GREMLIN Database
YEHT - Transcriptional regulatory protein YehT
UniProt: P0AFT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12006
Length: 239 (200)
Sequences: 63212 (46796)
Seq/√Len: 3308.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R32_E4.0431.00
14_R34_S3.7141.00
18_R32_E3.5131.00
40_I68_M2.8301.00
7_V39_G2.8121.00
31_G48_P2.6121.00
36_A60_I2.5941.00
37_V59_R2.4481.00
60_I68_M2.4231.00
33_C42_A2.4001.00
31_G42_A2.2761.00
20_F105_E2.2661.00
31_G46_L2.2561.00
3_K31_G2.2011.00
35_N59_R2.1881.00
18_R22_Q2.0701.00
3_K28_E2.0691.00
87_A107_R2.0621.00
79_F95_A2.0161.00
24_Q109_E2.0031.00
56_Q83_F1.9661.00
66_V77_I1.9441.00
42_A46_L1.9021.00
53_L65_M1.8481.00
97_D111_T1.8161.00
136_F149_Q1.7911.00
5_L33_C1.7611.00
35_N38_E1.7501.00
61_S64_E1.7411.00
34_S38_E1.7401.00
67_G93_E1.7111.00
36_A65_M1.6831.00
51_L75_P1.6811.00
96_F118_E1.6051.00
40_I65_M1.5811.00
43_V69_L1.5721.00
68_M71_P1.5371.00
66_V79_F1.5121.00
37_V60_I1.5111.00
60_I64_E1.5101.00
79_F90_A1.4731.00
42_A48_P1.4721.00
64_E67_G1.4311.00
55_I63_L1.4291.00
42_A45_K1.4051.00
40_I60_I1.3951.00
8_D14_R1.3931.00
193_R196_L1.3881.00
165_V182_L1.3651.00
3_K46_L1.3521.00
176_E196_L1.3491.00
198_N201_H1.3211.00
21_L112_L1.3201.00
55_I79_F1.3151.00
53_L66_V1.3121.00
164_Y168_H1.3101.00
11_P34_S1.3011.00
33_C39_G1.2961.00
96_F115_L1.2691.00
70_D96_F1.2681.00
7_V57_M1.2571.00
138_P147_L1.2361.00
83_F86_Y1.2341.00
63_L89_K1.2221.00
89_K93_E1.2201.00
41_G45_K1.2201.00
109_E113_A1.2191.00
5_L48_P1.2151.00
145_I152_D1.2121.00
76_Y118_E1.2031.00
9_D54_D1.2011.00
4_V27_I1.1941.00
63_L90_A1.1911.00
50_V112_L1.1901.00
92_E113_A1.1881.00
67_G89_K1.1691.00
141_G164_Y1.1691.00
37_V41_G1.1661.00
38_E41_G1.1591.00
78_V115_L1.1571.00
6_I17_L1.1521.00
40_I44_H1.1471.00
5_L39_G1.1381.00
169_E172_E1.1321.00
24_Q113_A1.1121.00
140_T143_S1.1111.00
87_A100_L1.1081.00
147_L152_D1.1061.00
178_T182_L1.1041.00
28_E31_G1.1031.00
39_G65_M1.0951.00
11_P15_E1.0921.00
38_E42_A1.0611.00
76_Y122_Q1.0551.00
39_G43_V1.0541.00
158_S161_S1.0381.00
33_C38_E1.0381.00
51_L69_L1.0361.00
78_V111_T1.0171.00
51_L77_I1.0171.00
55_I61_S1.0041.00
175_T178_T1.0021.00
52_F108_L1.0021.00
66_V93_E0.9751.00
5_L42_A0.9701.00
44_H72_E0.9591.00
170_G174_F0.9581.00
97_D114_R0.9581.00
27_I113_A0.9561.00
84_D100_L0.9531.00
92_E110_K0.9511.00
64_E68_M0.9501.00
17_L108_L0.9471.00
7_V51_L0.9451.00
89_K92_E0.9441.00
181_T185_R0.9441.00
15_E32_E0.9391.00
107_R111_T0.9371.00
80_L103_I0.9341.00
85_E89_K0.9301.00
88_I92_E0.9281.00
72_E75_P0.9271.00
197_V200_A0.9261.00
139_C167_S0.9251.00
12_L16_N0.9191.00
110_K114_R0.9191.00
158_S184_S0.9181.00
65_M69_L0.9091.00
76_Y119_R0.8961.00
52_F112_L0.8941.00
178_T181_T0.8841.00
17_L80_L0.8791.00
200_A204_E0.8791.00
10_E13_A0.8781.00
15_E18_R0.8771.00
133_A138_P0.8651.00
43_V72_E0.8621.00
50_V116_R0.8621.00
105_E109_E0.8621.00
114_R117_Q0.8581.00
119_R123_D0.8571.00
15_E19_V0.8561.00
57_M65_M0.8531.00
41_G44_H0.8481.00
67_G71_P0.8461.00
180_R184_S0.8441.00
13_A103_I0.8431.00
16_N20_F0.8391.00
11_P14_R0.8371.00
63_L93_E0.8321.00
5_L43_V0.8281.00
3_K48_P0.8241.00
53_L77_I0.8241.00
52_F80_L0.8201.00
55_I86_Y0.8201.00
56_Q82_A0.8131.00
139_C160_M0.8131.00
19_V23_E0.8121.00
165_V174_F0.8121.00
107_R110_K0.8111.00
69_L77_I0.8051.00
36_A40_I0.8041.00
177_L181_T0.8011.00
53_L79_F0.7981.00
8_D57_M0.7971.00
74_R122_Q0.7901.00
85_E106_A0.7871.00
147_L150_M0.7851.00
4_V50_V0.7841.00
7_V33_C0.7841.00
194_Q198_N0.7811.00
76_Y96_F0.7811.00
5_L31_G0.7801.00
174_F178_T0.7781.00
103_I108_L0.7731.00
88_I106_A0.7711.00
55_I83_F0.7711.00
43_V75_P0.7631.00
87_A104_D0.7591.00
6_I14_R0.7551.00
66_V95_A0.7511.00
172_E178_T0.7501.00
165_V169_E0.7451.00
27_I109_E0.7451.00
7_V65_M0.7421.00
43_V51_L0.7391.00
115_L118_E0.7381.00
81_T87_A0.7361.00
52_F78_V0.7351.00
43_V48_P0.7321.00
18_R30_V0.7301.00
60_I65_M0.7251.00
76_Y115_L0.7221.00
20_F109_E0.7201.00
136_F148_L0.7141.00
33_C36_A0.7111.00
144_R161_S0.7061.00
118_E122_Q0.7031.00
111_T115_L0.7021.00
14_R18_R0.7001.00
104_D107_R0.7001.00
92_E97_D0.6991.00
3_K49_D0.6981.00
144_R160_M0.6951.00
106_A110_K0.6931.00
6_I18_R0.6891.00
161_S164_Y0.6731.00
85_E88_I0.6721.00
119_R122_Q0.6711.00
90_A95_A0.6701.00
86_Y89_K0.6691.00
116_R119_R0.6671.00
113_A117_Q0.6661.00
91_F111_T0.6661.00
40_I43_V0.6631.00
157_S161_S0.6601.00
13_A16_N0.6571.00
82_A102_P0.6551.00
7_V36_A0.6521.00
36_A59_R0.6431.00
74_R121_K0.6391.00
69_L75_P0.6371.00
148_L151_K0.6361.00
4_V21_L0.6331.00
197_V201_H0.6331.00
142_H172_E0.6311.00
113_A116_R0.6291.00
116_R120_S0.6241.00
92_E107_R0.6241.00
137_I148_L0.6231.00
6_I32_E0.6201.00
192_H196_L0.6121.00
44_H68_M0.6111.00
148_L207_L0.6101.00
7_V53_L0.6071.00
167_S170_G0.6071.00
69_L73_H0.6051.00
53_L69_L0.6051.00
53_L57_M0.5951.00
55_I90_A0.5951.00
117_Q120_S0.5831.00
165_V179_L0.5831.00
6_I30_V0.5811.00
140_T145_I0.5811.00
110_K113_A0.5801.00
20_F24_Q0.5771.00
117_Q121_K0.5751.00
43_V73_H0.5731.00
141_G168_H0.5731.00
114_R118_E0.5721.00
43_V65_M0.5721.00
91_F95_A0.5721.00
17_L103_I0.5711.00
21_L27_I0.5681.00
202_L206_R0.5661.00
96_F111_T0.5651.00
112_L116_R0.5641.00
27_I116_R0.5631.00
88_I91_F0.5621.00
70_D75_P0.5621.00
11_P32_E0.5591.00
191_C194_Q0.5591.00
160_M164_Y0.5581.00
121_K124_V0.5571.00
199_L203_Q0.5561.00
79_F93_E0.5551.00
16_N19_V0.5511.00
35_N57_M0.5501.00
12_L15_E0.5441.00
121_K125_S0.5431.00
128_P132_Q0.5401.00
139_C146_Y0.5381.00
36_A57_M0.5371.00
196_L200_A0.5311.00
5_L51_L0.5301.00
138_P150_M0.5261.00
28_E46_L0.5261.00
173_G177_L0.5251.00
134_L137_I0.5231.00
189_L199_L0.5201.00
47_R73_H0.5191.00
146_Y153_V0.5181.00
133_A136_F0.5171.00
112_L115_L0.5151.00
193_R197_V0.5151.00
159_R205_I0.5151.00
173_G176_E0.5131.00
134_L167_S0.5131.00
201_H204_E0.5121.00
24_Q27_I0.5111.00
139_C164_Y0.5101.00
78_V97_D0.5081.00
176_E180_R0.5051.00
23_E105_E0.5041.00
120_S123_D0.5031.00
177_L192_H0.5031.00
66_V70_D0.5011.00
188_L191_C0.5011.00
50_V115_L0.5001.00
4_V52_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cbvA 2 0.954 100 0.308 Contact Map
4g97A 1 0.5356 100 0.378 Contact Map
3n0rA 1 0.5021 100 0.382 Contact Map
4kfcA 2 0.9163 100 0.385 Contact Map
1kgsA 1 0.8954 100 0.388 Contact Map
2oqrA 2 0.9247 99.9 0.392 Contact Map
1ys7A 2 0.9247 99.9 0.392 Contact Map
3r0jA 2 0.9038 99.9 0.394 Contact Map
3q9sA 1 0.8703 99.9 0.394 Contact Map
3breA 4 0.9916 99.9 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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