GREMLIN Database
SANA - Protein SanA
UniProt: P0AFY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12025
Length: 239 (187)
Sequences: 3047 (2402)
Seq/√Len: 175.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_L106_L3.3601.00
77_Y115_D3.3311.00
129_I157_A2.7691.00
87_L116_I2.7181.00
45_R142_I2.6851.00
97_N100_M2.6821.00
50_V73_A2.6121.00
48_G82_V2.5831.00
103_R107_I2.4751.00
72_G75_N2.4411.00
103_R113_P2.3951.00
48_G144_I2.3261.00
74_I106_L2.2951.00
49_V141_F2.2891.00
74_I78_N2.2031.00
77_Y112_D2.0941.00
86_L132_T2.0801.00
121_A131_R2.0091.00
150_C166_C1.9931.00
145_T150_C1.9841.00
71_Q105_D1.9831.00
119_D128_S1.9751.00
126_L130_V1.9501.00
67_R71_Q1.9001.00
123_F127_D1.8861.00
84_Y117_V1.8581.00
99_P118_L1.8371.00
84_Y115_D1.8361.00
103_R118_L1.8271.00
154_L166_C1.7631.00
100_M120_Y1.7271.00
72_G167_Y1.7171.00
46_Q140_D1.7161.00
119_D122_G1.7111.00
154_L164_A1.7101.00
87_L102_M1.6921.00
129_I160_M1.6661.00
156_I189_A1.6211.00
122_G128_S1.6041.00
124_R127_D1.5871.00
72_G169_V1.5861.00
74_I109_A1.5691.00
107_I113_P1.5301.00
96_Y104_K1.5031.00
70_I106_L1.4581.00
181_R185_A1.4131.00
73_A106_L1.4101.00
85_L106_L1.4071.00
112_D115_D1.3931.00
119_D131_R1.3821.00
136_F141_F1.3221.00
15_L19_T1.3111.00
154_L158_L1.2861.00
51_L143_I1.2791.00
75_N79_S1.2691.00
128_S131_R1.2571.00
126_L160_M1.2501.00
130_V134_K1.2431.00
128_S132_T1.2391.00
62_I70_I1.2231.00
157_A164_A1.2201.00
88_S122_G1.2151.00
76_A167_Y1.2141.00
47_V86_L1.2081.00
19_T23_L1.2031.00
70_I105_D1.1901.00
97_N120_Y1.1891.00
51_L153_A1.1841.00
53_T66_Y1.1631.00
150_C168_A1.1471.00
66_Y105_D1.1461.00
73_A85_L1.1341.00
77_Y111_V1.1331.00
49_V128_S1.1121.00
90_D98_E1.1101.00
68_Y169_V1.0991.00
131_R134_K1.0961.00
141_F162_I1.0921.00
48_G83_N1.0891.00
92_A123_F1.0881.00
100_M104_K1.0841.00
127_D131_R1.0811.00
88_S132_T1.0791.00
143_I157_A1.0771.00
71_Q109_A1.0761.00
111_V116_I1.0661.00
48_G76_A1.0641.00
87_L118_L1.0541.00
80_G83_N1.0491.00
24_D27_M1.0400.99
70_I102_M1.0390.99
53_T65_Y1.0370.99
28_S31_T1.0360.99
100_M103_R1.0270.99
148_F178_V1.0180.99
53_T63_N1.0140.99
107_I116_I1.0120.99
129_I143_I0.9980.99
130_V160_M0.9770.99
86_L136_F0.9750.99
26_W30_K0.9690.99
122_G131_R0.9640.99
77_Y80_G0.9610.99
45_R165_Q0.9600.99
180_I184_A0.9550.99
20_V24_D0.9490.99
140_D163_Q0.9440.99
104_K108_A0.9430.99
70_I87_L0.9410.99
16_L20_V0.9270.99
49_V132_T0.9270.99
148_F181_R0.9230.99
28_S32_A0.9210.99
104_K107_I0.9160.99
74_I111_V0.9080.99
27_M35_I0.9050.99
63_N67_R0.8980.99
145_T153_A0.8970.98
64_Q67_R0.8940.98
50_V87_L0.8930.98
90_D122_G0.8930.98
125_T149_H0.8900.98
54_A57_Y0.8880.98
24_D32_A0.8880.98
141_F164_A0.8770.98
21_L25_R0.8750.98
91_N97_N0.8730.98
66_Y102_M0.8690.98
47_V141_F0.8530.98
156_I160_M0.8490.98
62_I66_Y0.8490.98
119_D132_T0.8470.98
47_V136_F0.8380.98
96_Y100_M0.8330.98
86_L135_V0.8310.98
88_S119_D0.8300.98
124_R185_A0.8260.97
142_I165_Q0.8170.97
91_N120_Y0.8160.97
81_K142_I0.8090.97
33_P36_Y0.8030.97
44_Y83_N0.8010.97
82_V144_I0.7990.97
58_R63_N0.7980.97
117_V135_V0.7970.97
158_L163_Q0.7940.97
29_W32_A0.7920.97
60_G96_Y0.7910.97
44_Y140_D0.7900.97
99_P119_D0.7880.97
47_V138_T0.7840.96
46_Q83_N0.7820.96
63_N66_Y0.7820.96
155_F158_L0.7750.96
51_L128_S0.7740.96
32_A36_Y0.7680.96
179_R183_F0.7580.96
19_T32_A0.7510.96
20_V23_L0.7500.95
90_D99_P0.7490.95
50_V106_L0.7490.95
103_R116_I0.7470.95
59_T95_S0.7430.95
34_Y158_L0.7410.95
46_Q138_T0.7360.95
6_F9_L0.7340.95
25_R32_A0.7270.95
189_A193_L0.7270.95
76_A144_I0.7240.95
100_M118_L0.7240.95
173_K176_L0.7190.94
88_S128_S0.7160.94
155_F159_H0.7160.94
66_Y70_I0.7110.94
126_L156_I0.6990.93
24_D35_I0.6980.93
10_L17_L0.6970.93
133_R160_M0.6920.93
96_Y101_T0.6910.93
62_I67_R0.6850.93
62_I101_T0.6830.93
11_V18_L0.6820.93
77_Y85_L0.6810.93
56_Y62_I0.6780.92
138_T141_F0.6770.92
22_G27_M0.6740.92
23_L31_T0.6730.92
177_S180_I0.6730.92
65_Y178_V0.6680.92
8_S11_V0.6680.92
122_G127_D0.6670.92
23_L27_M0.6660.92
188_G192_D0.6660.92
15_L32_A0.6660.92
32_A35_I0.6610.91
28_S35_I0.6580.91
19_T24_D0.6550.91
71_Q74_I0.6540.91
10_L30_K0.6510.91
146_Q170_P0.6500.91
22_G29_W0.6480.91
168_A171_S0.6450.90
71_Q75_N0.6450.90
140_D165_Q0.6400.90
105_D109_A0.6280.89
57_Y61_V0.6220.89
47_V83_N0.6210.89
24_D31_T0.6080.88
98_E181_R0.6070.88
158_L164_A0.6070.88
70_I74_I0.6060.88
48_G85_L0.6050.87
73_A87_L0.6030.87
27_M30_K0.6010.87
102_M156_I0.6000.87
88_S102_M0.5990.87
68_Y170_P0.5990.87
159_H189_A0.5970.87
38_E41_D0.5950.87
91_N95_S0.5940.86
16_L21_L0.5930.86
74_I87_L0.5920.86
143_I153_A0.5920.86
15_L26_W0.5890.86
151_E186_R0.5830.85
25_R29_W0.5830.85
35_I154_L0.5800.85
51_L149_H0.5790.85
51_L125_T0.5760.85
11_V21_L0.5750.85
59_T94_Q0.5730.84
183_F186_R0.5730.84
46_Q139_N0.5700.84
129_I162_I0.5680.84
94_Q97_N0.5660.84
8_S19_T0.5640.84
147_R171_S0.5630.83
125_T145_T0.5590.83
98_E128_S0.5570.83
11_V15_L0.5560.83
142_I167_Y0.5550.83
99_P120_Y0.5540.82
16_L19_T0.5540.82
31_T34_Y0.5530.82
147_R151_E0.5500.82
101_T105_D0.5490.82
10_L21_L0.5470.82
147_R170_P0.5460.82
91_N94_Q0.5460.82
91_N100_M0.5440.81
27_M32_A0.5440.81
155_F186_R0.5440.81
155_F189_A0.5440.81
10_L13_I0.5430.81
21_L24_D0.5430.81
143_I189_A0.5420.81
57_Y101_T0.5420.81
83_N115_D0.5400.81
25_R28_S0.5390.81
24_D28_S0.5370.80
52_G102_M0.5340.80
89_G125_T0.5310.80
132_T136_F0.5280.79
45_R83_N0.5280.79
188_G191_A0.5230.79
54_A62_I0.5210.78
7_L187_F0.5200.78
50_V102_M0.5150.78
90_D97_N0.5130.77
30_K33_P0.5110.77
21_L32_A0.5070.77
60_G67_R0.5070.77
53_T178_V0.5070.77
151_E154_L0.5050.76
74_I105_D0.5050.76
21_L36_Y0.5040.76
124_R192_D0.5040.76
147_R179_R0.5030.76
89_G149_H0.5010.76
63_N105_D0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ca8A 1 0.8577 100 0.527 Contact Map
2kgwA 1 0.4603 61.3 0.938 Contact Map
2hqsH 1 0.4017 58.3 0.939 Contact Map
1r1mA 1 0.4519 57.5 0.94 Contact Map
4g4xA 1 0.3933 55 0.94 Contact Map
4rhaA 2 0.4184 45.4 0.944 Contact Map
3td3A 2 0.4603 44.4 0.944 Contact Map
2aizP 1 0.4603 43.2 0.945 Contact Map
3ldtA 2 0.5272 40.4 0.945 Contact Map
3oonA 2 0.41 35.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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