GREMLIN Database
HPF - Ribosome hibernation promoting factor
UniProt: P0AFX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11681
Length: 95 (93)
Sequences: 1426 (800)
Seq/√Len: 82.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_G73_A4.8971.00
20_V41_L2.9881.00
16_L70_M2.7731.00
7_G12_I2.7201.00
30_Y82_A2.5241.00
14_E18_E2.5221.00
49_T66_E2.2511.00
41_L50_S2.2231.00
18_E22_A2.1961.00
52_A77_L2.0691.00
65_A76_G1.9161.00
86_T90_D1.9031.00
13_T71_Y1.8761.00
2_Q36_Q1.7251.00
43_V48_H1.6881.00
41_L70_M1.6801.00
5_I41_L1.6581.00
63_A77_L1.6291.00
16_L41_L1.6171.00
15_A19_F1.5160.99
53_T62_H1.4550.99
7_G13_T1.4510.99
17_R21_T1.3840.99
24_F52_A1.3420.99
43_V71_Y1.3330.99
48_H70_M1.2920.98
12_I17_R1.2750.98
44_E49_T1.2470.98
47_T66_E1.2470.98
19_F72_A1.2440.98
56_V85_L1.2320.98
50_S77_L1.2080.97
20_V39_V1.1740.97
27_L85_L1.1680.97
29_Q82_A1.1670.97
77_L80_K1.1550.97
52_A81_L1.1400.96
56_V88_H1.1220.96
4_N38_Y1.0900.95
55_H60_E1.0880.95
83_R87_K1.0840.95
13_T16_L1.0750.95
14_E21_T0.9970.92
83_R86_T0.9880.92
5_I12_I0.9840.92
15_A71_Y0.9810.92
35_N57_N0.9720.91
30_Y86_T0.9600.91
60_E64_S0.9550.91
40_V91_K0.9450.90
70_M74_I0.9410.90
22_A25_A0.9380.90
11_E17_R0.9160.89
25_A28_E0.9050.88
53_T60_E0.9020.88
75_D89_K0.9010.88
5_I20_V0.8960.88
31_F92_L0.8810.87
23_K61_I0.8580.85
26_K45_K0.8580.85
3_L39_V0.8530.85
20_V50_S0.8330.84
13_T74_I0.8230.83
51_D62_H0.8200.83
56_V59_G0.8110.82
31_F85_L0.8080.82
43_V70_M0.8080.82
63_A84_Q0.8080.82
62_H85_L0.8010.81
76_G80_K0.7930.80
50_S70_M0.7910.80
58_G88_H0.7910.80
67_G72_A0.7840.80
40_V70_M0.7730.79
3_L28_E0.7690.78
28_E37_V0.7640.78
16_L74_I0.7620.78
51_D87_K0.7580.77
24_F28_E0.7430.76
65_A77_L0.7350.75
10_V71_Y0.7250.74
19_F74_I0.7210.74
68_Q80_K0.7120.73
8_N42_K0.7120.73
11_E18_E0.7030.72
19_F50_S0.7010.72
13_T48_H0.7000.72
11_E71_Y0.6910.71
18_E21_T0.6890.70
48_H73_A0.6870.70
69_D82_A0.6820.70
4_N36_Q0.6790.69
82_A86_T0.6780.69
6_T40_V0.6770.69
18_E36_Q0.6760.69
84_Q87_K0.6690.68
14_E17_R0.6690.68
33_R57_N0.6680.68
49_T64_S0.6640.68
44_E85_L0.6580.67
3_L58_G0.6420.65
31_F51_D0.6420.65
67_G76_G0.6370.64
88_H92_L0.6340.64
53_T64_S0.6200.62
3_L80_K0.6190.62
6_T38_Y0.6130.61
18_E67_G0.6110.61
1_M84_Q0.6010.60
75_D79_D0.5990.60
5_I21_T0.5840.58
7_G10_V0.5760.57
42_K60_E0.5730.56
38_Y53_T0.5730.56
26_K30_Y0.5700.56
40_V53_T0.5690.56
22_A85_L0.5670.56
34_I60_E0.5660.55
26_K79_D0.5600.55
51_D86_T0.5570.54
24_F78_I0.5560.54
38_Y76_G0.5400.52
28_E63_A0.5380.52
61_I69_D0.5320.51
26_K87_K0.5270.50
28_E34_I0.5260.50
9_N44_E0.5230.50
25_A93_K0.5230.50
6_T19_F0.5220.50
23_K79_D0.5190.49
48_H71_Y0.5180.49
51_D89_K0.5180.49
72_A75_D0.5120.48
51_D64_S0.5090.48
52_A61_I0.5090.48
10_V16_L0.5010.47
5_I80_K0.5010.47
38_Y68_Q0.5010.47
38_Y44_E0.5000.47
30_Y54_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v2cY 1 0.9895 100 0.187 Contact Map
3v26X 1 1 100 0.188 Contact Map
3tqmA 1 0.9789 100 0.197 Contact Map
4heiA 1 0.9684 100 0.197 Contact Map
1imuA 1 1 100 0.199 Contact Map
2ywqA 1 0.9158 100 0.224 Contact Map
1pu1A 1 0.7895 19.2 0.917 Contact Map
3nbxX 1 0.9474 7.7 0.931 Contact Map
4i8oA 2 0.8421 7.6 0.931 Contact Map
3ghgA 2 1 7.5 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0055 seconds.