GREMLIN Database
UBIX - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein
UniProt: P0AG03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11044
Length: 189 (183)
Sequences: 1825 (1223)
Seq/√Len: 90.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_R140_E3.2861.00
129_L139_A3.1121.00
133_R137_Q3.0251.00
92_L135_M2.9911.00
138_A143_A2.8991.00
129_L136_T2.6541.00
19_R164_N2.5641.00
3_R31_E2.5451.00
7_G104_L2.4451.00
129_L140_E2.3951.00
19_R22_Q2.3841.00
168_N183_F2.2801.00
35_V72_I2.2051.00
93_S99_Y2.1821.00
85_L121_C2.1711.00
172_D185_R2.1641.00
33_H63_H2.0951.00
9_S104_L2.0781.00
8_I17_G2.0731.00
132_L136_T2.0211.00
89_I122_V1.9381.00
83_V170_V1.9111.00
39_A68_I1.8191.00
63_H71_S1.7801.00
20_L83_V1.7341.00
37_S104_L1.6811.00
115_R139_A1.6741.00
127_L149_V1.6451.00
159_L162_V1.6381.00
82_M111_V1.6321.00
112_L143_A1.5801.00
92_L138_A1.5221.00
85_L170_V1.5191.00
136_T140_E1.5181.00
129_L141_I1.5101.00
87_C92_L1.5031.00
121_C170_V1.5021.00
160_D164_N1.4961.00
169_R183_F1.4841.00
94_G99_Y1.4691.00
79_T111_V1.4540.99
6_V21_L1.4500.99
133_R136_T1.4370.99
49_D155_R1.4350.99
115_R144_V1.3930.99
14_A44_L1.3910.99
138_A145_I1.3910.99
4_L174_F1.3880.99
65_A102_G1.3830.99
98_S134_L1.3800.99
119_V174_F1.3690.99
38_Q66_R1.3580.99
78_Q179_P1.3460.99
157_Q161_D1.3360.99
81_G174_F1.3330.99
17_G85_L1.3080.99
109_D131_H1.2740.99
144_V173_Q1.2730.99
93_S134_L1.2580.98
20_L85_L1.2220.98
5_I111_V1.2090.98
93_S97_H1.2050.98
33_H77_F1.2040.98
90_K99_Y1.2010.98
146_M166_T1.1910.98
44_L48_T1.1800.98
20_L167_V1.1660.97
152_F163_I1.1630.97
16_Y150_P1.1540.97
130_G134_L1.1480.97
100_T109_D1.1460.97
121_C166_T1.1400.97
122_V146_M1.1370.97
95_I108_A1.1270.97
21_L32_T1.1250.97
117_P173_Q1.1220.97
98_S130_G1.1160.97
16_Y148_P1.1130.97
38_Q65_A1.1120.97
90_K105_T1.1090.97
130_G141_I1.1050.97
5_I79_T1.1010.96
83_V174_F1.0960.96
84_I95_I1.0900.96
89_I134_L1.0850.96
94_G101_D1.0840.96
78_Q175_A1.0820.96
6_V32_T1.0730.96
6_V85_L1.0650.96
112_L141_I1.0610.96
121_C148_P1.0490.95
82_M107_A1.0480.95
23_V182_L1.0420.95
138_A141_I1.0340.95
38_Q41_R1.0200.95
27_V176_I0.9940.94
89_I93_S0.9840.93
5_I72_I0.9800.93
125_T146_M0.9800.93
139_A143_A0.9800.93
90_K94_G0.9730.93
151_A165_Q0.9710.93
112_L128_H0.9700.93
15_I163_I0.9600.93
41_R56_Q0.9540.92
23_V26_D0.9480.92
63_H67_D0.9460.92
20_L170_V0.9430.92
18_V44_L0.9400.92
25_R60_D0.9300.91
125_T166_T0.9280.91
82_M108_A0.9220.91
19_R160_D0.9190.91
84_I108_A0.9150.91
75_G113_K0.8990.90
94_G105_T0.8990.90
101_D105_T0.8900.89
89_I131_H0.8870.89
117_P175_A0.8840.89
16_Y166_T0.8790.89
156_P161_D0.8690.88
148_P166_T0.8680.88
129_L143_A0.8680.88
139_A145_I0.8630.88
69_A73_S0.8600.88
8_I40_A0.8570.88
137_Q141_I0.8560.88
146_M170_V0.8560.88
92_L134_L0.8560.88
45_S51_S0.8520.87
36_M40_A0.8430.87
30_I176_I0.8390.87
121_C146_M0.8380.86
7_G82_M0.8370.86
53_R56_Q0.8370.86
128_H134_L0.8360.86
75_G110_V0.8340.86
42_Q68_I0.8330.86
111_V118_L0.8300.86
146_M169_R0.8290.86
18_V48_T0.8230.85
119_V173_Q0.8200.85
46_L69_A0.8000.84
75_G114_E0.7970.84
134_L138_A0.7970.84
8_I14_A0.7870.83
165_Q183_F0.7870.83
43_T90_K0.7840.83
30_I80_L0.7820.82
90_K109_D0.7810.82
73_S103_L0.7800.82
21_L34_L0.7770.82
120_L138_A0.7760.82
54_E57_A0.7740.82
38_Q42_Q0.7690.81
110_V113_K0.7660.81
42_Q45_S0.7640.81
34_L59_A0.7620.81
146_M173_Q0.7590.81
96_V137_Q0.7570.80
137_Q140_E0.7540.80
132_L138_A0.7490.80
42_Q46_L0.7490.80
100_T105_T0.7460.79
12_S39_A0.7460.79
168_N180_E0.7410.79
95_I120_L0.7380.79
4_L30_I0.7380.79
23_V167_V0.7340.78
122_V149_V0.7300.78
107_A111_V0.7290.78
102_G105_T0.7260.77
148_P165_Q0.7180.77
34_L62_T0.7170.77
122_V127_L0.7160.77
111_V116_R0.7140.76
97_H134_L0.7060.76
31_E77_F0.7010.75
84_I120_L0.6990.75
87_C120_L0.6990.75
82_M118_L0.6980.75
78_Q116_R0.6890.74
99_Y102_G0.6880.74
23_V164_N0.6880.74
19_R167_V0.6820.73
169_R173_Q0.6760.72
3_R80_L0.6750.72
83_V119_V0.6740.72
61_V71_S0.6680.71
42_Q69_A0.6640.71
110_V114_E0.6600.71
16_Y163_I0.6590.70
129_L138_A0.6570.70
5_I82_M0.6520.70
36_M62_T0.6460.69
96_V138_A0.6430.69
66_R69_A0.6420.68
14_A17_G0.6400.68
36_M52_L0.6400.68
90_K100_T0.6400.68
36_M55_V0.6360.68
5_I107_A0.6360.68
122_V132_L0.6340.67
59_A62_T0.6260.66
55_V59_A0.6260.66
94_G102_G0.6230.66
158_S161_D0.6200.66
50_F54_E0.6160.65
94_G131_H0.6130.65
32_T59_A0.6090.64
56_Q62_T0.6070.64
18_V22_Q0.6050.64
5_I35_V0.6040.64
150_P162_V0.6030.64
93_S96_V0.6030.64
31_E61_V0.6020.63
20_L171_L0.5990.63
150_P169_R0.5990.63
3_R78_Q0.5970.63
164_N167_V0.5950.63
71_S188_G0.5940.62
16_Y152_F0.5930.62
14_A40_A0.5910.62
68_I73_S0.5900.62
9_S88_S0.5870.62
109_D128_H0.5850.61
119_V170_V0.5820.61
41_R65_A0.5810.61
98_S128_H0.5810.61
88_S149_V0.5770.60
77_F81_G0.5770.60
113_K131_H0.5760.60
71_S187_Q0.5700.59
115_R173_Q0.5700.59
4_L81_G0.5700.59
180_E183_F0.5690.59
108_A118_L0.5680.59
55_V58_L0.5680.59
36_M44_L0.5640.59
100_T128_H0.5640.59
31_E80_L0.5640.59
8_I36_M0.5600.58
19_R163_I0.5550.57
81_G116_R0.5530.57
136_T139_A0.5480.56
37_S183_F0.5470.56
89_I109_D0.5460.56
83_V171_L0.5430.56
4_L176_I0.5400.55
120_L145_I0.5400.55
127_L135_M0.5370.55
22_Q58_L0.5350.55
3_R33_H0.5310.54
66_R157_Q0.5300.54
149_V166_T0.5260.53
87_C91_T0.5230.53
43_T148_P0.5230.53
50_F55_V0.5210.53
78_Q185_R0.5210.53
161_D164_N0.5210.53
33_H61_V0.5170.52
16_Y96_V0.5170.52
64_D71_S0.5140.52
43_T87_C0.5110.51
22_Q50_F0.5110.51
75_G109_D0.5060.51
8_I21_L0.5060.51
164_N182_L0.5060.51
40_A46_L0.5050.50
82_M116_R0.5040.50
159_L163_I0.5040.50
44_L52_L0.5030.50
36_M39_A0.5020.50
125_T147_P0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rhfA 6 0.9735 100 0.329 Contact Map
4zavA 6 0.9841 100 0.332 Contact Map
2ejbA 6 0.9101 100 0.334 Contact Map
1sbzA 6 0.9841 100 0.342 Contact Map
3lqkA 5 0.963 100 0.482 Contact Map
3mcuA 5 0.9048 100 0.513 Contact Map
1g63A 6 0.8095 100 0.523 Contact Map
1qzuA 3 0.7513 100 0.526 Contact Map
1p3y1 6 0.8413 100 0.541 Contact Map
3wisA 4 0.836 100 0.549 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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