GREMLIN Database
GLRR - Transcriptional regulatory protein GlrR
UniProt: P0AFU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11285
Length: 444 (428)
Sequences: 9631 (6663)
Seq/√Len: 322.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_A288_E3.8341.00
165_Q308_A3.7661.00
209_A219_N3.7531.00
33_V50_V3.2181.00
410_T420_M3.2161.00
194_G246_V3.0691.00
223_L258_R2.9421.00
282_K286_R2.8771.00
150_A173_F2.6731.00
225_Q259_P2.6381.00
63_D66_Q2.6071.00
38_G62_M2.5941.00
256_K265_D2.5881.00
257_V268_I2.5331.00
18_L36_E2.5011.00
37_S40_E2.4431.00
416_H419_R2.4231.00
256_K267_D2.4201.00
324_Q357_V2.4011.00
278_R283_A2.3941.00
410_T417_A2.3771.00
400_L404_R2.3731.00
224_F251_V2.3671.00
198_E243_P2.3531.00
101_F120_A2.3451.00
402_Y406_L2.2481.00
315_P341_M2.2451.00
18_L34_T2.2081.00
279_D282_K2.1671.00
233_F275_A2.1631.00
336_F360_I2.1541.00
36_E40_E2.1071.00
11_V41_G2.0881.00
69_A98_Q2.0741.00
7_H31_S2.0691.00
337_S373_S2.0641.00
318_A336_F2.0611.00
9_L35_A2.0481.00
173_F304_I2.0331.00
258_R265_D1.9991.00
152_L368_S1.9951.00
349_W359_V1.9931.00
283_A286_R1.9911.00
229_G269_N1.8871.00
253_Q357_V1.8871.00
209_A262_S1.8871.00
239_D278_R1.8621.00
347_A350_P1.8621.00
282_K285_A1.8121.00
315_P345_M1.8031.00
409_I420_M1.7871.00
252_L272_I1.7821.00
39_A61_E1.7781.00
130_E133_R1.7641.00
209_A259_P1.7561.00
311_T315_P1.7521.00
224_F232_L1.7181.00
311_T314_I1.6711.00
139_R316_L1.6631.00
183_R269_N1.6631.00
52_L117_I1.6551.00
22_G34_T1.6521.00
168_T304_I1.6421.00
42_L70_E1.6341.00
163_N303_K1.6281.00
46_N74_V1.6191.00
151_R180_A1.6171.00
319_N341_M1.6101.00
45_L71_I1.5981.00
340_A344_L1.5721.00
274_S297_L1.5701.00
320_H324_Q1.5631.00
311_T348_S1.5601.00
22_G26_T1.5441.00
70_E73_K1.5431.00
7_H33_V1.5421.00
33_V44_V1.5401.00
426_T430_K1.5381.00
396_N434_R1.5381.00
399_E431_L1.5351.00
318_A360_I1.5341.00
55_S67_L1.5291.00
202_E247_K1.5131.00
75_Q78_M1.5051.00
337_S340_A1.4931.00
262_S266_I1.4921.00
53_V71_I1.4681.00
335_A371_V1.4661.00
221_E225_Q1.4661.00
126_P129_D1.4661.00
228_E268_I1.4651.00
163_N301_S1.4641.00
35_A44_V1.4601.00
251_V257_V1.4581.00
140_S312_E1.4571.00
406_L410_T1.4551.00
81_I116_A1.4521.00
340_A374_D1.4511.00
59_M62_M1.4271.00
220_R263_N1.4191.00
146_L302_L1.4181.00
372_I377_V1.4071.00
143_M147_L1.4031.00
317_L321_L1.4031.00
303_K309_E1.3951.00
208_H213_F1.3941.00
339_D374_D1.3931.00
94_A98_Q1.3931.00
228_E269_N1.3911.00
171_E250_R1.3831.00
328_R361_E1.3691.00
148_E151_R1.3671.00
153_V300_V1.3631.00
55_S82_I1.3631.00
28_E114_Y1.3601.00
54_I117_I1.3571.00
158_V361_E1.3571.00
138_T143_M1.3551.00
343_R374_D1.3371.00
89_I93_V1.3351.00
341_M345_M1.3341.00
157_D328_R1.3271.00
238_G276_T1.3241.00
336_F341_M1.3111.00
334_R370_P1.2991.00
70_E74_V1.2961.00
347_A355_Q1.2941.00
325_A364_V1.2881.00
147_L150_A1.2871.00
38_G67_L1.2871.00
44_V50_V1.2861.00
280_L289_F1.2801.00
406_L420_M1.2771.00
186_K229_G1.2721.00
405_K409_I1.2651.00
91_D103_F1.2591.00
37_S61_E1.2561.00
68_F80_V1.2511.00
8_L30_Y1.2501.00
138_T147_L1.2491.00
406_L421_A1.2491.00
340_A372_I1.2441.00
322_L336_F1.2441.00
322_L364_V1.2331.00
257_V267_D1.2251.00
391_F394_A1.2241.00
38_G59_M1.2241.00
145_R148_E1.2141.00
158_V329_H1.2141.00
426_T429_Y1.2111.00
24_R110_K1.2071.00
373_S376_L1.2031.00
30_Y118_D1.2031.00
378_E381_L1.1971.00
404_R408_Q1.1961.00
53_V78_M1.1941.00
149_Q366_L1.1931.00
162_I273_I1.1901.00
225_Q266_I1.1891.00
427_E431_L1.1881.00
201_L244_L1.1841.00
424_N427_E1.1821.00
414_V429_Y1.1811.00
239_D277_H1.1811.00
12_D18_L1.1811.00
165_Q306_A1.1811.00
204_E220_R1.1801.00
136_I147_L1.1771.00
259_P262_S1.1761.00
402_Y421_A1.1741.00
315_P318_A1.1691.00
208_H212_A1.1641.00
321_L357_V1.1641.00
416_H420_M1.1631.00
198_E241_P1.1621.00
150_A176_A1.1611.00
68_F82_I1.1601.00
192_N239_D1.1521.00
12_D59_M1.1511.00
203_S208_H1.1501.00
342_K346_T1.1501.00
194_G239_D1.1471.00
146_L304_I1.1461.00
413_N425_R1.1421.00
255_R267_D1.1421.00
42_L62_M1.1411.00
57_L91_D1.1351.00
337_S371_V1.1321.00
326_A334_R1.1271.00
394_A398_F1.1221.00
430_K434_R1.1191.00
321_L325_A1.1191.00
395_R398_F1.1181.00
367_T376_L1.1171.00
413_N416_H1.1161.00
175_Q190_A1.1131.00
415_T419_R1.1081.00
33_V48_E1.1061.00
157_D183_R1.1051.00
238_G280_L1.1021.00
58_R86_H1.1011.00
137_V320_H1.0991.00
225_Q257_V1.0881.00
35_A41_G1.0871.00
323_R327_E1.0851.00
285_A291_E1.0821.00
146_L173_F1.0781.00
325_A360_I1.0781.00
403_L428_F1.0771.00
312_E345_M1.0761.00
136_I172_I1.0751.00
212_A260_L1.0721.00
54_I113_L1.0711.00
150_A177_I1.0711.00
65_M95_A1.0691.00
38_G42_L1.0681.00
7_H48_E1.0661.00
391_F395_R1.0641.00
319_N323_R1.0631.00
162_I173_F1.0541.00
188_F230_G1.0531.00
321_L360_I1.0511.00
155_Q182_P1.0481.00
55_S59_M1.0471.00
55_S80_V1.0471.00
161_L274_S1.0401.00
326_A332_F1.0381.00
281_P285_A1.0331.00
417_A420_M1.0321.00
52_L121_L1.0301.00
7_H50_V1.0231.00
171_E190_A1.0191.00
213_F216_A1.0171.00
66_Q69_A1.0171.00
28_E118_D1.0161.00
208_H260_L1.0131.00
272_I297_L1.0131.00
71_I80_V1.0121.00
231_T273_I1.0111.00
10_L32_V1.0111.00
94_A97_Q1.0111.00
424_N430_K1.0101.00
406_L417_A1.0091.00
150_A302_L1.0061.00
415_T425_R1.0051.00
390_T393_E1.0011.00
201_L205_L0.9951.00
136_I173_F0.9901.00
228_E270_V0.9861.00
407_L432_L0.9841.00
159_S255_R0.9711.00
339_D373_S0.9671.00
281_P380_A0.9661.00
138_T173_F0.9661.00
135_A179_N0.9641.00
311_T345_M0.9631.00
362_Q366_L0.9601.00
363_C367_T0.9601.00
203_S213_F0.9581.00
210_R218_S0.9491.00
57_L82_I0.9491.00
165_Q168_T0.9471.00
158_V299_V0.9451.00
67_L71_I0.9411.00
401_N405_K0.9391.00
226_A263_N0.9371.00
314_I344_L0.9361.00
69_A94_A0.9311.00
398_F402_Y0.9301.00
176_A180_A0.9191.00
314_I318_A0.9181.00
404_R437_L0.9171.00
141_P145_R0.9151.00
201_L240_M0.9141.00
414_V426_T0.9091.00
298_N301_S0.9081.00
299_V358_N0.9061.00
232_L272_I0.9061.00
17_L108_V0.9061.00
43_R47_R0.9031.00
232_L251_V0.9021.00
54_I81_I0.8971.00
25_L117_I0.8961.00
143_M146_L0.8941.00
51_D124_S0.8921.00
40_E43_R0.8911.00
189_I227_A0.8881.00
160_V177_I0.8861.00
259_P266_I0.8841.00
138_T316_L0.8821.00
326_A333_V0.8801.00
403_L421_A0.8791.00
190_A250_R0.8771.00
336_F372_I0.8751.00
414_V421_A0.8701.00
175_Q179_N0.8681.00
12_D17_L0.8651.00
37_S59_M0.8651.00
157_D182_P0.8641.00
342_K345_M0.8631.00
319_N335_A0.8631.00
162_I304_I0.8611.00
403_L431_L0.8581.00
407_L414_V0.8541.00
192_N240_M0.8521.00
405_K408_Q0.8521.00
208_H220_R0.8451.00
414_V432_L0.8441.00
357_V361_E0.8441.00
390_T422_G0.8421.00
40_E44_V0.8411.00
43_R46_N0.8411.00
124_S128_T0.8391.00
11_V67_L0.8391.00
15_P18_L0.8381.00
44_V48_E0.8371.00
13_D56_D0.8361.00
428_F431_L0.8311.00
401_N404_R0.8291.00
189_I226_A0.8281.00
115_Q126_P0.8231.00
115_Q119_D0.8201.00
257_V266_I0.8191.00
62_M66_Q0.8171.00
224_F270_V0.8171.00
44_V47_R0.8161.00
421_A431_L0.8161.00
427_E430_K0.8161.00
122_E125_A0.8151.00
407_L417_A0.8151.00
119_D126_P0.8151.00
423_R427_E0.8111.00
240_M244_L0.8101.00
97_Q102_S0.8081.00
208_H216_A0.8081.00
55_S71_I0.8071.00
52_L79_P0.8061.00
38_G61_E0.8051.00
39_A43_R0.8031.00
142_L145_R0.8031.00
54_I83_L0.8021.00
146_L150_A0.8021.00
139_R144_L0.8001.00
66_Q70_E0.7991.00
10_L21_L0.7971.00
338_T341_M0.7971.00
281_P294_Y0.7961.00
396_N435_H0.7951.00
42_L67_L0.7951.00
109_D112_A0.7901.00
159_S274_S0.7881.00
147_L173_F0.7881.00
138_T150_A0.7881.00
400_L435_H0.7871.00
298_N362_Q0.7861.00
93_V97_Q0.7851.00
144_L148_E0.7851.00
122_E126_P0.7841.00
35_A38_G0.7781.00
412_G432_L0.7761.00
378_E382_E0.7751.00
429_Y433_S0.7751.00
363_C372_I0.7731.00
284_M294_Y0.7721.00
163_N281_P0.7721.00
331_P364_V0.7721.00
197_P260_L0.7701.00
55_S68_F0.7691.00
62_M70_E0.7681.00
219_N259_P0.7671.00
122_E127_A0.7630.99
45_L53_V0.7600.99
147_L176_A0.7580.99
336_F340_A0.7580.99
11_V53_V0.7570.99
21_L113_L0.7570.99
318_A341_M0.7560.99
425_R429_Y0.7560.99
158_V300_V0.7540.99
250_R254_E0.7520.99
69_A73_K0.7520.99
424_N429_Y0.7500.99
8_L25_L0.7500.99
224_F268_I0.7470.99
226_A262_S0.7470.99
35_A40_E0.7450.99
281_P291_E0.7420.99
240_M248_L0.7390.99
219_N264_R0.7370.99
153_V160_V0.7360.99
221_E226_A0.7360.99
72_Q79_P0.7350.99
136_I143_M0.7330.99
395_R402_Y0.7320.99
421_A427_E0.7290.99
68_F100_V0.7290.99
394_A397_Q0.7280.99
89_I92_A0.7250.99
359_V363_C0.7250.99
9_L50_V0.7240.99
135_A176_A0.7230.99
429_Y432_L0.7230.99
154_A181_S0.7190.99
238_G277_H0.7160.99
45_L75_Q0.7150.99
314_I345_M0.7150.99
315_P319_N0.7140.99
30_Y114_Y0.7110.99
428_F432_L0.7110.99
83_L108_V0.7060.99
158_V365_A0.7060.99
92_A100_V0.7050.99
118_D122_E0.7050.99
39_A62_M0.7050.99
13_D85_A0.7040.99
403_L432_L0.7020.99
87_G105_T0.7000.99
223_L226_A0.7000.99
10_L22_G0.7000.99
13_D106_K0.6990.99
137_V316_L0.6990.99
331_P334_R0.6980.99
56_D106_K0.6960.99
306_A309_E0.6950.99
13_D84_T0.6930.99
24_R114_Y0.6930.99
425_R430_K0.6920.99
191_I232_L0.6910.99
393_E397_Q0.6890.99
294_Y298_N0.6890.99
318_A363_C0.6840.99
237_I297_L0.6800.99
152_L376_L0.6800.99
144_L147_L0.6790.99
212_A216_A0.6790.99
21_L83_L0.6790.99
214_T275_A0.6770.99
221_E263_N0.6770.99
219_N262_S0.6770.99
103_F112_A0.6760.99
90_P94_A0.6750.99
45_L78_M0.6750.99
87_G92_A0.6740.99
325_A357_V0.6740.99
432_L437_L0.6720.99
14_D17_L0.6710.99
423_R428_F0.6660.99
141_P144_L0.6650.99
79_P127_A0.6620.99
7_H51_D0.6620.99
410_T416_H0.6600.99
334_R364_V0.6590.99
64_G106_K0.6580.99
152_L331_P0.6570.98
65_M94_A0.6570.98
431_L435_H0.6560.98
197_P200_L0.6560.98
325_A329_H0.6560.98
392_V406_L0.6560.98
196_L205_L0.6540.98
311_T316_L0.6530.98
363_C377_V0.6510.98
162_I174_A0.6490.98
224_F257_V0.6470.98
343_R377_V0.6470.98
281_P301_S0.6460.98
208_H217_V0.6460.98
15_P19_K0.6460.98
220_R223_L0.6450.98
343_R347_A0.6450.98
11_V59_M0.6450.98
338_T342_K0.6430.98
116_A120_A0.6430.98
211_G216_A0.6410.98
45_L50_V0.6390.98
133_R176_A0.6380.98
152_L366_L0.6370.98
102_S116_A0.6370.98
13_D64_G0.6370.98
108_V113_L0.6370.98
430_K433_S0.6350.98
57_L63_D0.6340.98
53_V67_L0.6310.98
209_A266_I0.6290.98
394_A402_Y0.6230.98
139_R312_E0.6220.98
133_R147_L0.6190.98
413_N429_Y0.6190.98
208_H219_N0.6150.98
200_L214_T0.6150.98
23_L27_S0.6140.98
210_R216_A0.6140.98
104_L108_V0.6130.98
238_G289_F0.6130.98
414_V431_L0.6100.98
393_E401_N0.6100.98
214_T277_H0.6090.98
281_P284_M0.6090.98
408_Q412_G0.6070.97
238_G275_A0.6050.97
209_A225_Q0.6050.97
391_F421_A0.6030.97
238_G278_R0.6020.97
79_P123_Q0.6010.97
148_E368_S0.6010.97
255_R270_V0.6010.97
414_V425_R0.6000.97
426_T433_S0.5990.97
172_I176_A0.5990.97
146_L149_Q0.5990.97
141_P312_E0.5960.97
142_L309_E0.5940.97
414_V417_A0.5940.97
322_L360_I0.5920.97
20_L24_R0.5910.97
149_Q152_L0.5890.97
166_S239_D0.5890.97
399_E403_L0.5870.97
9_L41_G0.5870.97
392_V431_L0.5850.97
224_F272_I0.5840.97
123_Q126_P0.5840.97
391_F398_F0.5830.97
318_A322_L0.5830.97
154_A180_A0.5820.97
396_N400_L0.5820.97
407_L412_G0.5810.97
220_R226_A0.5790.97
326_A364_V0.5780.97
46_N70_E0.5760.97
329_H364_V0.5760.97
101_F116_A0.5750.97
228_E267_D0.5740.96
146_L153_V0.5740.96
406_L424_N0.5730.96
229_G270_V0.5710.96
53_V80_V0.5710.96
84_T106_K0.5700.96
41_G67_L0.5690.96
423_R431_L0.5690.96
155_Q181_S0.5690.96
395_R431_L0.5680.96
325_A328_R0.5680.96
397_Q401_N0.5670.96
233_F273_I0.5660.96
223_L265_D0.5650.96
343_R381_L0.5640.96
300_V365_A0.5600.96
26_T32_V0.5600.96
398_F421_A0.5600.96
325_A361_E0.5600.96
403_L435_H0.5580.96
87_G103_F0.5570.96
83_L86_H0.5560.96
425_R428_F0.5560.96
50_V78_M0.5550.96
79_P124_S0.5550.96
90_P112_A0.5540.96
108_V429_Y0.5520.96
18_L38_G0.5520.96
228_E255_R0.5510.96
326_A331_P0.5500.96
22_G32_V0.5480.95
112_A115_Q0.5470.95
150_A180_A0.5440.95
71_I78_M0.5440.95
171_E254_E0.5440.95
210_R217_V0.5440.95
221_E257_V0.5430.95
37_S60_D0.5420.95
414_V430_K0.5390.95
37_S62_M0.5380.95
415_T418_A0.5370.95
204_E223_L0.5370.95
173_F176_A0.5360.95
105_T112_A0.5350.95
112_A116_A0.5350.95
251_V254_E0.5350.95
226_A257_V0.5340.95
413_N417_A0.5340.95
16_G20_L0.5330.95
413_N430_K0.5330.95
402_Y417_A0.5330.95
359_V381_L0.5330.95
156_S365_A0.5320.95
293_L297_L0.5320.95
397_Q400_L0.5320.95
200_L260_L0.5320.95
138_T176_A0.5310.95
203_S211_G0.5300.95
333_V364_V0.5300.95
191_I223_L0.5290.94
121_L124_S0.5290.94
83_L104_L0.5280.94
209_A212_A0.5270.94
192_N195_A0.5270.94
316_L319_N0.5270.94
110_K114_Y0.5260.94
157_D329_H0.5230.94
402_Y429_Y0.5230.94
192_N246_V0.5220.94
149_Q300_V0.5220.94
58_R88_S0.5220.94
148_E152_L0.5210.94
101_F123_Q0.5210.94
136_I176_A0.5200.94
223_L263_N0.5200.94
235_D354_R0.5190.94
251_V268_I0.5180.94
10_L25_L0.5180.94
8_L121_L0.5170.94
278_R288_E0.5170.94
25_L32_V0.5160.94
191_I205_L0.5150.94
183_R186_K0.5150.94
64_G85_A0.5150.94
219_N266_I0.5140.94
322_L333_V0.5140.94
312_E315_P0.5140.94
402_Y414_V0.5140.94
238_G283_A0.5130.94
145_R149_Q0.5130.94
205_L244_L0.5120.94
8_L52_L0.5120.94
213_F220_R0.5110.93
142_L312_E0.5100.93
421_A428_F0.5100.93
426_T431_L0.5090.93
13_D59_M0.5090.93
200_L213_F0.5090.93
186_K228_E0.5080.93
59_M64_G0.5080.93
392_V395_R0.5080.93
209_A260_L0.5070.93
174_A188_F0.5070.93
168_T172_I0.5060.93
322_L326_A0.5050.93
187_P226_A0.5030.93
59_M63_D0.5020.93
212_A219_N0.5020.93
57_L108_V0.5020.93
176_A179_N0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.8491 100 0.124 Contact Map
3dzdA 2 0.8288 100 0.285 Contact Map
1ojlA 3 0.6757 100 0.467 Contact Map
4fwgA 3 0.7815 100 0.632 Contact Map
1r6bX 1 0.8626 100 0.659 Contact Map
3pxiA 3 0.8086 100 0.663 Contact Map
1qvrA 3 0.8378 100 0.666 Contact Map
4d2uA 3 0.8559 100 0.674 Contact Map
4qhsA 3 0.5495 100 0.674 Contact Map
4ciuA 1 0.8401 100 0.674 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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