GREMLIN Database
YHID - Putative magnesium transporter YhiD
UniProt: P0AFV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11400
Length: 215 (202)
Sequences: 1853 (1468)
Seq/√Len: 103.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_A43_A5.5581.00
16_C39_G4.8071.00
45_F106_A4.4941.00
44_L122_G4.3011.00
73_V109_M4.1831.00
111_I119_G3.3261.00
46_M109_M3.1291.00
103_V126_T3.0801.00
15_A111_I2.9151.00
15_A123_S2.6171.00
17_G32_L2.6121.00
13_A36_V2.4771.00
72_Q75_T2.3961.00
41_G103_V2.2571.00
65_D68_R2.2031.00
15_A119_G2.1371.00
8_R114_G2.0661.00
50_K55_D2.0581.00
6_I121_Y2.0241.00
19_I104_T1.9581.00
35_H100_D1.9471.00
45_F69_I1.8491.00
17_G36_V1.8471.00
128_L132_V1.8391.00
5_F118_L1.8361.00
107_I123_S1.8101.00
42_S105_A1.7601.00
36_V129_V1.7221.00
46_M113_S1.6531.00
15_A120_I1.6371.00
37_L41_G1.6181.00
71_A75_T1.5851.00
115_M118_L1.5831.00
43_A111_I1.5711.00
52_G67_S1.5511.00
45_F74_V1.5351.00
64_L67_S1.5351.00
40_M125_M1.5331.00
107_I126_T1.5331.00
16_C104_T1.5281.00
8_R116_Y1.5201.00
48_V113_S1.5141.00
69_I74_V1.5071.00
6_I10_I1.5071.00
41_G105_A1.4741.00
18_A127_L1.4491.00
10_I14_I1.4331.00
84_N101_I1.4181.00
82_A86_L1.4031.00
11_L120_I1.3911.00
9_L125_M1.3130.99
13_A125_M1.3010.99
70_A106_A1.2810.99
69_I115_M1.2740.99
166_Q202_L1.2630.99
96_T130_L1.2530.99
4_E8_R1.2350.99
35_H104_T1.2070.99
35_H130_L1.2010.99
53_F64_L1.1990.99
151_L154_G1.1980.99
80_I85_I1.1960.99
201_R204_K1.1780.99
4_E116_Y1.1620.98
92_I127_L1.1620.98
13_A40_M1.1590.98
84_N109_M1.1580.98
100_D130_L1.1520.98
121_Y124_V1.1320.98
202_L206_M1.1260.98
41_G77_V1.1250.98
5_F8_R1.1230.98
32_L36_V1.1160.98
87_V90_Q1.1160.98
46_M70_A1.0990.98
70_A74_V1.0980.98
191_H194_T1.0950.98
74_V106_A1.0940.98
162_W166_Q1.0920.98
53_F66_P1.0920.98
76_G105_A1.0920.98
53_F67_S1.0860.97
45_F75_T1.0750.97
198_D201_R1.0750.97
48_V110_V1.0700.97
201_R205_G1.0660.97
160_L170_T1.0640.97
120_I124_V1.0600.97
8_R47_I1.0320.97
46_M73_V1.0300.96
49_S70_A1.0300.96
68_R77_V1.0220.96
165_Q202_L1.0200.96
37_L103_V1.0110.96
13_A129_V1.0090.96
48_V69_I1.0080.96
53_F88_R0.9970.96
41_G72_Q0.9920.96
195_S198_D0.9880.96
16_C43_A0.9880.96
84_N87_V0.9850.95
38_I100_D0.9790.95
46_M112_G0.9690.95
10_I125_M0.9640.95
38_I101_I0.9610.95
12_A141_M0.9600.95
28_K72_Q0.9600.95
63_G69_I0.9580.95
24_Q32_L0.9580.95
15_A130_L0.9570.95
74_V105_A0.9550.95
88_R93_V0.9540.95
147_L155_N0.9470.94
50_K113_S0.9450.94
11_L111_I0.9360.94
49_S113_S0.9210.94
28_K88_R0.9120.93
28_K84_N0.9120.93
24_Q130_L0.9020.93
25_M37_L0.9010.93
66_P72_Q0.9010.93
65_D72_Q0.8990.93
15_A107_I0.8920.92
11_L116_Y0.8880.92
38_I84_N0.8860.92
24_Q134_H0.8820.92
49_S72_Q0.8750.92
163_F168_I0.8690.91
76_G98_A0.8680.91
46_M64_L0.8620.91
24_Q78_G0.8520.91
158_S161_D0.8520.91
16_C87_V0.8510.91
161_D165_Q0.8470.90
139_R142_N0.8460.90
45_F109_M0.8430.90
162_W165_Q0.8380.90
130_L134_H0.8340.90
24_Q141_M0.8270.89
12_A16_C0.8250.89
18_A148_Q0.8190.89
145_Y151_L0.8140.89
21_M73_V0.8130.88
47_I51_Y0.8110.88
32_L130_L0.8070.88
40_M103_V0.8050.88
70_A109_M0.8040.88
75_T106_A0.7960.87
152_V155_N0.7950.87
17_G133_F0.7900.87
30_A41_G0.7890.87
203_L209_V0.7870.87
82_A125_M0.7830.87
96_T109_M0.7830.87
161_D164_K0.7790.86
37_L126_T0.7790.86
52_G87_V0.7720.86
38_I80_I0.7710.86
6_I123_S0.7640.85
30_A101_I0.7510.84
33_R36_V0.7500.84
152_V203_L0.7480.84
26_R43_A0.7440.84
129_V133_F0.7410.83
12_A39_G0.7400.83
53_F115_M0.7340.83
144_N181_H0.7310.83
69_I109_M0.7290.82
38_I200_L0.7250.82
97_T101_I0.7200.82
111_I116_Y0.7170.81
30_A100_D0.7120.81
73_V105_A0.7110.81
183_V210_K0.7110.81
52_G55_D0.7100.81
79_F83_G0.7090.81
53_F65_D0.7040.80
39_G115_M0.7030.80
50_K86_L0.7020.80
28_K101_I0.7020.80
165_Q198_D0.7000.80
73_V135_Q0.6960.79
7_I116_Y0.6940.79
32_L137_T0.6920.79
126_T130_L0.6910.79
37_L130_L0.6870.78
30_A37_L0.6850.78
52_G64_L0.6850.78
101_I151_L0.6840.78
117_E121_Y0.6820.78
104_T130_L0.6770.77
77_V105_A0.6760.77
68_R92_I0.6740.77
14_I17_G0.6740.77
152_V207_A0.6720.77
45_F63_G0.6650.76
39_G104_T0.6610.76
139_R174_S0.6610.76
14_I138_F0.6600.76
27_G141_M0.6550.75
64_L115_M0.6500.75
124_V183_V0.6490.74
92_I95_L0.6480.74
152_V210_K0.6460.74
24_Q137_T0.6440.74
101_I134_H0.6440.74
47_I114_G0.6410.74
44_L70_A0.6340.73
92_I174_S0.6320.73
82_A95_L0.6290.72
164_K169_K0.6260.72
88_R91_N0.6220.71
117_E128_L0.6210.71
163_F175_L0.6210.71
158_S191_H0.6170.71
202_L205_G0.6160.71
36_V133_F0.6140.70
148_Q181_H0.6130.70
30_A97_T0.6130.70
181_H206_M0.6120.70
72_Q76_G0.6120.70
15_A50_K0.6120.70
17_G116_Y0.6100.70
121_Y153_N0.6090.70
5_F112_G0.6050.69
42_S125_M0.6040.69
13_A26_R0.6010.69
148_Q199_L0.6010.69
78_G83_G0.5980.68
120_I154_G0.5970.68
48_V112_G0.5950.68
22_E91_N0.5940.68
177_E180_D0.5930.68
74_V147_L0.5900.67
174_S185_A0.5900.67
130_L137_T0.5890.67
163_F186_I0.5880.67
9_L121_Y0.5870.67
182_E190_L0.5810.66
40_M159_M0.5770.66
48_V126_T0.5730.65
122_G208_G0.5730.65
195_S201_R0.5730.65
146_H167_K0.5720.65
71_A74_V0.5720.65
206_M209_V0.5710.65
198_D202_L0.5700.65
161_D179_E0.5680.64
25_M129_V0.5680.64
38_I77_V0.5640.64
50_K69_I0.5630.64
67_S72_Q0.5620.64
19_I163_F0.5620.64
45_F111_I0.5610.63
66_P69_I0.5610.63
19_I35_H0.5610.63
35_H38_I0.5580.63
4_E86_L0.5570.63
171_D189_Q0.5570.63
158_S206_M0.5570.63
159_M203_L0.5550.63
29_G77_V0.5540.62
54_A62_V0.5540.62
106_A111_I0.5530.62
28_K48_V0.5530.62
8_R51_Y0.5460.61
197_E200_L0.5450.61
36_V104_T0.5440.61
187_D195_S0.5420.61
28_K33_R0.5380.60
33_R123_S0.5360.60
78_G119_G0.5350.60
197_E201_R0.5330.60
26_R29_G0.5330.60
169_K189_Q0.5320.59
35_H134_H0.5320.59
51_Y115_M0.5320.59
168_I203_L0.5270.59
39_G137_T0.5260.59
68_R79_F0.5250.58
168_I191_H0.5250.58
48_V72_Q0.5240.58
43_A47_I0.5240.58
29_G36_V0.5220.58
87_V91_N0.5220.58
81_G86_L0.5210.58
19_I95_L0.5210.58
37_L93_V0.5200.58
128_L186_I0.5150.57
20_G23_R0.5120.57
169_K191_H0.5120.57
193_T201_R0.5110.56
164_K196_I0.5110.56
38_I46_M0.5100.56
5_F15_A0.5090.56
92_I190_L0.5070.56
188_I211_G0.5060.56
27_G103_V0.5060.56
161_D198_D0.5040.55
38_I49_S0.5020.55
51_Y118_L0.5010.55
101_I189_Q0.5000.55
41_G107_I0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ko1A 2 0.3535 94.6 0.913 Contact Map
1y7pA 5 0.3442 94 0.916 Contact Map
2lvwA 2 0.3674 91.4 0.923 Contact Map
2pc6A 2 0.3395 90.8 0.924 Contact Map
1zpvA 3 0.3488 89.9 0.925 Contact Map
2f1fA 4 0.3349 89.1 0.926 Contact Map
2lqjA 1 0.3628 86.3 0.93 Contact Map
2fgcA 2 0.3395 74.9 0.938 Contact Map
2djwA 6 0.3302 46.7 0.948 Contact Map
2cviA 2 0.3302 45.3 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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