GREMLIN Database
YEJB - Inner membrane ABC transporter permease protein YejB
UniProt: P0AFU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12038
Length: 364 (278)
Sequences: 9514 (6020)
Seq/√Len: 361.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K101_E3.6091.00
91_H96_D3.3901.00
97_K105_K3.3001.00
104_F108_W3.1521.00
83_P87_A2.9411.00
108_W112_R2.9401.00
251_F278_V2.6441.00
264_R270_E2.6181.00
272_N276_K2.5191.00
100_H104_F2.4941.00
202_F226_W2.3681.00
316_L320_E2.3571.00
260_V278_V2.3211.00
128_L317_L2.3201.00
142_W232_V2.2981.00
135_V311_L2.2461.00
287_I355_V2.2151.00
123_A127_T2.2021.00
146_I236_V2.1591.00
124_S127_T2.1501.00
194_A204_L2.1371.00
222_T226_W2.1281.00
88_E92_R2.0911.00
202_F229_T2.0771.00
101_E105_K2.0201.00
87_A91_H2.0101.00
87_A90_T1.9731.00
109_D114_D1.9481.00
86_I90_T1.9441.00
262_T266_K1.9331.00
291_P348_S1.9281.00
85_V88_E1.9031.00
121_R128_L1.8791.00
271_K275_W1.8741.00
161_Y164_S1.8591.00
209_S223_D1.8531.00
255_V278_V1.8101.00
165_R169_W1.7751.00
254_E259_Y1.7751.00
269_S272_N1.7691.00
154_L170_S1.7651.00
254_E257_K1.7641.00
321_A329_V1.7451.00
160_V274_L1.7401.00
351_S354_L1.7211.00
288_A352_Y1.7041.00
157_R161_Y1.7001.00
105_K108_W1.6731.00
149_L153_P1.6721.00
166_F170_S1.6551.00
266_K277_H1.6541.00
157_R166_F1.6351.00
125_V332_G1.5951.00
223_D227_H1.5881.00
110_Y115_F1.5741.00
138_T224_Y1.5731.00
82_D85_V1.5421.00
207_L311_L1.5251.00
232_V236_V1.5221.00
192_F198_Y1.4741.00
188_L192_F1.4411.00
192_F199_F1.4361.00
148_Y290_F1.4311.00
150_V153_P1.4241.00
161_Y166_F1.4221.00
159_A251_F1.4161.00
189_L234_A1.4041.00
135_V207_L1.4021.00
103_Y107_L1.4001.00
260_V273_I1.3871.00
167_D248_K1.3771.00
128_L329_V1.3771.00
98_P101_E1.3761.00
89_I92_R1.3761.00
105_K109_D1.3761.00
229_T233_L1.3621.00
101_E104_F1.3621.00
156_I251_F1.3491.00
284_L352_Y1.3451.00
236_V240_F1.3341.00
126_L130_K1.3341.00
184_L188_L1.3321.00
254_E260_V1.3251.00
225_L229_T1.3211.00
259_Y281_N1.3151.00
191_V198_Y1.3141.00
318_G333_T1.3121.00
350_I354_L1.3071.00
220_K223_D1.3011.00
159_A255_V1.2941.00
123_A131_D1.2931.00
89_I93_Y1.2851.00
115_F126_L1.2801.00
138_T207_L1.2751.00
115_F332_G1.2741.00
147_I239_G1.2441.00
268_V272_N1.2411.00
223_D226_W1.2411.00
193_F199_F1.2301.00
254_E282_A1.2261.00
234_A238_G1.2211.00
258_Q261_V1.2151.00
317_L329_V1.2101.00
159_A252_L1.1951.00
302_S305_I1.1911.00
140_G298_F1.1741.00
217_W221_I1.1651.00
127_T130_K1.1551.00
319_Y323_V1.1541.00
347_V351_S1.1441.00
130_K134_P1.1431.00
117_D124_S1.1421.00
270_E273_I1.1421.00
155_G159_A1.1311.00
247_T286_V1.1311.00
268_V273_I1.1281.00
217_W220_K1.1251.00
144_T290_F1.1241.00
150_V240_F1.1231.00
123_A128_L1.1181.00
189_L230_L1.1131.00
163_G167_D1.1111.00
151_S247_T1.1011.00
135_V138_T1.0971.00
151_S243_L1.0871.00
118_S326_D1.0841.00
158_K170_S1.0831.00
287_I351_S1.0801.00
220_K224_Y1.0711.00
180_I185_F1.0691.00
127_T131_D1.0651.00
78_G81_L1.0581.00
207_L224_Y1.0481.00
186_A308_M1.0431.00
108_W111_I1.0401.00
333_T337_F1.0391.00
177_G241_A1.0381.00
218_Y222_T1.0361.00
222_T225_L1.0351.00
119_L328_P1.0321.00
160_V270_E1.0311.00
110_Y335_Y1.0271.00
182_A305_I1.0271.00
146_I232_V1.0231.00
155_G247_T1.0191.00
88_E91_H1.0171.00
162_N256_R1.0171.00
353_T359_I1.0161.00
132_S317_L1.0161.00
170_S244_T1.0111.00
91_H97_K1.0101.00
259_Y263_A1.0031.00
193_F201_L0.9991.00
77_G81_L0.9961.00
97_K100_H0.9941.00
248_K252_L0.9801.00
120_F324_S0.9781.00
131_D134_P0.9781.00
344_L348_S0.9681.00
94_G105_K0.9671.00
247_T251_F0.9651.00
264_R273_I0.9611.00
186_A234_A0.9581.00
208_V220_K0.9561.00
163_G168_V0.9471.00
154_L244_T0.9401.00
104_F107_L0.9391.00
143_S236_V0.9331.00
174_I244_T0.9311.00
169_W173_F0.9301.00
282_A285_L0.9301.00
141_L295_I0.9291.00
317_L321_A0.9231.00
139_L232_V0.9211.00
254_E278_V0.9141.00
221_I225_L0.9111.00
320_E324_S0.9091.00
94_G97_K0.9081.00
153_P156_I0.9081.00
156_I275_W0.9021.00
296_S341_G0.8921.00
87_A96_D0.8921.00
270_E274_L0.8861.00
263_A273_I0.8801.00
165_R168_V0.8741.00
141_L145_L0.8721.00
193_F202_F0.8701.00
136_S140_G0.8671.00
128_L131_D0.8661.00
106_M110_Y0.8661.00
221_I224_Y0.8651.00
182_A238_G0.8651.00
153_P157_R0.8641.00
173_F177_G0.8641.00
84_E88_E0.8641.00
307_V316_L0.8621.00
330_M334_L0.8611.00
152_I247_T0.8561.00
291_P344_L0.8511.00
148_Y153_P0.8351.00
206_G227_H0.8341.00
208_V223_D0.8341.00
134_P137_I0.8331.00
167_D252_L0.8311.00
83_P86_I0.8301.00
77_G89_I0.8261.00
228_I232_V0.8231.00
107_L111_I0.8221.00
121_R329_V0.8201.00
138_T142_W0.8181.00
117_D122_S0.8171.00
272_N275_W0.8141.00
103_Y106_M0.8141.00
229_T232_V0.8091.00
235_T302_S0.8061.00
155_G251_F0.8041.00
202_F230_L0.8031.00
350_I353_T0.7991.00
142_W311_L0.7971.00
138_T228_I0.7961.00
295_I344_L0.7931.00
195_G198_Y0.7921.00
331_F334_L0.7881.00
216_P219_Q0.7871.00
184_L187_I0.7841.00
143_S235_T0.7831.00
166_F169_W0.7821.00
246_L289_G0.7801.00
263_A268_V0.7791.00
234_A305_I0.7781.00
189_L233_L0.7771.00
109_D112_R0.7741.00
320_E323_V0.7741.00
139_L311_L0.7701.00
162_N252_L0.7671.00
151_S244_T0.7651.00
182_A237_I0.7651.00
208_V224_Y0.7621.00
273_I278_V0.7611.00
133_L137_I0.7611.00
303_L307_V0.7551.00
84_E87_A0.7541.00
151_S155_G0.7531.00
312_N316_L0.7511.00
233_L236_V0.7501.00
247_T279_F0.7501.00
171_S244_T0.7501.00
191_V195_G0.7481.00
169_W172_A0.7461.00
198_Y201_L0.7461.00
142_W229_T0.7451.00
160_V275_W0.7451.00
250_S282_A0.7411.00
129_I332_G0.7391.00
185_F237_I0.7371.00
321_A330_M0.7351.00
317_L333_T0.7341.00
150_V236_V0.7341.00
343_L347_V0.7331.00
240_F244_T0.7321.00
226_W229_T0.7231.00
275_W278_V0.7190.99
205_R310_S0.7160.99
138_T311_L0.7100.99
139_L228_I0.7080.99
215_L219_Q0.7040.99
156_I279_F0.7030.99
143_S147_I0.7030.99
332_G336_I0.7010.99
199_F202_F0.6990.99
322_T330_M0.6980.99
303_L319_Y0.6960.99
339_L343_L0.6950.99
283_M355_V0.6940.99
142_W228_I0.6920.99
194_A200_D0.6900.99
85_V89_I0.6890.99
101_E108_W0.6880.99
307_V319_Y0.6870.99
353_T361_F0.6860.99
129_I333_T0.6860.99
107_L110_Y0.6830.99
177_G237_I0.6820.99
190_I204_L0.6810.99
108_W113_F0.6800.99
247_T250_S0.6770.99
147_I236_V0.6710.99
215_L220_K0.6700.99
263_A266_K0.6680.99
140_G144_T0.6650.99
170_S174_I0.6640.99
287_I348_S0.6620.99
345_N348_S0.6620.99
193_F230_L0.6600.99
172_A176_I0.6580.99
98_P102_R0.6570.99
81_L86_I0.6560.99
191_V194_A0.6540.99
296_S344_L0.6540.99
307_V320_E0.6530.99
182_A304_L0.6520.99
144_T295_I0.6480.99
130_K133_L0.6440.99
250_S286_V0.6430.99
99_I102_R0.6420.99
129_I314_L0.6380.99
146_I150_V0.6370.99
239_G242_A0.6270.99
144_T148_Y0.6160.98
102_R327_Y0.6140.98
148_Y243_L0.6140.98
243_L294_F0.6110.98
341_G344_L0.6100.98
136_S302_S0.6100.98
146_I233_L0.6080.98
306_E313_G0.6080.98
207_L210_A0.6070.98
235_T305_I0.6060.98
352_Y359_I0.6050.98
90_T96_D0.6050.98
203_P206_G0.6020.98
154_L240_F0.6020.98
243_L289_G0.6000.98
251_F279_F0.5980.98
218_Y221_I0.5950.98
174_I241_A0.5940.98
113_F335_Y0.5910.98
158_K167_D0.5910.98
239_G243_L0.5910.98
318_G337_F0.5890.98
319_Y322_T0.5880.98
208_V219_Q0.5860.98
281_N284_L0.5850.98
246_L250_S0.5790.98
138_T141_L0.5770.98
167_D171_S0.5730.97
346_I350_I0.5720.97
325_R331_F0.5700.97
190_I194_A0.5700.97
299_F337_F0.5690.97
134_P138_T0.5690.97
303_L315_G0.5690.97
182_A234_A0.5680.97
245_M249_N0.5670.97
216_P221_I0.5670.97
230_L234_A0.5670.97
329_V333_T0.5660.97
327_Y331_F0.5650.97
140_G302_S0.5630.97
162_N168_V0.5620.97
152_I286_V0.5620.97
284_L359_I0.5620.97
161_Y270_E0.5570.97
283_M286_V0.5560.97
224_Y227_H0.5550.97
296_S340_I0.5550.97
219_Q222_T0.5540.97
268_V277_H0.5510.97
247_T282_A0.5490.97
159_A167_D0.5490.97
275_W280_R0.5480.97
184_L308_M0.5480.97
92_R122_S0.5470.97
90_T95_F0.5440.97
209_S224_Y0.5410.96
162_N167_D0.5400.96
274_L278_V0.5390.96
137_I141_L0.5380.96
277_H281_N0.5380.96
225_L228_I0.5370.96
303_L318_G0.5370.96
208_V227_H0.5370.96
357_P360_D0.5370.96
314_L337_F0.5360.96
216_P220_K0.5340.96
224_Y228_I0.5310.96
209_S218_Y0.5300.96
340_I344_L0.5290.96
275_W279_F0.5290.96
132_S316_L0.5290.96
203_P226_W0.5290.96
318_G334_L0.5280.96
328_P331_F0.5280.96
300_T304_L0.5270.96
283_M287_I0.5260.96
210_A217_W0.5250.96
158_K171_S0.5220.96
142_W146_I0.5220.96
129_I317_L0.5220.96
161_Y275_W0.5200.96
337_F341_G0.5190.96
142_W225_L0.5190.96
115_F335_Y0.5160.95
145_L149_L0.5160.95
154_L166_F0.5150.95
194_A198_Y0.5150.95
321_A324_S0.5150.95
219_Q223_D0.5140.95
135_V224_Y0.5140.95
258_Q262_T0.5130.95
139_L235_T0.5120.95
168_V171_S0.5120.95
133_L314_L0.5100.95
209_S227_H0.5080.95
178_Y241_A0.5070.95
164_S169_W0.5070.95
348_S351_S0.5060.95
99_I103_Y0.5060.95
158_K244_T0.5040.95
269_S273_I0.5040.95
118_S121_R0.5040.95
112_R127_T0.5040.95
156_I160_V0.5020.95
137_I299_F0.5020.95
138_T225_L0.5010.95
203_P227_H0.5010.95
206_G209_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.5742 99.9 0.719 Contact Map
4tquM 1 0.7445 99.9 0.734 Contact Map
3rlfF 1 0.7527 99.9 0.743 Contact Map
2onkC 2 0.6868 99.9 0.747 Contact Map
4ymuD 2 0.5769 99.8 0.753 Contact Map
3d31C 2 0.6731 99.8 0.756 Contact Map
4tquN 1 0.7033 99.8 0.765 Contact Map
3rlfG 1 0.7637 99.8 0.775 Contact Map
3wdoA 1 0.25 21.5 0.965 Contact Map
4pypA 1 0.0852 10.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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