GREMLIN Database
YCFH - Uncharacterized deoxyribonuclease YcfH
UniProt: P0AFQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12303
Length: 265 (249)
Sequences: 7050 (4981)
Seq/√Len: 315.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_R122_E3.2681.00
114_I144_E3.0521.00
161_R194_Y2.8131.00
230_Y233_V2.7291.00
99_Y137_D2.5971.00
55_G86_E2.4591.00
28_K220_Q2.3651.00
117_I127_V2.3501.00
152_G172_F2.2191.00
248_D252_R2.1971.00
229_E239_V2.1571.00
143_R166_K2.1341.00
189_R230_Y2.0311.00
110_Q137_D1.9851.00
131_T138_T1.9441.00
118_Q145_E1.8651.00
197_L245_V1.8591.00
84_A92_L1.8411.00
63_S91_A1.8361.00
197_L235_K1.8341.00
19_H22_V1.8281.00
244_Q248_D1.8211.00
237_V242_L1.8081.00
21_D218_E1.7931.00
8_C37_C1.7931.00
114_I145_E1.7921.00
27_A31_A1.7841.00
192_A231_M1.7701.00
99_Y106_K1.7521.00
54_V62_F1.7321.00
36_F61_V1.7241.00
197_L237_V1.7121.00
63_S128_I1.7011.00
143_R170_L1.7001.00
228_A239_V1.6901.00
161_R165_G1.6901.00
136_A140_A1.6881.00
30_A59_N1.6761.00
111_E115_H1.6671.00
36_F251_A1.6451.00
23_D56_E1.6341.00
156_C177_S1.6271.00
48_L79_D1.6261.00
62_F89_V1.6191.00
6_S250_F1.6181.00
166_K169_D1.5991.00
154_L167_L1.5871.00
202_V228_A1.5731.00
95_T116_H1.5731.00
115_H118_Q1.5421.00
95_T127_V1.5411.00
186_E190_D1.5391.00
165_G169_D1.5331.00
176_F192_A1.5171.00
180_V231_M1.5111.00
165_G194_Y1.5061.00
131_T135_R1.4851.00
52_D56_E1.4661.00
77_V115_H1.4641.00
110_Q140_A1.4441.00
113_F129_V1.4381.00
153_V253_L1.4291.00
190_D193_R1.4201.00
160_D163_T1.4101.00
173_Y199_R1.4031.00
4_V36_F1.3821.00
173_Y252_R1.3751.00
229_E233_V1.3741.00
164_A174_I1.3711.00
43_T46_G1.3711.00
225_R229_E1.3681.00
81_R123_L1.3671.00
140_A144_E1.3601.00
139_L166_K1.3541.00
114_I141_I1.3511.00
247_T251_A1.3441.00
186_E189_R1.3261.00
84_A123_L1.3091.00
226_D229_E1.2951.00
4_V38_L1.2931.00
29_A37_C1.2901.00
124_N151_G1.2891.00
110_Q114_I1.2841.00
11_D46_G1.2821.00
189_R234_L1.2801.00
79_D82_R1.2761.00
121_R145_E1.2641.00
52_D55_G1.2601.00
241_E244_Q1.2581.00
196_P199_R1.2581.00
50_M62_F1.2461.00
174_I195_V1.2421.00
4_V247_T1.2411.00
99_Y110_Q1.2351.00
3_L228_A1.2291.00
113_F138_T1.2241.00
38_L90_V1.2211.00
69_L101_Y1.2141.00
3_L243_A1.2111.00
110_Q141_I1.2081.00
231_M242_L1.1961.00
8_C206_S1.1961.00
51_R62_F1.1911.00
214_H223_M1.1911.00
41_A47_Y1.1841.00
237_V241_E1.1811.00
238_A241_E1.1771.00
168_L199_R1.1641.00
105_T108_R1.1621.00
247_T250_F1.1591.00
228_A246_T1.1501.00
214_H226_D1.1491.00
176_F200_L1.1481.00
106_K110_Q1.1431.00
201_L253_L1.1271.00
44_L47_Y1.1271.00
39_A50_M1.1241.00
214_H217_K1.1241.00
102_T106_K1.1221.00
21_D24_D1.1041.00
246_T250_F1.1001.00
162_E165_G1.0981.00
24_D28_K1.0861.00
82_R85_A1.0771.00
40_V128_I1.0681.00
23_D27_A1.0651.00
118_Q122_E1.0631.00
230_Y234_L1.0631.00
55_G88_G1.0631.00
219_N223_M1.0591.00
135_R163_T1.0581.00
37_C60_V1.0491.00
81_R85_A1.0461.00
3_L224_V1.0441.00
136_A166_K1.0411.00
69_L104_E1.0411.00
71_Q112_S1.0411.00
39_A60_V1.0361.00
173_Y253_L1.0321.00
107_V111_E1.0311.00
136_A163_T1.0301.00
4_V250_F1.0241.00
70_N73_D1.0231.00
202_V224_V1.0191.00
190_D194_Y1.0161.00
28_K222_A1.0101.00
161_R191_A1.0001.00
48_L52_D0.9981.00
24_D27_A0.9941.00
202_V231_M0.9891.00
51_R86_E0.9881.00
182_F210_A0.9871.00
192_A235_K0.9851.00
180_V192_A0.9771.00
44_L79_D0.9671.00
49_H52_D0.9641.00
108_R111_E0.9591.00
245_V248_D0.9581.00
51_R64_C0.9581.00
107_V110_Q0.9521.00
159_E163_T0.9501.00
23_D57_R0.9471.00
38_L250_F0.9451.00
202_V246_T0.9421.00
183_R212_V0.9401.00
48_L83_L0.9371.00
161_R190_D0.9331.00
228_A243_A0.9321.00
15_Y218_E0.9311.00
6_S201_L0.9241.00
243_A247_T0.9201.00
220_Q223_M0.9171.00
192_A234_L0.9171.00
54_V60_V0.9111.00
176_F195_V0.9081.00
153_V254_F0.8981.00
10_L221_P0.8981.00
241_E245_V0.8961.00
85_A123_L0.8931.00
242_L246_T0.8861.00
78_E82_R0.8851.00
79_D83_L0.8821.00
152_G253_L0.8791.00
139_L167_L0.8781.00
51_R55_G0.8771.00
106_K137_D0.8761.00
77_V81_R0.8731.00
225_R239_V0.8721.00
235_K242_L0.8641.00
228_A242_L0.8631.00
81_R119_I0.8621.00
50_M54_V0.8611.00
175_S201_L0.8591.00
71_Q108_R0.8561.00
239_V243_A0.8551.00
129_V154_L0.8501.00
40_V63_S0.8441.00
197_L242_L0.8441.00
121_R148_T0.8431.00
100_Y133_D0.8421.00
78_E81_R0.8381.00
42_T46_G0.8371.00
224_V227_V0.8311.00
64_C89_V0.8201.00
26_L57_R0.8181.00
121_R146_K0.8131.00
168_L196_P0.8091.00
129_V138_T0.8061.00
15_Y19_H0.8051.00
6_S153_V0.7961.00
35_K247_T0.7911.00
124_N150_C0.7831.00
119_I123_L0.7801.00
74_P112_S0.7781.00
117_I121_R0.7781.00
141_I144_E0.7761.00
193_R234_L0.7751.00
89_V125_K0.7741.00
135_R159_E0.7700.99
139_L163_T0.7630.99
131_T159_E0.7620.99
137_D140_A0.7600.99
26_L37_C0.7600.99
135_R167_L0.7600.99
143_R169_D0.7590.99
231_M235_K0.7590.99
168_L174_I0.7590.99
92_L95_T0.7560.99
28_K31_A0.7550.99
240_E244_Q0.7490.99
3_L225_R0.7470.99
74_P77_V0.7470.99
141_I145_E0.7450.99
102_T105_T0.7440.99
38_L63_S0.7420.99
121_R147_V0.7380.99
248_D251_A0.7350.99
47_Y83_L0.7330.99
228_A232_A0.7320.99
43_T73_D0.7310.99
11_D49_H0.7300.99
3_L247_T0.7280.99
173_Y201_L0.7230.99
200_L242_L0.7230.99
121_R150_C0.7170.99
193_R236_G0.7150.99
147_V150_C0.7110.99
108_R112_S0.7050.99
12_G208_Y0.7020.99
114_I118_Q0.7000.99
69_L103_P0.6990.99
153_V175_S0.6970.99
200_L235_K0.6960.99
32_R225_R0.6950.99
19_H49_H0.6940.99
196_P235_K0.6930.99
91_A128_I0.6780.99
179_I209_L0.6780.99
237_V245_V0.6760.99
103_P106_K0.6720.99
124_N255_H0.6640.98
164_A195_V0.6600.98
6_S128_I0.6600.98
46_G50_M0.6590.98
26_L30_A0.6560.98
27_A30_A0.6560.98
164_A168_L0.6550.98
41_A50_M0.6500.98
61_V88_G0.6500.98
151_G255_H0.6470.98
131_T167_L0.6460.98
77_V119_I0.6370.98
3_L202_V0.6360.98
3_L239_V0.6310.98
15_Y21_D0.6310.98
117_I141_I0.6300.98
15_Y22_V0.6300.98
139_L143_R0.6290.98
157_F163_T0.6270.98
117_I145_E0.6270.98
188_L191_A0.6240.98
21_D25_V0.6230.98
195_V200_L0.6220.98
30_A35_K0.6150.98
164_A191_A0.6150.98
97_L134_A0.6130.97
47_Y64_C0.6110.97
200_L246_T0.6110.97
167_L174_I0.6100.97
179_I188_L0.6100.97
25_V218_E0.6090.97
210_A223_M0.6080.97
182_F212_V0.6080.97
168_L195_V0.6080.97
187_Q190_D0.6080.97
72_N108_R0.6080.97
61_V90_V0.6060.97
84_A89_V0.6060.97
29_A34_V0.6040.97
80_L84_A0.6010.97
82_R86_E0.5990.97
72_N105_T0.5960.97
135_R139_L0.5960.97
245_V252_R0.5960.97
128_I254_F0.5940.97
147_V151_G0.5930.97
112_S116_H0.5920.97
47_Y50_M0.5910.97
29_A220_Q0.5890.97
22_V25_V0.5880.97
198_D252_R0.5870.97
198_D245_V0.5870.97
179_I182_F0.5850.97
166_K170_L0.5820.97
47_Y62_F0.5820.97
154_L175_S0.5770.96
95_T112_S0.5770.96
11_D39_A0.5770.96
11_D42_T0.5740.96
26_L60_V0.5720.96
64_C83_L0.5700.96
201_L250_F0.5670.96
168_L194_Y0.5670.96
32_R222_A0.5660.96
85_A122_E0.5630.96
71_Q104_E0.5630.96
173_Y249_N0.5590.96
235_K245_V0.5580.96
186_E193_R0.5570.96
213_P216_G0.5560.96
45_P49_H0.5560.96
69_L102_T0.5530.95
47_Y80_L0.5520.95
139_L170_L0.5490.95
42_T70_N0.5490.95
119_I122_E0.5460.95
180_V189_R0.5460.95
51_R54_V0.5440.95
245_V249_N0.5440.95
135_R138_T0.5420.95
180_V188_L0.5420.95
4_V251_A0.5410.95
180_V242_L0.5410.95
232_A239_V0.5400.95
188_L192_A0.5360.95
29_A33_D0.5340.94
185_A189_R0.5330.94
45_P73_D0.5310.94
115_H119_I0.5310.94
38_L254_F0.5300.94
147_V172_F0.5270.94
72_N104_E0.5270.94
118_Q121_R0.5260.94
100_Y132_R0.5240.94
25_V28_K0.5230.94
175_S209_L0.5230.94
176_F179_I0.5210.94
22_V218_E0.5190.94
65_G116_H0.5170.93
153_V201_L0.5170.93
202_V242_L0.5170.93
177_S209_L0.5150.93
181_T212_V0.5150.93
66_V74_P0.5140.93
58_D88_G0.5130.93
51_R83_L0.5120.93
53_L60_V0.5100.93
40_V206_S0.5040.93
146_K172_F0.5040.93
182_F185_A0.5030.93
163_T167_L0.5010.92
182_F213_P0.5000.92
182_F216_G0.5000.92
97_L110_Q0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2vA 1 0.9547 100 0.197 Contact Map
3ipwA 1 0.9623 100 0.264 Contact Map
2xioA 1 0.9623 100 0.325 Contact Map
1j6oA 1 0.966 100 0.34 Contact Map
3gg7A 1 0.9057 100 0.357 Contact Map
3rcmA 1 0.9698 100 0.385 Contact Map
1xwyA 1 0.9509 100 0.392 Contact Map
2gzxA 1 0.9434 100 0.396 Contact Map
1yixA 1 1 100 0.401 Contact Map
1zzmA 1 0.9547 100 0.408 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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