GREMLIN Database
SBMA - Peptide antibiotic transporter SbmA
UniProt: P0AFY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10928
Length: 406 (315)
Sequences: 1716 (1070)
Seq/√Len: 60.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_T130_T4.4851.00
220_L244_V3.8371.00
113_A117_D3.6781.00
79_S85_Y3.4261.00
122_A345_G3.4121.00
134_F339_F3.1941.00
83_W86_W3.1381.00
177_N394_D3.0461.00
134_F343_V3.0431.00
161_H310_F2.9341.00
130_T133_Q2.8211.00
79_S82_R2.7641.00
80_P86_W2.7051.00
112_Y357_N2.6571.00
171_N279_Y2.5881.00
139_G143_G2.5611.00
261_V322_A2.5511.00
95_I210_I2.4631.00
259_A373_W2.4601.00
81_H85_Y2.4351.00
80_P85_Y2.2981.00
80_P83_W2.1761.00
174_Y195_T2.1731.00
272_N308_N2.1201.00
82_R86_W2.1031.00
106_V218_A2.0841.00
254_G326_Y2.0421.00
175_M298_V2.0151.00
315_H318_Y1.9961.00
122_A342_I1.9951.00
116_Y352_M1.9581.00
99_W214_M1.8871.00
267_G271_K1.8691.00
66_V391_H1.8321.00
249_V256_G1.8051.00
319_F323_R1.7890.99
93_L158_F1.7640.99
79_S83_W1.7620.99
258_L323_R1.7570.99
256_G260_V1.7520.99
172_E176_A1.7470.99
219_F222_V1.7190.99
228_A341_S1.7190.99
209_F369_L1.7140.99
106_V222_V1.6450.99
268_L312_L1.6360.99
177_N397_K1.6300.99
285_Y294_T1.6230.99
161_H165_R1.6180.99
142_L146_L1.5810.99
271_K274_R1.5470.98
111_W115_F1.5260.98
154_L317_M1.5250.98
330_D363_R1.5180.98
168_T306_R1.5160.98
141_F332_V1.5120.98
109_N222_V1.5030.98
63_Y383_Y1.5030.98
279_Y302_F1.4950.98
246_A337_L1.4810.98
136_R140_V1.4660.98
116_Y349_L1.4650.98
74_F166_W1.4550.98
148_A152_S1.4450.98
114_P117_D1.4440.98
271_K275_V1.4420.98
226_L355_I1.4410.98
84_Q165_R1.4380.98
59_I62_A1.4370.98
164_F199_A1.4240.97
260_V263_I1.4230.97
285_Y291_T1.4210.97
168_T172_E1.4100.97
135_Y139_G1.3960.97
131_I135_Y1.3960.97
69_G394_D1.3870.97
105_G361_Q1.3790.97
278_A304_A1.3730.97
153_V317_M1.3710.97
79_S86_W1.3700.97
193_E196_M1.3690.97
186_G278_A1.3640.97
281_K288_D1.3530.96
118_L133_Q1.3420.96
83_W87_S1.3330.96
251_S255_T1.3290.96
380_M384_K1.3280.96
186_G281_K1.3200.96
193_E273_Q1.3090.96
141_F328_Q1.3030.96
390_E394_D1.2960.95
259_A369_L1.2940.95
194_D385_R1.2910.95
174_Y390_E1.2800.95
85_Y88_I1.2780.95
342_I349_L1.2770.95
303_S307_K1.2750.95
209_F213_I1.2740.95
176_A295_P1.2690.95
112_Y356_T1.2680.95
149_V324_I1.2680.95
102_V215_T1.2650.95
292_R295_P1.2620.95
108_V148_A1.2600.95
113_A351_L1.2550.95
218_A222_V1.2500.94
205_M376_L1.2470.94
361_Q364_G1.2460.94
216_L362_V1.2370.94
110_A113_A1.2360.94
121_T213_I1.2360.94
185_E190_R1.2320.94
285_Y288_D1.2230.94
221_P225_T1.2150.94
212_A215_T1.2140.94
183_H395_G1.2110.93
320_N324_I1.2070.93
84_Q87_S1.2060.93
281_K287_E1.2010.93
202_L379_L1.2000.93
109_N113_A1.1910.93
340_P350_G1.1870.93
219_F358_V1.1850.93
110_A114_P1.1840.93
197_R273_Q1.1690.92
81_H88_I1.1660.92
353_T356_T1.1590.92
97_V191_V1.1500.92
259_A263_I1.1500.92
104_V108_V1.1450.91
172_E213_I1.1380.91
171_N389_F1.1300.91
142_L149_V1.1260.91
291_T294_T1.1220.90
113_A354_Q1.1190.90
309_Y368_Y1.1170.90
334_G359_F1.1140.90
101_L105_G1.1060.90
71_F288_D1.1010.90
194_D280_R1.0990.90
164_F306_R1.0910.89
116_Y353_T1.0890.89
175_M279_Y1.0800.89
141_F145_A1.0790.89
62_A66_V1.0710.88
262_G359_F1.0600.88
95_I282_E1.0570.88
258_L319_F1.0500.87
145_A331_N1.0490.87
185_E278_A1.0470.87
60_F63_Y1.0450.87
97_V151_I1.0380.87
104_V110_A1.0340.86
343_V355_I1.0310.86
146_L150_V1.0300.86
166_W169_A1.0270.86
117_D348_T1.0230.86
69_G387_R1.0220.86
161_H313_Y1.0220.86
258_L322_A1.0210.86
162_Y203_E1.0170.86
74_F169_A1.0140.85
339_F343_V1.0140.85
219_F251_S1.0090.85
113_A116_Y1.0040.85
224_V227_S0.9960.84
167_R280_R0.9700.83
79_S88_I0.9690.83
133_Q137_E0.9660.83
252_L255_T0.9630.82
264_K267_G0.9610.82
171_N298_V0.9590.82
109_N357_N0.9550.82
92_A217_I0.9510.82
80_P84_Q0.9500.81
79_S84_Q0.9450.81
66_V72_A0.9440.81
160_S313_Y0.9340.80
220_L248_I0.9310.80
380_M387_R0.9260.80
189_Q277_A0.9240.80
140_V332_V0.9220.79
251_S362_V0.9220.79
177_N390_E0.9160.79
331_N335_L0.9100.79
280_R385_R0.9080.78
304_A391_H0.9080.78
105_G148_A0.9060.78
171_N302_F0.9000.78
268_L315_H0.8990.78
189_Q194_D0.8990.78
195_T376_L0.8960.77
109_N219_F0.8960.77
96_F136_R0.8950.77
338_L367_Q0.8930.77
92_A253_M0.8920.77
350_G354_Q0.8900.77
73_L379_L0.8890.77
148_A324_I0.8870.77
156_N211_N0.8840.77
196_M200_S0.8830.76
177_N393_L0.8810.76
65_I260_V0.8760.76
111_W116_Y0.8740.76
146_L325_L0.8710.75
156_N320_N0.8710.75
333_F337_L0.8700.75
281_K285_Y0.8690.75
212_A363_R0.8680.75
183_H392_E0.8670.75
117_D121_T0.8660.75
194_D219_F0.8650.75
112_Y116_Y0.8650.75
222_V349_L0.8640.75
81_H84_Q0.8630.75
325_L329_V0.8590.74
149_V325_L0.8570.74
109_N358_V0.8520.74
227_S254_G0.8460.73
289_D294_T0.8430.73
327_L367_Q0.8420.73
108_V353_T0.8410.73
335_L356_T0.8390.73
178_W368_Y0.8360.72
172_E200_S0.8360.72
82_R85_Y0.8350.72
251_S366_F0.8330.72
139_G346_T0.8300.72
153_V321_I0.8280.72
163_V200_S0.8250.71
132_E300_E0.8230.71
224_V334_G0.8210.71
150_V191_V0.8140.70
137_E140_V0.8100.70
379_L383_Y0.8090.70
247_A353_T0.8080.70
70_L138_V0.8020.69
360_G364_G0.7960.69
116_Y343_V0.7950.69
109_N115_F0.7940.68
274_R278_A0.7930.68
384_K387_R0.7910.68
139_G220_L0.7900.68
65_I114_P0.7890.68
178_W328_Q0.7880.68
201_T375_T0.7860.68
119_I343_V0.7860.68
382_I389_F0.7860.68
192_Q272_N0.7850.68
334_G358_V0.7830.67
103_E107_A0.7790.67
68_V72_A0.7770.67
372_S375_T0.7760.67
176_A225_T0.7720.66
245_I317_M0.7710.66
59_I63_Y0.7690.66
112_Y335_L0.7650.66
154_L158_F0.7650.66
215_T327_L0.7640.65
314_F318_Y0.7620.65
81_H168_T0.7620.65
187_A313_Y0.7600.65
186_G190_R0.7590.65
75_W192_Q0.7550.65
273_Q379_L0.7520.64
273_Q276_E0.7520.64
254_G370_I0.7510.64
151_I325_L0.7490.64
370_I376_L0.7480.64
145_A364_G0.7470.64
368_Y382_I0.7430.63
163_V309_Y0.7420.63
87_S93_L0.7380.63
281_K284_V0.7380.63
224_V358_V0.7380.63
253_M292_R0.7340.62
350_G358_V0.7330.62
272_N276_E0.7330.62
136_R139_G0.7280.62
167_R194_D0.7260.62
102_V120_Q0.7250.61
275_V308_N0.7250.61
251_S281_K0.7240.61
195_T306_R0.7230.61
65_I69_G0.7230.61
223_L262_G0.7220.61
138_V387_R0.7210.61
70_L134_F0.7200.61
65_I96_F0.7190.61
167_R276_E0.7180.61
268_L308_N0.7160.60
219_F262_G0.7160.60
323_R370_I0.7160.60
266_P380_M0.7150.60
177_N195_T0.7150.60
98_T211_N0.7150.60
341_S346_T0.7140.60
273_Q373_W0.7110.60
111_W353_T0.7110.60
92_A96_F0.7090.60
369_L373_W0.7080.60
300_E304_A0.7050.59
143_G146_L0.7050.59
325_L335_L0.7030.59
309_Y313_Y0.7010.59
369_L384_K0.6980.59
176_A292_R0.6960.58
179_Q188_A0.6920.58
178_W369_L0.6900.58
357_N360_G0.6880.57
69_G391_H0.6880.57
211_N215_T0.6860.57
176_A394_D0.6830.57
273_Q381_S0.6810.57
118_L137_E0.6780.56
386_L389_F0.6770.56
228_A231_P0.6750.56
295_P299_R0.6720.56
82_R88_I0.6720.56
326_Y370_I0.6660.55
299_R303_S0.6640.55
262_G358_V0.6620.55
139_G299_R0.6620.55
65_I132_E0.6590.54
198_F377_V0.6590.54
68_V74_F0.6570.54
59_I64_Y0.6570.54
144_I153_V0.6570.54
138_V333_F0.6570.54
249_V252_L0.6540.54
250_W285_Y0.6530.54
216_L365_A0.6520.53
62_A65_I0.6520.53
81_H86_W0.6510.53
188_A290_A0.6500.53
266_P287_E0.6500.53
305_V309_Y0.6500.53
79_S87_S0.6490.53
253_M303_S0.6490.53
72_A92_A0.6490.53
71_F170_M0.6480.53
296_P307_K0.6470.53
147_I263_I0.6460.53
112_Y330_D0.6450.53
338_L352_M0.6410.52
203_E207_V0.6410.52
178_W245_I0.6390.52
319_F338_L0.6380.52
80_P89_L0.6380.52
247_A261_V0.6360.52
83_W88_I0.6360.52
201_T290_A0.6350.51
140_V143_G0.6320.51
177_N181_L0.6290.51
246_A365_A0.6260.50
72_A84_Q0.6240.50
173_Y177_N0.6240.50
144_I148_A0.6230.50
368_Y372_S0.6220.50
87_S172_E0.6220.50
181_L397_K0.6220.50
97_V158_F0.6180.50
101_L211_N0.6160.49
299_R307_K0.6110.49
164_F313_Y0.6100.49
195_T199_A0.6100.49
92_A132_E0.6090.49
112_Y141_F0.6080.48
84_Q391_H0.6070.48
132_E394_D0.6070.48
330_D355_I0.6060.48
262_G319_F0.6050.48
286_G387_R0.6050.48
265_L283_L0.6020.48
209_F216_L0.6010.48
209_F368_Y0.6000.48
170_M329_V0.5990.47
94_I352_M0.5960.47
72_A256_G0.5950.47
209_F344_A0.5950.47
178_W379_L0.5930.47
187_A287_E0.5900.46
357_N363_R0.5900.46
85_Y169_A0.5890.46
215_T328_Q0.5890.46
391_H395_G0.5880.46
135_Y142_L0.5870.46
166_W230_V0.5870.46
104_V144_I0.5870.46
72_A296_P0.5860.46
219_F340_P0.5850.46
208_S368_Y0.5840.46
163_V178_W0.5830.46
75_W340_P0.5820.46
327_L372_S0.5810.45
145_A328_Q0.5800.45
219_F265_L0.5800.45
92_A225_T0.5750.45
155_N211_N0.5750.45
113_A353_T0.5740.45
186_G294_T0.5730.45
286_G291_T0.5720.44
227_S268_L0.5710.44
156_N209_F0.5710.44
93_L176_A0.5710.44
225_T228_A0.5700.44
306_R313_Y0.5700.44
211_N364_G0.5700.44
165_R290_A0.5690.44
81_H169_A0.5640.44
88_I96_F0.5590.43
131_I195_T0.5590.43
336_F339_F0.5580.43
107_A144_I0.5580.43
160_S320_N0.5570.43
251_S254_G0.5550.43
181_L292_R0.5550.43
282_E366_F0.5550.43
375_T378_E0.5550.43
71_F74_F0.5540.42
302_F313_Y0.5510.42
218_A361_Q0.5510.42
275_V302_F0.5440.41
265_L381_S0.5430.41
155_N159_V0.5420.41
222_V350_G0.5410.41
345_G348_T0.5400.41
179_Q186_G0.5400.41
65_I344_A0.5390.41
152_S211_N0.5390.41
159_V278_A0.5380.41
196_M276_E0.5380.41
160_S208_S0.5370.41
101_L155_N0.5370.41
197_R378_E0.5360.40
256_G289_D0.5350.40
94_I157_F0.5350.40
324_I370_I0.5340.40
219_F228_A0.5340.40
113_A120_Q0.5330.40
222_V227_S0.5320.40
278_A301_L0.5320.40
105_G211_N0.5310.40
194_D359_F0.5300.40
105_G372_S0.5300.40
114_P140_V0.5280.40
317_M321_I0.5260.39
111_W137_E0.5260.39
86_W92_A0.5240.39
75_W79_S0.5240.39
72_A275_V0.5230.39
253_M388_S0.5210.39
252_L394_D0.5190.39
256_G305_V0.5180.39
279_Y287_E0.5140.38
111_W141_F0.5130.38
350_G359_F0.5110.38
310_F314_F0.5110.38
335_L360_G0.5100.38
229_H249_V0.5100.38
61_Y64_Y0.5090.38
298_V388_S0.5090.38
160_S382_I0.5040.37
328_Q331_N0.5030.37
262_G350_G0.5030.37
264_K343_V0.5020.37
96_F292_R0.5020.37
189_Q280_R0.5020.37
292_R296_P0.5010.37
66_V300_E0.5010.37
98_T152_S0.5000.37
96_F100_F0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4hB 1 0.803 99.5 0.842 Contact Map
4a82A 2 0.7833 99.5 0.845 Contact Map
3b5xA 2 0.7734 99.5 0.845 Contact Map
3b60A 2 0.7709 99.5 0.845 Contact Map
4q4hA 1 0.7734 99.4 0.852 Contact Map
4mrsA 2 0.8103 99.4 0.852 Contact Map
3zdqA 2 0.7734 99.4 0.854 Contact Map
4pl0A 2 0.7734 99.3 0.861 Contact Map
3wmgA 1 0.7808 99.3 0.862 Contact Map
4q9hA 1 0.7956 99.3 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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