GREMLIN Database
MEPS - Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase
UniProt: P0AFV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14076
Length: 188 (158)
Sequences: 3012 (2512)
Seq/√Len: 199.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_I166_I3.0601.00
86_G91_G2.7311.00
77_W80_V2.6161.00
75_A166_I2.4591.00
111_P120_M2.4051.00
159_S163_G2.3911.00
87_S112_R2.3181.00
162_S165_I2.2911.00
129_L181_A2.1681.00
74_Y156_V2.1391.00
92_I100_R2.1361.00
75_A156_V2.1321.00
98_V148_I2.0601.00
114_T118_Q1.9871.00
157_H167_S1.9771.00
78_K156_V1.9411.00
125_S128_N1.9281.00
178_Y181_A1.9221.00
98_V117_Q1.8771.00
71_M150_I1.8371.00
88_T91_G1.8041.00
134_L146_V1.8031.00
98_V134_L1.7181.00
73_Q77_W1.6691.00
20_V24_L1.6221.00
113_S116_E1.6161.00
138_R144_R1.5791.00
123_S182_R1.5531.00
22_V26_A1.4931.00
26_A30_N1.4881.00
80_V88_T1.4871.00
73_Q106_F1.4871.00
121_G182_R1.4841.00
24_L28_S1.4651.00
99_Q112_R1.4641.00
31_N34_K1.4181.00
126_R129_L1.4131.00
80_V92_I1.4051.00
27_C31_N1.4001.00
98_V110_L1.4001.00
154_Q168_S1.3941.00
137_F147_G1.3931.00
137_F155_F1.3931.00
68_S72_D1.3921.00
67_K71_M1.3911.00
97_F101_T1.3871.00
80_V91_G1.3811.00
70_I106_F1.3801.00
30_N34_K1.3791.00
80_V164_V1.3771.00
118_Q143_G1.3661.00
73_Q105_Q1.3631.00
68_S131_T1.3611.00
136_L146_V1.3581.00
25_S29_A1.3111.00
159_S162_S1.3051.00
21_A25_S1.2931.00
99_Q103_R1.2841.00
118_Q180_E1.2571.00
81_R91_G1.2531.00
154_Q166_I1.2481.00
87_S99_Q1.2291.00
80_V86_G1.2221.00
73_Q100_R1.2211.00
159_S165_I1.2121.00
89_K92_I1.2001.00
114_T143_G1.1941.00
20_V23_L1.1881.00
35_N39_E1.1671.00
37_H41_R1.1541.00
160_T163_G1.1461.00
25_S28_S1.1461.00
23_L27_C1.1451.00
126_R178_Y1.1381.00
155_F169_M1.1361.00
100_R105_Q1.1311.00
31_N35_N1.1161.00
35_N38_P1.1121.00
28_S32_T1.0901.00
24_L27_C1.0891.00
73_Q101_T1.0861.00
29_A33_A1.0841.00
71_M75_A1.0811.00
71_M156_V1.0801.00
116_E119_E1.0541.00
32_T36_M1.0521.00
147_G155_F1.0511.00
92_I164_V1.0491.00
78_K166_I1.0431.00
149_Y153_N1.0421.00
74_Y148_I1.0371.00
139_A144_R1.0361.00
21_A24_L1.0351.00
102_F110_L1.0351.00
99_Q117_Q1.0231.00
27_C30_N1.0021.00
129_L169_M0.9951.00
101_T106_F0.9771.00
33_A37_H0.9550.99
111_P116_E0.9530.99
73_Q76_D0.9510.99
143_G179_N0.9300.99
135_V147_G0.9080.99
129_L149_Y0.9050.99
75_A150_I0.9010.99
73_Q92_I0.9010.99
118_Q121_G0.8950.99
103_R109_E0.8930.99
157_H165_I0.8920.99
38_P42_A0.8810.99
36_M40_T0.8760.99
30_N33_A0.8620.99
86_G96_G0.8490.99
23_L26_A0.8460.99
78_K163_G0.8460.99
72_D75_A0.8360.98
75_A78_K0.8310.98
42_A46_E0.8290.98
52_A55_D0.8280.98
138_R142_T0.8270.98
129_L135_V0.8220.98
137_F144_R0.8170.98
23_L31_N0.8050.98
149_Y152_N0.8020.98
112_R116_E0.7980.98
49_S55_D0.7890.98
29_A32_T0.7870.98
83_R86_G0.7820.98
22_V25_S0.7810.98
34_K38_P0.7780.98
22_V29_A0.7780.98
51_Q54_Q0.7570.97
37_H40_T0.7470.97
40_T44_G0.7400.97
144_R177_R0.7310.96
118_Q179_N0.7270.96
139_A177_R0.7270.96
150_I154_Q0.7250.96
28_S31_N0.7250.96
77_W88_T0.7220.96
98_V146_V0.7200.96
131_T149_Y0.7200.96
99_Q110_L0.7130.96
77_W101_T0.7110.96
112_R120_M0.7070.96
40_T45_S0.7000.95
110_L117_Q0.6950.95
47_T51_Q0.6910.95
114_T146_V0.6900.95
41_R44_G0.6860.95
23_L30_N0.6790.95
50_L56_E0.6760.94
126_R170_N0.6730.94
121_G124_V0.6720.94
39_E42_A0.6700.94
20_V27_C0.6660.94
21_A29_A0.6640.94
77_W106_F0.6630.94
21_A27_C0.6610.94
70_I101_T0.6610.94
70_I148_I0.6610.94
83_R91_G0.6600.94
23_L29_A0.6590.94
87_S92_I0.6550.94
42_A45_S0.6510.93
26_A31_N0.6510.93
147_G157_H0.6430.93
84_L96_G0.6420.93
43_V47_T0.6380.93
138_R179_N0.6380.93
48_S54_Q0.6370.93
32_T35_N0.6350.92
126_R135_V0.6330.92
70_I102_F0.6320.92
98_V102_F0.6260.92
45_S50_L0.6230.92
69_R72_D0.6210.92
80_V90_K0.6160.91
45_S48_S0.6120.91
50_L54_Q0.6110.91
136_L143_G0.6080.91
138_R177_R0.6030.90
153_N169_M0.6030.90
112_R115_Y0.6010.90
124_V128_N0.6010.90
118_Q136_L0.6000.90
115_Y143_G0.5990.90
39_E43_V0.5950.90
67_K131_T0.5930.90
77_W100_R0.5890.89
37_H44_G0.5890.89
46_E50_L0.5880.89
102_F148_I0.5880.89
131_T150_I0.5820.89
25_S33_A0.5770.88
125_S129_L0.5760.88
160_T164_V0.5740.88
123_S180_E0.5740.88
21_A26_A0.5730.88
44_G47_T0.5710.88
155_F170_N0.5680.88
150_I156_V0.5640.87
27_C35_N0.5640.87
92_I96_G0.5620.87
69_R106_F0.5610.87
27_C34_K0.5600.87
22_V30_N0.5580.87
84_L113_S0.5580.87
87_S113_S0.5550.86
162_S167_S0.5530.86
38_P44_G0.5530.86
47_T52_A0.5500.86
99_Q113_S0.5450.85
67_K70_I0.5450.85
87_S100_R0.5410.85
34_K37_H0.5400.85
26_A29_A0.5390.85
157_H170_N0.5380.85
135_V180_E0.5350.84
36_M39_E0.5300.84
49_S54_Q0.5290.84
100_R103_R0.5290.84
47_T50_L0.5280.84
46_E49_S0.5280.84
134_L148_I0.5280.84
60_L63_N0.5270.83
124_V183_R0.5200.83
31_N37_H0.5200.83
149_Y154_Q0.5190.83
53_S56_E0.5180.82
77_W97_F0.5170.82
31_N39_E0.5130.82
143_G182_R0.5080.81
115_Y118_Q0.5080.81
137_F178_Y0.5040.81
47_T53_S0.5030.81
38_P41_R0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1gA 1 0.6755 100 0.311 Contact Map
4q4gX 1 0.7181 100 0.312 Contact Map
3npfA 2 0.9096 100 0.334 Contact Map
3h41A 1 0.984 100 0.335 Contact Map
4hpeA 1 0.8777 100 0.346 Contact Map
4xcmA 2 0.9096 100 0.348 Contact Map
4fdyA 1 0.9149 100 0.353 Contact Map
2hbwA 1 0.9149 100 0.357 Contact Map
4lj1A 1 0.6064 100 0.372 Contact Map
3pbiA 1 0.9149 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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