GREMLIN Database
SOHB - Probable protease SohB
UniProt: P0AG14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10956
Length: 349 (332)
Sequences: 580 (387)
Seq/√Len: 21.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_D140_R5.5551.00
210_F236_L5.4921.00
7_Y16_T5.3681.00
224_H233_L5.2351.00
138_V171_T4.8751.00
22_A27_I4.5781.00
334_D340_W4.2381.00
270_D273_Q3.9631.00
103_V138_V3.9511.00
191_V300_V3.8451.00
192_S291_V3.8401.00
228_Q242_E3.8171.00
162_R188_D3.7111.00
273_Q288_K3.3681.00
221_I236_L3.3661.00
111_S115_H3.3561.00
291_V294_I3.2961.00
112_M147_M3.0200.99
147_M150_G2.8470.99
159_Q163_D2.8110.99
212_R220_D2.7760.99
159_Q265_M2.7240.99
233_L244_R2.4700.98
103_V171_T2.3030.96
262_V271_I2.2130.95
9_L12_A2.2000.95
224_H248_R2.1940.95
111_S116_E2.1680.95
210_F221_I2.1380.94
172_V198_V2.1310.94
204_V220_D2.1030.94
167_P189_K2.0770.93
131_F166_I2.0500.93
204_V221_I2.0080.92
254_T257_L1.9770.92
189_K293_E1.9760.92
224_H251_L1.9550.91
257_L281_Y1.9430.91
253_E284_Q1.9230.90
125_T302_L1.8800.89
250_E279_H1.8770.89
3_L30_N1.8760.89
75_Q78_K1.8300.88
15_V18_V1.7960.87
21_I24_I1.7610.86
121_R298_D1.7540.86
18_V24_I1.7490.86
22_A31_V1.7450.85
17_V21_I1.7380.85
136_Q300_V1.7240.85
78_K82_E1.7130.84
163_D281_Y1.7080.84
254_T281_Y1.6850.83
103_V304_L1.6850.83
23_A27_I1.6760.83
106_L127_V1.6350.81
268_S289_G1.6280.81
14_I20_A1.6140.81
204_V223_L1.5630.78
224_H242_E1.5570.78
156_S193_A1.5440.77
22_A26_A1.5430.77
46_N309_E1.5310.77
222_E244_R1.5250.77
201_I274_V1.4900.75
336_L340_W1.4900.75
149_H254_T1.4750.74
55_K59_A1.4730.74
25_A29_V1.4640.74
33_Q36_K1.4420.72
167_P188_D1.4360.72
207_M236_L1.4350.72
112_M115_H1.4060.70
23_A37_R1.4010.70
56_E59_A1.3940.70
165_N188_D1.3880.69
64_D67_Q1.3860.69
20_A29_V1.3700.68
17_V127_V1.3680.68
59_A71_W1.3610.68
305_M310_V1.3530.67
205_A247_F1.3530.67
136_Q169_T1.3410.67
69_K73_K1.3370.66
69_K76_K1.3180.65
103_V308_R1.3150.65
139_L161_L1.3070.65
149_H247_F1.2820.63
334_D339_R1.2750.63
215_K218_D1.2500.61
197_I279_H1.2490.61
295_N300_V1.2290.60
23_A127_V1.2180.59
14_I35_N1.2120.59
243_G262_V1.2090.58
5_S18_V1.2090.58
11_L32_A1.2040.58
12_A16_T1.2010.58
204_V251_L1.1990.58
42_L58_L1.1840.57
304_L308_R1.1780.56
11_L16_T1.1750.56
176_A180_G1.1600.55
62_L102_R1.1510.55
73_K80_K1.1400.54
191_V295_N1.1380.54
7_Y11_L1.1370.54
31_V337_L1.1320.53
44_V64_D1.1310.53
332_S336_L1.1200.53
15_V20_A1.1110.52
281_Y294_I1.1010.51
150_G174_K1.1000.51
18_V27_I1.0990.51
107_D312_N1.0950.51
11_L15_V1.0950.51
103_V310_V1.0760.50
43_R50_Q1.0750.50
210_F235_L1.0730.49
52_K56_E1.0730.49
100_K309_E1.0710.49
65_S68_Q1.0600.49
3_L294_I1.0560.48
13_K16_T1.0530.48
138_V308_R1.0520.48
224_H244_R1.0510.48
148_V275_A1.0480.48
56_E75_Q1.0430.47
279_H288_K1.0420.47
257_L282_G1.0350.47
20_A32_A1.0340.47
7_Y12_A1.0200.46
9_L13_K1.0170.46
63_M68_Q1.0140.45
24_I31_V1.0120.45
62_L104_W1.0080.45
283_Q286_V1.0060.45
138_V304_L1.0000.45
21_I35_N0.9920.44
12_A20_A0.9840.44
264_R283_Q0.9820.43
14_I17_V0.9790.43
248_R252_N0.9690.43
170_V190_I0.9630.42
20_A24_I0.9630.42
36_K48_S0.9600.42
8_G31_V0.9560.42
156_S261_F0.9540.42
197_I284_Q0.9530.41
143_S151_Y0.9510.41
19_L95_V0.9500.41
3_L13_K0.9470.41
15_V19_L0.9460.41
190_I310_V0.9430.41
38_Q144_P0.9390.41
18_V37_R0.9380.41
134_Q164_K0.9300.40
27_I328_S0.9300.40
147_M197_I0.9290.40
103_V150_G0.9250.40
8_G25_A0.9230.40
204_V229_Y0.9190.39
27_I30_N0.9180.39
219_I310_V0.9180.39
231_R237_G0.9180.39
272_E306_E0.9130.39
11_L139_L0.9130.39
79_H83_A0.9120.39
254_T282_G0.9110.39
52_K189_K0.9090.39
27_I31_V0.9080.39
279_H284_Q0.9050.38
116_E147_M0.9050.38
106_L312_N0.9050.38
164_K306_E0.9050.38
326_T330_A0.9030.38
152_G297_S0.9030.38
284_Q288_K0.9000.38
165_N219_I0.8980.38
18_V29_V0.8980.38
128_L161_L0.8930.38
149_H174_K0.8910.38
173_D297_S0.8900.37
71_W74_A0.8820.37
154_A257_L0.8800.37
121_R156_S0.8800.37
103_V191_V0.8760.37
102_R309_E0.8740.36
327_G333_A0.8670.36
251_L281_Y0.8660.36
106_L139_L0.8650.36
25_A28_I0.8570.35
52_K262_V0.8560.35
63_M66_H0.8480.35
60_A139_L0.8400.34
157_Q298_D0.8360.34
21_I170_V0.8360.34
224_H282_G0.8360.34
45_N312_N0.8350.34
2_E6_E0.8340.34
19_L70_Q0.8310.34
228_Q281_Y0.8280.34
30_N34_R0.8200.33
7_Y139_L0.8150.33
13_K210_F0.8150.33
52_K124_I0.8120.33
2_E164_K0.8090.33
122_E187_A0.8070.32
75_Q79_H0.8070.32
254_T261_F0.7990.32
325_F337_L0.7940.32
24_I166_I0.7930.32
330_A335_R0.7900.31
5_S11_L0.7870.31
15_V26_A0.7850.31
67_Q72_H0.7850.31
22_A37_R0.7850.31
5_S103_V0.7840.31
134_Q166_I0.7840.31
60_A68_Q0.7820.31
76_K80_K0.7820.31
74_A78_K0.7800.31
239_N244_R0.7800.31
198_V291_V0.7790.31
198_V250_E0.7790.31
135_D231_R0.7780.31
144_P182_M0.7760.31
49_E55_K0.7750.31
6_E14_I0.7740.31
51_Y129_A0.7730.30
252_N256_Q0.7720.30
30_N60_A0.7660.30
69_K80_K0.7650.30
45_N66_H0.7640.30
124_I139_L0.7640.30
6_E28_I0.7610.30
9_L122_E0.7600.30
26_A33_Q0.7590.30
81_Q85_A0.7560.30
43_R64_D0.7550.29
31_V37_R0.7530.29
25_A31_V0.7530.29
23_A26_A0.7520.29
173_D237_G0.7500.29
21_I34_R0.7450.29
27_I52_K0.7430.29
29_V34_R0.7410.29
60_A163_D0.7380.29
205_A243_G0.7380.29
62_L311_V0.7360.28
144_P223_L0.7350.28
289_G320_R0.7350.28
127_V313_V0.7340.28
6_E102_R0.7330.28
15_V29_V0.7330.28
291_V333_A0.7320.28
187_A191_V0.7310.28
6_E13_K0.7290.28
295_N299_E0.7260.28
30_N216_S0.7240.28
121_R157_Q0.7220.28
80_K84_K0.7220.28
222_E239_N0.7200.28
14_I23_A0.7200.28
287_E307_G0.7190.28
60_A63_M0.7180.27
48_S113_D0.7170.27
25_A33_Q0.7170.27
2_E21_I0.7160.27
150_G197_I0.7110.27
299_E302_L0.7110.27
35_N43_R0.7070.27
162_R233_L0.7070.27
19_L56_E0.7050.27
191_V293_E0.7030.27
28_I49_E0.7020.27
6_E62_L0.6980.26
176_A209_N0.6970.26
40_G315_Y0.6970.26
9_L16_T0.6960.26
28_I293_E0.6960.26
58_L127_V0.6920.26
205_A238_E0.6920.26
116_E315_Y0.6910.26
225_T251_L0.6910.26
4_L8_G0.6900.26
25_A83_A0.6900.26
164_K313_V0.6890.26
14_I295_N0.6890.26
253_E299_E0.6890.26
144_P212_R0.6880.26
43_R228_Q0.6870.26
207_M244_R0.6860.26
185_C257_L0.6850.26
24_I27_I0.6840.26
253_E289_G0.6840.26
145_G277_G0.6790.25
18_V21_I0.6780.25
67_Q71_W0.6710.25
185_C262_V0.6650.25
217_K274_V0.6630.25
146_G258_F0.6620.25
178_S258_F0.6620.25
146_G178_S0.6620.25
178_S200_S0.6610.25
146_G200_S0.6610.25
200_S258_F0.6610.25
156_S195_F0.6600.24
145_G200_S0.6590.24
200_S277_G0.6590.24
15_V44_V0.6580.24
242_E324_R0.6570.24
146_G199_G0.6550.24
178_S199_G0.6550.24
199_G258_F0.6550.24
163_D229_Y0.6540.24
179_G280_W0.6530.24
220_D235_L0.6500.24
17_V26_A0.6490.24
135_D183_M0.6490.24
300_V304_L0.6470.24
258_F277_G0.6470.24
178_S277_G0.6470.24
146_G277_G0.6470.24
145_G178_S0.6470.24
145_G258_F0.6470.24
21_I25_A0.6440.24
145_G199_G0.6410.24
199_G277_G0.6410.24
139_L240_T0.6400.24
31_V35_N0.6400.24
210_F223_L0.6380.23
53_E56_E0.6380.23
24_I60_A0.6370.23
3_L36_K0.6370.23
152_G255_H0.6370.23
338_L341_W0.6360.23
63_M67_Q0.6330.23
4_L15_V0.6320.23
15_V159_Q0.6300.23
4_L106_L0.6270.23
25_A95_V0.6230.23
29_V55_K0.6230.23
98_D321_L0.6220.23
166_I294_I0.6220.23
18_V23_A0.6210.23
260_D284_Q0.6200.23
150_G155_A0.6180.22
112_M235_L0.6170.22
22_A284_Q0.6160.22
171_T304_L0.6160.22
137_V184_A0.6140.22
224_H229_Y0.6140.22
48_S111_S0.6140.22
322_I326_T0.6100.22
229_Y272_E0.6100.22
18_V39_R0.6090.22
200_S266_R0.6090.22
178_S266_R0.6090.22
146_G266_R0.6090.22
258_F266_R0.6090.22
9_L186_V0.6080.22
222_E236_L0.6080.22
17_V22_A0.6070.22
151_Y247_F0.6060.22
12_A122_E0.6050.22
113_D116_E0.6040.22
254_T284_Q0.6040.22
5_S30_N0.6030.22
199_G266_R0.6020.22
108_F214_L0.6010.22
12_A210_F0.6000.22
152_G195_F0.5960.21
145_G266_R0.5940.21
266_R277_G0.5940.21
48_S150_G0.5920.21
225_T237_G0.5920.21
29_V51_Y0.5910.21
19_L23_A0.5910.21
106_L314_R0.5900.21
148_V158_L0.5860.21
32_A35_N0.5860.21
3_L32_A0.5850.21
165_N189_K0.5850.21
152_G160_R0.5830.21
117_V324_R0.5810.21
108_F152_G0.5810.21
188_D323_D0.5810.21
152_G180_G0.5790.21
331_E334_D0.5780.21
165_N335_R0.5770.21
73_K149_H0.5760.21
79_H82_E0.5760.21
142_E206_Q0.5740.20
25_A339_R0.5730.20
269_L289_G0.5720.20
54_M70_Q0.5720.20
33_Q41_E0.5710.20
72_H324_R0.5710.20
164_K265_M0.5710.20
65_S78_K0.5700.20
14_I31_V0.5690.20
279_H299_E0.5690.20
301_I310_V0.5680.20
39_R50_Q0.5680.20
204_V212_R0.5680.20
228_Q236_L0.5680.20
43_R241_E0.5660.20
174_K185_C0.5640.20
3_L9_L0.5630.20
26_A30_N0.5630.20
195_F296_T0.5600.20
22_A29_V0.5600.20
102_R305_M0.5600.20
5_S32_A0.5590.20
39_R316_M0.5590.20
184_A297_S0.5590.20
22_A32_A0.5590.20
126_A131_F0.5590.20
147_M315_Y0.5590.20
38_Q45_N0.5590.20
14_I301_I0.5570.20
242_E252_N0.5560.20
4_L26_A0.5550.20
36_K303_S0.5550.20
320_R327_G0.5540.20
41_E70_Q0.5530.20
14_I38_Q0.5530.20
211_N215_K0.5530.20
41_E48_S0.5510.20
2_E19_L0.5500.19
149_H185_C0.5490.19
251_L269_L0.5490.19
97_T306_E0.5480.19
32_A42_L0.5470.19
53_E166_I0.5470.19
36_K41_E0.5460.19
28_I32_A0.5460.19
250_E278_E0.5450.19
151_Y250_E0.5440.19
39_R56_E0.5430.19
35_N44_V0.5420.19
14_I29_V0.5420.19
3_L52_K0.5410.19
44_V302_L0.5410.19
215_K219_I0.5410.19
162_R187_A0.5410.19
251_L255_H0.5400.19
2_E52_K0.5390.19
123_E151_Y0.5380.19
70_Q189_K0.5370.19
123_E127_V0.5360.19
17_V48_S0.5350.19
4_L107_D0.5350.19
151_Y183_M0.5350.19
222_E233_L0.5340.19
219_I291_V0.5330.19
27_I59_A0.5320.19
3_L144_P0.5290.19
322_I327_G0.5280.19
243_G326_T0.5240.18
14_I24_I0.5230.18
108_F195_F0.5210.18
5_S289_G0.5210.18
22_A62_L0.5200.18
152_G225_T0.5190.18
26_A29_V0.5190.18
113_D250_E0.5190.18
24_I306_E0.5180.18
28_I39_R0.5180.18
124_I170_V0.5170.18
187_A325_F0.5170.18
49_E81_Q0.5160.18
232_T246_K0.5150.18
155_A316_M0.5140.18
20_A23_A0.5130.18
22_A38_Q0.5120.18
21_I328_S0.5120.18
151_Y208_P0.5110.18
128_L341_W0.5100.18
273_Q320_R0.5100.18
41_E50_Q0.5100.18
173_D255_H0.5080.18
172_V322_I0.5080.18
195_F208_P0.5080.18
7_Y167_P0.5070.18
162_R265_M0.5060.18
32_A50_Q0.5060.18
337_L341_W0.5060.18
205_A246_K0.5040.18
31_V133_P0.5040.18
22_A25_A0.5030.18
58_L207_M0.5020.18
152_G173_D0.5010.17
50_Q82_E0.5010.17
219_I329_A0.5000.17
66_H312_N0.5000.17
148_V196_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bf0A 3 0.8338 100 0.601 Contact Map
4kwbA 5 0.6476 100 0.674 Contact Map
3rstA 3 0.6246 100 0.684 Contact Map
3vivA 2 0.5616 99.9 0.787 Contact Map
4gm2A 3 0.4756 99.9 0.791 Contact Map
2f6iA 5 0.5072 99.9 0.799 Contact Map
3p2lA 4 0.5272 99.9 0.803 Contact Map
2cbyA 3 0.467 99.9 0.81 Contact Map
1yg6A 4 0.533 99.9 0.81 Contact Map
4u0gA 4 0.5473 99.9 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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