GREMLIN Database
PUR1 - Amidophosphoribosyltransferase
UniProt: P0AG16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10794
Length: 505 (447)
Sequences: 3243 (1574)
Seq/√Len: 74.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_A207_V6.2191.00
285_E316_I4.8591.00
278_N281_T4.4441.00
424_D427_R4.4231.00
114_K163_L3.9851.00
193_L225_V3.9581.00
292_E436_I3.8751.00
282_K445_D3.6981.00
355_R359_R3.6901.00
422_E425_E3.5251.00
195_K220_D3.4951.00
5_V20_A3.4621.00
49_N81_S3.2101.00
17_I69_G3.1601.00
362_N390_K3.0911.00
207_V233_I3.0181.00
68_M173_M2.9341.00
290_E442_D2.9181.00
35_I43_F2.9051.00
295_D362_N2.8881.00
282_K285_E2.8871.00
281_T316_I2.8491.00
197_D203_T2.8111.00
193_L207_V2.8091.00
347_V374_T2.6361.00
35_I45_L2.6221.00
266_F271_S2.6011.00
439_D442_D2.5981.00
100_A171_V2.5921.00
381_E385_E2.5591.00
132_L170_C2.5411.00
139_E159_A2.5211.00
440_L463_N2.4961.00
290_E439_D2.4161.00
298_V363_V2.4061.00
192_V214_L2.3961.00
214_L219_F2.3791.00
412_S415_E2.3021.00
417_I426_I2.2821.00
277_V315_R2.2351.00
459_C463_N2.1961.00
282_K442_D2.1821.00
426_I437_F2.1771.00
234_T239_L2.1451.00
215_D352_N2.1321.00
192_V211_S2.1171.00
296_I364_L2.1041.00
31_A86_A2.0771.00
193_L231_I2.0621.00
294_L394_A2.0491.00
281_T315_R2.0231.00
181_A231_I2.0081.00
168_Y185_P2.0021.00
404_N458_E1.9981.00
392_Y434_G1.9941.00
193_L233_I1.9931.00
188_I468_T1.9871.00
444_I459_C1.9741.00
406_Y468_T1.9711.00
394_A436_I1.9511.00
9_G13_V1.8681.00
376_S393_L1.8651.00
234_T237_G1.8471.00
226_A242_R1.8181.00
152_N155_A1.8111.00
180_V232_Y1.8081.00
178_G232_Y1.8081.00
178_G234_T1.8051.00
275_A279_M1.8051.00
300_I324_G1.8041.00
9_G204_E1.7651.00
234_T238_Q1.7621.00
195_K203_T1.7601.00
274_S356_A1.7531.00
273_Y308_D1.7521.00
427_R435_L1.7481.00
344_R374_T1.7321.00
170_C182_F1.7151.00
254_L447_V1.7101.00
31_A49_N1.7051.00
334_T346_S1.7051.00
284_G316_I1.6981.00
57_E60_H1.6941.00
118_E138_S1.6731.00
270_I275_A1.6321.00
254_L457_F1.6311.00
5_V17_I1.6221.00
205_Y233_I1.6161.00
113_K117_E1.6151.00
424_D428_Q1.6030.99
191_L225_V1.5990.99
205_Y222_L1.5910.99
48_A83_A1.5820.99
300_I365_L1.5780.99
223_R229_E1.5690.99
38_D41_N1.5650.99
3_G73_V1.5560.99
423_V427_R1.5390.99
393_L430_I1.5300.99
211_S221_F1.5220.99
406_Y460_S1.5150.99
207_V231_I1.5090.99
161_N182_F1.5060.99
384_R433_D1.5020.99
400_I410_M1.4970.99
399_E418_A1.4970.99
427_R432_A1.4930.99
35_I98_T1.4850.99
193_L238_Q1.4560.99
171_V181_A1.4390.99
175_I178_G1.4250.99
224_D268_D1.4200.99
421_R429_I1.4180.99
193_L223_R1.4050.99
393_L432_A1.3880.98
418_A426_I1.3740.98
192_V221_F1.3710.98
362_N389_K1.3670.98
277_V322_R1.3630.98
208_A213_A1.3630.98
296_I319_K1.3590.98
110_E165_R1.3570.98
404_N460_S1.3490.98
301_P307_C1.3470.98
206_M214_L1.3450.98
215_D355_R1.3430.98
381_E431_G1.3340.98
307_C323_Q1.3330.98
293_D394_A1.3270.98
358_F383_A1.3270.98
105_L164_I1.3270.98
458_E461_V1.3200.98
177_H235_E1.3150.98
193_L205_Y1.3130.98
363_V383_A1.3120.98
323_Q329_R1.3110.98
45_L90_Y1.3100.98
169_A188_I1.3050.98
195_K222_L1.3040.98
7_I16_S1.2990.98
304_E329_R1.2830.97
48_A55_V1.2670.97
180_V230_A1.2630.97
314_A317_L1.2500.97
6_G179_M1.2450.97
36_T69_G1.2430.97
181_A233_I1.2310.97
306_S351_L1.2250.97
46_R60_H1.2240.97
36_T44_R1.2210.97
440_L459_C1.2200.97
17_I71_G1.2190.97
7_I204_E1.2150.96
12_P15_Q1.2140.96
447_V457_F1.2090.96
196_R204_E1.2000.96
423_V435_L1.2000.96
70_I171_V1.1980.96
279_M443_L1.1840.96
225_V231_I1.1820.96
293_D436_I1.1570.95
349_R352_N1.1530.95
360_D389_K1.1510.95
3_G32_A1.1470.95
309_I396_A1.1440.95
377_E429_I1.1420.95
267_I272_V1.1400.95
129_S132_L1.1380.95
399_E423_V1.1360.95
254_L459_C1.1350.95
307_C321_Y1.1280.95
2_C102_N1.1260.95
402_F413_A1.1240.94
32_A56_F1.1190.94
49_N82_S1.1150.94
106_T165_R1.1100.94
253_C404_N1.1010.94
425_E428_Q1.1010.94
274_S278_N1.0900.94
365_L393_L1.0900.94
6_G171_V1.0880.93
161_N168_Y1.0870.93
365_L383_A1.0860.93
364_L394_A1.0800.93
159_A162_R1.0780.93
314_A319_K1.0590.93
157_I180_V1.0580.92
5_V206_M1.0550.92
193_L222_L1.0520.92
30_D76_P1.0510.92
225_V238_Q1.0440.92
179_M233_I1.0440.92
294_L436_I1.0420.92
292_E295_D1.0420.92
158_A242_R1.0400.92
77_T102_N1.0320.92
182_F230_A1.0290.91
122_H134_N1.0250.91
252_P268_D1.0200.91
370_I393_L1.0190.91
93_S96_G1.0170.91
401_R464_G1.0160.91
394_A434_G1.0150.91
254_L443_L1.0150.91
223_R240_F1.0100.91
340_Q344_R1.0060.90
76_P81_S1.0050.90
238_Q241_T1.0000.90
157_I172_A1.0000.90
279_M396_A0.9980.90
186_N251_N0.9810.89
233_I238_Q0.9810.89
278_N282_K0.9750.89
384_R391_V0.9610.88
70_I173_M0.9570.88
5_V208_A0.9530.88
59_R63_R0.9460.88
418_A437_F0.9460.88
273_Y277_V0.9410.87
50_G56_F0.9390.87
325_F357_E0.9360.87
16_S196_R0.9350.87
139_E163_L0.9340.87
78_A126_T0.9300.87
81_S85_E0.9290.87
240_F243_Q0.9260.86
257_Y268_D0.9260.86
37_I40_N0.9200.86
20_A206_M0.9200.86
397_A462_F0.9190.86
376_S379_I0.9180.86
270_I278_N0.9180.86
114_K118_E0.9170.86
440_L443_L0.9160.86
4_I171_V0.9100.85
52_V56_F0.9090.85
5_V217_L0.9090.85
32_A73_V0.9060.85
93_S137_A0.9050.85
406_Y470_D0.9040.85
358_F388_A0.9010.85
250_S456_Q0.8990.85
404_N461_V0.8990.85
136_F160_T0.8980.85
172_A180_V0.8960.85
353_A358_F0.8930.84
107_N111_L0.8920.84
154_F239_L0.8900.84
7_I217_L0.8880.84
403_P412_S0.8870.84
359_R389_K0.8860.84
78_A104_N0.8800.83
74_R77_T0.8790.83
165_R469_K0.8790.83
14_N64_L0.8780.83
444_I457_F0.8760.83
311_L314_A0.8750.83
402_F464_G0.8740.83
141_D155_A0.8740.83
195_K205_Y0.8650.82
105_L125_T0.8600.82
139_E156_A0.8590.82
22_T349_R0.8580.82
442_D445_D0.8560.82
279_M438_Q0.8550.82
36_T66_G0.8520.81
341_Q345_K0.8460.81
379_I382_M0.8450.81
302_I379_I0.8390.80
110_E472_D0.8390.80
15_Q58_A0.8340.80
6_G181_A0.8330.80
55_V60_H0.8280.80
136_F157_I0.8280.80
85_E126_T0.8270.80
158_A162_R0.8230.79
91_V133_L0.8210.79
345_K349_R0.8200.79
413_A419_H0.8190.79
304_E307_C0.8150.79
136_F140_L0.8150.79
2_C77_T0.8140.78
223_R241_T0.8130.78
294_L319_K0.8010.77
61_M64_L0.7990.77
211_S265_S0.7980.77
77_T104_N0.7950.77
21_L71_G0.7880.76
132_L164_I0.7880.76
358_F363_V0.7880.76
400_I408_I0.7880.76
337_M346_S0.7860.76
16_S217_L0.7850.76
133_L137_A0.7810.75
89_F127_S0.7800.75
313_I364_L0.7790.75
3_G24_L0.7760.75
22_T53_S0.7750.75
296_I317_L0.7730.75
441_N445_D0.7680.74
388_A391_V0.7660.74
254_L258_V0.7660.74
86_A156_A0.7650.74
301_P327_K0.7630.74
8_A68_M0.7630.74
77_T260_F0.7610.74
186_N248_P0.7610.74
36_T64_L0.7580.73
106_T468_T0.7580.73
399_E461_V0.7570.73
8_A235_E0.7550.73
279_M447_V0.7540.73
206_M217_L0.7530.73
302_I325_F0.7530.73
211_S215_D0.7520.73
258_V400_I0.7510.73
8_A234_T0.7500.73
78_A108_A0.7490.72
458_E467_V0.7490.72
370_I395_S0.7480.72
423_V436_I0.7480.72
304_E323_Q0.7440.72
232_Y241_T0.7440.72
403_P410_M0.7440.72
157_I230_A0.7440.72
127_S132_L0.7430.72
10_V204_E0.7410.72
154_F232_Y0.7410.72
273_Y374_T0.7400.72
290_E436_I0.7360.71
47_K50_G0.7350.71
399_E437_F0.7330.71
5_V204_E0.7330.71
411_P415_E0.7320.71
44_R48_A0.7270.70
37_I68_M0.7250.70
328_N352_N0.7240.70
51_L54_D0.7220.70
70_I100_A0.7220.70
387_G391_V0.7210.70
164_I168_Y0.7200.69
51_L55_V0.7190.69
165_R470_D0.7190.69
52_V55_V0.7170.69
188_I406_Y0.7170.69
237_G240_F0.7130.69
157_I182_F0.7120.69
7_I206_M0.7100.68
15_Q19_D0.7100.68
427_R434_G0.7090.68
300_I363_V0.7070.68
112_R123_I0.7050.68
102_N260_F0.7040.68
292_E394_A0.7040.68
13_V69_G0.7040.68
153_I157_I0.7030.68
4_I191_L0.7000.67
74_R79_G0.6990.67
121_R138_S0.6990.67
12_P65_Q0.6970.67
292_E362_N0.6970.67
109_H113_K0.6970.67
181_A205_Y0.6960.67
154_F241_T0.6960.67
137_A255_F0.6910.66
294_L434_G0.6900.66
206_M219_F0.6900.66
275_A447_V0.6880.66
89_F124_N0.6860.66
337_M342_L0.6810.65
112_R116_F0.6800.65
22_T352_N0.6790.65
154_F230_A0.6770.65
168_Y244_C0.6770.65
165_R468_T0.6750.64
226_A250_S0.6750.64
30_D77_T0.6750.64
214_L217_L0.6730.64
279_M446_A0.6710.64
227_P404_N0.6700.64
262_R352_N0.6690.64
181_A222_L0.6690.64
151_D159_A0.6670.64
313_I317_L0.6670.64
398_P443_L0.6660.63
249_V456_Q0.6650.63
39_A67_N0.6640.63
161_N230_A0.6630.63
344_R378_Q0.6630.63
67_N235_E0.6630.63
196_R206_M0.6620.63
282_K446_A0.6610.63
279_M301_P0.6600.63
101_H129_S0.6590.63
13_V36_T0.6590.63
443_L446_A0.6580.62
444_I455_Q0.6550.62
2_C260_F0.6550.62
11_M67_N0.6550.62
167_A461_V0.6540.62
304_E326_V0.6540.62
41_N48_A0.6520.62
361_K437_F0.6510.62
233_I240_F0.6500.62
51_L56_F0.6500.62
14_N66_G0.6490.61
252_P301_P0.6480.61
232_Y239_L0.6480.61
37_I173_M0.6480.61
301_P323_Q0.6450.61
94_P117_E0.6440.61
298_V322_R0.6440.61
134_N137_A0.6430.61
285_E445_D0.6410.60
72_H102_N0.6400.60
97_I136_F0.6400.60
340_Q374_T0.6390.60
116_F120_R0.6370.60
188_I251_N0.6370.60
264_D328_N0.6340.60
167_A409_D0.6340.60
397_A400_I0.6340.60
120_R123_I0.6330.60
307_C329_R0.6330.60
264_D352_N0.6330.60
187_G227_P0.6330.60
378_Q382_M0.6320.59
391_V432_A0.6320.59
46_R56_F0.6300.59
444_I449_A0.6300.59
167_A188_I0.6300.59
442_D446_A0.6300.59
342_L345_K0.6290.59
254_L462_F0.6280.59
121_R134_N0.6260.59
12_P17_I0.6260.59
361_K417_I0.6260.59
294_L362_N0.6260.59
308_D354_N0.6250.59
77_T129_S0.6250.59
30_D338_P0.6250.59
208_A214_L0.6240.58
89_F125_T0.6240.58
304_E461_V0.6230.58
410_M416_L0.6220.58
216_T327_K0.6200.58
252_P267_I0.6200.58
216_T331_V0.6190.58
221_F266_F0.6190.58
58_A62_Q0.6180.58
252_P457_F0.6180.58
50_G54_D0.6180.58
131_I135_I0.6170.58
323_Q327_K0.6170.58
426_I430_I0.6170.58
299_V364_L0.6150.57
396_A415_E0.6140.57
79_G104_N0.6130.57
294_L392_Y0.6120.57
339_G342_L0.6110.57
48_A51_L0.6110.57
114_K117_E0.6090.57
197_D204_E0.6090.57
268_D329_R0.6090.57
171_V207_V0.6080.56
364_L436_I0.6080.56
49_N86_A0.6080.56
106_T188_I0.6080.56
271_S308_D0.6070.56
258_V443_L0.6070.56
443_L447_V0.6050.56
427_R430_I0.6050.56
50_G55_V0.6050.56
78_A81_S0.6040.56
344_R347_V0.6040.56
380_I391_V0.6020.56
460_S463_N0.6020.56
17_I36_T0.6020.56
363_V391_V0.6010.56
154_F158_A0.6000.55
100_A167_A0.6000.55
367_D395_S0.5990.55
226_A229_E0.5990.55
11_M341_Q0.5990.55
21_L73_V0.5960.55
125_T130_E0.5960.55
79_G102_N0.5960.55
262_R328_N0.5960.55
70_I219_F0.5950.55
38_D44_R0.5940.55
313_I394_A0.5930.55
356_A359_R0.5930.55
222_L380_I0.5920.54
118_E121_R0.5910.54
181_A193_L0.5910.54
311_L321_Y0.5910.54
251_N465_V0.5900.54
197_D220_D0.5890.54
48_A60_H0.5880.54
17_I217_L0.5880.54
155_A158_A0.5880.54
301_P329_R0.5870.54
353_A432_A0.5870.54
48_A56_F0.5860.54
10_V13_V0.5860.54
105_L132_L0.5850.54
20_A426_I0.5850.54
75_Y102_N0.5850.54
89_F415_E0.5850.54
18_Y396_A0.5840.53
438_Q442_D0.5840.53
96_G321_Y0.5830.53
183_R268_D0.5820.53
325_F358_F0.5810.53
20_A208_A0.5810.53
167_A460_S0.5800.53
133_L408_I0.5800.53
403_P413_A0.5800.53
110_E163_L0.5780.53
104_N409_D0.5780.53
134_N139_E0.5750.52
305_T312_E0.5750.52
127_S273_Y0.5740.52
158_A241_T0.5730.52
83_A86_A0.5730.52
23_V217_L0.5720.52
170_C255_F0.5710.52
294_L390_K0.5700.52
44_R225_V0.5700.52
188_I268_D0.5700.52
52_V59_R0.5690.52
302_I432_A0.5690.52
49_N85_E0.5690.52
21_L25_Q0.5690.52
257_Y267_I0.5680.51
70_I186_N0.5670.51
134_N140_L0.5660.51
96_G137_A0.5640.51
326_V354_N0.5630.51
154_F178_G0.5630.51
254_L440_L0.5620.51
300_I321_Y0.5610.51
319_K434_G0.5600.50
221_F224_D0.5600.50
319_K364_L0.5600.50
281_T312_E0.5590.50
9_G167_A0.5590.50
414_T420_G0.5570.50
293_D362_N0.5560.50
214_L221_F0.5560.50
277_V311_L0.5560.50
130_E134_N0.5550.50
22_T211_S0.5550.50
298_V324_G0.5540.50
136_F180_V0.5530.50
187_G253_C0.5520.49
380_I432_A0.5520.49
34_I64_L0.5510.49
162_R246_D0.5500.49
183_R255_F0.5500.49
376_S430_I0.5500.49
133_L329_R0.5500.49
307_C311_L0.5490.49
223_R226_A0.5480.49
130_E139_E0.5480.49
460_S467_V0.5470.49
72_H77_T0.5470.49
56_F66_G0.5460.49
250_S268_D0.5450.49
262_R334_T0.5450.49
105_L408_I0.5450.49
183_R187_G0.5440.48
30_D78_A0.5440.48
268_D327_K0.5440.48
251_N406_Y0.5430.48
325_F383_A0.5430.48
395_S436_I0.5430.48
332_G416_L0.5420.48
161_N243_Q0.5420.48
274_S277_V0.5410.48
38_D65_Q0.5410.48
129_S133_L0.5410.48
115_L123_I0.5410.48
258_V447_V0.5410.48
113_K247_N0.5410.48
446_A449_A0.5400.48
277_V281_T0.5400.48
351_L376_S0.5390.48
192_V268_D0.5380.48
351_L410_M0.5370.48
23_V215_D0.5360.47
7_I208_A0.5360.47
365_L380_I0.5360.47
99_L129_S0.5340.47
19_D342_L0.5340.47
182_F418_A0.5330.47
152_N359_R0.5330.47
401_R463_N0.5320.47
412_S419_H0.5320.47
140_L152_N0.5310.47
261_A267_I0.5310.47
60_H63_R0.5300.47
196_R219_F0.5300.47
78_A411_P0.5290.47
220_D355_R0.5290.47
76_P415_E0.5290.47
207_V225_V0.5290.47
56_F64_L0.5280.46
186_N249_V0.5280.46
390_K394_A0.5280.46
457_F462_F0.5280.46
110_E114_K0.5280.46
216_T349_R0.5280.46
445_D448_R0.5260.46
24_L214_L0.5260.46
205_Y238_Q0.5260.46
85_E127_S0.5260.46
22_T332_G0.5260.46
18_Y32_A0.5250.46
347_V351_L0.5240.46
254_L267_I0.5230.46
75_Y260_F0.5230.46
341_Q377_E0.5230.46
258_V448_R0.5230.46
47_K51_L0.5230.46
444_I456_Q0.5220.46
79_G128_D0.5220.46
48_A52_V0.5220.46
127_S131_I0.5220.46
230_A307_C0.5210.46
348_R385_E0.5200.45
308_D311_L0.5200.45
22_T328_N0.5190.45
270_I447_V0.5190.45
129_S260_F0.5190.45
5_V71_G0.5180.45
161_N164_I0.5180.45
140_L156_A0.5170.45
90_Y106_T0.5160.45
118_E159_A0.5160.45
451_N463_N0.5140.45
182_F357_E0.5140.45
315_R381_E0.5130.45
2_C72_H0.5130.45
296_I362_N0.5130.45
301_P321_Y0.5130.45
451_N465_V0.5110.44
30_D75_Y0.5110.44
377_E412_S0.5100.44
117_E141_D0.5080.44
152_N165_R0.5070.44
284_G317_L0.5070.44
460_S466_Y0.5070.44
403_P415_E0.5060.44
131_I138_S0.5050.44
248_P389_K0.5040.44
160_T164_I0.5040.44
306_S312_E0.5040.44
133_L327_K0.5040.44
31_A255_F0.5040.44
414_T419_H0.5020.43
266_F356_A0.5020.43
48_A54_D0.5020.43
18_Y349_R0.5020.43
337_M426_I0.5010.43
7_I175_I0.5010.43
300_I393_L0.5010.43
77_T128_D0.5000.43
180_V416_L0.5000.43
410_M419_H0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.9901 100 0.355 Contact Map
1ao0A 3 0.895 100 0.415 Contact Map
4amvA 2 0.897 100 0.744 Contact Map
1xffA 2 0.4673 100 0.746 Contact Map
1te5A 2 0.4416 100 0.753 Contact Map
3mdnA 4 0.396 100 0.767 Contact Map
1ofdA 1 0.9069 100 0.774 Contact Map
1ea0A 1 0.9287 100 0.778 Contact Map
1ct9A 2 0.7208 100 0.778 Contact Map
1jgtA 2 0.695 100 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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