GREMLIN Database
TRKH - Trk system potassium uptake protein TrkH
UniProt: P0AFZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11021
Length: 483 (406)
Sequences: 5308 (3973)
Seq/√Len: 197.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
411_S461_N4.2321.00
345_G351_G4.2271.00
100_D455_K3.5201.00
243_A309_F3.3431.00
197_A211_I3.3431.00
99_T456_W3.1871.00
200_L242_I3.1521.00
196_C245_F2.9661.00
414_A457_I2.9051.00
136_W193_T2.9011.00
325_S328_R2.6401.00
203_A235_S2.5881.00
346_C356_V2.5271.00
135_Q216_A2.3861.00
226_H232_Y2.3841.00
199_A241_I2.3681.00
102_F459_I2.3471.00
228_A232_Y2.3371.00
421_D424_S2.3351.00
203_A237_T2.3101.00
415_I454_A2.2901.00
132_Q212_G2.2731.00
300_S303_M2.2301.00
315_M337_L2.1601.00
201_W207_A2.1441.00
125_H129_F2.1311.00
99_T459_I2.0971.00
412_M426_F2.0961.00
128_L208_F2.0791.00
203_A241_I2.0491.00
239_N307_Q2.0421.00
216_A321_F2.0171.00
106_F459_I2.0171.00
197_A207_A2.0071.00
213_H224_S1.9811.00
250_G277_F1.9791.00
96_L122_S1.9331.00
65_K68_E1.9261.00
118_V121_D1.9231.00
239_N306_N1.9181.00
243_A313_V1.9121.00
126_A130_Y1.9061.00
203_A238_I1.8521.00
99_T452_P1.8351.00
247_L281_Q1.8251.00
230_I242_I1.7921.00
281_Q316_A1.7811.00
285_V309_F1.7791.00
201_W210_A1.7741.00
97_T100_D1.7571.00
338_L430_V1.7491.00
237_T241_I1.7481.00
247_L313_V1.7461.00
64_L68_E1.7351.00
199_A237_T1.7201.00
81_G98_I1.7171.00
239_N323_T1.6941.00
411_S457_I1.6891.00
218_I249_S1.6871.00
428_S443_V1.6841.00
302_L306_N1.6791.00
240_T244_I1.6611.00
362_L401_F1.6581.00
408_F430_V1.6531.00
115_T119_G1.6521.00
236_P306_N1.6491.00
414_A453_V1.6481.00
293_W297_V1.6381.00
288_C312_V1.6311.00
85_A98_I1.6291.00
284_L340_S1.6071.00
431_A436_L1.6041.00
361_L389_L1.5981.00
240_T306_N1.5931.00
291_V336_L1.5911.00
276_M360_L1.5741.00
289_T308_A1.5421.00
367_N371_K1.5261.00
183_K187_L1.5151.00
354_L359_I1.5141.00
119_G122_S1.5141.00
226_H233_F1.5061.00
408_F433_L1.4961.00
246_L319_A1.4941.00
197_A214_S1.4871.00
418_T451_N1.4811.00
289_T305_I1.4801.00
85_A89_I1.4731.00
424_S440_L1.4721.00
64_L72_I1.4651.00
107_S223_F1.4651.00
246_L314_S1.4531.00
96_L123_L1.4441.00
217_T242_I1.4351.00
439_G443_V1.4301.00
200_L238_I1.4281.00
278_I282_F1.4211.00
456_W460_A1.4201.00
285_V313_V1.4081.00
98_I102_F1.4071.00
104_E116_T1.4021.00
420_V442_V1.3991.00
244_I248_I1.3961.00
412_M429_V1.3941.00
312_V315_M1.3931.00
99_T455_K1.3931.00
212_G225_T1.3871.00
318_T436_L1.3821.00
199_A203_A1.3811.00
240_T302_L1.3811.00
128_L132_Q1.3721.00
292_L333_L1.3711.00
68_E72_I1.3681.00
280_V360_L1.3661.00
381_S388_A1.3651.00
292_L337_L1.3631.00
339_C343_I1.3631.00
135_Q221_G1.3621.00
81_G106_F1.3611.00
456_W459_I1.3601.00
205_M238_I1.3591.00
89_I126_A1.3591.00
343_I356_V1.3441.00
404_Y433_L1.3421.00
106_F463_L1.3341.00
209_D226_H1.3281.00
102_F456_W1.3201.00
120_L227_D1.3161.00
205_M209_D1.3151.00
326_I337_L1.2981.00
311_Q323_T1.2971.00
297_V304_T1.2951.00
234_D303_M1.2941.00
338_L426_F1.2841.00
207_A211_I1.2801.00
105_S134_L1.2801.00
334_P440_L1.2711.00
217_T321_F1.2671.00
108_G223_F1.2661.00
240_T309_F1.2651.00
408_F412_M1.2621.00
274_F278_I1.2601.00
283_T287_I1.2571.00
301_A305_I1.2521.00
96_L117_L1.2461.00
280_V356_V1.2461.00
196_C214_S1.2411.00
420_V425_A1.2311.00
231_G322_T1.2281.00
411_S429_V1.2231.00
201_W206_D1.2231.00
240_T305_I1.2221.00
179_A183_K1.2211.00
125_H208_F1.2201.00
192_L248_I1.2191.00
64_L67_R1.2171.00
293_W304_T1.2141.00
442_V449_S1.2141.00
119_G227_D1.2021.00
287_I291_V1.2001.00
213_H225_T1.1981.00
307_Q311_Q1.1971.00
81_G102_F1.1921.00
88_F134_L1.1891.00
342_F408_F1.1871.00
100_D116_T1.1851.00
236_P239_N1.1831.00
450_M458_L1.1801.00
460_A464_F1.1791.00
231_G325_S1.1781.00
429_V461_N1.1761.00
102_F106_F1.1691.00
343_I359_I1.1661.00
239_N243_A1.1661.00
303_M307_Q1.1581.00
97_T452_P1.1481.00
123_L131_R1.1441.00
365_Q398_W1.1391.00
247_L278_I1.1391.00
118_V227_D1.1361.00
326_I329_W1.1311.00
132_Q208_F1.1301.00
287_I332_F1.1261.00
132_Q211_I1.1251.00
293_W301_A1.1231.00
251_C274_F1.1201.00
258_S271_D1.1191.00
307_Q324_D1.1111.00
91_S124_P1.1101.00
361_L394_L1.1001.00
285_V289_T1.0851.00
246_L313_V1.0851.00
418_T454_A1.0771.00
81_G85_A1.0721.00
279_G283_T1.0701.00
338_L427_A1.0671.00
217_T245_F1.0601.00
192_L256_H1.0601.00
84_G105_S1.0571.00
187_L191_L1.0571.00
391_E395_E1.0521.00
291_V333_L1.0511.00
347_A357_I1.0511.00
284_L312_V1.0511.00
326_I440_L1.0471.00
401_F405_A1.0441.00
198_L202_F1.0421.00
129_F133_M1.0391.00
67_R72_I1.0351.00
88_F126_A1.0351.00
67_R70_F1.0331.00
132_Q215_F1.0301.00
451_N454_A1.0261.00
450_M454_A1.0221.00
412_M425_A1.0171.00
236_P240_T1.0161.00
279_G385_G1.0151.00
200_L217_T1.0151.00
196_C241_I1.0111.00
117_L123_L1.0091.00
228_A231_G1.0071.00
206_D210_A1.0051.00
330_P333_L1.0051.00
432_T458_L1.0051.00
193_T214_S0.9971.00
307_Q323_T0.9931.00
94_P124_P0.9891.00
334_P424_S0.9881.00
407_V464_F0.9881.00
240_T243_A0.9871.00
125_H128_L0.9851.00
236_P302_L0.9841.00
444_A449_S0.9841.00
361_L397_V0.9831.00
416_I425_A0.9821.00
282_F286_V0.9760.99
429_V458_L0.9750.99
415_I429_V0.9740.99
224_S229_S0.9700.99
196_C242_I0.9660.99
277_F346_C0.9590.99
91_S128_L0.9560.99
284_L288_C0.9550.99
255_L274_F0.9470.99
292_L295_H0.9380.99
196_C217_T0.9340.99
104_E131_R0.9280.99
327_A334_P0.9240.99
129_F208_F0.9230.99
74_V463_L0.9220.99
202_F237_T0.9210.99
108_G131_R0.9200.99
453_V457_I0.9200.99
412_M422_D0.9190.99
275_R385_G0.9160.99
342_F404_Y0.9160.99
272_P385_G0.9140.99
200_L241_I0.9120.99
140_M186_W0.9110.99
284_L336_L0.9090.99
68_E71_L0.9090.99
89_I98_I0.9080.99
332_F413_L0.9080.99
196_C200_L0.9070.99
119_G123_L0.9060.99
369_E395_E0.9010.99
90_F96_L0.8990.99
247_L285_V0.8980.99
418_T453_V0.8960.99
243_A289_T0.8960.99
454_A458_L0.8950.99
90_F95_N0.8940.99
213_H226_H0.8920.99
65_K72_I0.8910.99
289_T293_W0.8880.99
286_V289_T0.8880.99
363_F367_N0.8750.99
121_D227_D0.8750.99
224_S227_D0.8750.99
268_Y274_F0.8740.99
235_S238_I0.8740.99
428_S439_G0.8740.99
106_F472_L0.8740.99
84_G87_P0.8730.99
341_A436_L0.8730.99
315_M438_P0.8720.99
407_V461_N0.8720.99
104_E119_G0.8630.99
200_L230_I0.8620.99
132_Q135_Q0.8610.99
364_K384_L0.8580.99
431_A439_G0.8550.99
415_I458_L0.8540.99
258_S274_F0.8540.99
371_K380_Y0.8460.99
225_T233_F0.8430.98
188_I192_L0.8410.98
230_I238_I0.8410.98
89_I124_P0.8400.98
256_H268_Y0.8380.98
248_I256_H0.8370.98
433_L461_N0.8370.98
119_G131_R0.8370.98
282_F285_V0.8340.98
331_L423_F0.8330.98
135_Q219_A0.8320.98
327_A440_L0.8310.98
194_V198_L0.8270.98
311_Q337_L0.8190.98
67_R71_L0.8150.98
80_L84_G0.8120.98
132_Q216_A0.8100.98
347_A356_V0.8050.98
312_V340_S0.8030.98
365_Q394_L0.8010.98
163_A177_R0.8010.98
116_T119_G0.8010.98
197_A201_W0.8000.98
69_G72_I0.8000.98
192_L218_I0.8000.98
77_W109_L0.7940.98
311_Q326_I0.7920.98
114_A431_A0.7900.98
206_D209_D0.7900.98
262_G265_L0.7890.98
289_T309_F0.7880.98
403_A470_F0.7880.98
76_F109_L0.7880.98
177_R180_E0.7870.98
276_M356_V0.7870.98
86_L90_F0.7860.98
271_D385_G0.7820.98
338_L423_F0.7820.98
366_G399_G0.7790.97
336_L413_L0.7780.97
180_E183_K0.7760.97
449_S452_P0.7740.97
430_V434_N0.7720.97
209_D213_H0.7700.97
184_T257_F0.7690.97
285_V308_A0.7650.97
364_K382_I0.7650.97
416_I422_D0.7640.97
109_L134_L0.7600.97
221_G318_T0.7580.97
71_L75_L0.7550.97
341_A431_A0.7550.97
212_G216_A0.7530.97
329_W333_L0.7530.97
198_L201_W0.7460.97
362_L402_S0.7450.97
293_W308_A0.7380.96
98_I456_W0.7360.96
191_L195_A0.7350.96
291_V295_H0.7340.96
82_S102_F0.7330.96
206_D233_F0.7320.96
427_A438_P0.7310.96
362_L366_G0.7290.96
145_L186_W0.7280.96
124_P127_I0.7260.96
104_E115_T0.7240.96
301_A304_T0.7230.96
266_K269_W0.7220.96
71_L463_L0.7200.96
302_L305_I0.7170.96
368_R382_I0.7110.96
213_H242_I0.7110.96
91_S127_I0.7100.96
250_G345_G0.7070.96
335_V422_D0.7070.96
324_D329_W0.7050.95
366_G403_A0.7040.95
469_V473_L0.7040.95
243_A247_L0.6990.95
77_W106_F0.6980.95
135_Q215_F0.6970.95
311_Q314_S0.6920.95
188_I256_H0.6910.95
99_T458_L0.6900.95
114_A432_T0.6900.95
115_T131_R0.6850.95
251_C256_H0.6850.95
423_F440_L0.6840.95
204_G208_F0.6840.95
189_Y219_A0.6830.95
266_K270_R0.6810.95
322_T325_S0.6790.94
220_I249_S0.6790.94
80_L134_L0.6780.94
362_L398_W0.6770.94
220_I350_T0.6750.94
285_V312_V0.6750.94
193_T197_A0.6710.94
208_F212_G0.6710.94
272_P276_M0.6690.94
256_H260_L0.6680.94
252_N273_E0.6670.94
135_Q321_F0.6660.94
255_L271_D0.6660.94
425_A442_V0.6660.94
364_K367_N0.6640.94
136_W189_Y0.6630.94
272_P275_R0.6610.94
404_Y434_N0.6600.94
379_V383_K0.6600.94
443_V450_M0.6600.94
103_F116_T0.6580.93
412_M416_I0.6580.93
254_G348_G0.6560.93
305_I309_F0.6550.93
243_A285_V0.6540.93
213_H321_F0.6500.93
272_P360_L0.6500.93
368_R391_E0.6490.93
403_A407_V0.6480.93
203_A233_F0.6470.93
158_M179_A0.6470.93
297_V301_A0.6460.93
281_Q313_V0.6460.93
427_A439_G0.6460.93
309_F313_V0.6460.93
455_K459_I0.6450.93
322_T438_P0.6450.93
121_D226_H0.6450.93
194_V197_A0.6450.93
289_T312_V0.6440.93
214_S245_F0.6440.93
239_N311_Q0.6430.93
315_M340_S0.6430.93
331_L334_P0.6430.93
115_T120_L0.6420.93
196_C199_A0.6420.93
230_I233_F0.6410.93
230_I239_N0.6410.93
86_L126_A0.6400.92
181_T349_S0.6400.92
207_A210_A0.6400.92
82_S98_I0.6390.92
234_D239_N0.6390.92
417_A451_N0.6370.92
78_T81_G0.6370.92
422_D425_A0.6360.92
231_G323_T0.6360.92
439_G444_A0.6340.92
120_L128_L0.6340.92
265_L269_W0.6320.92
90_F122_S0.6320.92
86_L89_I0.6320.92
191_L194_V0.6310.92
101_A105_S0.6290.92
407_V433_L0.6280.92
237_T240_T0.6270.92
339_C409_I0.6260.92
163_A179_A0.6250.92
186_W190_V0.6250.92
288_C308_A0.6240.92
220_I319_A0.6240.92
283_T286_V0.6230.91
406_L410_V0.6190.91
234_D307_Q0.6180.91
276_M384_L0.6170.91
464_F472_L0.6160.91
114_A438_P0.6140.91
93_S96_L0.6130.91
74_V78_T0.6110.91
193_T215_F0.6110.91
315_M326_I0.6110.91
251_C277_F0.6090.91
415_I420_V0.6090.91
97_T101_A0.6080.90
424_S442_V0.6080.90
229_S436_L0.6070.90
312_V337_L0.6070.90
202_F210_A0.6050.90
117_L122_S0.6050.90
276_M364_K0.6050.90
452_P455_K0.6040.90
247_L282_F0.6000.90
189_Y193_T0.6000.90
415_I450_M0.5990.90
427_A431_A0.5990.90
273_E277_F0.5990.90
114_A439_G0.5950.90
431_A443_V0.5950.90
366_G402_S0.5950.90
163_A166_P0.5930.89
209_D225_T0.5920.89
310_F321_F0.5910.89
425_A429_V0.5900.89
420_V450_M0.5870.89
288_C291_V0.5870.89
288_C333_L0.5870.89
96_L100_D0.5870.89
280_V343_I0.5860.89
117_L120_L0.5850.89
404_Y408_F0.5850.89
433_L469_V0.5840.89
229_S233_F0.5830.89
338_L342_F0.5810.88
426_F430_V0.5810.88
230_I310_F0.5780.88
298_Y307_Q0.5750.88
281_Q285_V0.5750.88
415_I432_T0.5750.88
192_L249_S0.5730.88
452_P456_W0.5730.88
294_F297_V0.5710.88
314_S438_P0.5690.87
428_S431_A0.5690.87
150_L475_L0.5690.87
428_S438_P0.5660.87
408_F426_F0.5660.87
129_F204_G0.5640.87
65_K71_L0.5630.87
408_F429_V0.5620.87
286_V301_A0.5610.87
85_A95_N0.5600.87
111_T220_I0.5600.87
193_T218_I0.5600.87
327_A442_V0.5570.86
289_T292_L0.5570.86
420_V424_S0.5550.86
414_A418_T0.5550.86
114_A443_V0.5540.86
428_S458_L0.5540.86
415_I418_T0.5530.86
129_F132_Q0.5500.86
332_F417_A0.5500.86
254_G258_S0.5500.86
74_V472_L0.5490.85
230_I323_T0.5470.85
114_A428_S0.5470.85
361_L365_Q0.5470.85
391_E394_L0.5460.85
345_G356_V0.5450.85
350_T355_K0.5450.85
175_R181_T0.5430.85
338_L440_L0.5420.85
70_F474_V0.5410.85
115_T216_A0.5410.85
213_H230_I0.5400.84
449_S453_V0.5400.84
311_Q329_W0.5400.84
220_I316_A0.5390.84
115_T322_T0.5390.84
383_K388_A0.5380.84
112_T435_N0.5380.84
153_L156_G0.5380.84
88_F127_I0.5380.84
417_A425_A0.5370.84
280_V316_A0.5370.84
284_L343_I0.5370.84
116_T455_K0.5360.84
215_F219_A0.5360.84
200_L321_F0.5360.84
81_G84_G0.5360.84
85_A96_L0.5350.84
101_A123_L0.5330.84
76_F80_L0.5330.84
318_T352_G0.5330.84
143_I450_M0.5300.83
412_M430_V0.5290.83
335_V339_C0.5270.83
64_L71_L0.5270.83
77_W110_T0.5270.83
341_A434_N0.5260.83
167_G170_K0.5260.83
314_S319_A0.5250.83
211_I214_S0.5240.83
81_G105_S0.5220.82
117_L131_R0.5220.82
314_S326_I0.5200.82
247_L274_F0.5200.82
424_S450_M0.5190.82
370_L477_T0.5190.82
188_I191_L0.5190.82
417_A454_A0.5190.82
197_A215_F0.5190.82
354_L401_F0.5180.82
322_T326_I0.5180.82
97_T455_K0.5180.82
95_N116_T0.5170.82
253_Y349_S0.5160.82
239_N310_F0.5140.82
107_S112_T0.5140.82
89_I101_A0.5120.81
246_L312_V0.5120.81
94_P127_I0.5120.81
185_L466_R0.5120.81
310_F323_T0.5120.81
129_F212_G0.5110.81
122_S125_H0.5090.81
291_V332_F0.5080.81
304_T308_A0.5070.81
242_I321_F0.5070.81
116_T120_L0.5070.81
318_T435_N0.5060.81
82_S85_A0.5060.81
178_I182_A0.5050.80
181_T186_W0.5050.80
353_G359_I0.5050.80
305_I308_A0.5040.80
275_R279_G0.5030.80
390_P393_I0.5020.80
233_F238_I0.5020.80
77_W84_G0.5020.80
370_L473_L0.5010.80
229_S323_T0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.9648 100 0.071 Contact Map
4j7cI 2 0.8219 100 0.303 Contact Map
3ukmA 2 0.472 96.6 0.941 Contact Map
4twkA 2 0.4948 95.8 0.945 Contact Map
4bw5A 2 0.4907 95.4 0.947 Contact Map
4wfeA 2 0.4803 93.3 0.952 Contact Map
2a9hA 4 0.1967 91.6 0.954 Contact Map
2q67A 3 0.2153 91.1 0.955 Contact Map
3vouA 4 0.2754 90.4 0.956 Contact Map
2ih3C 4 0.1967 88.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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