GREMLIN Database
RSSA - NTE family protein RssA
UniProt: P0AFR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12120
Length: 301 (278)
Sequences: 4639 (3508)
Seq/√Len: 210.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_N151_Y5.0321.00
29_K283_Q3.9771.00
280_A284_L3.7701.00
44_S136_S3.6931.00
26_A283_Q3.6731.00
19_S285_A3.4941.00
289_K292_E3.3181.00
26_A287_E3.2651.00
25_N283_Q3.2211.00
115_N122_L3.1611.00
113_A124_F3.1431.00
48_A133_I3.0491.00
25_N59_E3.0181.00
26_A29_K2.9171.00
47_G109_F2.9031.00
117_S151_Y2.5331.00
34_I176_I2.4651.00
147_A152_W2.3981.00
10_L20_H2.3791.00
276_H280_A2.2571.00
122_L153_L2.2201.00
274_R277_A2.2181.00
283_Q287_E2.1181.00
147_A150_G2.0791.00
94_R130_H2.0701.00
60_D64_S2.0101.00
59_E63_T1.9931.00
28_K55_L1.9861.00
26_A30_V1.9711.00
92_Q96_I1.9561.00
26_A286_V1.9061.00
284_L288_R1.8911.00
160_N165_S1.8721.00
17_G42_I1.8501.00
133_I136_S1.7821.00
90_F131_L1.7771.00
23_V178_V1.7761.00
115_N118_T1.7171.00
271_D274_R1.7101.00
25_N56_S1.7021.00
280_A283_Q1.6881.00
38_A167_T1.6871.00
90_F134_R1.6801.00
286_V290_M1.6631.00
30_V290_M1.6581.00
30_V287_E1.6451.00
63_T276_H1.6391.00
140_P158_V1.6131.00
40_C112_V1.5931.00
138_S146_V1.5921.00
121_E160_N1.5921.00
29_K55_L1.5881.00
162_I177_A1.5851.00
91_N95_E1.5691.00
100_T104_N1.5571.00
12_S161_P1.5341.00
23_V286_V1.5331.00
82_G144_A1.5101.00
154_V158_V1.5041.00
38_A110_A1.5011.00
7_G167_T1.4981.00
5_K35_D1.4761.00
6_I174_I1.4301.00
148_H153_L1.4131.00
29_K287_E1.4061.00
14_A139_I1.3851.00
10_L47_G1.3831.00
124_F132_A1.3691.00
9_A167_T1.3661.00
11_G162_I1.3551.00
24_I50_Y1.3481.00
260_I285_A1.3441.00
42_I62_V1.2921.00
121_E159_V1.2841.00
56_S60_D1.2591.00
284_L287_E1.2551.00
167_T172_A1.2421.00
48_A109_F1.2351.00
166_L170_L1.2321.00
112_V123_W1.2261.00
8_L24_I1.2241.00
86_G134_R1.2221.00
10_L37_V1.2131.00
116_L145_P1.2081.00
251_M255_P1.1981.00
7_G36_I1.1831.00
26_A290_M1.1821.00
112_V121_E1.1791.00
131_L146_V1.1791.00
54_R57_A1.1721.00
116_L154_V1.1711.00
110_A166_L1.1681.00
238_S241_V1.1441.00
243_E246_L1.1431.00
44_S137_C1.1371.00
203_N208_P1.1321.00
37_V47_G1.1251.00
51_A105_C1.1091.00
113_A132_A1.1071.00
251_M256_P1.1051.00
5_K173_D1.1041.00
37_V51_A1.0991.00
128_D131_L1.0941.00
168_R175_V1.0941.00
219_S222_T1.0831.00
242_L245_R1.0811.00
233_E236_T1.0711.00
48_A111_A1.0621.00
239_I242_L1.0591.00
267_I278_A1.0581.00
105_C129_L1.0561.00
263_V285_A1.0561.00
113_A153_L1.0541.00
258_I262_P1.0541.00
238_S243_E1.0511.00
101_E104_N1.0491.00
36_I170_L1.0421.00
117_S152_W1.0421.00
110_A170_L1.0361.00
114_T159_V1.0351.00
8_L34_I1.0331.00
283_Q286_V1.0271.00
281_A285_A1.0271.00
72_R75_D1.0141.00
253_G257_D1.0111.00
230_T233_E1.0111.00
7_G172_A1.0101.00
242_L246_L1.0091.00
203_N206_S1.0041.00
68_W71_L1.0021.00
8_L37_V1.0011.00
165_S169_A0.9981.00
30_V291_D0.9931.00
99_E130_H0.9901.00
258_I261_Q0.9831.00
234_I238_S0.9801.00
255_P258_I0.9801.00
205_D208_P0.9801.00
166_L169_A0.9731.00
252_A256_P0.9711.00
90_F137_C0.9701.00
238_S242_L0.9691.00
20_H46_V0.9671.00
157_A161_P0.9631.00
213_L217_L0.9571.00
115_N153_L0.9531.00
270_L273_H0.9501.00
36_I167_T0.9440.99
98_P101_E0.9360.99
145_P154_V0.9340.99
10_L178_V0.9320.99
41_S155_D0.9300.99
91_N94_R0.9280.99
42_I180_L0.9270.99
179_D261_Q0.9270.99
269_T273_H0.9250.99
55_L58_L0.9240.99
219_S223_R0.9230.99
138_S154_V0.9180.99
140_P156_G0.9170.99
64_S95_E0.9160.99
201_S204_G0.9140.99
241_V246_L0.9110.99
76_L85_R0.9100.99
202_E206_S0.9060.99
216_R222_T0.9060.99
7_G175_V0.9030.99
44_S133_I0.9020.99
33_E53_D0.9000.99
252_A255_P0.9000.99
12_S40_C0.9000.99
242_L248_R0.9000.99
28_K53_D0.8990.99
51_A109_F0.8990.99
57_A60_D0.8970.99
277_A281_A0.8950.99
216_R219_S0.8900.99
281_A284_L0.8880.99
6_I34_I0.8830.99
49_A97_M0.8800.99
238_S246_L0.8780.99
61_W65_F0.8760.99
257_D262_P0.8710.99
16_R181_Q0.8690.99
278_A281_A0.8620.99
20_H178_V0.8590.99
27_L176_I0.8550.99
21_I55_L0.8540.99
122_L151_Y0.8480.99
204_G208_P0.8440.99
18_W62_V0.8410.99
6_I176_I0.8410.99
237_T241_V0.8400.99
69_D75_D0.8380.99
229_P232_T0.8360.99
228_A232_T0.8330.99
123_W166_L0.8300.99
201_S205_D0.8280.99
285_A288_R0.8280.99
51_A107_R0.8260.99
216_R220_I0.8230.99
183_D261_Q0.8170.98
242_L247_K0.8130.98
36_I172_A0.8090.98
28_K50_Y0.8080.98
268_S271_D0.8080.98
208_P211_A0.8070.98
11_G180_L0.8050.98
218_G221_T0.8030.98
217_L222_T0.8010.98
244_N248_R0.7970.98
213_L216_R0.7960.98
234_I237_T0.7900.98
244_N247_K0.7890.98
69_D73_L0.7870.98
112_V136_S0.7870.98
98_P130_H0.7850.98
145_P152_W0.7830.98
23_V260_I0.7770.98
92_Q95_E0.7760.98
110_A123_W0.7700.98
10_L17_G0.7690.98
256_P259_L0.7660.98
35_D108_R0.7650.98
267_I270_L0.7590.98
239_I243_E0.7570.98
267_I271_D0.7560.97
266_Q270_L0.7560.97
253_G256_P0.7540.97
235_M238_S0.7540.97
73_L76_L0.7530.97
53_D101_E0.7520.97
180_L183_D0.7510.97
245_R249_N0.7510.97
39_G163_P0.7500.97
90_F94_R0.7490.97
260_I286_V0.7480.97
212_R216_R0.7470.97
27_L286_V0.7410.97
59_E276_H0.7390.97
213_L218_G0.7390.97
179_D183_D0.7380.97
139_I154_V0.7330.97
15_A66_S0.7300.97
103_E126_E0.7270.97
62_V71_L0.7270.97
269_T272_F0.7270.97
25_N29_K0.7270.97
21_I59_E0.7250.97
243_E247_K0.7240.97
215_E218_G0.7160.97
130_H134_R0.7150.97
237_T242_L0.7120.96
45_L137_C0.7100.96
59_E65_F0.7100.96
236_T242_L0.7090.96
236_T241_V0.7050.96
210_H213_L0.7030.96
24_I27_L0.6990.96
286_V289_K0.6980.96
249_N252_A0.6970.96
36_I108_R0.6950.96
84_L142_L0.6940.96
20_H24_I0.6930.96
255_P262_P0.6910.96
113_A122_L0.6910.96
227_T230_T0.6910.96
218_G222_T0.6900.96
108_R170_L0.6890.96
99_E128_D0.6880.96
87_E91_N0.6840.96
277_A280_A0.6810.95
211_A215_E0.6810.95
38_A166_L0.6800.95
33_E50_Y0.6780.95
216_R221_T0.6760.95
59_E279_I0.6740.95
260_I263_V0.6740.95
207_L211_A0.6720.95
21_I279_I0.6720.95
203_N207_L0.6720.95
124_F148_H0.6650.95
36_I110_A0.6650.95
206_S214_K0.6630.95
39_G179_D0.6570.94
179_D182_H0.6560.94
232_T236_T0.6530.94
135_A148_H0.6490.94
202_E205_D0.6470.94
255_P260_I0.6470.94
45_L93_Y0.6440.94
251_M254_D0.6430.94
275_A279_I0.6400.94
234_I241_V0.6370.93
268_S272_F0.6370.93
11_G161_P0.6360.93
7_G171_G0.6350.93
6_I35_D0.6340.93
134_R146_V0.6310.93
102_I105_C0.6300.93
245_R248_R0.6290.93
150_G153_L0.6250.93
204_G209_W0.6250.93
231_A235_M0.6240.93
201_S207_L0.6220.93
238_S245_R0.6220.93
263_V281_A0.6210.93
11_G181_Q0.6200.93
217_L221_T0.6190.92
246_L249_N0.6180.92
111_A129_L0.6120.92
248_R253_G0.6110.92
48_A136_S0.6110.92
266_Q281_A0.6080.92
49_A57_A0.6070.92
235_M242_L0.6070.92
212_R218_G0.6060.92
58_L62_V0.6050.92
49_A58_L0.6040.92
24_I34_I0.6010.91
45_L89_V0.6010.91
69_D72_R0.5980.91
205_D211_A0.5980.91
211_A214_K0.5980.91
229_P238_S0.5960.91
225_A229_P0.5930.91
254_D260_I0.5920.91
213_L221_T0.5910.91
37_V50_Y0.5910.91
86_G143_M0.5890.91
21_I46_V0.5870.90
52_C97_M0.5870.90
243_E248_R0.5850.90
86_G144_A0.5830.90
233_E241_V0.5820.90
18_W46_V0.5810.90
167_T175_V0.5790.90
70_V89_V0.5790.90
172_A175_V0.5790.90
210_H214_K0.5790.90
239_I244_N0.5790.90
241_V248_R0.5780.90
123_W160_N0.5770.90
252_A257_D0.5770.90
232_T242_L0.5750.89
232_T235_M0.5750.89
82_G86_G0.5740.89
214_K220_I0.5740.89
41_S161_P0.5710.89
18_W42_I0.5710.89
24_I28_K0.5710.89
42_I139_I0.5670.89
240_Q244_N0.5670.89
20_H180_L0.5650.89
19_S180_L0.5640.89
103_E107_R0.5640.89
9_A164_I0.5600.88
237_T240_Q0.5600.88
148_H151_Y0.5580.88
207_L212_R0.5580.88
229_P243_E0.5580.88
214_K218_G0.5570.88
38_A170_L0.5570.88
212_R217_L0.5570.88
208_P212_R0.5560.88
40_C121_E0.5510.87
285_A289_K0.5500.87
112_V163_P0.5470.87
244_N251_M0.5460.87
17_G157_A0.5450.87
212_R215_E0.5450.87
125_T128_D0.5450.87
22_G26_A0.5410.86
135_A138_S0.5410.86
113_A135_A0.5410.86
209_W213_L0.5400.86
228_A234_I0.5390.86
47_G51_A0.5390.86
257_D260_I0.5380.86
101_E128_D0.5380.86
53_D105_C0.5380.86
263_V288_R0.5360.86
228_A241_V0.5360.86
98_P104_N0.5330.86
287_E291_D0.5310.85
259_L262_P0.5300.85
217_L220_I0.5290.85
164_I167_T0.5290.85
14_A44_S0.5290.85
110_A167_T0.5280.85
11_G179_D0.5280.85
210_H219_S0.5270.85
10_L15_A0.5260.85
134_R138_S0.5240.85
206_S213_L0.5230.85
228_A238_S0.5230.85
288_R292_E0.5220.84
33_E133_I0.5220.84
254_D258_I0.5220.84
254_D257_D0.5220.84
206_S211_A0.5210.84
230_T238_S0.5210.84
232_T237_T0.5200.84
114_T153_L0.5170.84
52_C57_A0.5150.84
45_L133_I0.5150.84
70_V73_L0.5150.84
65_F70_V0.5130.83
11_G42_I0.5110.83
116_L152_W0.5110.83
239_I249_N0.5100.83
5_K172_A0.5090.83
241_V244_N0.5080.83
131_L148_H0.5060.83
260_I289_K0.5030.82
213_L223_R0.5010.82
65_F88_R0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4akfA 2 0.9269 100 0.308 Contact Map
4qmkA 2 0.6645 100 0.316 Contact Map
3tu3B 1 0.7342 100 0.337 Contact Map
4pk9A 2 0.9203 100 0.349 Contact Map
1cjyA 1 0.7641 99.3 0.785 Contact Map
2uytA 1 0.2924 81.3 0.928 Contact Map
2itmA 2 0.3256 81.1 0.928 Contact Map
4c23A 1 0.2525 77.2 0.931 Contact Map
3g25A 3 0.3322 74.3 0.932 Contact Map
2w40A 3 0.3256 72.2 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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