GREMLIN Database
RNK - Regulator of nucleoside diphosphate kinase
UniProt: P0AFW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12637
Length: 136 (116)
Sequences: 3752 (2200)
Seq/√Len: 204.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K123_E3.2031.00
61_K70_V2.8511.00
82_T85_N2.6731.00
63_R120_E2.6361.00
63_R68_G2.4741.00
63_R122_L2.4701.00
108_H118_H2.4341.00
61_K72_V2.3431.00
103_V123_E2.3161.00
97_A109_W2.2651.00
63_R70_V2.2091.00
61_K125_E2.2031.00
108_H115_V2.0941.00
106_S118_H1.9101.00
59_R74_T1.9081.00
78_P91_M1.9021.00
37_E79_A1.8261.00
72_V125_E1.7651.00
36_A40_R1.7651.00
101_L105_D1.7561.00
53_V102_R1.7421.00
65_L120_E1.7101.00
62_F119_L1.6391.00
74_T87_Q1.6101.00
62_F71_R1.5991.00
54_V60_V1.5921.00
75_L95_G1.5851.00
59_R125_E1.4961.00
65_L118_H1.4621.00
64_N67_D1.4451.00
56_M77_Y1.4381.00
33_A37_E1.4211.00
76_V87_Q1.4141.00
62_F73_R1.3881.00
111_L116_A1.3761.00
62_F98_L1.3761.00
52_D102_R1.3651.00
110_E115_V1.3651.00
101_L107_I1.3631.00
65_L106_S1.3491.00
70_V122_L1.3371.00
24_A27_G1.3121.00
111_L115_V1.3011.00
106_S120_E1.2941.00
75_L90_V1.2831.00
57_N80_K1.2581.00
103_V124_L1.2421.00
54_V121_V1.2391.00
59_R72_V1.2241.00
13_A17_D1.2141.00
17_D23_P1.1631.00
98_L107_I1.1521.00
61_K122_L1.1071.00
20_L24_A1.0841.00
101_L121_V1.0391.00
104_G120_E1.0231.00
57_N77_Y1.0181.00
19_L22_Q1.0051.00
11_L16_I0.9560.99
34_L38_L0.9470.99
78_P90_V0.9370.99
54_V75_L0.9300.99
64_N119_L0.9280.99
92_A112_P0.8980.99
33_A36_A0.8950.99
116_A119_L0.8900.99
36_A39_D0.8740.99
14_E18_I0.8600.99
49_M52_D0.8600.99
94_V111_L0.8480.99
49_M55_T0.8440.99
64_N116_A0.8200.98
45_S48_E0.8180.98
14_E19_L0.8140.98
46_P55_T0.8140.98
15_R18_I0.8130.98
18_I22_Q0.8060.98
45_S49_M0.8030.98
10_D14_E0.8020.98
88_L94_V0.8020.98
32_D36_A0.7980.98
73_R88_L0.7910.98
23_P27_G0.7760.98
29_P33_A0.7750.98
15_R19_L0.7740.98
16_I24_A0.7720.98
55_T58_S0.7710.98
35_N39_D0.7600.97
14_E22_Q0.7500.97
82_T87_Q0.7460.97
78_P95_G0.7430.97
94_V109_W0.7380.97
13_A21_E0.7370.97
76_V82_T0.7350.97
30_I33_A0.7350.97
109_W119_L0.7340.97
31_A35_N0.7240.96
92_A95_G0.7170.96
37_E107_I0.7140.96
10_D45_S0.7040.96
58_S124_L0.7010.96
22_Q25_Y0.6960.96
37_E40_R0.6860.95
9_N13_A0.6860.95
60_V98_L0.6850.95
14_E21_E0.6830.95
50_P53_V0.6820.95
38_L41_A0.6820.95
64_N71_R0.6820.95
13_A23_P0.6820.95
50_P58_S0.6780.95
15_R22_Q0.6770.95
62_F94_V0.6750.95
53_V100_G0.6720.95
107_I121_V0.6710.95
32_D86_T0.6670.94
90_V99_L0.6600.94
42_Q48_E0.6480.94
10_D25_Y0.6430.93
104_G122_L0.6380.93
20_L23_P0.6330.93
28_L31_A0.6260.92
14_E17_D0.6260.92
51_H58_S0.6210.92
83_D88_L0.6180.92
35_N92_A0.6170.92
22_Q26_A0.6160.92
17_D20_L0.6110.91
111_L119_L0.6110.91
113_G116_A0.6080.91
81_M87_Q0.6080.91
18_I26_A0.6020.91
11_L15_R0.6000.91
65_L68_G0.6000.91
20_L27_G0.5990.91
9_N12_D0.5970.90
15_R77_Y0.5920.90
17_D21_E0.5920.90
63_R106_S0.5900.90
93_P112_P0.5860.90
12_D16_I0.5850.90
77_Y90_V0.5820.89
18_I25_Y0.5760.89
11_L24_A0.5740.89
11_L17_D0.5710.88
33_A39_D0.5690.88
78_P89_S0.5660.88
14_E26_A0.5650.88
49_M53_V0.5630.88
66_S69_E0.5610.88
67_D70_V0.5570.87
12_D56_M0.5540.87
108_H116_A0.5540.87
57_N90_V0.5530.87
90_V95_G0.5530.87
94_V119_L0.5510.87
66_S118_H0.5510.87
12_D20_L0.5360.85
24_A95_G0.5320.85
71_R116_A0.5320.85
11_L77_Y0.5310.85
16_I20_L0.5290.84
65_L122_L0.5200.83
101_L109_W0.5180.83
14_E25_Y0.5170.83
25_Y28_L0.5160.83
23_P29_P0.5160.83
102_R105_D0.5160.83
26_A80_K0.5100.82
46_P56_M0.5050.82
110_E113_G0.5020.81
19_L26_A0.5010.81
56_M90_V0.5000.81
23_P46_P0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bmbA 1 0.9926 100 0.185 Contact Map
2pn0A 2 0.9118 100 0.203 Contact Map
2p4vA 1 0.9191 100 0.292 Contact Map
1grjA 1 0.8824 100 0.3 Contact Map
2f23A 1 0.9044 100 0.355 Contact Map
2piaA 1 0.5221 57.6 0.912 Contact Map
4ylfA 1 0.7574 48.4 0.916 Contact Map
3gtyX 1 0.8603 41.7 0.92 Contact Map
1w26A 1 0.8971 41.1 0.92 Contact Map
1fdrA 1 0.7279 36.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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