
687_L	712_M	1.556	0.99
87_A	111_R	1.549	0.99
228_Y	329_P	1.543	0.99
196_W	222_R	1.533	0.99
85_A	104_V	1.526	0.99
501_R	541_E	1.525	0.99
501_R	505_I	1.508	0.99
425_L	483_V	1.501	0.99
383_W	387_M	1.501	0.99
179_T	257_Y	1.500	0.99
676_R	679_L	1.500	0.99
31_S	35_L	1.500	0.99
257_Y	261_R	1.491	0.99
728_K	731_Q	1.481	0.99
94_V	98_S	1.481	0.99
91_S	94_V	1.464	0.99
424_P	444_I	1.460	0.99
544_A	547_G	1.449	0.99
85_A	111_R	1.446	0.99
230_E	234_G	1.444	0.99
203_F	207_H	1.444	0.99
494_A	498_K	1.442	0.99
230_E	233_V	1.433	0.99
203_F	256_I	1.417	0.99
160_L	201_Y	1.415	0.99
235_H	300_Y	1.413	0.99
39_W	98_S	1.409	0.99
38_T	42_C	1.406	0.99
690_E	728_K	1.402	0.99
320_Q	346_D	1.395	0.98
306_E	325_V	1.395	0.98
240_M	292_A	1.395	0.98
65_I	161_R	1.392	0.98
222_R	226_E	1.392	0.98
680_L	697_V	1.381	0.98
83_P	86_D	1.381	0.98
232_F	279_V	1.380	0.98
216_K	220_E	1.366	0.98
595_G	599_V	1.365	0.98
87_A	159_H	1.363	0.98
158_A	162_E	1.362	0.98
159_H	162_E	1.360	0.98
240_M	247_A	1.349	0.98
405_R	417_D	1.339	0.98
297_H	324_T	1.334	0.98
15_F	19_K	1.327	0.98
31_S	34_C	1.322	0.98
66_L	76_L	1.320	0.98
241_K	247_A	1.319	0.98
90_V	94_V	1.319	0.98
687_L	694_V	1.314	0.98
86_D	111_R	1.305	0.98
21_I	25_G	1.302	0.98
670_R	711_D	1.301	0.98
204_R	215_A	1.297	0.98
233_V	249_V	1.294	0.98
622_V	652_I	1.291	0.97
442_A	449_V	1.288	0.97
296_V	336_I	1.283	0.97
215_A	256_I	1.282	0.97
167_P	170_E	1.280	0.97
354_H	357_Y	1.274	0.97
430_H	487_R	1.270	0.97
86_D	159_H	1.268	0.97
686_I	725_V	1.264	0.97
676_R	734_D	1.261	0.97
43_L	94_V	1.259	0.97
39_W	43_L	1.254	0.97
196_W	253_P	1.250	0.97
719_L	723_G	1.250	0.97
151_I	187_N	1.247	0.97
87_A	112_D	1.244	0.97
473_R	496_F	1.233	0.97
672_V	737_D	1.233	0.97
641_L	652_I	1.232	0.97
296_V	326_V	1.228	0.97
37_E	41_Y	1.226	0.97
679_L	708_A	1.219	0.96
528_K	532_P	1.216	0.96
673_A	708_A	1.216	0.96
486_S	490_S	1.212	0.96
169_D	173_L	1.211	0.96
449_V	453_Y	1.208	0.96
101_K	105_N	1.204	0.96
610_A	632_S	1.203	0.96
623_G	653_V	1.195	0.96
49_H	159_H	1.194	0.96
49_H	87_A	1.193	0.96
686_I	690_E	1.189	0.96
44_Q	87_A	1.187	0.96
41_Y	45_Q	1.183	0.96
44_Q	83_P	1.176	0.96
624_F	651_R	1.176	0.96
198_L	202_C	1.173	0.96
406_V	457_M	1.172	0.96
699_S	710_I	1.171	0.95
293_L	338_I	1.162	0.95
283_A	288_D	1.160	0.95
683_I	710_I	1.160	0.95
495_W	499_Q	1.158	0.95
49_H	158_A	1.153	0.95
687_L	692_V	1.152	0.95
211_Y	215_A	1.150	0.95
66_L	110_V	1.146	0.95
422_S	484_T	1.144	0.95
90_V	98_S	1.139	0.95
166_A	170_E	1.138	0.95
49_H	55_L	1.138	0.95
375_A	378_R	1.132	0.95
424_P	449_V	1.131	0.95
43_L	90_V	1.130	0.95
522_S	525_E	1.127	0.94
596_R	599_V	1.127	0.94
56_L	59_G	1.124	0.94
22_A	30_K	1.123	0.94
378_R	381_I	1.121	0.94
252_R	358_K	1.121	0.94
45_Q	48_G	1.116	0.94
203_F	210_E	1.115	0.94
212_K	216_K	1.113	0.94
687_L	714_I	1.113	0.94
427_F	431_I	1.112	0.94
58_R	158_A	1.112	0.94
669_V	714_I	1.110	0.94
44_Q	55_L	1.110	0.94
49_H	83_P	1.105	0.94
155_E	159_H	1.101	0.94
529_H	532_P	1.100	0.94
49_H	52_A	1.099	0.94
160_L	163_V	1.099	0.94
693_N	715_E	1.098	0.94
233_V	279_V	1.092	0.93
700_R	711_D	1.091	0.93
59_G	159_H	1.089	0.93
42_C	46_T	1.089	0.93
237_R	248_E	1.088	0.93
666_S	715_E	1.086	0.93
672_V	709_T	1.085	0.93
44_Q	49_H	1.082	0.93
83_P	159_H	1.077	0.93
44_Q	86_D	1.076	0.93
217_L	271_D	1.076	0.93
679_L	682_D	1.075	0.93
352_A	358_K	1.072	0.93
20_W	64_E	1.072	0.93
21_I	67_S	1.071	0.93
434_D	437_H	1.070	0.93
597_V	621_I	1.060	0.92
64_E	68_T	1.059	0.92
243_E	295_I	1.058	0.92
670_R	739_R	1.055	0.92
29_Q	73_I	1.054	0.92
66_L	71_M	1.054	0.92
424_P	455_L	1.052	0.92
466_Q	469_P	1.051	0.92
406_V	453_Y	1.046	0.92
87_A	158_A	1.045	0.92
239_E	243_E	1.037	0.92
677_S	691_K	1.035	0.91
21_I	24_L	1.034	0.91
620_E	635_R	1.030	0.91
470_N	495_W	1.029	0.91
666_S	713_T	1.027	0.91
669_V	712_M	1.027	0.91
87_A	162_E	1.026	0.91
664_G	715_E	1.025	0.91
61_E	64_E	1.024	0.91
668_V	711_D	1.024	0.91
327_L	331_G	1.023	0.91
82_F	178_C	1.022	0.91
23_S	422_S	1.020	0.91
149_V	185_L	1.020	0.91
679_L	732_V	1.019	0.91
423_T	482_Y	1.018	0.91
288_D	292_A	1.016	0.91
690_E	724_R	1.015	0.91
395_D	398_R	1.015	0.91
59_G	82_F	1.011	0.91
44_Q	59_G	1.010	0.90
726_L	730_N	1.009	0.90
278_A	354_H	1.006	0.90
55_L	87_A	1.004	0.90
111_R	159_H	1.003	0.90
43_L	89_V	1.002	0.90
634_H	638_C	1.002	0.90
83_P	111_R	0.996	0.90
112_D	159_H	0.996	0.90
59_G	87_A	0.993	0.90
294_G	297_H	0.993	0.90
439_C	451_F	0.993	0.90
438_R	468_Q	0.990	0.90
290_Y	294_G	0.987	0.89
441_G	464_I	0.986	0.89
82_F	159_H	0.985	0.89
678_G	693_N	0.984	0.89
247_A	292_A	0.982	0.89
172_V	206_L	0.982	0.89
407_Y	417_D	0.982	0.89
377_L	383_W	0.977	0.89
342_Q	345_E	0.976	0.89
86_D	162_E	0.975	0.89
228_Y	232_F	0.973	0.89
354_H	358_K	0.973	0.89
160_L	178_C	0.972	0.89
55_L	83_P	0.972	0.89
262_K	357_Y	0.970	0.89
86_D	158_A	0.969	0.89
626_T	640_Q	0.969	0.89
44_Q	159_H	0.968	0.89
218_L	276_V	0.967	0.88
83_P	88_N	0.967	0.88
613_C	638_C	0.967	0.88
82_F	86_D	0.966	0.88
681_R	688_A	0.965	0.88
141_A	406_V	0.964	0.88
239_E	295_I	0.963	0.88
542_L	551_I	0.963	0.88
109_G	137_R	0.962	0.88
49_H	58_R	0.957	0.88
112_D	155_E	0.957	0.88
170_E	173_L	0.955	0.88
437_H	495_W	0.954	0.88
25_G	73_I	0.953	0.88
49_H	82_F	0.951	0.88
670_R	709_T	0.950	0.88
262_K	358_K	0.948	0.87
302_H	312_A	0.944	0.87
545_A	551_I	0.942	0.87
15_F	34_C	0.942	0.87
696_G	713_T	0.942	0.87
25_G	28_S	0.938	0.87
59_G	158_A	0.937	0.87
59_G	86_D	0.937	0.87
95_L	104_V	0.935	0.87
679_L	734_D	0.935	0.87
345_E	349_L	0.934	0.87
263_M	270_F	0.932	0.87
44_Q	58_R	0.930	0.86
673_A	735_V	0.930	0.86
416_V	430_H	0.928	0.86
49_H	59_G	0.927	0.86
262_K	335_E	0.926	0.86
335_E	354_H	0.926	0.86
17_P	22_A	0.926	0.86
260_W	264_Q	0.924	0.86
236_L	336_I	0.922	0.86
47_Q	86_D	0.922	0.86
682_D	732_V	0.922	0.86
44_Q	47_Q	0.921	0.86
78_A	151_I	0.921	0.86
65_I	197_E	0.920	0.86
15_F	18_E	0.918	0.86
62_M	155_E	0.913	0.85
48_G	54_L	0.911	0.85
55_L	159_H	0.910	0.85
142_M	146_F	0.909	0.85
516_L	557_V	0.907	0.85
16_D	20_W	0.905	0.85
17_P	20_W	0.903	0.85
352_A	357_Y	0.902	0.85
370_H	374_I	0.901	0.85
16_D	64_E	0.901	0.85
58_R	62_M	0.900	0.85
262_K	354_H	0.898	0.84
231_E	234_G	0.897	0.84
63_V	79_A	0.896	0.84
136_R	329_P	0.896	0.84
252_R	357_Y	0.893	0.84
613_C	634_H	0.892	0.84
598_V	656_V	0.889	0.84
697_V	701_S	0.889	0.84
616_I	667_L	0.888	0.84
49_H	162_E	0.886	0.84
410_T	431_I	0.885	0.84
218_L	270_F	0.885	0.84
609_I	616_I	0.885	0.84
685_T	689_N	0.884	0.84
235_H	299_H	0.883	0.83
232_F	300_Y	0.880	0.83
55_L	158_A	0.880	0.83
166_A	173_L	0.877	0.83
82_F	158_A	0.873	0.83
483_V	488_G	0.872	0.83
51_D	165_D	0.870	0.83
74_D	77_R	0.870	0.83
19_K	23_S	0.869	0.82
732_V	735_V	0.866	0.82
254_K	354_H	0.865	0.82
82_F	87_A	0.863	0.82
59_G	83_P	0.862	0.82
132_V	488_G	0.862	0.82
662_S	671_V	0.861	0.82
329_P	680_L	0.861	0.82
344_H	348_E	0.860	0.82
675_D	701_S	0.858	0.82
58_R	159_H	0.858	0.82
49_H	86_D	0.857	0.82
86_D	155_E	0.857	0.82
21_I	26_I	0.856	0.82
81_L	103_V	0.854	0.81
254_K	262_K	0.852	0.81
473_R	500_D	0.852	0.81
111_R	162_E	0.851	0.81
44_Q	111_R	0.851	0.81
58_R	82_F	0.849	0.81
320_Q	640_Q	0.849	0.81
47_Q	87_A	0.848	0.81
290_Y	293_L	0.847	0.81
442_A	463_I	0.841	0.80
88_N	159_H	0.840	0.80
677_S	693_N	0.839	0.80
290_Y	297_H	0.838	0.80
224_D	227_H	0.838	0.80
49_H	111_R	0.838	0.80
695_L	715_E	0.838	0.80
286_L	298_T	0.836	0.80
514_D	517_E	0.836	0.80
235_H	239_E	0.835	0.80
678_G	684_T	0.835	0.80
55_L	88_N	0.833	0.80
126_S	129_S	0.832	0.80
252_R	278_A	0.831	0.80
644_L	652_I	0.831	0.80
443_K	464_I	0.828	0.79
599_V	655_A	0.828	0.79
83_P	178_C	0.827	0.79
170_E	174_A	0.826	0.79
44_Q	162_E	0.823	0.79
44_Q	82_F	0.822	0.79
74_D	103_V	0.821	0.79
722_L	726_L	0.821	0.79
152_K	159_H	0.821	0.79
297_H	307_F	0.820	0.79
335_E	357_Y	0.818	0.78
612_C	634_H	0.818	0.78
204_R	212_K	0.814	0.78
425_L	439_C	0.814	0.78
55_L	58_R	0.813	0.78
641_L	645_R	0.810	0.78
220_E	377_L	0.810	0.78
44_Q	158_A	0.810	0.78
35_L	77_R	0.810	0.78
59_G	88_N	0.809	0.78
138_M	142_M	0.809	0.78
718_N	721_V	0.809	0.78
631_I	655_A	0.808	0.78
33_E	73_I	0.808	0.78
676_R	732_V	0.807	0.78
47_Q	88_N	0.807	0.78
47_Q	55_L	0.806	0.77
111_R	158_A	0.806	0.77
602_V	605_L	0.806	0.77
308_D	325_V	0.805	0.77
135_V	300_Y	0.805	0.77
55_L	86_D	0.803	0.77
88_N	162_E	0.803	0.77
681_R	685_T	0.802	0.77
335_E	358_K	0.802	0.77
19_K	22_A	0.801	0.77
241_K	246_K	0.799	0.77
79_A	151_I	0.798	0.77
519_L	557_V	0.798	0.77
52_A	58_R	0.796	0.77
58_R	162_E	0.794	0.76
87_A	155_E	0.793	0.76
541_E	544_A	0.792	0.76
280_R	337_Q	0.792	0.76
83_P	112_D	0.791	0.76
59_G	62_M	0.790	0.76
55_L	59_G	0.789	0.76
676_R	683_I	0.788	0.76
262_K	278_A	0.787	0.76
88_N	111_R	0.786	0.76
261_R	265_K	0.785	0.76
51_D	87_A	0.784	0.75
240_M	249_V	0.784	0.75
622_V	636_A	0.783	0.75
666_S	695_L	0.781	0.75
44_Q	51_D	0.781	0.75
303_L	333_T	0.781	0.75
157_I	194_L	0.780	0.75
58_R	155_E	0.779	0.75
433_S	495_W	0.778	0.75
109_G	148_C	0.778	0.75
537_N	541_E	0.777	0.75
692_V	725_V	0.776	0.75
240_M	245_V	0.774	0.75
335_E	352_A	0.773	0.74
82_F	155_E	0.772	0.74
673_A	710_I	0.772	0.74
515_E	518_H	0.771	0.74
701_S	708_A	0.770	0.74
65_I	154_A	0.770	0.74
254_K	335_E	0.769	0.74
28_S	31_S	0.769	0.74
252_R	354_H	0.766	0.74
30_K	34_C	0.765	0.74
134_N	409_F	0.764	0.74
87_A	170_E	0.760	0.73
180_N	398_R	0.760	0.73
718_N	722_L	0.760	0.73
370_H	373_R	0.759	0.73
675_D	706_Q	0.757	0.73
612_C	638_C	0.756	0.73
611_R	614_Q	0.755	0.73
228_Y	330_G	0.754	0.73
66_L	641_L	0.754	0.73
371_E	378_R	0.753	0.73
82_F	111_R	0.753	0.73
49_H	88_N	0.752	0.72
424_P	454_Q	0.751	0.72
55_L	82_F	0.751	0.72
164_K	204_R	0.751	0.72
225_R	253_P	0.750	0.72
86_D	109_G	0.750	0.72
280_R	354_H	0.750	0.72
209_T	212_K	0.749	0.72
88_N	112_D	0.748	0.72
433_S	491_K	0.748	0.72
437_H	496_F	0.748	0.72
236_L	439_C	0.747	0.72
221_R	225_R	0.747	0.72
58_R	112_D	0.747	0.72
112_D	162_E	0.747	0.72
252_R	335_E	0.746	0.72
278_A	358_K	0.745	0.72
108_H	137_R	0.745	0.72
18_E	30_K	0.743	0.72
236_L	279_V	0.743	0.72
172_V	336_I	0.743	0.72
171_R	443_K	0.742	0.71
262_K	352_A	0.741	0.71
281_I	726_L	0.741	0.71
44_Q	88_N	0.739	0.71
231_E	235_H	0.739	0.71
159_H	170_E	0.738	0.71
155_E	158_A	0.738	0.71
686_I	728_K	0.737	0.71
29_Q	32_C	0.737	0.71
645_R	652_I	0.735	0.71
278_A	357_Y	0.735	0.71
55_L	111_R	0.735	0.71
49_H	112_D	0.734	0.71
55_L	162_E	0.734	0.71
46_T	54_L	0.733	0.70
58_R	83_P	0.732	0.70
356_K	378_R	0.732	0.70
258_S	358_K	0.731	0.70
379_K	383_W	0.730	0.70
137_R	148_C	0.729	0.70
83_P	107_I	0.729	0.70
114_A	174_A	0.729	0.70
83_P	158_A	0.728	0.70
254_K	357_Y	0.726	0.70
614_Q	668_V	0.724	0.70
506_L	510_Q	0.724	0.70
530_L	556_M	0.722	0.69
528_K	539_V	0.722	0.69
21_I	30_K	0.721	0.69
86_D	110_V	0.721	0.69
443_K	448_I	0.721	0.69
140_L	187_N	0.721	0.69
112_D	158_A	0.720	0.69
368_S	371_E	0.720	0.69
534_Y	551_I	0.719	0.69
218_L	259_I	0.719	0.69
166_A	171_R	0.719	0.69
53_S	58_R	0.717	0.69
49_H	155_E	0.717	0.69
49_H	170_E	0.716	0.69
97_E	101_K	0.715	0.69
497_R	548_G	0.714	0.68
72_D	75_T	0.713	0.68
626_T	630_G	0.712	0.68
96_R	100_G	0.707	0.68
516_L	543_L	0.707	0.68
82_F	162_E	0.706	0.68
150_V	191_I	0.705	0.68
22_A	28_S	0.703	0.67
226_E	253_P	0.700	0.67
376_W	383_W	0.700	0.67
252_R	352_A	0.700	0.67
293_L	297_H	0.700	0.67
139_L	143_V	0.700	0.67
280_R	357_Y	0.698	0.67
92_E	95_L	0.698	0.67
241_K	560_L	0.698	0.67
515_E	519_L	0.698	0.67
501_R	540_D	0.698	0.67
498_K	502_D	0.697	0.67
254_K	358_K	0.697	0.67
608_H	629_R	0.696	0.67
58_R	87_A	0.692	0.66
263_M	310_Y	0.692	0.66
490_S	494_A	0.691	0.66
26_I	29_Q	0.690	0.66
58_R	84_L	0.690	0.66
39_W	95_L	0.689	0.66
482_Y	487_R	0.688	0.66
59_G	162_E	0.688	0.66
433_S	674_N	0.687	0.66
204_R	222_R	0.685	0.65
431_I	434_D	0.685	0.65
86_D	112_D	0.685	0.65
425_L	444_I	0.684	0.65
545_A	550_D	0.681	0.65
683_I	687_L	0.681	0.65
112_D	152_K	0.681	0.65
57_W	61_E	0.679	0.65
26_I	30_K	0.679	0.65
140_L	402_F	0.679	0.65
393_M	398_R	0.679	0.65
508_G	547_G	0.679	0.65
566_K	569_A	0.679	0.65
216_K	219_H	0.678	0.64
227_H	230_E	0.677	0.64
434_D	438_R	0.677	0.64
136_R	471_P	0.674	0.64
633_V	653_V	0.674	0.64
131_Q	138_M	0.672	0.64
18_E	21_I	0.671	0.64
25_G	493_H	0.669	0.63
183_A	198_L	0.667	0.63
27_T	31_S	0.667	0.63
44_Q	112_D	0.667	0.63
294_G	298_T	0.667	0.63
723_G	727_G	0.666	0.63
409_F	414_D	0.666	0.63
96_R	105_N	0.665	0.63
163_V	171_R	0.665	0.63
431_I	492_I	0.665	0.63
247_A	542_L	0.665	0.63
52_A	111_R	0.664	0.63
513_D	523_L	0.664	0.63
203_F	266_K	0.663	0.63
181_I	382_A	0.663	0.63
214_I	217_L	0.662	0.63
83_P	170_E	0.661	0.63
278_A	336_I	0.661	0.63
600_E	656_V	0.661	0.63
665_Y	716_I	0.660	0.62
275_D	335_E	0.659	0.62
210_E	260_W	0.657	0.62
427_F	463_I	0.657	0.62
260_W	483_V	0.657	0.62
200_D	204_R	0.657	0.62
262_K	280_R	0.656	0.62
686_I	732_V	0.655	0.62
275_D	354_H	0.655	0.62
86_D	170_E	0.654	0.62
110_V	113_M	0.654	0.62
59_G	112_D	0.654	0.62
76_L	79_A	0.653	0.62
218_L	330_G	0.651	0.61
51_D	58_R	0.651	0.61
438_R	466_Q	0.650	0.61
83_P	162_E	0.650	0.61
160_L	175_A	0.648	0.61
67_S	203_F	0.648	0.61
17_P	80_L	0.647	0.61
280_R	335_E	0.647	0.61
47_Q	83_P	0.647	0.61
65_I	76_L	0.647	0.61
52_A	159_H	0.643	0.60
159_H	178_C	0.643	0.60
318_G	341_K	0.642	0.60
687_L	725_V	0.642	0.60
155_E	162_E	0.642	0.60
58_R	111_R	0.640	0.60
276_V	703_T	0.640	0.60
245_V	292_A	0.640	0.60
146_F	150_V	0.639	0.60
664_G	717_Y	0.639	0.60
151_I	202_C	0.639	0.60
88_N	158_A	0.638	0.60
225_R	312_A	0.637	0.60
662_S	717_Y	0.637	0.60
599_V	653_V	0.636	0.60
62_M	79_A	0.636	0.60
333_T	496_F	0.635	0.59
50_P	174_A	0.635	0.59
670_R	741_L	0.635	0.59
268_L	272_E	0.634	0.59
406_V	421_G	0.634	0.59
51_D	55_L	0.633	0.59
535_N	550_D	0.633	0.59
257_Y	260_W	0.632	0.59
444_I	448_I	0.632	0.59
562_S	565_N	0.632	0.59
291_A	295_I	0.632	0.59
290_Y	312_A	0.631	0.59
58_R	86_D	0.630	0.59
667_L	693_N	0.630	0.59
606_M	631_I	0.629	0.59
163_V	166_A	0.629	0.59
278_A	461_I	0.629	0.59
224_D	276_V	0.628	0.59
252_R	262_K	0.628	0.59
680_L	699_S	0.627	0.58
44_Q	107_I	0.627	0.58
681_R	684_T	0.627	0.58
231_E	453_Y	0.625	0.58
506_L	509_R	0.625	0.58
155_E	178_C	0.624	0.58
44_Q	170_E	0.624	0.58
364_G	725_V	0.624	0.58
635_R	679_L	0.622	0.58
624_F	644_L	0.622	0.58
32_C	38_T	0.621	0.58
444_I	461_I	0.621	0.58
505_I	667_L	0.620	0.58
529_H	563_Q	0.619	0.58
521_I	561_Q	0.619	0.58
160_L	171_R	0.618	0.57
47_Q	159_H	0.618	0.57
438_R	485_T	0.616	0.57
717_Y	721_V	0.616	0.57
54_L	87_A	0.616	0.57
167_P	660_S	0.615	0.57
318_G	346_D	0.614	0.57
69_L	194_L	0.614	0.57
175_A	206_L	0.614	0.57
553_L	557_V	0.613	0.57
676_R	708_A	0.613	0.57
390_S	730_N	0.612	0.57
429_Y	471_P	0.611	0.57
420_A	454_Q	0.610	0.56
107_I	156_R	0.607	0.56
262_K	337_Q	0.607	0.56
472_S	496_F	0.607	0.56
71_M	191_I	0.607	0.56
78_A	107_I	0.606	0.56
254_K	278_A	0.606	0.56
265_K	270_F	0.606	0.56
59_G	111_R	0.606	0.56
133_D	617_P	0.605	0.56
91_S	714_I	0.605	0.56
160_L	210_E	0.604	0.56
275_D	337_Q	0.604	0.56
457_M	721_V	0.604	0.56
17_P	64_E	0.603	0.56
683_I	732_V	0.603	0.56
448_I	464_I	0.603	0.56
239_E	298_T	0.603	0.56
509_R	540_D	0.603	0.56
196_W	199_E	0.602	0.55
399_S	407_Y	0.602	0.55
513_D	543_L	0.602	0.55
37_E	60_V	0.601	0.55
135_V	217_L	0.601	0.55
193_Q	633_V	0.601	0.55
238_A	241_K	0.601	0.55
697_V	708_A	0.601	0.55
680_L	693_N	0.600	0.55
88_N	91_S	0.600	0.55
131_Q	150_V	0.600	0.55
328_G	332_K	0.600	0.55
156_R	177_E	0.599	0.55
183_A	255_H	0.599	0.55
25_G	103_V	0.599	0.55
626_T	651_R	0.598	0.55
512_L	556_M	0.598	0.55
20_W	23_S	0.598	0.55
318_G	345_E	0.597	0.55
254_K	337_Q	0.596	0.55
262_K	275_D	0.595	0.55
461_I	586_T	0.595	0.55
674_N	736_I	0.594	0.54
44_Q	54_L	0.594	0.54
152_K	156_R	0.594	0.54
18_E	34_C	0.594	0.54
51_D	112_D	0.593	0.54
246_K	735_V	0.593	0.54
600_E	658_G	0.593	0.54
225_R	251_G	0.592	0.54
178_C	198_L	0.592	0.54
356_K	371_E	0.592	0.54
337_Q	354_H	0.592	0.54
684_T	688_A	0.592	0.54
135_V	375_A	0.591	0.54
85_A	91_S	0.590	0.54
316_P	367_R	0.589	0.54
424_P	453_Y	0.588	0.54
531_L	543_L	0.588	0.54
15_F	41_Y	0.588	0.54
179_T	202_C	0.586	0.53
675_D	678_G	0.585	0.53
323_H	339_R	0.585	0.53
688_A	694_V	0.585	0.53
278_A	335_E	0.584	0.53
720_Q	724_R	0.584	0.53
642_A	669_V	0.583	0.53
162_E	170_E	0.583	0.53
22_A	34_C	0.583	0.53
25_G	29_Q	0.582	0.53
603_G	606_M	0.582	0.53
244_G	461_I	0.581	0.53
414_D	434_D	0.581	0.53
337_Q	357_Y	0.580	0.53
406_V	486_S	0.580	0.53
485_T	491_K	0.580	0.53
82_F	107_I	0.580	0.53
62_M	82_F	0.580	0.53
275_D	357_Y	0.579	0.53
377_L	380_L	0.579	0.53
172_V	176_K	0.579	0.53
369_G	373_R	0.578	0.52
88_N	155_E	0.578	0.52
19_K	29_Q	0.578	0.52
644_L	648_A	0.577	0.52
697_V	710_I	0.576	0.52
176_K	206_L	0.576	0.52
252_R	258_S	0.575	0.52
229_I	450_P	0.575	0.52
143_V	302_H	0.575	0.52
110_V	114_A	0.574	0.52
425_L	547_G	0.574	0.52
97_E	587_P	0.573	0.52
233_V	250_Y	0.573	0.52
115_A	425_L	0.572	0.52
15_F	725_V	0.572	0.52
200_D	205_Y	0.572	0.52
669_V	738_A	0.571	0.52
591_S	633_V	0.571	0.52
301_R	409_F	0.571	0.52
132_V	401_V	0.570	0.51
215_A	219_H	0.570	0.51
110_V	294_G	0.570	0.51
373_R	383_W	0.570	0.51
512_L	542_L	0.569	0.51
55_L	62_M	0.568	0.51
649_P	652_I	0.568	0.51
39_W	45_Q	0.567	0.51
671_V	683_I	0.567	0.51
26_I	31_S	0.566	0.51
265_K	268_L	0.566	0.51
616_I	740_R	0.566	0.51
273_L	652_I	0.565	0.51
402_F	497_R	0.564	0.51
561_Q	564_F	0.563	0.51
402_F	457_M	0.562	0.50
633_V	692_V	0.562	0.50
198_L	408_V	0.562	0.50
388_A	485_T	0.562	0.50
279_V	443_K	0.562	0.50
51_D	62_M	0.561	0.50
433_S	441_G	0.559	0.50
399_S	405_R	0.559	0.50
104_V	108_H	0.558	0.50
51_D	86_D	0.556	0.50
111_R	155_E	0.556	0.50
202_C	421_G	0.555	0.50
533_R	562_S	0.555	0.50
424_P	451_F	0.555	0.50
75_T	110_V	0.554	0.49
142_M	320_Q	0.554	0.49
281_I	567_P	0.554	0.49
564_F	568_S	0.554	0.49
220_E	277_R	0.553	0.49
207_H	360_G	0.553	0.49
598_V	609_I	0.553	0.49
49_H	53_S	0.552	0.49
35_L	38_T	0.552	0.49
52_A	62_M	0.552	0.49
451_F	502_D	0.552	0.49
294_G	307_F	0.552	0.49
85_A	94_V	0.551	0.49
546_I	552_R	0.551	0.49
254_K	352_A	0.551	0.49
320_Q	342_Q	0.550	0.49
110_V	152_K	0.550	0.49
369_G	489_R	0.550	0.49
277_R	332_K	0.550	0.49
536_F	551_I	0.550	0.49
516_L	560_L	0.550	0.49
681_R	694_V	0.549	0.49
583_K	586_T	0.548	0.49
53_S	158_A	0.548	0.49
37_E	498_K	0.548	0.49
15_F	38_T	0.548	0.49
321_S	339_R	0.548	0.49
412_K	463_I	0.547	0.49
582_Q	585_Y	0.546	0.48
275_D	280_R	0.546	0.48
39_W	94_V	0.546	0.48
496_F	632_S	0.545	0.48
546_I	688_A	0.545	0.48
158_A	170_E	0.545	0.48
182_Y	431_I	0.544	0.48
517_E	599_V	0.544	0.48
82_F	112_D	0.544	0.48
195_K	259_I	0.544	0.48
52_A	107_I	0.542	0.48
81_L	95_L	0.540	0.48
623_G	655_A	0.540	0.48
407_Y	603_G	0.540	0.48
44_Q	155_E	0.540	0.48
57_W	79_A	0.539	0.48
278_A	452_T	0.539	0.48
75_T	106_L	0.539	0.48
683_I	686_I	0.538	0.47
50_P	167_P	0.538	0.47
278_A	338_I	0.537	0.47
202_C	205_Y	0.536	0.47
105_N	279_V	0.535	0.47
51_D	159_H	0.535	0.47
51_D	88_N	0.534	0.47
463_I	592_K	0.534	0.47
228_Y	277_R	0.533	0.47
491_K	494_A	0.533	0.47
544_A	548_G	0.533	0.47
619_D	635_R	0.532	0.47
675_D	680_L	0.532	0.47
83_P	155_E	0.532	0.47
456_Q	459_D	0.531	0.47
290_Y	324_T	0.531	0.47
438_R	465_T	0.531	0.47
718_N	731_Q	0.531	0.47
381_I	401_V	0.531	0.47
124_T	130_E	0.531	0.47
360_G	363_A	0.531	0.47
344_H	349_L	0.530	0.46
684_T	710_I	0.530	0.46
439_C	684_T	0.529	0.46
70_S	139_L	0.529	0.46
727_G	730_N	0.527	0.46
424_P	448_I	0.527	0.46
703_T	707_L	0.525	0.46
58_R	99_V	0.525	0.46
483_V	562_S	0.525	0.46
167_P	174_A	0.524	0.46
292_A	398_R	0.523	0.46
332_K	610_A	0.523	0.46
255_H	474_D	0.522	0.45
205_Y	445_G	0.522	0.45
222_R	256_I	0.522	0.45
195_K	199_E	0.522	0.45
139_L	487_R	0.522	0.45
273_L	667_L	0.522	0.45
258_S	335_E	0.521	0.45
407_Y	630_G	0.521	0.45
19_K	27_T	0.521	0.45
546_I	556_M	0.521	0.45
138_M	383_W	0.520	0.45
581_Q	587_P	0.520	0.45
54_L	58_R	0.520	0.45
156_R	174_A	0.520	0.45
82_F	88_N	0.519	0.45
298_T	673_A	0.519	0.45
228_Y	332_K	0.519	0.45
33_E	45_Q	0.519	0.45
68_T	696_G	0.518	0.45
51_D	162_E	0.518	0.45
311_V	630_G	0.518	0.45
70_S	356_K	0.517	0.45
95_L	174_A	0.516	0.45
377_L	381_I	0.516	0.45
684_T	734_D	0.516	0.45
504_N	544_A	0.516	0.45
375_A	379_K	0.516	0.45
407_Y	601_G	0.515	0.45
431_I	607_H	0.515	0.45
438_R	692_V	0.514	0.44
49_H	54_L	0.514	0.44
592_K	633_V	0.513	0.44
254_K	280_R	0.513	0.44
584_S	588_Q	0.513	0.44
29_Q	35_L	0.513	0.44
176_K	207_H	0.513	0.44
397_V	431_I	0.513	0.44
146_F	317_N	0.512	0.44
81_L	85_A	0.512	0.44
510_Q	514_D	0.512	0.44
293_L	312_A	0.512	0.44
461_I	694_V	0.512	0.44
511_I	546_I	0.512	0.44
74_D	100_G	0.511	0.44
329_P	334_V	0.511	0.44
721_V	725_V	0.511	0.44
86_D	152_K	0.511	0.44
42_C	98_S	0.510	0.44
255_H	344_H	0.509	0.44
567_P	571_E	0.509	0.44
442_A	491_K	0.509	0.44
204_R	296_V	0.508	0.44
49_H	152_K	0.508	0.44
132_V	135_V	0.508	0.44
31_S	38_T	0.508	0.44
313_N	318_G	0.507	0.44
146_F	305_D	0.506	0.44
353_A	357_Y	0.506	0.44
152_K	155_E	0.506	0.44
686_I	714_I	0.506	0.44
85_A	105_N	0.506	0.44
422_S	736_I	0.506	0.44
392_E	466_Q	0.505	0.43
79_A	374_I	0.505	0.43
438_R	467_K	0.505	0.43
67_S	294_G	0.504	0.43
555_Q	559_F	0.504	0.43
106_L	113_M	0.503	0.43
40_A	477_N	0.503	0.43
54_L	83_P	0.503	0.43
301_R	313_N	0.503	0.43
565_N	669_V	0.503	0.43
191_I	359_E	0.502	0.43
160_L	170_E	0.502	0.43
411_P	432_H	0.502	0.43
449_V	729_L	0.502	0.43
280_R	339_R	0.501	0.43
52_A	155_E	0.501	0.43
596_R	601_G	0.501	0.43
507_A	510_Q	0.501	0.43
332_K	439_C	0.501	0.43
296_V	299_H	0.501	0.43
194_L	588_Q	0.501	0.43
511_I	553_L	0.501	0.43
151_I	655_A	0.501	0.43
450_P	453_Y	0.500	0.43
598_V	658_G	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vj7A	1	0.4503	100	0.522	Contact Map
3l9dA	1	0.25	100	0.77	Contact Map
4yf1A	2	0.207	100	0.828	Contact Map
3nr1A	2	0.2339	100	0.836	Contact Map
2be3A	2	0.2581	100	0.836	Contact Map
3nqwA	2	0.2298	100	0.842	Contact Map
2ekiA	1	0.1129	99.9	0.924	Contact Map
3hvzA	2	0.086	99.7	0.937	Contact Map
1wxqA	1	0.2863	99.4	0.948	Contact Map
1wwtA	1	0.1169	99.4	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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