GREMLIN Database
WZZE - Lipopolysaccharide biosynthesis protein WzzE
UniProt: P0AG00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11295
Length: 348 (307)
Sequences: 5866 (4975)
Seq/√Len: 283.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_A171_A3.7831.00
27_W30_K3.2481.00
172_N313_E3.1981.00
44_A329_W3.1911.00
119_L135_D3.1031.00
59_A179_V2.9191.00
272_Q275_G2.9061.00
56_S318_D2.8951.00
56_S164_I2.8141.00
176_R311_P2.5831.00
259_L275_G2.5641.00
259_L262_P2.4611.00
47_Y51_A2.4061.00
172_N176_R2.2751.00
48_T325_L2.2571.00
120_Q177_Q2.2521.00
291_T294_V2.2301.00
169_P173_N2.0861.00
294_V297_T2.0771.00
165_A170_D2.0441.00
218_A222_R2.0361.00
201_R204_Q2.0341.00
163_L174_L2.0331.00
177_Q181_F2.0301.00
18_D21_G2.0271.00
29_G344_R2.0091.00
288_M291_T1.9911.00
57_S171_A1.8961.00
163_L175_L1.8901.00
265_Q269_E1.8881.00
197_A200_A1.8771.00
296_P299_D1.8571.00
279_D283_D1.8501.00
104_F182_A1.7981.00
115_R119_L1.7941.00
54_E164_I1.7891.00
212_Q285_N1.7641.00
321_R324_F1.7621.00
283_D286_R1.7381.00
184_Q188_S1.7331.00
122_D125_K1.7201.00
56_S162_K1.7021.00
206_K210_K1.6851.00
297_T300_P1.6831.00
36_M40_F1.6811.00
337_G341_A1.6781.00
214_E218_A1.6621.00
291_T300_P1.6541.00
120_Q181_F1.6501.00
219_I223_R1.6321.00
58_T160_S1.5991.00
211_R215_V1.5971.00
164_I319_S1.5921.00
48_T326_M1.5861.00
40_F329_W1.5741.00
283_D287_A1.5681.00
45_L326_M1.5541.00
207_A211_R1.5471.00
264_L268_L1.5381.00
329_W333_G1.5331.00
41_A330_G1.5191.00
260_G263_M1.5071.00
288_M300_P1.5031.00
177_Q180_A1.5001.00
145_N163_L1.4991.00
161_V175_L1.4981.00
209_V282_Y1.4871.00
240_S243_A1.4801.00
194_L197_A1.4571.00
52_R166_E1.4401.00
116_E181_F1.4121.00
238_N242_S1.4081.00
33_I37_G1.3871.00
181_F184_Q1.3861.00
180_A184_Q1.3831.00
259_L272_Q1.3711.00
293_N296_P1.3691.00
295_G299_D1.3621.00
59_A175_L1.3591.00
37_G334_G1.3501.00
212_Q215_V1.3471.00
40_F333_G1.3461.00
114_R142_M1.3091.00
57_S314_P1.3051.00
288_M297_T1.3021.00
288_M296_P1.2991.00
288_M298_L1.2971.00
151_G160_S1.2971.00
237_H241_R1.2971.00
217_K221_D1.2851.00
261_R265_Q1.2731.00
30_K34_I1.2721.00
241_R244_T1.2551.00
44_A48_T1.2421.00
45_L49_F1.2391.00
291_T297_T1.2311.00
116_E120_Q1.2291.00
333_G337_G1.2271.00
111_W309_R1.2261.00
115_R135_D1.2241.00
48_T329_W1.2231.00
269_E272_Q1.2181.00
238_N241_R1.2131.00
57_S172_N1.2071.00
295_G298_L1.2071.00
32_W36_M1.2031.00
203_I206_K1.1991.00
231_L234_A1.1971.00
268_L272_Q1.1971.00
231_L235_E1.1941.00
249_E252_P1.1871.00
232_K235_E1.1691.00
41_A326_M1.1651.00
116_E119_L1.1601.00
176_R180_A1.1431.00
173_N177_Q1.1391.00
281_D285_N1.1391.00
204_Q208_Q1.1391.00
114_R178_Y1.1311.00
60_I160_S1.1291.00
265_Q272_Q1.1251.00
100_A104_F1.1231.00
118_W123_Y1.1221.00
277_A281_D1.1161.00
210_K214_E1.1151.00
192_D196_G1.1141.00
60_I158_N1.1141.00
48_T51_A1.1131.00
164_I318_D1.1111.00
29_G341_A1.1111.00
180_A310_T1.1101.00
33_I341_A1.1061.00
146_I163_L1.1061.00
250_E254_S1.1011.00
37_G41_A1.1011.00
216_A282_Y1.0971.00
43_I47_Y1.0931.00
120_Q180_A1.0931.00
234_A237_H1.0921.00
213_E280_L1.0911.00
208_Q285_N1.0901.00
195_K199_A1.0851.00
234_A238_N1.0841.00
158_N308_L1.0831.00
230_A235_E1.0761.00
114_R174_L1.0661.00
250_E253_D1.0571.00
203_I207_A1.0561.00
106_M109_A1.0531.00
58_T162_K1.0421.00
292_L295_G1.0411.00
257_F261_R1.0381.00
118_W138_L1.0381.00
288_M299_D1.0381.00
261_R275_G1.0341.00
296_P300_P1.0341.00
179_V307_Y1.0331.00
114_R143_I1.0321.00
271_L274_V1.0271.00
249_E253_D1.0201.00
167_T170_D1.0201.00
175_L311_P1.0151.00
149_I160_S1.0131.00
142_M163_L1.0101.00
291_T298_L1.0071.00
141_E145_N1.0051.00
237_H243_A1.0021.00
54_E319_S1.0011.00
117_F181_F0.9931.00
112_D309_R0.9901.00
261_R272_Q0.9881.00
25_T345_R0.9871.00
209_V213_E0.9841.00
33_I338_A0.9841.00
215_V281_D0.9831.00
262_P265_Q0.9831.00
47_Y325_L0.9821.00
271_L275_G0.9821.00
170_D174_L0.9811.00
152_D155_R0.9771.00
126_Q170_D0.9711.00
263_M267_R0.9711.00
291_T295_G0.9701.00
60_I309_R0.9611.00
324_F328_M0.9591.00
115_R139_L0.9591.00
288_M295_G0.9581.00
40_F44_A0.9511.00
111_W312_E0.9481.00
239_I243_A0.9441.00
140_D144_N0.9381.00
40_F336_I0.9371.00
276_P279_D0.9361.00
196_G199_A0.9351.00
37_G40_F0.9331.00
289_L293_N0.9301.00
226_S230_A0.9271.00
252_P255_E0.9271.00
237_H244_T0.9261.00
106_M158_N0.9251.00
270_N273_A0.9101.00
17_L22_L0.9051.00
105_V109_A0.9051.00
293_N297_T0.9041.00
282_Y285_N0.9041.00
235_E238_N0.9031.00
145_N165_A0.9011.00
111_W115_R0.8981.00
53_Q322_R0.8981.00
212_Q216_A0.8981.00
112_D310_T0.8931.00
48_T322_R0.8891.00
264_L271_L0.8881.00
172_N311_P0.8831.00
286_R289_L0.8831.00
118_W139_L0.8821.00
54_E166_E0.8791.00
251_L254_S0.8731.00
106_M151_G0.8721.00
207_A210_K0.8711.00
46_A50_F0.8701.00
294_V298_L0.8691.00
270_N274_V0.8691.00
256_M259_L0.8571.00
36_M337_G0.8551.00
218_A221_D0.8521.00
295_G300_P0.8521.00
51_A54_E0.8521.00
113_T178_Y0.8511.00
237_H242_S0.8461.00
111_W139_L0.8451.00
135_D139_L0.8451.00
116_E185_R0.8451.00
237_H240_S0.8421.00
289_L294_V0.8391.00
25_T342_L0.8381.00
230_A234_A0.8351.00
39_A46_A0.8311.00
118_W142_M0.8301.00
53_Q317_R0.8241.00
240_S244_T0.8231.00
290_N294_V0.8221.00
294_V300_P0.8211.00
259_L263_M0.8201.00
114_R139_L0.8191.00
236_Q239_I0.8171.00
103_E157_V0.8161.00
44_A333_G0.8150.99
208_Q211_R0.8120.99
267_R270_N0.8120.99
340_V344_R0.8080.99
269_E273_A0.8060.99
268_L275_G0.8040.99
258_L261_R0.8020.99
37_G337_G0.8020.99
289_L298_L0.8010.99
276_P280_L0.8000.99
102_K150_P0.7980.99
117_F178_Y0.7970.99
185_R188_S0.7970.99
317_R322_R0.7950.99
189_H306_R0.7950.99
287_A290_N0.7920.99
61_T179_V0.7900.99
230_A233_I0.7890.99
261_R264_L0.7890.99
101_Y104_F0.7880.99
279_D282_Y0.7860.99
72_Y75_Q0.7840.99
44_A325_L0.7830.99
238_N244_T0.7800.99
239_I242_S0.7790.99
105_V159_D0.7730.99
37_G330_G0.7720.99
294_V299_D0.7680.99
266_A270_N0.7680.99
23_F27_W0.7650.99
117_F174_L0.7640.99
280_L285_N0.7620.99
121_T177_Q0.7590.99
117_F177_Q0.7590.99
205_M208_Q0.7590.99
39_A43_I0.7570.99
54_E318_D0.7570.99
284_Q287_A0.7540.99
32_W35_G0.7470.99
118_W121_T0.7460.99
170_D173_N0.7460.99
175_L179_V0.7440.99
268_L274_V0.7440.99
113_T117_F0.7420.99
234_A241_R0.7410.99
332_V339_G0.7390.99
266_A269_E0.7330.99
236_Q240_S0.7320.99
319_S322_R0.7310.99
140_D143_I0.7310.99
110_S113_T0.7300.99
233_I236_Q0.7300.99
29_G32_W0.7280.99
36_M340_V0.7230.99
171_A175_L0.7220.99
268_L271_L0.7220.99
265_Q268_L0.7170.99
210_K213_E0.7160.99
205_M285_N0.7160.99
146_I178_Y0.7110.99
25_T29_G0.7090.99
276_P285_N0.7070.99
57_S311_P0.7030.99
41_A48_T0.7030.99
250_E255_E0.7030.99
322_R325_L0.7030.99
179_V311_P0.7020.99
169_P313_E0.7010.98
32_W344_R0.6990.98
26_L338_A0.6990.98
60_I106_M0.6900.98
213_E286_R0.6890.98
176_R310_T0.6870.98
179_V183_S0.6870.98
42_L46_A0.6870.98
142_M178_Y0.6850.98
292_L298_L0.6840.98
238_N243_A0.6800.98
259_L271_L0.6780.98
61_T108_L0.6750.98
57_S312_E0.6750.98
188_S192_D0.6720.98
59_A161_V0.6650.98
208_Q281_D0.6640.98
140_D316_K0.6630.98
105_V148_F0.6610.98
43_I46_A0.6600.98
78_F82_L0.6600.98
123_Y174_L0.6570.98
282_Y286_R0.6500.98
41_A45_L0.6480.97
339_G343_T0.6470.97
27_W31_L0.6470.97
288_M294_V0.6460.97
108_L113_T0.6390.97
109_A148_F0.6390.97
245_D248_A0.6380.97
186_A304_T0.6380.97
49_F326_M0.6370.97
290_N293_N0.6350.97
29_G345_R0.6340.97
62_D103_E0.6340.97
57_S313_E0.6320.97
35_G39_A0.6310.97
230_A237_H0.6290.97
108_L182_A0.6270.97
41_A334_G0.6250.97
182_A305_Y0.6230.97
134_A137_A0.6230.97
276_P282_Y0.6220.97
33_I40_F0.6200.97
49_F322_R0.6190.97
263_M266_A0.6170.97
231_L236_Q0.6170.97
342_L346_C0.6150.97
118_W122_D0.6130.97
104_F107_Q0.6090.96
147_Q162_K0.6080.96
215_V218_A0.6070.96
190_L304_T0.6060.96
277_A280_L0.6020.96
116_E184_Q0.6010.96
107_Q182_A0.6000.96
168_A314_P0.5960.96
316_K323_A0.5940.96
307_Y310_T0.5940.96
202_T288_M0.5910.96
257_F260_G0.5910.96
20_R24_R0.5880.96
51_A325_L0.5860.95
289_L299_D0.5840.95
20_R27_W0.5820.95
169_P172_N0.5810.95
338_A342_L0.5800.95
292_L296_P0.5800.95
28_A345_R0.5760.95
161_V179_V0.5760.95
112_D185_R0.5750.95
120_Q184_Q0.5750.95
107_Q110_S0.5750.95
252_P256_M0.5740.95
149_I162_K0.5740.95
267_R275_G0.5720.95
62_D104_F0.5710.95
250_E259_L0.5710.95
25_T341_A0.5700.95
186_A305_Y0.5680.95
262_P275_G0.5680.95
142_M174_L0.5680.95
205_M291_T0.5660.95
328_M332_V0.5650.95
322_R326_M0.5640.94
231_L237_H0.5630.94
233_I240_S0.5620.94
255_E258_L0.5620.94
212_Q219_I0.5620.94
35_G42_L0.5590.94
168_A171_A0.5580.94
151_G156_A0.5570.94
191_N197_A0.5560.94
314_P317_R0.5550.94
231_L243_A0.5550.94
232_K237_H0.5550.94
104_F186_A0.5540.94
260_G272_Q0.5530.94
325_L328_M0.5520.94
121_T174_L0.5520.94
145_N164_I0.5510.94
289_L295_G0.5510.94
232_K236_Q0.5500.94
121_T173_N0.5500.94
234_A243_A0.5490.94
183_S186_A0.5490.94
261_R274_V0.5480.94
256_M260_G0.5470.94
36_M39_A0.5450.93
334_G337_G0.5450.93
259_L264_L0.5440.93
251_L255_E0.5390.93
291_T296_P0.5360.93
278_F285_N0.5330.93
102_K106_M0.5300.92
258_L264_L0.5290.92
244_T248_A0.5270.92
236_Q242_S0.5270.92
280_L283_D0.5250.92
195_K198_W0.5240.92
64_P157_V0.5220.92
37_G333_G0.5220.92
188_S195_K0.5210.92
113_T181_F0.5210.92
54_E145_N0.5180.92
116_E188_S0.5170.92
281_D284_Q0.5150.91
231_L238_N0.5150.91
32_W39_A0.5150.91
257_F272_Q0.5150.91
204_Q207_A0.5130.91
319_S325_L0.5120.91
230_A238_N0.5110.91
264_L272_Q0.5100.91
51_A319_S0.5100.91
24_R28_A0.5090.91
249_E254_S0.5080.91
17_L21_G0.5080.91
253_D256_M0.5080.91
219_I278_F0.5080.91
102_K152_D0.5070.91
139_L143_I0.5050.91
257_F275_G0.5050.91
260_G267_R0.5030.90
123_Y128_M0.5010.90
173_N176_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wl1A 3 0.6264 100 0.331 Contact Map
3b8oA 3 0.6351 99.7 0.723 Contact Map
3b8mA 3 0.7011 99.5 0.745 Contact Map
4e29A 3 0.6695 99.4 0.77 Contact Map
4cgkA 3 0.7299 70.4 0.932 Contact Map
4rsiA 1 0.3132 64.3 0.935 Contact Map
3ioxA 1 0.431 43.6 0.943 Contact Map
2m8rA 1 0.3075 43.2 0.943 Contact Map
3vp9A 3 0.2098 36.1 0.945 Contact Map
3hnwA 2 0.342 34.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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