GREMLIN Database
YECS - Inner membrane amino-acid ABC transporter permease protein YecS
UniProt: P0AFT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14037
Length: 222 (203)
Sequences: 24362 (14680)
Seq/√Len: 1030.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_A132_T3.3241.00
32_F96_S3.2431.00
150_S207_Q3.0591.00
184_E187_T3.0071.00
91_A163_A2.9051.00
128_T131_Q2.8981.00
20_G24_Q2.8731.00
43_M55_A2.5121.00
28_G92_M2.4381.00
130_W134_R2.4181.00
123_A132_T2.3181.00
205_T209_H2.2561.00
65_T70_Q2.2101.00
175_A192_A2.1701.00
119_W132_T2.1461.00
118_Q140_Q2.0761.00
40_L104_A2.0531.00
50_P54_L2.0321.00
40_L100_A2.0031.00
50_P53_W1.9311.00
119_W123_A1.8691.00
41_A107_L1.8571.00
44_R56_R1.8371.00
173_R177_L1.7521.00
36_L100_A1.7471.00
30_M153_F1.7331.00
49_W53_W1.7271.00
21_Y24_Q1.7231.00
209_H212_N1.6991.00
16_L20_G1.6411.00
24_Q88_I1.6341.00
74_I94_G1.5731.00
201_T205_T1.5711.00
131_Q135_R1.5681.00
205_T208_N1.5581.00
129_P133_M1.5501.00
38_F107_L1.5441.00
45_L112_S1.5351.00
86_D89_P1.5341.00
174_Q177_L1.5301.00
19_A199_M1.5271.00
197_W201_T1.5241.00
17_K20_G1.5191.00
49_W52_R1.5131.00
128_T132_T1.4951.00
123_A129_P1.4781.00
35_L39_I1.4401.00
110_A145_A1.4401.00
113_S144_V1.4351.00
21_Y168_V1.4261.00
127_M131_Q1.4161.00
59_I104_A1.4121.00
33_G99_T1.4041.00
179_T185_V1.3961.00
206_L209_H1.3941.00
14_F17_K1.3841.00
105_E108_R1.3511.00
173_R176_Q1.3321.00
25_L163_A1.3281.00
48_I53_W1.3271.00
119_W137_I1.3221.00
108_R112_S1.3151.00
131_Q134_R1.3151.00
103_A152_S1.3011.00
26_S157_V1.2971.00
175_A179_T1.2851.00
171_L174_Q1.2731.00
103_A149_L1.2721.00
176_Q179_T1.2691.00
122_A127_M1.2421.00
107_L145_A1.2381.00
26_S153_F1.2371.00
32_F92_M1.2351.00
122_A136_A1.2351.00
175_A188_M1.2291.00
70_Q98_N1.2271.00
129_P132_T1.2201.00
28_G96_S1.1871.00
48_I51_V1.1731.00
89_P92_M1.1601.00
39_I43_M1.1601.00
88_I92_M1.1301.00
40_L55_A1.1291.00
26_S160_T1.1251.00
177_L181_R1.1241.00
52_R56_R1.1151.00
37_G103_A1.1141.00
24_Q28_G1.1141.00
92_M96_S1.1031.00
209_H213_Q1.1011.00
53_W57_F1.0941.00
116_K120_E1.0911.00
54_L58_Y1.0851.00
54_L57_F1.0771.00
110_A144_V1.0661.00
62_F97_L1.0551.00
111_I137_I1.0521.00
179_T189_Y1.0471.00
14_F174_Q1.0441.00
71_L163_A1.0371.00
170_E174_Q1.0371.00
17_K21_Y1.0361.00
65_T98_N1.0331.00
106_T152_S1.0311.00
71_L94_G1.0181.00
56_R108_R1.0181.00
29_G96_S1.0161.00
208_N211_E1.0051.00
13_P17_K1.0011.00
169_P173_R0.9941.00
30_M156_L0.9891.00
34_L149_L0.9821.00
87_P167_Q0.9671.00
175_A178_I0.9661.00
106_T148_P0.9651.00
176_Q180_S0.9611.00
202_V206_L0.9421.00
42_L133_M0.9401.00
43_M46_S0.9381.00
28_G32_F0.9361.00
70_Q74_I0.9331.00
208_N212_N0.9331.00
114_I141_A0.9251.00
133_M138_L0.9231.00
41_A111_I0.9231.00
127_M135_R0.9201.00
67_L159_D0.9171.00
60_S201_T0.9151.00
155_S159_D0.9131.00
116_K119_W0.9101.00
45_L111_I0.9041.00
157_V199_M0.9001.00
187_T190_L0.8971.00
182_T185_V0.8911.00
55_A104_A0.8781.00
67_L98_N0.8721.00
88_I168_V0.8671.00
44_R105_E0.8611.00
165_T169_P0.8611.00
31_F35_L0.8611.00
43_M51_V0.8551.00
111_I141_A0.8531.00
74_I90_S0.8531.00
29_G156_L0.8501.00
77_G81_F0.8471.00
191_A195_I0.8381.00
163_A168_V0.8331.00
22_T157_V0.8251.00
206_L210_F0.8241.00
157_V203_L0.8221.00
144_V148_P0.8171.00
190_L193_S0.8161.00
57_F60_S0.8161.00
133_M137_I0.8161.00
99_T152_S0.8151.00
85_L89_P0.8141.00
70_Q94_G0.8111.00
62_F101_A0.8081.00
36_L96_S0.8071.00
33_G103_A0.8041.00
114_I144_V0.8011.00
201_T204_S0.7961.00
71_L162_L0.7891.00
48_I54_L0.7881.00
170_E173_R0.7841.00
27_I31_F0.7831.00
161_S196_Y0.7771.00
107_L111_I0.7751.00
82_G85_L0.7721.00
68_I165_T0.7721.00
32_F35_L0.7671.00
53_W56_R0.7641.00
73_M77_G0.7611.00
119_W129_P0.7581.00
48_I52_R0.7581.00
103_A107_L0.7561.00
45_L119_W0.7531.00
99_T156_L0.7521.00
58_Y100_A0.7521.00
47_P52_R0.7491.00
44_R59_I0.7461.00
73_M190_L0.7451.00
189_Y193_S0.7451.00
29_G95_L0.7431.00
19_A195_I0.7421.00
38_F138_L0.7401.00
117_G120_E0.7321.00
89_P93_I0.7301.00
190_L194_L0.7291.00
178_I188_M0.7231.00
203_L207_Q0.7201.00
46_S55_A0.7181.00
28_G88_I0.7171.00
37_G107_L0.7091.00
87_P90_S0.7091.00
72_F76_Y0.7081.00
204_S208_N0.7011.00
71_L166_I0.6951.00
18_G174_Q0.6921.00
181_R184_E0.6881.00
13_P16_L0.6871.00
163_A170_E0.6861.00
174_Q178_I0.6861.00
137_I140_Q0.6851.00
19_A171_L0.6851.00
87_P168_V0.6841.00
28_G31_F0.6841.00
56_R60_S0.6821.00
25_L88_I0.6811.00
26_S30_M0.6801.00
117_G121_A0.6741.00
172_F176_Q0.6701.00
98_N159_D0.6681.00
148_P151_N0.6581.00
47_P50_P0.6581.00
21_Y88_I0.6561.00
46_S129_P0.6541.00
41_A45_L0.6541.00
198_I202_V0.6501.00
91_A166_I0.6501.00
58_Y62_F0.6501.00
40_L43_M0.6491.00
51_V54_L0.6491.00
60_S197_W0.6451.00
62_F70_Q0.6441.00
44_R52_R0.6431.00
23_L27_I0.6421.00
58_Y101_A0.6411.00
75_Y90_S0.6411.00
189_Y192_A0.6371.00
40_L44_R0.6361.00
96_S100_A0.6311.00
162_L167_Q0.6281.00
95_L163_A0.6281.00
116_K123_A0.6251.00
37_G104_A0.6241.00
95_L156_L0.6231.00
25_L91_A0.6191.00
114_I137_I0.6181.00
25_L29_G0.6131.00
172_F175_A0.6081.00
171_L175_A0.6061.00
77_G80_Q0.6011.00
26_S29_G0.5951.00
37_G41_A0.5951.00
157_V200_A0.5941.00
16_L19_A0.5931.00
169_P174_Q0.5911.00
197_W200_A0.5891.00
95_L160_T0.5881.00
74_I78_L0.5871.00
153_F203_L0.5871.00
57_F61_I0.5841.00
61_I65_T0.5831.00
30_M34_L0.5761.00
34_L107_L0.5721.00
210_F214_L0.5721.00
20_G23_L0.5701.00
164_A173_R0.5691.00
43_M54_L0.5671.00
114_I140_Q0.5631.00
186_F190_L0.5601.00
170_E175_A0.5601.00
24_Q89_P0.5591.00
91_A168_V0.5571.00
86_D90_S0.5561.00
35_L38_F0.5561.00
44_R104_A0.5551.00
161_S164_A0.5531.00
200_A204_S0.5531.00
45_L48_I0.5511.00
67_L95_L0.5511.00
121_A124_S0.5511.00
75_Y166_I0.5501.00
127_M132_T0.5491.00
99_T159_D0.5451.00
177_L180_S0.5451.00
152_S155_S0.5441.00
122_A125_I0.5441.00
170_E180_S0.5421.00
147_P211_E0.5411.00
128_T135_R0.5381.00
22_T196_Y0.5371.00
162_L165_T0.5361.00
47_P129_P0.5341.00
115_D144_V0.5341.00
36_L39_I0.5311.00
146_L210_F0.5271.00
207_Q210_F0.5261.00
202_V209_H0.5261.00
99_T103_A0.5231.00
193_S196_Y0.5221.00
79_P82_G0.5181.00
164_A167_Q0.5151.00
172_F189_Y0.5111.00
46_S52_R0.5111.00
202_V205_T0.5111.00
146_L214_L0.5111.00
172_F177_L0.5081.00
143_R214_L0.5071.00
183_L186_F0.5041.00
30_M103_A0.5021.00
172_F192_A0.5011.00
194_L198_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9685 100 0.339 Contact Map
2onkC 2 0.955 100 0.398 Contact Map
3d31C 2 0.9279 100 0.41 Contact Map
3tuiA 2 0.9414 100 0.421 Contact Map
3rlfF 1 0.9234 99.9 0.436 Contact Map
4tquM 1 0.964 99.9 0.443 Contact Map
3rlfG 1 0.991 99.9 0.468 Contact Map
4tquN 1 0.9324 99.9 0.51 Contact Map
3w9iA 3 0.7703 32.8 0.928 Contact Map
4dx5A 3 0.8198 21.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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