GREMLIN Database
TQSA - AI-2 transport protein TqsA
UniProt: P0AFS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13928
Length: 344 (317)
Sequences: 11032 (8655)
Seq/√Len: 486.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_W227_G4.8811.00
214_M267_G4.8621.00
53_H57_W3.8471.00
86_A90_L3.2881.00
85_S90_L3.1081.00
298_S318_T3.0181.00
45_V190_I2.8631.00
53_H56_R2.8151.00
90_L95_P2.6971.00
208_G231_F2.5911.00
55_V61_R2.5451.00
60_P63_L2.3921.00
262_L266_A2.3871.00
212_W216_A2.3581.00
259_Y263_L2.3441.00
43_I158_V2.3361.00
249_I265_L2.2791.00
208_G227_G2.2431.00
59_V67_I2.1981.00
322_K326_E2.1671.00
93_T96_Q2.0361.00
75_A79_L1.9521.00
215_L220_V1.9311.00
40_A158_V1.8941.00
266_A270_L1.8691.00
120_S123_Q1.8631.00
184_A327_Q1.8541.00
159_L163_L1.8231.00
249_I261_A1.8101.00
201_T235_Y1.7781.00
199_L283_I1.7771.00
21_V25_C1.7741.00
113_Q116_G1.7701.00
263_L266_A1.7171.00
62_V66_S1.7091.00
188_R327_Q1.7041.00
48_N52_Q1.6921.00
213_A216_A1.6771.00
211_A230_A1.6761.00
95_P99_N1.6361.00
189_A320_I1.6331.00
28_R31_A1.6321.00
154_L158_V1.6291.00
173_Q183_M1.6221.00
77_V81_A1.6131.00
211_A271_I1.6131.00
99_N102_M1.6061.00
123_Q126_H1.6031.00
164_E291_S1.5931.00
119_V122_D1.5891.00
157_T293_L1.5861.00
122_D125_A1.5731.00
257_G260_E1.5661.00
121_V124_L1.5591.00
212_W223_A1.5381.00
282_R286_R1.5231.00
119_V123_Q1.5141.00
37_F297_L1.5101.00
229_L233_L1.5061.00
48_N61_R1.4911.00
157_T161_M1.4871.00
221_R255_F1.4871.00
51_V68_L1.4801.00
216_A223_A1.4781.00
223_A227_G1.4771.00
65_V69_M1.4631.00
207_T234_N1.4611.00
210_V271_I1.4491.00
106_Q109_E1.4481.00
303_G311_M1.4291.00
50_L68_L1.4291.00
118_D122_D1.4141.00
117_I120_S1.4121.00
233_L244_A1.4101.00
260_E263_L1.4061.00
104_P108_L1.3951.00
20_L24_L1.3921.00
51_V65_V1.3821.00
120_S124_L1.3821.00
269_L273_L1.3751.00
51_V61_R1.3661.00
125_A128_I1.3601.00
90_L94_L1.3441.00
100_S104_P1.3401.00
54_M71_I1.3311.00
279_L283_I1.3201.00
88_N92_R1.3091.00
65_V159_L1.3091.00
96_Q99_N1.3051.00
245_A249_I1.2961.00
111_L114_R1.2961.00
274_V279_L1.2831.00
97_Y101_I1.2791.00
170_G174_Q1.2741.00
122_D126_H1.2671.00
100_S103_T1.2571.00
258_F261_A1.2481.00
87_L90_L1.2481.00
265_L269_L1.2441.00
226_W248_P1.2441.00
111_L115_V1.2421.00
252_V264_V1.2421.00
214_M218_L1.2411.00
85_S95_P1.2401.00
259_Y262_L1.2361.00
192_S319_I1.2351.00
248_P264_V1.2261.00
47_L162_L1.2241.00
73_V77_V1.2131.00
112_L115_V1.2111.00
125_A129_D1.2091.00
99_N103_T1.2071.00
120_S125_A1.2071.00
17_L21_V1.2011.00
203_I275_F1.2001.00
96_Q100_S1.2001.00
59_V64_A1.1991.00
51_V162_L1.1861.00
60_P64_A1.1831.00
299_L311_M1.1791.00
294_V318_T1.1691.00
44_A161_M1.1691.00
126_H129_D1.1681.00
40_A154_L1.1621.00
207_T271_I1.1561.00
214_M263_L1.1561.00
227_G231_F1.1441.00
89_E93_T1.1431.00
55_V64_A1.1421.00
24_L28_R1.1391.00
272_N276_G1.1381.00
104_P107_A1.1321.00
218_L267_G1.1221.00
62_V163_L1.1181.00
65_V79_L1.1161.00
164_E167_Q1.1121.00
51_V55_V1.1031.00
13_I17_L1.1021.00
48_N165_V1.1001.00
302_W306_L1.0991.00
121_V125_A1.0971.00
43_I154_L1.0961.00
107_A110_P1.0921.00
59_V63_L1.0911.00
258_F262_L1.0891.00
36_P40_A1.0881.00
198_V202_A1.0871.00
93_T97_Y1.0871.00
185_A324_A1.0861.00
126_H130_P1.0821.00
220_V252_V1.0761.00
213_A217_A1.0731.00
188_R326_E1.0711.00
64_A68_L1.0671.00
212_W224_F1.0651.00
204_S234_N1.0591.00
127_Y130_P1.0571.00
276_G280_E1.0561.00
309_V313_L1.0561.00
61_R65_V1.0531.00
302_W318_T1.0451.00
47_L72_I1.0401.00
167_Q170_G1.0371.00
103_T107_A1.0361.00
253_L261_A1.0361.00
298_S302_W1.0311.00
153_L157_T1.0301.00
123_Q127_Y1.0281.00
51_V64_A1.0201.00
214_M271_I1.0201.00
107_A111_L1.0191.00
294_V322_K1.0161.00
137_L141_L1.0161.00
203_I207_T1.0161.00
201_T205_I1.0131.00
102_M106_Q1.0111.00
203_I279_L1.0101.00
195_H199_L1.0091.00
50_L53_H1.0081.00
14_V18_G1.0041.00
41_L161_M1.0021.00
66_S70_T0.9981.00
157_T297_L0.9901.00
39_L154_L0.9851.00
215_L230_A0.9851.00
25_C29_F0.9841.00
263_L267_G0.9791.00
110_P113_Q0.9771.00
37_F157_T0.9751.00
208_G212_W0.9731.00
207_T211_A0.9711.00
60_P65_V0.9701.00
252_V261_A0.9681.00
147_A151_I0.9681.00
200_K280_E0.9601.00
278_I282_R0.9571.00
40_A44_A0.9571.00
63_L66_S0.9561.00
106_Q110_P0.9511.00
261_A265_L0.9501.00
89_E92_R0.9441.00
218_L260_E0.9441.00
215_L264_V0.9431.00
120_S127_Y0.9421.00
207_T241_S0.9371.00
124_L127_Y0.9361.00
215_L226_W0.9351.00
85_S89_E0.9331.00
222_F225_V0.9321.00
61_R166_P0.9311.00
270_L274_V0.9281.00
84_G87_L0.9271.00
109_E113_Q0.9241.00
218_L264_V0.9231.00
251_Q255_F0.9201.00
321_V325_L0.9191.00
124_L128_I0.9171.00
103_T106_Q0.9161.00
229_L244_A0.9161.00
118_D125_A0.9111.00
18_G22_I0.9071.00
165_V169_P0.9041.00
267_G271_I0.9021.00
298_S314_S0.9011.00
209_L212_W0.8981.00
205_I231_F0.8981.00
171_K174_Q0.8891.00
61_R64_A0.8891.00
105_L109_E0.8871.00
206_I210_V0.8831.00
92_R95_P0.8771.00
202_A206_I0.8731.00
274_V278_I0.8711.00
184_A188_R0.8701.00
52_Q55_V0.8691.00
290_L318_T0.8631.00
231_F235_Y0.8631.00
140_L144_L0.8621.00
62_V65_V0.8601.00
243_L247_P0.8601.00
209_L213_A0.8591.00
250_A254_V0.8571.00
203_I280_E0.8541.00
203_I234_N0.8541.00
275_F280_E0.8491.00
21_V24_L0.8481.00
84_G88_N0.8461.00
227_G230_A0.8431.00
167_Q171_K0.8411.00
88_N91_T0.8401.00
121_V127_Y0.8401.00
211_A215_L0.8291.00
234_N241_S0.8251.00
324_A328_T0.8231.00
195_H287_G0.8231.00
17_L20_L0.8221.00
171_K175_M0.8221.00
273_L277_N0.8201.00
69_M158_V0.8181.00
40_A157_T0.8131.00
86_A89_E0.8071.00
14_V17_L0.8041.00
26_G30_A0.8021.00
75_A78_L0.8001.00
297_L301_F0.8001.00
185_A327_Q0.8001.00
169_P173_Q0.7971.00
245_A268_Y0.7941.00
141_L145_S0.7931.00
226_W251_Q0.7911.00
314_S318_T0.7891.00
191_D195_H0.7881.00
205_I209_L0.7871.00
33_I301_F0.7861.00
203_I284_M0.7811.00
253_L258_F0.7771.00
15_I19_M0.7741.00
62_V159_L0.7731.00
110_P114_R0.7711.00
218_L263_L0.7681.00
16_M20_L0.7671.00
91_T95_P0.7671.00
216_A219_D0.7631.00
83_L86_A0.7601.00
44_A158_V0.7591.00
71_I74_M0.7581.00
284_M295_V0.7521.00
216_A227_G0.7501.00
158_V162_L0.7501.00
234_N280_E0.7451.00
117_I121_V0.7441.00
87_L91_T0.7411.00
112_L116_G0.7411.00
178_R181_E0.7381.00
255_F260_E0.7321.00
230_A234_N0.7281.00
125_A130_P0.7251.00
204_S208_G0.7251.00
285_G295_V0.7241.00
94_L97_Y0.7211.00
74_M77_V0.7151.00
207_T280_E0.7121.00
202_A283_I0.7121.00
60_P75_A0.7071.00
183_M187_Q0.7051.00
194_S198_V0.7041.00
97_Y104_P0.7031.00
19_M23_I0.7031.00
204_S235_Y0.7021.00
117_I122_D0.7001.00
173_Q181_E0.6981.00
185_A189_A0.6971.00
37_F161_M0.6951.00
188_R323_I0.6931.00
230_A244_A0.6931.00
249_I253_L0.6911.00
288_L315_V0.6841.00
87_L95_P0.6821.00
280_E284_M0.6801.00
53_H58_R0.6801.00
111_L116_G0.6791.00
206_I279_L0.6781.00
23_I26_G0.6781.00
78_L82_Y0.6771.00
101_I104_P0.6761.00
47_L50_L0.6691.00
280_E283_I0.6671.00
146_N150_S0.6671.00
117_I124_L0.6661.00
208_G224_F0.6631.00
98_R102_M0.6631.00
85_S99_N0.6621.00
52_Q166_P0.6611.00
77_V80_L0.6581.00
90_L97_Y0.6581.00
188_R192_S0.6561.00
292_T296_F0.6561.00
60_P79_L0.6551.00
36_P285_G0.6551.00
211_A227_G0.6531.00
175_M325_L0.6521.00
203_I283_I0.6511.00
189_A323_I0.6501.00
47_L68_L0.6491.00
64_A75_A0.6481.00
272_N275_F0.6441.00
133_A137_L0.6421.00
44_A48_N0.6411.00
48_N162_L0.6411.00
173_Q176_M0.6411.00
39_L43_I0.6381.00
29_F32_E0.6381.00
241_S272_N0.6381.00
252_V257_G0.6381.00
192_S195_H0.6381.00
105_L111_L0.6371.00
171_K294_V0.6361.00
118_D121_V0.6351.00
177_A181_E0.6321.00
318_T322_K0.6321.00
204_S207_T0.6301.00
221_R224_F0.6261.00
108_L111_L0.6251.00
134_M137_L0.6251.00
132_A135_T0.6190.99
238_N292_T0.6160.99
143_Q146_N0.6140.99
302_W317_L0.6140.99
170_G183_M0.6110.99
138_T142_T0.6100.99
61_R75_A0.6090.99
200_K234_N0.6060.99
133_A136_L0.6060.99
230_A268_Y0.6010.99
47_L158_V0.6000.99
95_P101_I0.5990.99
200_K204_S0.5990.99
109_E112_L0.5980.99
25_C28_R0.5960.99
177_A180_V0.5950.99
91_T94_L0.5940.99
241_S244_A0.5930.99
36_P150_S0.5920.99
189_A193_V0.5890.99
193_V196_Y0.5890.99
20_L23_I0.5890.99
208_G228_L0.5880.99
52_Q56_R0.5880.99
244_A248_P0.5880.99
98_R101_I0.5880.99
173_Q177_A0.5880.99
84_G90_L0.5860.99
13_I16_M0.5820.99
308_P311_M0.5800.99
299_L315_V0.5800.99
207_T272_N0.5800.99
229_L247_P0.5800.99
203_I241_S0.5790.99
220_V255_F0.5780.99
93_T221_R0.5780.99
54_M59_V0.5760.99
192_S323_I0.5750.99
44_A162_L0.5750.99
211_A267_G0.5750.99
200_K203_I0.5750.99
202_A205_I0.5740.99
143_Q147_A0.5730.99
306_L310_G0.5730.99
170_G173_Q0.5700.99
151_I155_L0.5690.99
141_L144_L0.5680.99
204_S231_F0.5640.99
279_L282_R0.5640.99
275_F279_L0.5640.99
210_V275_F0.5630.99
195_H198_V0.5620.99
168_L171_K0.5580.99
187_Q191_D0.5570.99
157_T300_I0.5570.99
231_F234_N0.5560.99
220_V223_A0.5560.99
153_L300_I0.5540.99
211_A231_F0.5540.99
290_L295_V0.5530.99
207_T275_F0.5530.99
295_V315_V0.5520.99
94_L98_R0.5510.99
54_M67_I0.5500.99
104_P109_E0.5500.99
90_L99_N0.5450.99
72_I79_L0.5420.99
149_S153_L0.5410.99
198_V287_G0.5410.99
118_D129_D0.5400.99
188_R191_D0.5390.99
244_A315_V0.5370.99
136_L140_L0.5370.99
210_V214_M0.5360.99
97_Y113_Q0.5330.99
234_N275_F0.5320.98
161_M293_L0.5310.98
90_L101_I0.5300.98
199_L319_I0.5290.98
160_F164_E0.5270.98
160_F291_S0.5260.98
230_A241_S0.5260.98
132_A136_L0.5250.98
169_P187_Q0.5250.98
285_G289_G0.5240.98
90_L93_T0.5220.98
35_V38_I0.5210.98
273_L276_G0.5200.98
146_N277_N0.5190.98
207_T231_F0.5180.98
252_V255_F0.5170.98
291_S322_K0.5160.98
169_P186_I0.5160.98
259_Y266_A0.5150.98
254_V258_F0.5140.98
200_K235_Y0.5130.98
144_L148_M0.5120.98
119_V126_H0.5120.98
220_V248_P0.5110.98
231_F238_N0.5100.98
109_E116_G0.5090.98
208_G245_A0.5090.98
246_I250_A0.5080.98
207_T210_V0.5080.98
172_F175_M0.5060.98
189_A192_S0.5060.98
234_N276_G0.5040.98
204_S268_Y0.5030.98
323_I327_Q0.5030.98
76_M80_L0.5020.98
85_S88_N0.5010.98
67_I71_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9884 51.2 0.944 Contact Map
3w4tA 1 0.8837 49.5 0.944 Contact Map
4humA 1 0.9128 42.3 0.946 Contact Map
4lz6A 1 0.8924 20.4 0.954 Contact Map
2kv5A 1 0.0959 15.6 0.957 Contact Map
2ksdA 1 0.218 11.3 0.959 Contact Map
2kncA 1 0.1541 9.3 0.961 Contact Map
4b19A 1 0.0872 8.5 0.961 Contact Map
4r0cA 3 0.6308 8.3 0.962 Contact Map
4tkrA 2 0.3256 7.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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