GREMLIN Database
PURE - N5-carboxyaminoimidazole ribonucleotide mutase
UniProt: P0AG18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10793
Length: 169 (153)
Sequences: 3223 (1472)
Seq/√Len: 119.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_K162_N2.6511.00
11_A54_F2.6151.00
77_P107_I2.5051.00
119_L132_L2.4981.00
59_E149_N2.4291.00
89_L119_L2.3831.00
135_Q152_R2.3651.00
101_V105_Y2.3161.00
13_V80_I2.2801.00
33_L134_A2.2251.00
64_Q140_H2.2011.00
112_R127_A2.1931.00
12_I27_A2.1601.00
9_R64_Q2.1281.00
49_D56_E2.0601.00
31_E37_H1.9951.00
40_E50_K1.9711.00
52_F83_K1.9641.00
59_E145_H1.9241.00
137_L144_L1.9141.00
11_A63_Y1.8861.00
35_V134_A1.8361.00
23_M69_G1.7951.00
94_Q97_A1.7461.00
27_A37_H1.7341.00
24_Q28_E1.7251.00
32_I154_A1.7111.00
38_H61_N1.6951.00
23_M91_V1.6791.00
157_D161_E1.6721.00
120_A125_G1.6651.00
98_L121_I1.6521.00
53_S57_S1.6381.00
151_W155_Q1.6341.00
59_E85_L1.6181.00
47_T159_V1.6171.00
153_K157_D1.5901.00
89_L136_I1.5901.00
94_Q99_S1.5671.00
29_I130_A1.5011.00
42_V51_L1.4981.00
104_L108_V1.4741.00
134_A144_L1.4721.00
138_A144_L1.4711.00
57_S60_E1.4431.00
50_K160_L1.4381.00
94_Q122_G1.4091.00
27_A39_V1.4061.00
89_L117_G1.3861.00
9_R36_P1.3811.00
143_E147_R1.3801.00
146_Q150_D1.3641.00
150_D154_A1.3641.00
85_L149_N1.2901.00
153_K156_T1.2851.00
66_I86_V1.2811.00
85_L145_H1.2200.99
38_H63_Y1.2100.99
25_F28_E1.1990.99
154_A158_E1.1950.99
54_F63_Y1.1940.99
34_N147_R1.1900.99
64_Q141_D1.1740.99
104_L121_I1.1570.99
51_L80_I1.1410.99
33_L147_R1.1400.99
55_A66_I1.1390.99
56_E83_K1.1310.99
49_D83_K1.1280.99
47_T50_K1.1180.99
95_S99_S1.1130.99
25_F127_A1.0910.98
21_A24_Q1.0880.98
28_E32_I1.0420.98
51_L79_M1.0300.98
136_I139_T1.0290.98
131_L134_A1.0170.98
158_E162_N1.0160.98
51_L55_A1.0100.97
29_I32_I1.0080.97
29_I127_A1.0080.97
10_V65_V1.0050.97
130_A134_A1.0050.97
72_G96_A0.9940.97
22_T94_Q0.9790.97
49_D53_S0.9730.97
22_T122_G0.9640.97
144_L147_R0.9520.96
85_L148_L0.9500.96
64_Q139_T0.9430.96
42_V50_K0.9390.96
27_A31_E0.9340.96
20_W39_V0.9210.96
20_W27_A0.9130.95
29_I131_L0.9060.95
72_G103_S0.8800.94
96_A103_S0.8710.94
26_A69_G0.8680.94
17_K41_V0.8600.94
127_A151_W0.8570.94
79_M82_A0.8540.93
146_Q149_N0.8530.93
42_V79_M0.8520.93
149_N153_K0.8500.93
138_A148_L0.8440.93
8_A64_Q0.8430.93
154_A157_D0.8410.93
49_D156_T0.8380.93
112_R125_G0.8340.93
55_A58_A0.8250.92
55_A80_I0.8220.92
90_G107_I0.8220.92
156_T160_L0.8150.92
69_G93_V0.8130.92
28_E31_E0.8120.92
148_L152_R0.8110.92
114_I152_R0.8070.91
145_H149_N0.8030.91
22_T93_V0.7990.91
117_G132_L0.7980.91
29_I33_L0.7800.90
38_H54_F0.7800.90
59_E138_A0.7710.89
97_A101_V0.7710.89
8_A36_P0.7570.89
65_V137_L0.7570.89
89_L132_L0.7520.88
11_A38_H0.7450.88
50_K159_V0.7420.88
26_A67_I0.7410.87
57_S61_N0.7410.87
23_M126_A0.7380.87
152_R155_Q0.7370.87
49_D52_F0.7370.87
98_L108_V0.7340.87
98_L104_L0.7330.87
9_R141_D0.7300.87
33_L151_W0.7240.86
101_V121_I0.7090.85
131_L152_R0.7050.85
64_Q145_H0.7040.85
95_S103_S0.6870.83
11_A66_I0.6840.83
53_S56_E0.6820.83
51_L77_P0.6790.83
141_D144_L0.6780.82
157_D160_L0.6780.82
30_F134_A0.6670.81
98_L101_V0.6640.81
22_T25_F0.6560.80
101_V108_V0.6520.80
142_K145_H0.6490.80
150_D153_K0.6470.79
13_V66_I0.6470.79
112_R120_A0.6440.79
54_F61_N0.6440.79
13_V54_F0.6380.78
119_L125_G0.6350.78
52_F56_E0.6310.78
158_E161_E0.6270.77
32_I151_W0.6240.77
95_S105_Y0.6200.76
50_K156_T0.6140.76
119_L136_I0.6120.76
41_V162_N0.6110.75
51_L107_I0.6090.75
68_A77_P0.6090.75
119_L135_Q0.6070.75
68_A107_I0.6070.75
135_Q148_L0.6070.75
99_S105_Y0.6020.74
97_A121_I0.6020.74
155_Q158_E0.6000.74
130_A135_Q0.5960.74
69_G91_V0.5930.73
68_A80_I0.5920.73
115_P148_L0.5900.73
55_A86_V0.5890.73
50_K53_S0.5890.73
65_V136_I0.5850.72
52_F55_A0.5850.72
90_G115_P0.5830.72
48_P82_A0.5810.72
15_G19_D0.5790.71
72_G79_M0.5770.71
95_S120_A0.5730.71
9_R63_Y0.5720.71
65_V119_L0.5700.70
72_G112_R0.5700.70
20_W24_Q0.5690.70
108_V121_I0.5680.70
79_M107_I0.5650.70
12_I39_V0.5650.70
10_V35_V0.5650.70
11_A61_N0.5620.69
55_A83_K0.5620.69
14_M23_M0.5600.69
77_P90_G0.5600.69
132_L136_I0.5590.69
56_E60_E0.5570.69
63_Y66_I0.5570.69
16_S19_D0.5530.68
25_F122_G0.5530.68
143_E146_Q0.5510.68
101_V104_L0.5500.68
21_A25_F0.5490.67
31_E34_N0.5460.67
35_V144_L0.5400.66
55_A63_Y0.5390.66
134_A137_L0.5390.66
69_G130_A0.5370.66
63_Y86_V0.5360.66
17_K114_I0.5350.65
41_V93_V0.5330.65
40_E162_N0.5250.64
32_I147_R0.5230.64
89_L139_T0.5230.64
42_V72_G0.5190.63
17_K21_A0.5180.63
114_I148_L0.5110.62
58_A66_I0.5050.61
126_A130_A0.5050.61
112_R130_A0.5050.61
17_K20_W0.5050.61
29_I151_W0.5050.61
45_H76_L0.5040.61
31_E39_V0.5030.61
134_A147_R0.5030.61
44_A76_L0.5010.60
103_S106_S0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kuuA 5 1 100 0.153 Contact Map
3trhA 5 0.9704 100 0.154 Contact Map
3orsA 5 0.9527 100 0.156 Contact Map
3lp6A 5 0.9882 100 0.156 Contact Map
3oowA 5 0.9586 100 0.157 Contact Map
1u11A 6 0.9586 100 0.158 Contact Map
4ay3A 2 0.9467 100 0.162 Contact Map
4grdA 5 0.9704 100 0.163 Contact Map
1o4vA 5 0.9467 100 0.174 Contact Map
3rg8A 6 0.9349 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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