SOHB - ECOLI - GREMLIN Contacts

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SOHB - Probable protease SohB

UniProt:	P0AG14	Sequences: MELLSEYGLFLAKIVTVVLAIAAIAAIIVNVAQRNKRQRGELRVNNLSEQYKEMKEELAAALMDSHQQKQWHKAQKKKHKQEAKAAKAKAKLGEVATDSKPRVWVLDFKGSMDAHEVNSLREEITAVLAAFKPQDQVVLRLESPGGMVHGYGLAASQLQRLRDKNIPLTVTVDKVAASGGYMMACVADKIVSAPFAIVGSIGVVAQMPNFNRFLKSKDIDIELHTAGQYKRTLTLLGENTEEGREKFREELNETHQLFKDFVKRMRPSLDIEQVATGEHWYGQQAVEKGLVDEINTSDEVILSLMEGREVVNVRYMQRKRLIDRFTGSAAESADRLLLRWWQRGQKPLM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10956
Length:	349 (332)
Sequences:	580 (387)
Seq/√Len:	21.2

ECOLI - SOHB SPPA
BACSU - SPPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_D	140_R	5.555	1.00
210_F	236_L	5.492	1.00
7_Y	16_T	5.368	1.00
224_H	233_L	5.235	1.00
138_V	171_T	4.875	1.00
22_A	27_I	4.578	1.00
334_D	340_W	4.238	1.00
270_D	273_Q	3.963	1.00
103_V	138_V	3.951	1.00
191_V	300_V	3.845	1.00
192_S	291_V	3.840	1.00
228_Q	242_E	3.817	1.00
162_R	188_D	3.711	1.00
273_Q	288_K	3.368	1.00
221_I	236_L	3.366	1.00
111_S	115_H	3.356	1.00
291_V	294_I	3.296	1.00
112_M	147_M	3.020	0.99
147_M	150_G	2.847	0.99
159_Q	163_D	2.811	0.99
212_R	220_D	2.776	0.99
159_Q	265_M	2.724	0.99
233_L	244_R	2.470	0.98
103_V	171_T	2.303	0.96
262_V	271_I	2.213	0.95
9_L	12_A	2.200	0.95
224_H	248_R	2.194	0.95
111_S	116_E	2.168	0.95
210_F	221_I	2.138	0.94
172_V	198_V	2.131	0.94
204_V	220_D	2.103	0.94
167_P	189_K	2.077	0.93
131_F	166_I	2.050	0.93
204_V	221_I	2.008	0.92
254_T	257_L	1.977	0.92
189_K	293_E	1.976	0.92
224_H	251_L	1.955	0.91
257_L	281_Y	1.943	0.91
253_E	284_Q	1.923	0.90
125_T	302_L	1.880	0.89
250_E	279_H	1.877	0.89
3_L	30_N	1.876	0.89
75_Q	78_K	1.830	0.88
15_V	18_V	1.796	0.87
21_I	24_I	1.761	0.86
121_R	298_D	1.754	0.86
18_V	24_I	1.749	0.86
22_A	31_V	1.745	0.85
17_V	21_I	1.738	0.85
136_Q	300_V	1.724	0.85
78_K	82_E	1.713	0.84
163_D	281_Y	1.708	0.84
254_T	281_Y	1.685	0.83
103_V	304_L	1.685	0.83
23_A	27_I	1.676	0.83
106_L	127_V	1.635	0.81
268_S	289_G	1.628	0.81
14_I	20_A	1.614	0.81
204_V	223_L	1.563	0.78
224_H	242_E	1.557	0.78
156_S	193_A	1.544	0.77
22_A	26_A	1.543	0.77
46_N	309_E	1.531	0.77
222_E	244_R	1.525	0.77
201_I	274_V	1.490	0.75
336_L	340_W	1.490	0.75
149_H	254_T	1.475	0.74
55_K	59_A	1.473	0.74
25_A	29_V	1.464	0.74
33_Q	36_K	1.442	0.72
167_P	188_D	1.436	0.72
207_M	236_L	1.435	0.72
112_M	115_H	1.406	0.70
23_A	37_R	1.401	0.70
56_E	59_A	1.394	0.70
165_N	188_D	1.388	0.69
64_D	67_Q	1.386	0.69
20_A	29_V	1.370	0.68
17_V	127_V	1.368	0.68
59_A	71_W	1.361	0.68
305_M	310_V	1.353	0.67
205_A	247_F	1.353	0.67
136_Q	169_T	1.341	0.67
69_K	73_K	1.337	0.66
69_K	76_K	1.318	0.65
103_V	308_R	1.315	0.65
139_L	161_L	1.307	0.65
149_H	247_F	1.282	0.63
334_D	339_R	1.275	0.63
215_K	218_D	1.250	0.61
197_I	279_H	1.249	0.61
295_N	300_V	1.229	0.60
23_A	127_V	1.218	0.59
14_I	35_N	1.212	0.59
243_G	262_V	1.209	0.58
5_S	18_V	1.209	0.58
11_L	32_A	1.204	0.58
12_A	16_T	1.201	0.58
204_V	251_L	1.199	0.58
42_L	58_L	1.184	0.57
304_L	308_R	1.178	0.56
11_L	16_T	1.175	0.56
176_A	180_G	1.160	0.55
62_L	102_R	1.151	0.55
73_K	80_K	1.140	0.54
191_V	295_N	1.138	0.54
7_Y	11_L	1.137	0.54
31_V	337_L	1.132	0.53
44_V	64_D	1.131	0.53
332_S	336_L	1.120	0.53
15_V	20_A	1.111	0.52
281_Y	294_I	1.101	0.51
150_G	174_K	1.100	0.51
18_V	27_I	1.099	0.51
107_D	312_N	1.095	0.51
11_L	15_V	1.095	0.51
103_V	310_V	1.076	0.50
43_R	50_Q	1.075	0.50
210_F	235_L	1.073	0.49
52_K	56_E	1.073	0.49
100_K	309_E	1.071	0.49
65_S	68_Q	1.060	0.49
3_L	294_I	1.056	0.48
13_K	16_T	1.053	0.48
138_V	308_R	1.052	0.48
224_H	244_R	1.051	0.48
148_V	275_A	1.048	0.48
56_E	75_Q	1.043	0.47
279_H	288_K	1.042	0.47
257_L	282_G	1.035	0.47
20_A	32_A	1.034	0.47
7_Y	12_A	1.020	0.46
9_L	13_K	1.017	0.46
63_M	68_Q	1.014	0.45
24_I	31_V	1.012	0.45
62_L	104_W	1.008	0.45
283_Q	286_V	1.006	0.45
138_V	304_L	1.000	0.45
21_I	35_N	0.992	0.44
12_A	20_A	0.984	0.44
264_R	283_Q	0.982	0.43
14_I	17_V	0.979	0.43
248_R	252_N	0.969	0.43
170_V	190_I	0.963	0.42
20_A	24_I	0.963	0.42
36_K	48_S	0.960	0.42
8_G	31_V	0.956	0.42
156_S	261_F	0.954	0.42
197_I	284_Q	0.953	0.41
143_S	151_Y	0.951	0.41
19_L	95_V	0.950	0.41
3_L	13_K	0.947	0.41
15_V	19_L	0.946	0.41
190_I	310_V	0.943	0.41
38_Q	144_P	0.939	0.41
18_V	37_R	0.938	0.41
134_Q	164_K	0.930	0.40
27_I	328_S	0.930	0.40
147_M	197_I	0.929	0.40
103_V	150_G	0.925	0.40
8_G	25_A	0.923	0.40
204_V	229_Y	0.919	0.39
27_I	30_N	0.918	0.39
219_I	310_V	0.918	0.39
231_R	237_G	0.918	0.39
272_E	306_E	0.913	0.39
11_L	139_L	0.913	0.39
79_H	83_A	0.912	0.39
254_T	282_G	0.911	0.39
52_K	189_K	0.909	0.39
27_I	31_V	0.908	0.39
279_H	284_Q	0.905	0.38
116_E	147_M	0.905	0.38
106_L	312_N	0.905	0.38
164_K	306_E	0.905	0.38
326_T	330_A	0.903	0.38
152_G	297_S	0.903	0.38
284_Q	288_K	0.900	0.38
165_N	219_I	0.898	0.38
18_V	29_V	0.898	0.38
128_L	161_L	0.893	0.38
149_H	174_K	0.891	0.38
173_D	297_S	0.890	0.37
71_W	74_A	0.882	0.37
154_A	257_L	0.880	0.37
121_R	156_S	0.880	0.37
103_V	191_V	0.876	0.37
102_R	309_E	0.874	0.36
327_G	333_A	0.867	0.36
251_L	281_Y	0.866	0.36
106_L	139_L	0.865	0.36
25_A	28_I	0.857	0.35
52_K	262_V	0.856	0.35
63_M	66_H	0.848	0.35
60_A	139_L	0.840	0.34
157_Q	298_D	0.836	0.34
21_I	170_V	0.836	0.34
224_H	282_G	0.836	0.34
45_N	312_N	0.835	0.34
2_E	6_E	0.834	0.34
19_L	70_Q	0.831	0.34
228_Q	281_Y	0.828	0.34
30_N	34_R	0.820	0.33
7_Y	139_L	0.815	0.33
13_K	210_F	0.815	0.33
52_K	124_I	0.812	0.33
2_E	164_K	0.809	0.33
122_E	187_A	0.807	0.32
75_Q	79_H	0.807	0.32
254_T	261_F	0.799	0.32
325_F	337_L	0.794	0.32
24_I	166_I	0.793	0.32
330_A	335_R	0.790	0.31
5_S	11_L	0.787	0.31
15_V	26_A	0.785	0.31
67_Q	72_H	0.785	0.31
22_A	37_R	0.785	0.31
5_S	103_V	0.784	0.31
134_Q	166_I	0.784	0.31
60_A	68_Q	0.782	0.31
76_K	80_K	0.782	0.31
74_A	78_K	0.780	0.31
239_N	244_R	0.780	0.31
198_V	291_V	0.779	0.31
198_V	250_E	0.779	0.31
135_D	231_R	0.778	0.31
144_P	182_M	0.776	0.31
49_E	55_K	0.775	0.31
6_E	14_I	0.774	0.31
51_Y	129_A	0.773	0.30
252_N	256_Q	0.772	0.30
30_N	60_A	0.766	0.30
69_K	80_K	0.765	0.30
45_N	66_H	0.764	0.30
124_I	139_L	0.764	0.30
6_E	28_I	0.761	0.30
9_L	122_E	0.760	0.30
26_A	33_Q	0.759	0.30
81_Q	85_A	0.756	0.30
43_R	64_D	0.755	0.29
31_V	37_R	0.753	0.29
25_A	31_V	0.753	0.29
23_A	26_A	0.752	0.29
173_D	237_G	0.750	0.29
21_I	34_R	0.745	0.29
27_I	52_K	0.743	0.29
29_V	34_R	0.741	0.29
60_A	163_D	0.738	0.29
205_A	243_G	0.738	0.29
62_L	311_V	0.736	0.28
144_P	223_L	0.735	0.28
289_G	320_R	0.735	0.28
127_V	313_V	0.734	0.28
6_E	102_R	0.733	0.28
15_V	29_V	0.733	0.28
291_V	333_A	0.732	0.28
187_A	191_V	0.731	0.28
6_E	13_K	0.729	0.28
295_N	299_E	0.726	0.28
30_N	216_S	0.724	0.28
121_R	157_Q	0.722	0.28
80_K	84_K	0.722	0.28
222_E	239_N	0.720	0.28
14_I	23_A	0.720	0.28
287_E	307_G	0.719	0.28
60_A	63_M	0.718	0.27
48_S	113_D	0.717	0.27
25_A	33_Q	0.717	0.27
2_E	21_I	0.716	0.27
150_G	197_I	0.711	0.27
299_E	302_L	0.711	0.27
35_N	43_R	0.707	0.27
162_R	233_L	0.707	0.27
19_L	56_E	0.705	0.27
191_V	293_E	0.703	0.27
28_I	49_E	0.702	0.27
6_E	62_L	0.698	0.26
176_A	209_N	0.697	0.26
40_G	315_Y	0.697	0.26
9_L	16_T	0.696	0.26
28_I	293_E	0.696	0.26
58_L	127_V	0.692	0.26
205_A	238_E	0.692	0.26
116_E	315_Y	0.691	0.26
225_T	251_L	0.691	0.26
4_L	8_G	0.690	0.26
25_A	83_A	0.690	0.26
164_K	313_V	0.689	0.26
14_I	295_N	0.689	0.26
253_E	299_E	0.689	0.26
144_P	212_R	0.688	0.26
43_R	228_Q	0.687	0.26
207_M	244_R	0.686	0.26
185_C	257_L	0.685	0.26
24_I	27_I	0.684	0.26
253_E	289_G	0.684	0.26
145_G	277_G	0.679	0.25
18_V	21_I	0.678	0.25
67_Q	71_W	0.671	0.25
185_C	262_V	0.665	0.25
217_K	274_V	0.663	0.25
146_G	258_F	0.662	0.25
178_S	258_F	0.662	0.25
146_G	178_S	0.662	0.25
178_S	200_S	0.661	0.25
146_G	200_S	0.661	0.25
200_S	258_F	0.661	0.25
156_S	195_F	0.660	0.24
145_G	200_S	0.659	0.24
200_S	277_G	0.659	0.24
15_V	44_V	0.658	0.24
242_E	324_R	0.657	0.24
146_G	199_G	0.655	0.24
178_S	199_G	0.655	0.24
199_G	258_F	0.655	0.24
163_D	229_Y	0.654	0.24
179_G	280_W	0.653	0.24
220_D	235_L	0.650	0.24
17_V	26_A	0.649	0.24
135_D	183_M	0.649	0.24
300_V	304_L	0.647	0.24
258_F	277_G	0.647	0.24
178_S	277_G	0.647	0.24
146_G	277_G	0.647	0.24
145_G	178_S	0.647	0.24
145_G	258_F	0.647	0.24
21_I	25_A	0.644	0.24
145_G	199_G	0.641	0.24
199_G	277_G	0.641	0.24
139_L	240_T	0.640	0.24
31_V	35_N	0.640	0.24
210_F	223_L	0.638	0.23
53_E	56_E	0.638	0.23
24_I	60_A	0.637	0.23
3_L	36_K	0.637	0.23
152_G	255_H	0.637	0.23
338_L	341_W	0.636	0.23
63_M	67_Q	0.633	0.23
4_L	15_V	0.632	0.23
15_V	159_Q	0.630	0.23
4_L	106_L	0.627	0.23
25_A	95_V	0.623	0.23
29_V	55_K	0.623	0.23
98_D	321_L	0.622	0.23
166_I	294_I	0.622	0.23
18_V	23_A	0.621	0.23
260_D	284_Q	0.620	0.23
150_G	155_A	0.618	0.22
112_M	235_L	0.617	0.22
22_A	284_Q	0.616	0.22
171_T	304_L	0.616	0.22
137_V	184_A	0.614	0.22
224_H	229_Y	0.614	0.22
48_S	111_S	0.614	0.22
322_I	326_T	0.610	0.22
229_Y	272_E	0.610	0.22
18_V	39_R	0.609	0.22
200_S	266_R	0.609	0.22
178_S	266_R	0.609	0.22
146_G	266_R	0.609	0.22
258_F	266_R	0.609	0.22
9_L	186_V	0.608	0.22
222_E	236_L	0.608	0.22
17_V	22_A	0.607	0.22
151_Y	247_F	0.606	0.22
12_A	122_E	0.605	0.22
113_D	116_E	0.604	0.22
254_T	284_Q	0.604	0.22
5_S	30_N	0.603	0.22
199_G	266_R	0.602	0.22
108_F	214_L	0.601	0.22
12_A	210_F	0.600	0.22
152_G	195_F	0.596	0.21
145_G	266_R	0.594	0.21
266_R	277_G	0.594	0.21
48_S	150_G	0.592	0.21
225_T	237_G	0.592	0.21
29_V	51_Y	0.591	0.21
19_L	23_A	0.591	0.21
106_L	314_R	0.590	0.21
148_V	158_L	0.586	0.21
32_A	35_N	0.586	0.21
3_L	32_A	0.585	0.21
165_N	189_K	0.585	0.21
152_G	160_R	0.583	0.21
117_V	324_R	0.581	0.21
108_F	152_G	0.581	0.21
188_D	323_D	0.581	0.21
152_G	180_G	0.579	0.21
331_E	334_D	0.578	0.21
165_N	335_R	0.577	0.21
73_K	149_H	0.576	0.21
79_H	82_E	0.576	0.21
142_E	206_Q	0.574	0.20
25_A	339_R	0.573	0.20
269_L	289_G	0.572	0.20
54_M	70_Q	0.572	0.20
33_Q	41_E	0.571	0.20
72_H	324_R	0.571	0.20
164_K	265_M	0.571	0.20
65_S	78_K	0.570	0.20
14_I	31_V	0.569	0.20
279_H	299_E	0.569	0.20
301_I	310_V	0.568	0.20
39_R	50_Q	0.568	0.20
204_V	212_R	0.568	0.20
228_Q	236_L	0.568	0.20
43_R	241_E	0.566	0.20
174_K	185_C	0.564	0.20
3_L	9_L	0.563	0.20
26_A	30_N	0.563	0.20
195_F	296_T	0.560	0.20
22_A	29_V	0.560	0.20
102_R	305_M	0.560	0.20
5_S	32_A	0.559	0.20
39_R	316_M	0.559	0.20
184_A	297_S	0.559	0.20
22_A	32_A	0.559	0.20
126_A	131_F	0.559	0.20
147_M	315_Y	0.559	0.20
38_Q	45_N	0.559	0.20
14_I	301_I	0.557	0.20
242_E	252_N	0.556	0.20
4_L	26_A	0.555	0.20
36_K	303_S	0.555	0.20
320_R	327_G	0.554	0.20
41_E	70_Q	0.553	0.20
14_I	38_Q	0.553	0.20
211_N	215_K	0.553	0.20
41_E	48_S	0.551	0.20
2_E	19_L	0.550	0.19
149_H	185_C	0.549	0.19
251_L	269_L	0.549	0.19
97_T	306_E	0.548	0.19
32_A	42_L	0.547	0.19
53_E	166_I	0.547	0.19
36_K	41_E	0.546	0.19
28_I	32_A	0.546	0.19
250_E	278_E	0.545	0.19
151_Y	250_E	0.544	0.19
39_R	56_E	0.543	0.19
35_N	44_V	0.542	0.19
14_I	29_V	0.542	0.19
3_L	52_K	0.541	0.19
44_V	302_L	0.541	0.19
215_K	219_I	0.541	0.19
162_R	187_A	0.541	0.19
251_L	255_H	0.540	0.19
2_E	52_K	0.539	0.19
123_E	151_Y	0.538	0.19
70_Q	189_K	0.537	0.19
123_E	127_V	0.536	0.19
17_V	48_S	0.535	0.19
4_L	107_D	0.535	0.19
151_Y	183_M	0.535	0.19
222_E	233_L	0.534	0.19
219_I	291_V	0.533	0.19
27_I	59_A	0.532	0.19
3_L	144_P	0.529	0.19
322_I	327_G	0.528	0.19
243_G	326_T	0.524	0.18
14_I	24_I	0.523	0.18
108_F	195_F	0.521	0.18
5_S	289_G	0.521	0.18
22_A	62_L	0.520	0.18
152_G	225_T	0.519	0.18
26_A	29_V	0.519	0.18
113_D	250_E	0.519	0.18
24_I	306_E	0.518	0.18
28_I	39_R	0.518	0.18
124_I	170_V	0.517	0.18
187_A	325_F	0.517	0.18
49_E	81_Q	0.516	0.18
232_T	246_K	0.515	0.18
155_A	316_M	0.514	0.18
20_A	23_A	0.513	0.18
22_A	38_Q	0.512	0.18
21_I	328_S	0.512	0.18
151_Y	208_P	0.511	0.18
128_L	341_W	0.510	0.18
273_Q	320_R	0.510	0.18
41_E	50_Q	0.510	0.18
173_D	255_H	0.508	0.18
172_V	322_I	0.508	0.18
195_F	208_P	0.508	0.18
7_Y	167_P	0.507	0.18
162_R	265_M	0.506	0.18
32_A	50_Q	0.506	0.18
337_L	341_W	0.506	0.18
205_A	246_K	0.504	0.18
31_V	133_P	0.504	0.18
22_A	25_A	0.503	0.18
58_L	207_M	0.502	0.18
152_G	173_D	0.501	0.17
50_Q	82_E	0.501	0.17
219_I	329_A	0.500	0.17
66_H	312_N	0.500	0.17
148_V	196_A	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bf0A	3	0.8338	100	0.601	Contact Map
4kwbA	5	0.6476	100	0.674	Contact Map
3rstA	3	0.6246	100	0.684	Contact Map
3vivA	2	0.5616	99.9	0.787	Contact Map
4gm2A	3	0.4756	99.9	0.791	Contact Map
2f6iA	5	0.5072	99.9	0.799	Contact Map
3p2lA	4	0.5272	99.9	0.803	Contact Map
2cbyA	3	0.467	99.9	0.81	Contact Map
1yg6A	4	0.533	99.9	0.81	Contact Map
4u0gA	4	0.5473	99.9	0.81	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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