GREMLIN Database
YIBH - Inner membrane protein YibH
UniProt: P0AFV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11764
Length: 378 (317)
Sequences: 18569 (14688)
Seq/√Len: 824.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_E93_K3.3101.00
86_Q227_N3.2871.00
90_V221_V3.0171.00
295_T329_E2.7351.00
292_G328_I2.5801.00
142_F146_Q2.5311.00
93_K221_V2.3821.00
107_Q214_K2.3781.00
168_R172_L2.3771.00
277_D291_H2.3701.00
149_L168_R2.3361.00
78_T93_K2.2931.00
148_Y159_F2.2661.00
86_Q89_E2.2401.00
96_P100_Q2.1901.00
148_Y167_A2.1651.00
103_V210_L2.1291.00
149_L153_Q2.1211.00
142_F175_D2.1141.00
171_F175_D2.0951.00
90_V223_R2.0811.00
69_Q219_Q2.0431.00
87_K227_N2.0371.00
84_L229_Y2.0001.00
114_T207_R1.9651.00
145_Y164_I1.8961.00
78_T90_V1.8961.00
261_V325_L1.8931.00
152_S161_E1.8881.00
293_K331_D1.8701.00
142_F171_F1.8691.00
135_S182_V1.8671.00
163_D166_D1.8531.00
279_E291_H1.8511.00
293_K329_E1.8391.00
145_Y149_L1.8341.00
277_D293_K1.8151.00
161_E165_D1.8141.00
259_Q327_T1.8061.00
279_E289_V1.7921.00
104_D107_Q1.7821.00
231_T253_I1.7421.00
278_A328_I1.7291.00
103_V214_K1.7291.00
152_S164_I1.7221.00
262_A347_V1.7211.00
138_R171_F1.6831.00
41_S45_L1.6651.00
110_L210_L1.6601.00
80_K83_Q1.6601.00
135_S178_V1.6511.00
100_Q217_L1.6351.00
145_Y171_F1.6201.00
204_V207_R1.6001.00
103_V107_Q1.5911.00
296_S327_T1.5701.00
40_V44_I1.5571.00
102_R105_R1.5561.00
211_T214_K1.5521.00
140_R144_N1.5471.00
100_Q104_D1.5171.00
110_L114_T1.5121.00
164_I168_R1.5101.00
125_T128_Q1.5071.00
262_A328_I1.5071.00
128_Q189_Q1.5051.00
224_A252_F1.4991.00
60_A261_V1.4841.00
145_Y168_R1.4831.00
111_M114_T1.4781.00
260_I345_A1.4751.00
72_G94_L1.4731.00
92_F222_I1.4511.00
105_R209_Q1.4511.00
107_Q210_L1.4491.00
75_T95_D1.4491.00
138_R142_F1.4411.00
175_D179_K1.4381.00
132_T135_S1.4341.00
172_L175_D1.4221.00
301_V324_V1.4211.00
74_V235_I1.4151.00
166_D170_N1.4131.00
110_L207_R1.4111.00
74_V92_F1.3951.00
179_K182_V1.3821.00
131_T178_V1.3791.00
279_E350_Y1.3741.00
75_T93_K1.3721.00
144_N166_D1.3591.00
39_L43_L1.3581.00
210_L214_K1.3571.00
131_T185_Q1.3531.00
84_L255_E1.3371.00
212_E216_N1.3351.00
170_N173_A1.3341.00
41_S44_I1.3311.00
186_A189_Q1.3271.00
242_A247_R1.3221.00
147_R165_D1.3211.00
42_G46_L1.3191.00
139_D143_K1.3151.00
257_K329_E1.3081.00
102_R212_E1.3071.00
120_L123_Q1.3011.00
138_R175_D1.2951.00
116_N119_T1.2931.00
146_Q150_K1.2871.00
110_L203_I1.2861.00
141_L174_Q1.2841.00
178_V182_V1.2821.00
138_R178_V1.2711.00
103_V217_L1.2671.00
153_Q156_V1.2631.00
197_N200_Q1.2561.00
135_S139_D1.2541.00
76_E237_P1.2531.00
90_V93_K1.2531.00
288_Q338_A1.2501.00
128_Q185_Q1.2461.00
91_L250_M1.2451.00
214_K218_E1.2351.00
149_L164_I1.2341.00
207_R211_T1.2311.00
265_R268_S1.2311.00
230_V250_M1.2251.00
102_R216_N1.2161.00
117_I200_Q1.2141.00
65_P248_P1.2011.00
146_Q149_L1.2001.00
282_F345_A1.1931.00
162_R166_D1.1721.00
99_Y220_T1.1721.00
79_D89_E1.1691.00
150_K156_V1.1591.00
291_H331_D1.1491.00
83_Q89_E1.1361.00
264_F272_L1.1311.00
59_K260_I1.1271.00
107_Q111_M1.1271.00
131_T182_V1.1251.00
150_K153_Q1.1251.00
279_E348_A1.1211.00
105_R109_D1.1171.00
165_D168_R1.1141.00
40_V43_L1.1051.00
64_I226_S1.0951.00
294_L326_G1.0951.00
215_Y219_Q1.0911.00
109_D205_S1.0891.00
170_N174_Q1.0871.00
261_V327_T1.0841.00
96_P220_T1.0841.00
281_V348_A1.0801.00
133_Q177_L1.0791.00
185_Q189_Q1.0791.00
63_A251_V1.0761.00
144_N162_R1.0751.00
117_I203_I1.0661.00
68_P222_I1.0651.00
202_Q205_S1.0611.00
228_G252_F1.0611.00
38_F42_G1.0581.00
198_G202_Q1.0551.00
137_E173_A1.0521.00
241_A249_V1.0511.00
65_P251_V1.0511.00
109_D112_T1.0421.00
264_F326_G1.0421.00
334_D338_A1.0401.00
272_L349_V1.0391.00
116_N202_Q1.0381.00
134_V174_Q1.0361.00
104_D211_T1.0311.00
114_T118_K1.0181.00
272_L294_L1.0171.00
280_V330_L1.0071.00
139_D142_F1.0011.00
131_T135_S0.9981.00
77_V92_F0.9871.00
71_T243_A0.9821.00
81_N232_Q0.9821.00
233_V236_R0.9811.00
281_V289_V0.9801.00
77_V237_P0.9791.00
143_K165_D0.9791.00
79_D250_M0.9741.00
92_F249_V0.9731.00
173_A177_L0.9701.00
224_A227_N0.9701.00
232_Q251_V0.9691.00
200_Q204_V0.9661.00
119_T195_M0.9641.00
263_Q325_L0.9601.00
143_K146_Q0.9561.00
254_P257_K0.9551.00
112_T202_Q0.9511.00
29_L33_A0.9481.00
84_L227_N0.9461.00
112_T116_N0.9431.00
114_T203_I0.9311.00
106_L206_L0.9311.00
69_Q73_I0.9301.00
144_N148_Y0.9281.00
113_A116_N0.9231.00
73_I240_Y0.9181.00
62_I254_P0.9161.00
80_K233_V0.9151.00
298_L325_L0.9131.00
264_F349_V0.9101.00
68_P241_A0.9081.00
108_A208_A0.9041.00
43_L46_L0.9041.00
57_A260_I0.9031.00
273_K276_D0.8991.00
203_I207_R0.8971.00
37_V41_S0.8961.00
27_W31_T0.8951.00
183_A186_A0.8941.00
101_A215_Y0.8911.00
113_A206_L0.8821.00
71_T242_A0.8791.00
134_V137_E0.8781.00
177_L180_G0.8761.00
128_Q132_T0.8761.00
103_V213_A0.8721.00
148_Y163_D0.8701.00
167_A170_N0.8681.00
159_F163_D0.8661.00
209_Q212_E0.8651.00
102_R106_L0.8581.00
260_I347_V0.8581.00
137_E140_R0.8561.00
97_V215_Y0.8551.00
205_S209_Q0.8551.00
350_Y353_H0.8471.00
196_V200_Q0.8451.00
109_D113_A0.8401.00
269_L324_V0.8381.00
213_A216_N0.8371.00
92_F250_M0.8361.00
102_R213_A0.8341.00
180_G184_E0.8341.00
233_V250_M0.8341.00
85_I91_L0.8331.00
139_D172_L0.8311.00
354_F357_V0.8211.00
168_R171_F0.8211.00
280_V345_A0.8211.00
263_Q323_G0.8191.00
130_N133_Q0.8181.00
260_I280_V0.8181.00
280_V292_G0.8171.00
259_Q295_T0.8161.00
184_E187_Q0.8141.00
96_P221_V0.8121.00
43_L47_M0.8111.00
106_L109_D0.8111.00
215_Y218_E0.8101.00
109_D209_Q0.8071.00
93_K96_P0.8021.00
294_L328_I0.8021.00
285_L290_F0.8011.00
152_S159_F0.7881.00
74_V241_A0.7861.00
101_A208_A0.7821.00
199_E202_Q0.7821.00
75_T96_P0.7801.00
75_T78_T0.7751.00
157_N161_E0.7711.00
130_N184_E0.7701.00
62_I236_R0.7691.00
127_A130_N0.7671.00
79_D230_V0.7671.00
26_Q30_A0.7661.00
182_V186_A0.7661.00
130_N180_G0.7551.00
71_T240_Y0.7541.00
111_M204_V0.7531.00
106_L213_A0.7501.00
181_S184_E0.7481.00
59_K258_R0.7461.00
69_Q98_R0.7431.00
45_L48_N0.7411.00
99_Y213_A0.7401.00
208_A211_T0.7381.00
174_Q177_L0.7361.00
206_L210_L0.7361.00
234_L251_V0.7351.00
206_L209_Q0.7351.00
218_E223_R0.7341.00
114_T117_I0.7331.00
68_P249_V0.7301.00
134_V181_S0.7301.00
33_A37_V0.7281.00
134_V177_L0.7271.00
73_I95_D0.7261.00
66_I250_M0.7261.00
44_I48_N0.7241.00
282_F285_L0.7221.00
46_L49_Y0.7201.00
118_K121_R0.7161.00
123_Q187_Q0.7151.00
133_Q137_E0.7131.00
24_V27_W0.7121.00
87_K225_P0.7121.00
113_A199_E0.7121.00
26_Q37_V0.7091.00
278_A292_G0.7091.00
107_Q110_L0.7071.00
281_V287_G0.7061.00
66_I225_P0.7061.00
28_T32_A0.7061.00
124_L189_Q0.7041.00
54_T346_Q0.7011.00
113_A117_I0.7001.00
137_E170_N0.6991.00
274_P297_I0.6981.00
277_D350_Y0.6951.00
159_F164_I0.6941.00
101_A104_D0.6921.00
195_M198_G0.6851.00
126_E130_N0.6841.00
226_S252_F0.6831.00
78_T89_E0.6821.00
169_Q173_A0.6791.00
148_Y162_R0.6781.00
79_D83_Q0.6781.00
137_E177_L0.6771.00
134_V178_V0.6761.00
27_W30_A0.6761.00
202_Q206_L0.6751.00
163_D167_A0.6751.00
122_A125_T0.6741.00
281_V346_Q0.6721.00
259_Q329_E0.6721.00
120_L124_L0.6691.00
140_R166_D0.6681.00
302_P325_L0.6671.00
97_V218_E0.6661.00
181_S185_Q0.6661.00
98_R102_R0.6621.00
174_Q178_V0.6591.00
222_I249_V0.6581.00
123_Q126_E0.6561.00
100_Q103_V0.6531.00
286_P290_F0.6521.00
26_Q29_L0.6521.00
161_E164_I0.6521.00
115_H118_K0.6491.00
262_A349_V0.6421.00
141_L170_N0.6411.00
67_T240_Y0.6401.00
284_A343_I0.6391.00
175_D178_V0.6381.00
218_E221_V0.6381.00
149_L152_S0.6361.00
199_E203_I0.6331.00
276_D351_S0.6321.00
39_L42_G0.6301.00
186_A190_S0.6281.00
92_F233_V0.6251.00
229_Y255_E0.6241.00
70_V216_N0.6241.00
137_E141_L0.6241.00
25_N28_T0.6231.00
332_P337_D0.6221.00
79_D233_V0.6211.00
121_R125_T0.6211.00
98_R216_N0.6211.00
176_A179_K0.6181.00
64_I252_F0.6181.00
303_G322_D0.6171.00
258_R341_D0.6161.00
43_L357_V0.6161.00
144_N167_A0.6161.00
135_S138_R0.6151.00
184_E188_I0.6141.00
280_V328_I0.6131.00
266_Q344_Y0.6121.00
141_L167_A0.6101.00
124_L128_Q0.6101.00
36_G40_V0.6091.00
31_T38_F0.6071.00
136_A139_D0.6051.00
248_P251_V0.6051.00
162_R165_D0.6041.00
106_L110_L0.6041.00
96_P217_L0.6031.00
295_T327_T0.6011.00
280_V347_V0.5991.00
81_N233_V0.5971.00
49_Y52_P0.5951.00
138_R174_Q0.5941.00
68_P71_T0.5941.00
129_A132_T0.5931.00
324_V343_I0.5931.00
25_N29_L0.5921.00
216_N219_Q0.5911.00
106_L210_L0.5891.00
152_S157_N0.5881.00
179_K183_A0.5881.00
301_V322_D0.5871.00
131_T181_S0.5861.00
328_I347_V0.5861.00
147_R162_R0.5831.00
262_A326_G0.5831.00
110_L206_L0.5791.00
160_S163_D0.5781.00
99_Y216_N0.5771.00
55_F59_K0.5771.00
140_R169_Q0.5751.00
26_Q41_S0.5751.00
98_R219_Q0.5731.00
68_P92_F0.5711.00
126_E184_E0.5701.00
136_A140_R0.5701.00
109_D206_L0.5691.00
54_T348_A0.5681.00
58_Q261_V0.5671.00
274_P295_T0.5661.00
59_K339_L0.5661.00
47_M50_N0.5641.00
340_P343_I0.5621.00
207_R210_L0.5621.00
302_P305_S0.5611.00
127_A181_S0.5601.00
140_R143_K0.5541.00
38_F41_S0.5541.00
201_S204_V0.5521.00
146_Q171_F0.5491.00
285_L343_I0.5471.00
278_A347_V0.5451.00
144_N170_N0.5431.00
161_E168_R0.5431.00
88_G223_R0.5391.00
44_I47_M0.5381.00
64_I68_P0.5361.00
275_G293_K0.5341.00
282_F339_L0.5341.00
115_H119_T0.5331.00
147_R151_G0.5321.00
234_L248_P0.5311.00
119_T123_Q0.5311.00
177_L181_S0.5301.00
74_V77_V0.5301.00
209_Q213_A0.5291.00
217_L220_T0.5281.00
283_N346_Q0.5271.00
30_A34_L0.5271.00
127_A131_T0.5271.00
260_I330_L0.5271.00
98_R215_Y0.5261.00
105_R212_E0.5261.00
182_V185_Q0.5221.00
137_E174_Q0.5221.00
81_N327_T0.5211.00
141_L144_N0.5211.00
85_I224_A0.5211.00
231_T299_P0.5201.00
61_V259_Q0.5171.00
264_F347_V0.5161.00
143_K161_E0.5141.00
109_D202_Q0.5141.00
211_T215_Y0.5111.00
104_D208_A0.5111.00
77_V233_V0.5091.00
263_Q304_G0.5071.00
285_L288_Q0.5071.00
229_Y340_P0.5061.00
104_D108_A0.5051.00
142_F145_Y0.5031.00
99_Y103_V0.5021.00
195_M199_E0.5011.00
253_I341_D0.5011.00
165_D169_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkoB 1 0.7407 100 0.351 Contact Map
4dk0A 5 0.7593 100 0.369 Contact Map
3fppA 3 0.6958 100 0.381 Contact Map
3lnnA 6 0.7804 100 0.416 Contact Map
2f1mA 2 0.619 100 0.424 Contact Map
4l8jA 2 0.7011 100 0.449 Contact Map
1vf7A 5 0.6005 100 0.451 Contact Map
3ne5B 3 0.6958 100 0.474 Contact Map
4kkuA 1 0.537 100 0.525 Contact Map
2k32A 1 0.3042 99.8 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.