GREMLIN Database
RPE - Ribulose-phosphate 3-epimerase
UniProt: P0AG07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11960
Length: 225 (213)
Sequences: 4377 (2670)
Seq/√Len: 182.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_R20_E3.3101.00
165_I172_I3.2551.00
185_I196_F2.6071.00
173_R194_D2.4801.00
180_V188_I2.3291.00
26_L63_A2.2241.00
41_H72_K2.2091.00
67_V86_A2.1711.00
89_I111_C2.1701.00
205_Q211_V2.1681.00
124_S127_D2.1141.00
162_R166_D2.1101.00
79_P105_L2.1101.00
150_F155_L2.0821.00
152_P187_E2.0491.00
73_P76_R2.0231.00
136_I161_V2.0221.00
90_T116_V1.9941.00
100_D132_K1.9041.00
186_G190_A1.8751.00
35_F53_L1.8691.00
114_G135_V1.8571.00
207_D210_K1.8471.00
163_R167_E1.8291.00
82_A111_C1.8101.00
127_D160_E1.8091.00
138_L154_T1.7831.00
209_K213_D1.7571.00
64_P88_I1.7561.00
24_K208_Y1.7401.00
120_A142_N1.7311.00
156_D159_R1.7291.00
93_P125_Y1.7211.00
79_P83_A1.7201.00
75_D96_S1.7171.00
79_P109_N1.6911.00
5_L173_R1.6591.00
105_L108_E1.6381.00
31_D216_R1.6321.00
94_E121_T1.6111.00
91_F99_V1.6041.00
90_T135_V1.6031.00
140_S154_T1.6021.00
127_D164_R1.5851.00
107_K113_A1.5761.00
189_A196_F1.5581.00
19_G23_A1.5471.00
123_L161_V1.5431.00
23_A27_A1.5151.00
162_R165_I1.5081.00
75_D102_T1.4681.00
72_K97_E1.4681.00
181_K184_N1.4681.00
118_N142_N1.4591.00
35_F65_I1.4281.00
138_L161_V1.4011.00
32_V195_M1.4001.00
16_A19_G1.3721.00
184_N188_I1.3571.00
54_K83_A1.3501.00
104_Q108_E1.3481.00
155_L187_E1.3421.00
26_L62_T1.3411.00
98_H101_R1.3371.00
173_R195_M1.3371.00
21_D208_Y1.3361.00
210_K214_E1.3341.00
107_K134_D1.3311.00
182_V201_A1.3291.00
57_R87_S1.3121.00
25_A33_V1.3121.00
41_H73_P1.3011.00
53_L65_I1.3001.00
88_I112_K1.2931.00
57_R65_I1.2831.00
7_A195_M1.2761.00
16_A59_Y1.2631.00
21_D24_K1.2471.00
5_L195_M1.2361.00
7_A32_V1.2351.00
104_Q132_K1.2241.00
115_L133_L1.2211.00
99_V129_V1.2101.00
99_V115_L1.1941.00
123_L128_Y1.1781.00
124_S160_E1.1751.00
175_E197_V1.1601.00
82_A109_N1.1531.00
113_A134_D1.1531.00
22_T56_L1.1411.00
5_L32_V1.1401.00
165_I194_D1.1381.00
88_I135_V1.1201.00
213_D217_S1.1101.00
187_E190_A1.1081.00
103_L133_L1.1071.00
78_V109_N1.1011.00
38_M43_V1.0941.00
164_R168_S1.0891.00
11_L146_G1.0781.00
182_V214_E1.0771.00
102_T105_L1.0701.00
32_V88_I1.0651.00
105_L109_N1.0621.00
106_I113_A1.0591.00
33_V63_A1.0591.00
91_F102_T1.0591.00
42_Y94_E1.0521.00
10_I33_V1.0511.00
5_L31_D1.0451.00
83_A109_N1.0321.00
14_D17_R1.0311.00
32_V173_R1.0140.99
48_I52_V1.0080.99
66_D90_T0.9970.99
10_I35_F0.9970.99
210_K213_D0.9840.99
140_S150_F0.9840.99
99_V120_A0.9830.99
128_Y160_E0.9820.99
93_P99_V0.9810.99
4_Y189_A0.9760.99
50_P80_D0.9730.99
133_L136_I0.9620.99
75_D105_L0.9600.99
103_L107_K0.9600.99
20_E24_K0.9560.99
159_R163_R0.9510.99
27_A209_K0.9490.99
115_L129_V0.9480.99
80_D83_A0.9480.99
23_A26_L0.9420.99
103_L129_V0.9360.99
159_R190_A0.9300.99
112_K173_R0.9300.99
16_A55_S0.9230.99
51_M54_K0.9230.99
198_A201_A0.9210.99
165_I170_F0.9140.99
26_L61_I0.9110.99
175_E195_M0.9100.99
176_V193_A0.9070.99
103_L132_K0.9050.99
158_L176_V0.9030.99
103_L113_A0.9020.99
90_T114_G0.9000.99
51_M55_S0.8960.99
188_I196_F0.8960.99
6_I212_I0.8960.99
155_L191_A0.8960.99
198_A202_I0.8950.99
160_E164_R0.8950.99
61_I65_I0.8930.99
35_F48_I0.8880.99
165_I174_L0.8830.99
211_V214_E0.8810.99
71_V77_I0.8740.98
100_D153_Q0.8720.98
22_T33_V0.8640.98
31_D64_P0.8640.98
18_L52_V0.8610.98
98_H142_N0.8570.98
91_F103_L0.8540.98
163_R166_D0.8530.98
93_P126_L0.8520.98
131_D168_S0.8510.98
12_S47_T0.8480.98
42_Y121_T0.8480.98
76_R80_D0.8410.98
82_A89_I0.8410.98
93_P123_L0.8370.98
123_L164_R0.8290.98
45_N145_F0.8280.98
57_R61_I0.8270.98
46_L81_F0.8260.98
193_A196_F0.8120.97
20_E23_A0.8120.97
130_M170_F0.8110.97
123_L138_L0.8110.97
185_I189_A0.8060.97
96_S102_T0.8000.97
56_L65_I0.7950.97
69_L81_F0.7900.97
208_Y211_V0.7870.97
131_D153_Q0.7870.97
119_P141_V0.7850.97
13_A18_L0.7830.97
159_R191_A0.7770.97
37_V81_F0.7770.97
161_V174_L0.7720.97
54_K58_N0.7670.96
100_D104_Q0.7620.96
161_V165_I0.7580.96
41_H76_R0.7480.96
156_D160_E0.7480.96
123_L160_E0.7460.96
162_R172_I0.7440.96
185_I215_M0.7410.96
158_L174_L0.7410.96
201_A211_V0.7370.96
17_R21_D0.7310.95
91_F96_S0.7260.95
158_L193_A0.7240.95
128_Y131_D0.7240.95
155_L188_I0.7180.95
154_T157_K0.7170.95
121_T125_Y0.7130.95
47_T50_P0.7130.95
37_V53_L0.7120.95
12_S200_S0.7120.95
146_G179_G0.7100.95
164_R167_E0.7050.94
126_L136_I0.7040.94
25_A30_A0.7010.94
182_V215_M0.6970.94
182_V211_V0.6900.94
135_V195_M0.6890.94
11_L179_G0.6810.93
115_L126_L0.6790.93
13_A21_D0.6750.93
202_I208_Y0.6750.93
93_P117_F0.6740.93
168_S172_I0.6730.93
80_D84_A0.6670.93
176_V180_V0.6670.93
165_I168_S0.6620.92
106_I111_C0.6550.92
8_P30_A0.6540.92
55_S58_N0.6520.92
32_V135_V0.6490.92
64_P87_S0.6440.91
151_I154_T0.6410.91
133_L172_I0.6390.91
28_A208_Y0.6390.91
146_G199_G0.6360.91
202_I212_I0.6330.91
29_G213_D0.6310.90
70_M92_H0.6300.90
205_Q208_Y0.6300.90
22_T26_L0.6300.90
22_T63_A0.6300.90
4_Y196_F0.6290.90
99_V102_T0.6270.90
131_D170_F0.6260.90
152_P156_D0.6230.90
14_D21_D0.6220.90
69_L89_I0.6180.89
127_D168_S0.6180.89
181_K201_A0.6150.89
78_V102_T0.6140.89
160_E163_R0.6140.89
54_K80_D0.6100.89
104_Q107_K0.6060.89
50_P84_A0.6050.88
149_S183_N0.6030.88
26_L29_G0.6010.88
25_A208_Y0.6010.88
130_M165_I0.6000.88
126_L129_V0.5990.88
184_N215_M0.5970.88
119_P143_P0.5920.87
24_K209_K0.5910.87
46_L71_V0.5900.87
130_M172_I0.5890.87
71_V81_F0.5870.87
149_S181_K0.5860.87
201_A215_M0.5760.86
201_A214_E0.5740.86
23_A59_Y0.5740.86
33_V61_I0.5730.86
91_F115_L0.5650.85
78_V82_A0.5650.85
98_H129_V0.5590.84
141_V148_Q0.5580.84
12_S25_A0.5580.84
79_P108_E0.5550.84
46_L49_G0.5530.84
98_H120_A0.5530.84
117_F138_L0.5510.83
12_S21_D0.5500.83
140_S176_V0.5480.83
141_V146_G0.5440.83
59_Y64_P0.5440.83
87_S112_K0.5430.83
19_G59_Y0.5420.82
78_V106_I0.5410.82
123_L157_K0.5370.82
100_D142_N0.5360.82
180_V196_F0.5350.82
125_Y128_Y0.5340.81
87_S111_C0.5340.81
47_T53_L0.5330.81
104_Q142_N0.5320.81
25_A203_F0.5320.81
166_D169_G0.5310.81
78_V105_L0.5310.81
167_E170_F0.5310.81
130_M161_V0.5300.81
73_P97_E0.5280.81
47_T51_M0.5240.80
35_F56_L0.5240.80
107_K132_K0.5240.80
169_G172_I0.5210.80
97_E120_A0.5210.80
48_I51_M0.5190.80
132_K153_Q0.5190.80
7_A175_E0.5190.80
156_D168_S0.5180.79
136_I172_I0.5150.79
35_F67_V0.5140.79
128_Y132_K0.5100.78
214_E217_S0.5100.78
146_G198_A0.5080.78
145_F148_Q0.5050.78
98_H118_N0.5050.78
176_V188_I0.5040.78
155_L184_N0.5030.78
124_S128_Y0.5030.78
206_P211_V0.5010.77
81_F86_A0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cu2A 2 0.9556 100 0.345 Contact Map
3ctlA 4 0.96 100 0.443 Contact Map
3inpA 6 0.9689 100 0.45 Contact Map
1rpxA 4 0.9822 100 0.466 Contact Map
1tqjA 4 0.96 100 0.472 Contact Map
4df0A 2 0.8667 100 0.472 Contact Map
4muzA 2 0.9156 100 0.473 Contact Map
2yyuA 2 0.9111 100 0.474 Contact Map
1eixA 2 0.9067 100 0.474 Contact Map
1tqxA 2 0.9511 100 0.477 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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