GREMLIN Database
MEPM - Murein DD-endopeptidase MepM
UniProt: P0AFS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10013
Length: 440 (380)
Sequences: 4110 (3557)
Seq/√Len: 182.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_V363_L4.5691.00
296_S320_A4.3041.00
363_L381_A4.1021.00
338_A366_I4.0721.00
385_N389_S3.8101.00
367_L382_L3.4381.00
321_M383_S3.3891.00
329_S350_I3.2771.00
298_N408_L2.9931.00
352_H358_T2.9321.00
287_F319_F2.8541.00
332_D375_K2.8181.00
299_F404_A2.7941.00
247_Q251_L2.7311.00
344_A361_M2.6311.00
368_V372_Q2.6161.00
286_R376_R2.4841.00
326_P379_R2.4211.00
250_L254_R2.4191.00
248_S252_G2.3971.00
45_A49_V2.2991.00
334_E373_K2.2421.00
249_Q253_V2.2121.00
253_V257_S2.1721.00
251_L255_L2.1511.00
252_G256_R2.1471.00
131_R134_K2.1171.00
330_V358_T2.0991.00
358_T398_V2.0791.00
199_S203_A2.0611.00
256_R260_K2.0321.00
256_R259_G2.0301.00
330_V396_Y1.9661.00
255_L259_G1.9501.00
305_N308_T1.9251.00
323_Q392_P1.9251.00
349_A359_R1.8711.00
259_G263_Y1.8641.00
253_V256_R1.8581.00
247_Q250_L1.8511.00
379_R382_L1.7821.00
350_I380_I1.7681.00
257_S260_K1.7631.00
138_Q142_T1.7571.00
192_V196_F1.7441.00
254_R258_E1.7141.00
294_R320_A1.7091.00
336_V357_T1.7071.00
301_P313_P1.6771.00
308_T388_R1.6621.00
318_D395_H1.6611.00
251_L254_R1.6581.00
148_E152_L1.6441.00
305_N312_A1.6411.00
262_Y266_R1.6381.00
363_L366_I1.6341.00
297_S303_R1.6281.00
293_F319_F1.6281.00
406_N409_T1.6071.00
258_E262_Y1.6021.00
198_A201_R1.5991.00
120_I127_D1.5951.00
368_V378_D1.5941.00
375_K378_D1.5931.00
361_M397_E1.5661.00
258_E261_D1.5551.00
315_R397_E1.5501.00
261_D265_I1.5471.00
239_E242_D1.5331.00
300_N313_P1.5311.00
263_Y266_R1.5211.00
317_V408_L1.5211.00
257_S261_D1.5071.00
308_T312_A1.4991.00
347_Y361_M1.4851.00
343_A361_M1.4831.00
327_V383_S1.4821.00
323_Q364_R1.4751.00
254_R257_S1.4741.00
340_R346_Y1.4581.00
336_V351_R1.4551.00
346_Y386_T1.4321.00
317_V407_P1.4231.00
298_N406_N1.4211.00
347_Y359_R1.4131.00
103_G107_S1.4111.00
348_V380_I1.4101.00
156_V160_E1.4091.00
134_K142_T1.4061.00
195_S198_A1.4051.00
264_A267_A1.3911.00
178_M182_E1.3891.00
248_S251_L1.3651.00
255_L258_E1.3591.00
349_A357_T1.3481.00
263_Y267_A1.3471.00
49_V53_E1.3381.00
192_V195_S1.3291.00
229_G232_F1.3291.00
262_Y265_I1.3251.00
260_K264_A1.3221.00
252_G255_L1.3181.00
383_S394_L1.3151.00
335_V368_V1.2881.00
328_L379_R1.2821.00
100_V103_G1.2781.00
148_E153_T1.2761.00
399_W404_A1.2761.00
241_L244_K1.2631.00
297_S314_H1.2461.00
51_T55_E1.2451.00
123_L126_A1.2441.00
228_K232_F1.2441.00
39_Y42_H1.2411.00
261_D264_A1.2371.00
356_Y400_I1.2341.00
209_E212_A1.2331.00
318_D393_H1.2321.00
199_S202_N1.2311.00
56_Q59_I1.2311.00
369_K372_Q1.2301.00
344_A359_R1.2251.00
235_L239_E1.2151.00
364_R382_L1.2111.00
259_G262_Y1.2111.00
160_E163_T1.2051.00
334_E351_R1.2001.00
45_A48_I1.1961.00
348_V363_L1.1941.00
249_Q252_G1.1931.00
317_V411_K1.1921.00
246_E250_L1.1911.00
134_K143_L1.1771.00
167_T171_G1.1721.00
94_G98_Y1.1701.00
139_L142_T1.1631.00
88_K91_G1.1601.00
102_T106_L1.1591.00
196_F200_A1.1571.00
344_A397_E1.1571.00
314_H393_H1.1551.00
318_D362_H1.1541.00
314_H318_D1.1461.00
131_R143_L1.1411.00
105_T108_S1.1411.00
36_W39_Y1.1411.00
338_A368_V1.1411.00
140_S143_L1.1361.00
149_L154_W1.1361.00
367_L381_A1.1341.00
56_Q77_D1.1301.00
157_S160_E1.1261.00
230_D233_A1.1221.00
232_F235_L1.1211.00
121_T124_A1.1201.00
341_S347_Y1.1181.00
87_D91_G1.1091.00
260_K263_Y1.1051.00
205_L208_A1.1051.00
337_V349_A1.1041.00
138_Q143_L1.1001.00
102_T105_T1.0981.00
323_Q385_N1.0961.00
104_D108_S1.0911.00
236_M240_M1.0901.00
151_R154_W1.0841.00
359_R399_W1.0841.00
352_H360_Y1.0801.00
241_L245_R1.0791.00
60_R63_L1.0741.00
331_G376_R1.0721.00
365_K382_L1.0691.00
229_G233_A1.0681.00
206_T209_E1.0661.00
351_R355_S1.0651.00
44_D48_I1.0641.00
48_I56_Q1.0611.00
70_I74_A1.0571.00
139_L143_L1.0541.00
326_P382_L1.0521.00
321_M325_T1.0501.00
95_V98_Y1.0441.00
53_E56_Q1.0371.00
74_A77_D1.0341.00
163_T167_T1.0301.00
356_Y398_V1.0301.00
233_A237_S1.0271.00
181_G188_L1.0261.00
77_D81_P1.0261.00
234_V238_R1.0241.00
238_R242_D1.0231.00
349_A399_W1.0221.00
50_K53_E1.0130.99
385_N392_P1.0120.99
337_V347_Y1.0120.99
203_A207_S1.0070.99
220_Q223_F1.0070.99
147_G151_R1.0060.99
230_D234_V1.0050.99
62_L65_E1.0040.99
287_F293_F0.9980.99
30_T33_V0.9940.99
330_V360_Y0.9930.99
108_S112_Q0.9930.99
35_V38_P0.9870.99
116_D120_I0.9860.99
217_M220_Q0.9850.99
137_Q142_T0.9820.99
219_W222_D0.9780.99
84_E88_K0.9760.99
46_T50_K0.9730.99
56_Q60_R0.9700.99
237_S240_M0.9690.99
246_E249_Q0.9660.99
114_G117_M0.9570.99
385_N390_T0.9560.99
135_I143_L0.9520.99
113_Y120_I0.9510.99
110_L114_G0.9510.99
237_S241_L0.9510.99
242_D245_R0.9500.99
160_E167_T0.9490.99
289_T293_F0.9470.99
34_A37_R0.9460.99
72_Q76_E0.9430.99
123_L127_D0.9420.99
321_M324_G0.9390.99
57_N61_S0.9380.99
236_M239_E0.9370.99
33_V36_W0.9340.99
195_S199_S0.9320.99
155_E160_E0.9320.99
137_Q143_L0.9210.99
145_A148_E0.9180.99
226_L230_D0.9170.99
239_E243_G0.9140.99
344_A399_W0.9140.99
216_A219_W0.9090.99
189_K193_G0.9090.99
400_I405_V0.9060.99
37_R41_Y0.9060.99
157_S164_Y0.8940.99
360_Y396_Y0.8870.99
333_G350_I0.8830.99
55_E58_E0.8810.99
44_D47_P0.8800.99
167_T170_N0.8790.98
212_A215_K0.8710.98
202_N209_E0.8700.98
303_R314_H0.8650.98
107_S110_L0.8640.98
235_L238_R0.8640.98
250_L258_E0.8630.98
51_T54_L0.8620.98
209_E216_A0.8620.98
120_I124_A0.8600.98
131_R135_I0.8580.98
337_V341_S0.8570.98
148_E151_R0.8570.98
185_N188_L0.8540.98
86_D89_I0.8520.98
148_E154_W0.8480.98
194_G198_A0.8440.98
236_M243_G0.8420.98
155_E161_T0.8410.98
203_A206_T0.8410.98
56_Q69_P0.8410.98
184_V187_L0.8360.98
315_R404_A0.8360.98
65_E69_P0.8320.98
34_A38_P0.8310.98
367_L379_R0.8310.98
188_L192_V0.8290.98
361_M399_W0.8290.98
297_S318_D0.8280.98
116_D119_D0.8280.98
74_A78_E0.8270.98
164_Y167_T0.8260.98
232_F236_M0.8240.98
73_A76_E0.8230.98
124_A127_D0.8230.98
134_K137_Q0.8230.98
206_T210_V0.8200.98
235_L240_M0.8200.98
362_H387_G0.8190.98
70_I77_D0.8190.98
134_K139_L0.8190.98
180_Q184_V0.8180.98
197_V201_R0.8170.98
115_I119_D0.8160.98
28_V31_L0.8150.98
362_H393_H0.8150.98
155_E159_R0.8150.98
124_A128_K0.8150.98
191_T195_S0.8130.97
100_V104_D0.8120.97
55_E59_I0.8120.97
193_G196_F0.8110.97
346_Y366_I0.8100.97
278_T282_K0.8050.97
131_R142_T0.8040.97
109_I113_Y0.8040.97
301_P311_V0.8030.97
89_I93_A0.8030.97
345_G384_G0.8030.97
66_A69_P0.7990.97
88_K92_E0.7990.97
117_M121_T0.7970.97
226_L232_F0.7970.97
185_N189_K0.7890.97
191_T194_G0.7870.97
130_L134_K0.7860.97
165_D168_A0.7850.97
64_P67_S0.7840.97
231_E235_L0.7840.97
156_V161_T0.7840.97
169_A173_K0.7840.97
215_K219_W0.7810.97
133_L136_G0.7800.97
137_Q141_W0.7790.97
159_R167_T0.7750.97
144_T148_E0.7740.97
43_R46_T0.7740.97
363_L394_L0.7740.97
274_D278_T0.7740.97
319_F408_L0.7730.97
248_S255_L0.7720.97
201_R205_L0.7700.97
182_E186_N0.7660.96
131_R140_S0.7650.96
155_E167_T0.7640.96
344_A349_A0.7590.96
47_P51_T0.7570.96
150_Q154_W0.7560.96
337_V399_W0.7560.96
91_G94_G0.7530.96
73_A77_D0.7530.96
340_R343_A0.7530.96
348_V368_V0.7520.96
38_P41_Y0.7520.96
118_G122_Q0.7520.96
300_N311_V0.7500.96
120_I123_L0.7500.96
405_V410_A0.7490.96
210_V214_I0.7440.96
69_P72_Q0.7430.96
181_G185_N0.7420.96
343_A388_R0.7410.96
285_L356_Y0.7400.96
208_A212_A0.7390.96
201_R204_G0.7390.96
48_I51_T0.7370.96
233_A236_M0.7350.95
296_S393_H0.7320.95
314_H362_H0.7310.95
229_G237_S0.7300.95
397_E404_A0.7290.95
363_L383_S0.7270.95
158_R164_Y0.7260.95
31_L34_A0.7260.95
298_N317_V0.7240.95
155_E158_R0.7240.95
299_F313_P0.7230.95
196_F199_S0.7230.95
205_L209_E0.7210.95
96_H100_V0.7210.95
320_A391_G0.7200.95
308_T311_V0.7190.95
161_T164_Y0.7140.95
183_W187_L0.7140.95
265_I268_E0.7120.95
63_L67_S0.7100.95
240_M244_K0.7050.94
305_N310_R0.7050.94
289_T321_M0.7040.94
351_R357_T0.7040.94
211_S214_I0.7010.94
85_L89_I0.6990.94
207_S210_V0.6990.94
160_E178_M0.6960.94
131_R141_W0.6940.94
285_L410_A0.6930.94
49_V77_D0.6930.94
125_A129_E0.6910.94
172_F175_T0.6890.94
287_F411_K0.6890.94
61_S65_E0.6870.94
296_S314_H0.6820.93
158_R167_T0.6780.93
165_D182_E0.6770.93
157_S161_T0.6760.93
150_Q153_T0.6760.93
307_V388_R0.6750.93
306_P309_G0.6740.93
165_D169_A0.6730.93
62_L66_A0.6710.93
340_R386_T0.6710.93
149_L153_T0.6690.93
383_S392_P0.6680.93
314_H395_H0.6680.93
43_R47_P0.6660.92
356_Y410_A0.6660.92
48_I52_I0.6630.92
322_P325_T0.6620.92
352_H396_Y0.6620.92
57_N60_R0.6600.92
240_M243_G0.6590.92
250_L253_V0.6580.92
137_Q140_S0.6570.92
58_E62_L0.6560.92
305_N311_V0.6560.92
52_I56_Q0.6540.92
339_K366_I0.6500.92
46_T49_V0.6490.91
342_G389_S0.6490.91
106_L113_Y0.6480.91
113_Y117_M0.6450.91
318_D391_G0.6430.91
198_A202_N0.6430.91
306_P390_T0.6420.91
52_I70_I0.6410.91
159_R163_T0.6400.91
335_V338_A0.6380.91
366_I381_A0.6380.91
37_R40_V0.6370.91
135_I138_Q0.6360.91
202_N206_T0.6340.91
134_K138_Q0.6340.91
147_G153_T0.6340.91
59_I63_L0.6340.91
340_R366_I0.6330.90
256_R261_D0.6330.90
314_H391_G0.6320.90
338_A346_Y0.6320.90
314_H389_S0.6320.90
337_V370_P0.6300.90
232_F243_G0.6300.90
99_V106_L0.6300.90
209_E213_V0.6290.90
76_E79_A0.6280.90
109_I112_Q0.6280.90
95_V99_V0.6240.90
358_T396_Y0.6240.90
134_K140_S0.6240.90
168_A172_F0.6230.90
366_I382_L0.6230.90
344_A347_Y0.6200.90
199_S212_A0.6190.89
30_T35_V0.6180.89
145_A150_Q0.6160.89
305_N309_G0.6140.89
213_V217_M0.6130.89
323_Q383_S0.6120.89
219_W223_F0.6120.89
60_R64_P0.6100.89
122_Q126_A0.6100.89
50_K54_L0.6080.89
61_S64_P0.6070.89
156_V164_Y0.6070.89
285_L331_G0.6050.88
341_S344_A0.6040.88
45_A80_I0.6040.88
158_R161_T0.6040.88
38_P42_H0.6000.88
131_R138_Q0.6000.88
216_A220_Q0.6000.88
265_I269_D0.5990.88
284_F331_G0.5990.88
362_H395_H0.5980.88
278_T281_A0.5980.88
266_R269_D0.5980.88
172_F176_S0.5980.88
396_Y411_K0.5950.88
70_I73_A0.5940.87
29_L32_A0.5930.87
343_A399_W0.5920.87
217_M253_V0.5920.87
161_T167_T0.5920.87
133_L137_Q0.5910.87
175_T179_Q0.5910.87
84_E87_D0.5900.87
132_N138_Q0.5900.87
202_N216_A0.5900.87
362_H386_T0.5890.87
214_I217_M0.5850.87
332_D376_R0.5850.87
114_G118_G0.5850.87
234_V237_S0.5810.86
156_V170_N0.5790.86
338_A341_S0.5790.86
116_D124_A0.5780.86
116_D127_D0.5760.86
112_Q115_I0.5760.86
287_F292_Q0.5710.85
289_T319_F0.5710.85
245_R249_Q0.5700.85
347_Y399_W0.5670.85
384_G393_H0.5660.85
248_S256_R0.5650.85
295_I298_N0.5600.84
145_A154_W0.5590.84
359_R397_E0.5580.84
138_Q141_W0.5580.84
200_A203_A0.5570.84
81_P86_D0.5560.84
69_P73_A0.5550.84
299_F405_V0.5540.84
362_H384_G0.5540.84
42_H46_T0.5520.83
155_E164_Y0.5520.83
335_V350_I0.5520.83
156_V167_T0.5510.83
135_I141_W0.5490.83
101_S105_T0.5490.83
190_G193_G0.5470.83
41_Y44_D0.5440.83
49_V56_Q0.5410.82
177_E180_Q0.5390.82
325_T383_S0.5380.82
33_V38_P0.5380.82
44_D49_V0.5370.82
64_P68_E0.5370.82
160_E164_Y0.5350.82
34_A39_Y0.5350.82
286_R412_L0.5350.82
362_H389_S0.5350.82
142_T150_Q0.5330.81
281_A331_G0.5310.81
56_Q63_L0.5290.81
78_E81_P0.5280.81
257_S262_Y0.5270.81
98_Y102_T0.5250.80
203_A217_M0.5250.80
347_Y404_A0.5240.80
145_A151_R0.5240.80
314_H387_G0.5230.80
86_D90_A0.5230.80
66_A70_I0.5230.80
107_S111_N0.5220.80
255_L262_Y0.5210.80
54_L58_E0.5200.80
305_N315_R0.5200.80
343_A347_Y0.5200.80
86_D93_A0.5190.80
162_R167_T0.5190.80
270_G273_Y0.5180.79
389_S393_H0.5180.79
307_V310_R0.5150.79
312_A388_R0.5150.79
170_N173_K0.5150.79
79_A84_E0.5150.79
400_I409_T0.5120.79
357_T399_W0.5110.78
303_R306_P0.5100.78
131_R136_G0.5100.78
355_S401_N0.5090.78
227_K230_D0.5090.78
171_G174_M0.5090.78
54_L57_N0.5090.78
232_F240_M0.5090.78
264_A268_E0.5090.78
330_V398_V0.5080.78
225_K228_K0.5080.78
299_F403_Q0.5060.78
390_T393_H0.5050.78
156_V163_T0.5040.78
362_H391_G0.5020.77
229_G240_M0.5000.77
158_R165_D0.5000.77
289_T325_T0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnzA 1 0.7545 100 0.467 Contact Map
2gu1A 1 0.7227 100 0.488 Contact Map
3sluA 1 0.7886 100 0.491 Contact Map
2hsiA 1 0.5205 100 0.555 Contact Map
4bh5A 4 0.2955 100 0.559 Contact Map
3tufB 1 0.3182 100 0.562 Contact Map
3nyyA 2 0.5205 100 0.594 Contact Map
4qp5A 1 0.2909 100 0.595 Contact Map
1qwyA 1 0.5045 100 0.595 Contact Map
4lxcA 4 0.3591 100 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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