GREMLIN Database
YCIO - Uncharacterized protein YciO
UniProt: P0AFR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12967
Length: 206 (186)
Sequences: 6049 (3957)
Seq/√Len: 290.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_I28_G4.8401.00
32_Y41_G4.1331.00
28_G169_D3.2621.00
43_K46_D3.0721.00
70_R74_E2.7461.00
18_N135_A2.6301.00
76_S86_F2.4031.00
22_E26_K2.2891.00
44_I67_L2.2091.00
71_D134_E2.1991.00
43_K138_E2.1531.00
27_G46_D2.1121.00
161_K165_E2.0751.00
31_V168_V2.0641.00
32_Y129_A2.0041.00
63_H148_P1.9571.00
42_C49_A1.8731.00
51_E55_R1.8611.00
23_I170_L1.8311.00
89_M99_F1.8071.00
156_D159_E1.8031.00
147_L163_R1.8001.00
24_V136_L1.7791.00
29_V56_I1.7521.00
131_A134_E1.7401.00
72_L90_K1.7151.00
79_S101_L1.6801.00
28_G52_R1.6711.00
80_F102_K1.6691.00
70_R134_E1.6511.00
82_D85_A1.6351.00
70_R133_L1.6201.00
47_K110_R1.6151.00
74_E77_T1.5931.00
45_E138_E1.5311.00
52_R55_R1.5241.00
147_L167_Q1.5131.00
161_K171_I1.5031.00
186_D193_V1.4981.00
178_G199_V1.4931.00
86_F90_K1.4891.00
21_V136_L1.4821.00
69_C75_L1.4781.00
21_V135_A1.4721.00
131_A135_A1.4681.00
69_C123_V1.4651.00
98_T120_G1.4611.00
17_I135_A1.4041.00
100_I195_V1.4011.00
100_I118_T1.3941.00
71_D74_E1.3861.00
103_G113_Q1.3791.00
186_D189_D1.3781.00
123_V130_Q1.3221.00
78_Y121_M1.3141.00
150_S163_R1.3111.00
72_L123_V1.3011.00
21_V25_R1.2991.00
158_E162_D1.2981.00
31_V160_I1.2951.00
47_K108_P1.2921.00
51_E110_R1.2851.00
19_Q22_E1.2781.00
32_Y132_L1.2781.00
32_Y142_S1.2741.00
187_L192_P1.2401.00
72_L86_F1.2281.00
51_E61_D1.2031.00
17_I132_L1.2021.00
102_K117_K1.2011.00
47_K51_E1.1801.00
130_Q134_E1.1761.00
103_G109_R1.1641.00
52_R169_D1.1641.00
22_E25_R1.1611.00
81_V89_M1.1571.00
79_S121_M1.1521.00
54_C61_D1.1401.00
46_D49_A1.1371.00
156_D176_Y1.1351.00
132_L172_I1.1181.00
18_N22_E1.1061.00
118_T188_T1.1041.00
125_S130_Q1.1021.00
36_S182_T1.0981.00
68_M142_S1.0971.00
58_Q147_L1.0751.00
24_V140_M1.0731.00
186_D192_P1.0631.00
99_F185_I1.0621.00
41_G140_M1.0521.00
128_I174_G1.0481.00
23_I169_D1.0431.00
73_S76_S1.0431.00
14_Q131_A1.0301.00
77_T106_E1.0281.00
56_I167_Q1.0241.00
79_S104_T1.0201.00
42_C53_I1.0091.00
127_P131_A1.0031.00
128_I172_I0.9971.00
85_A89_M0.9881.00
31_V157_P0.9691.00
93_T97_Y0.9691.00
157_P173_H0.9681.00
85_A187_L0.9621.00
53_I141_L0.9591.00
14_Q18_N0.9581.00
124_P129_A0.9571.00
72_L89_M0.9541.00
124_P130_Q0.9361.00
88_L97_Y0.9341.00
180_K199_V0.9331.00
50_M110_R0.9291.00
66_T120_G0.9271.00
160_I171_I0.9261.00
83_N86_F0.9261.00
24_V132_L0.9251.00
56_I164_L0.9221.00
43_K136_L0.9081.00
75_L121_M0.8971.00
79_S119_I0.8951.00
188_T192_P0.8811.00
75_L81_V0.8791.00
97_Y185_I0.8781.00
31_V171_I0.8771.00
74_E133_L0.8681.00
59_L146_M0.8651.00
126_N129_A0.8611.00
45_E108_P0.8571.00
153_T160_I0.8571.00
92_N200_G0.8481.00
24_V138_E0.8471.00
84_V87_R0.8451.00
27_G43_K0.8411.00
35_D124_P0.8381.00
30_I170_L0.8341.00
89_M93_T0.8231.00
107_V119_I0.8201.00
103_G117_K0.8111.00
84_V187_L0.8060.99
58_Q167_Q0.8030.99
69_C74_E0.7900.99
25_R138_E0.7880.99
29_V169_D0.7840.99
168_V171_I0.7810.99
67_L78_Y0.7800.99
31_V40_L0.7770.99
97_Y183_T0.7760.99
68_M133_L0.7750.99
89_M123_V0.7740.99
37_G146_M0.7610.99
87_R91_N0.7610.99
152_F181_P0.7600.99
29_V52_R0.7590.99
93_T99_F0.7520.99
41_G129_A0.7490.99
45_E78_Y0.7480.99
77_T104_T0.7480.99
16_L19_Q0.7280.99
75_L101_L0.7270.99
118_T186_D0.7230.99
14_Q135_A0.7200.99
101_L187_L0.7190.99
23_I26_K0.7130.99
129_A142_S0.7100.99
84_V190_D0.7080.99
157_P171_I0.7060.99
93_T123_V0.7030.99
81_V101_L0.6990.99
85_A101_L0.6990.99
41_G142_S0.6990.99
76_S81_V0.6970.99
19_Q23_I0.6970.99
88_L92_N0.6970.99
63_H114_E0.6930.98
194_V197_E0.6900.98
157_P160_I0.6900.98
133_L140_M0.6840.98
88_L187_L0.6820.98
153_T163_R0.6790.98
16_L172_I0.6780.98
20_A132_L0.6780.98
20_A23_I0.6770.98
67_L111_L0.6750.98
188_T191_T0.6740.98
159_E163_R0.6670.98
136_L140_M0.6660.98
24_V43_K0.6590.98
67_L119_I0.6590.98
145_L160_I0.6590.98
85_A99_F0.6580.98
87_R90_K0.6570.98
97_Y200_G0.6560.98
147_L150_S0.6530.98
83_N87_R0.6510.98
37_G144_S0.6460.98
143_T146_M0.6440.98
16_L170_L0.6400.97
27_G48_N0.6390.97
92_N97_Y0.6390.97
162_D165_E0.6370.97
81_V86_F0.6360.97
89_M187_L0.6350.97
37_G181_P0.6320.97
153_T159_E0.6290.97
54_C65_F0.6290.97
38_Y175_G0.6270.97
127_P130_Q0.6260.97
153_T164_L0.6220.97
108_P111_L0.6170.97
66_T142_S0.6150.97
165_E168_V0.6120.97
62_G151_E0.6060.96
59_L148_P0.6050.96
189_D193_V0.6040.96
44_I50_M0.6030.96
35_D96_N0.6000.96
72_L76_S0.6000.96
17_I128_I0.5960.96
69_C78_Y0.5960.96
45_E139_P0.5950.96
47_K109_R0.5930.96
33_P174_G0.5920.96
55_R167_Q0.5910.96
120_G184_V0.5900.96
67_L107_V0.5890.96
132_L140_M0.5890.96
98_T122_R0.5850.96
19_Q26_K0.5850.96
80_F83_N0.5830.96
45_E106_E0.5820.96
161_K166_K0.5790.95
53_I142_S0.5760.95
101_L121_M0.5750.95
34_T41_G0.5750.95
57_R143_T0.5740.95
57_R146_M0.5740.95
36_S39_A0.5730.95
128_I131_A0.5710.95
123_V133_L0.5670.95
78_Y107_V0.5640.95
20_A170_L0.5630.95
48_N51_E0.5620.95
57_R63_H0.5600.95
19_Q170_L0.5580.94
71_D130_Q0.5560.94
59_L144_S0.5550.94
136_L139_P0.5540.94
18_N21_V0.5520.94
39_A59_L0.5470.94
74_E139_P0.5460.94
186_D195_V0.5450.94
35_D68_M0.5450.94
103_G107_V0.5440.94
124_P133_L0.5440.94
62_G110_R0.5440.94
29_V42_C0.5410.94
88_L99_F0.5410.94
133_L136_L0.5390.93
42_C141_L0.5360.93
96_N200_G0.5320.93
95_G183_T0.5310.93
32_Y68_M0.5280.93
147_L164_L0.5270.93
48_N52_R0.5250.93
122_R182_T0.5240.92
15_R19_Q0.5240.92
54_C59_L0.5230.92
70_R130_Q0.5220.92
126_N177_L0.5150.92
82_D190_D0.5140.92
74_E123_V0.5120.92
129_A133_L0.5090.91
102_K188_T0.5080.91
52_R56_I0.5060.91
127_P134_E0.5060.91
41_G132_L0.5040.91
54_C63_H0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eqaA 1 0.9806 100 0.073 Contact Map
1k7jA 1 0.9951 100 0.125 Contact Map
1jcuA 1 0.9709 100 0.15 Contact Map
3l7vA 1 0.932 100 0.164 Contact Map
1hruA 2 0.8835 100 0.219 Contact Map
3vthA 1 0.9757 100 0.221 Contact Map
4g9iA 1 0.9806 100 0.231 Contact Map
3ttcA 1 0.9369 100 0.283 Contact Map
3venA 1 0.8204 97.3 0.873 Contact Map
4nasA 2 0.8932 45.6 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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