GREMLIN Database
RUTC - Putative aminoacrylate peracid reductase RutC
UniProt: P0AFQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13857
Length: 128 (116)
Sequences: 7438 (4611)
Seq/√Len: 428.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R95_E3.3461.00
60_R70_M3.1071.00
68_G72_D2.8061.00
75_F121_A2.7081.00
47_D50_A2.6511.00
49_K88_A2.4411.00
53_R57_E2.1761.00
79_F107_I2.1131.00
49_K91_E2.0881.00
78_I89_I1.9901.00
59_I122_T1.9781.00
57_E96_F1.9541.00
34_L116_A1.9091.00
108_Q111_L1.9021.00
51_Q117_L1.8701.00
60_R64_E1.8571.00
63_I124_A1.8491.00
54_H58_T1.7361.00
53_R96_F1.6521.00
111_L115_D1.6281.00
83_W108_Q1.6221.00
76_N122_T1.6121.00
85_N117_L1.6111.00
28_V68_G1.5931.00
24_A74_T1.5261.00
57_E60_R1.4971.00
48_P52_T1.4911.00
43_L116_A1.4811.00
24_A125_H1.4751.00
69_T72_D1.4621.00
80_I89_I1.4261.00
35_A116_A1.4021.00
54_H57_E1.3831.00
29_Y123_I1.3721.00
23_L26_G1.3631.00
73_V122_T1.3451.00
37_D40_N1.3071.00
80_I106_C1.3001.00
85_N88_A1.2451.00
105_F121_A1.2401.00
88_A91_E1.2371.00
28_V66_A1.1941.00
92_I95_E1.1851.00
32_G119_E1.1841.00
45_A50_A1.1721.00
37_D44_F1.1551.00
23_L28_V1.1521.00
77_S121_A1.1421.00
63_I68_G1.1331.00
79_F109_C1.1281.00
81_T85_N1.1281.00
27_V125_H1.1241.00
30_V62_V1.1071.00
90_N104_R1.1051.00
35_A55_V1.1051.00
53_R92_I1.1041.00
93_Y104_R1.1021.00
23_L68_G1.0671.00
42_V114_P1.0421.00
84_K111_L1.0401.00
81_T111_L1.0381.00
10_G64_E1.0371.00
42_V45_A1.0081.00
98_P101_K1.0001.00
21_G62_V0.9971.00
30_V122_T0.9841.00
82_D85_N0.9781.00
60_R96_F0.9671.00
73_V97_F0.9671.00
11_S20_P0.9631.00
49_K92_I0.9571.00
52_T89_I0.9521.00
27_V74_T0.9501.00
64_E69_T0.9251.00
63_I73_V0.9201.00
79_F105_F0.9191.00
49_K53_R0.9171.00
48_P89_I0.9111.00
70_M73_V0.9101.00
91_E94_A0.8921.00
76_N93_Y0.8841.00
81_T115_D0.8811.00
81_T117_L0.8701.00
33_T62_V0.8461.00
91_E95_E0.8341.00
61_K64_E0.8331.00
37_D42_V0.8311.00
26_G125_H0.8201.00
48_P85_N0.8091.00
35_A51_Q0.7971.00
56_L96_F0.7841.00
86_Y106_C0.7761.00
56_L70_M0.7731.00
70_M96_F0.7401.00
49_K95_E0.7331.00
92_I96_F0.7261.00
38_Q61_K0.7251.00
56_L120_I0.7211.00
73_V124_A0.7201.00
46_D51_Q0.7191.00
48_P118_V0.7181.00
40_N44_F0.7131.00
81_T109_C0.7071.00
38_Q54_H0.7061.00
28_V124_A0.6971.00
76_N97_F0.6951.00
48_P92_I0.6901.00
81_T110_G0.6881.00
50_A53_R0.6861.00
68_G124_A0.6801.00
94_A101_K0.6741.00
36_F41_N0.6701.00
83_W111_L0.6701.00
30_V59_I0.6681.00
21_G66_A0.6671.00
46_D50_A0.6671.00
78_I104_R0.6651.00
10_G61_K0.6580.99
24_A29_Y0.6570.99
71_A98_P0.6530.99
87_A91_E0.6520.99
79_F121_A0.6480.99
52_T118_V0.6420.99
90_N93_Y0.6370.99
21_G28_V0.6360.99
47_D117_L0.6320.99
27_V123_I0.6290.99
77_S105_F0.6240.99
61_K65_T0.6180.99
47_D88_A0.6180.99
37_D41_N0.6150.99
78_I120_I0.6140.99
55_V120_I0.6120.99
48_P88_A0.6100.99
15_L114_P0.5990.99
56_L93_Y0.5930.99
77_S123_I0.5910.99
86_Y90_N0.5870.99
57_E61_K0.5830.99
17_P90_N0.5830.99
44_F54_H0.5740.99
39_H42_V0.5680.98
55_V118_V0.5580.98
80_I83_W0.5580.98
78_I118_V0.5540.98
68_G125_H0.5510.98
75_F105_F0.5470.98
22_T74_T0.5400.98
62_V65_T0.5390.98
63_I70_M0.5370.98
45_A117_L0.5360.98
25_D125_H0.5350.98
81_T108_Q0.5270.98
33_T59_I0.5260.98
18_F32_G0.5260.98
44_F50_A0.5250.97
73_V76_N0.5240.97
112_V116_A0.5240.97
34_L55_V0.5230.97
28_V62_V0.5220.97
63_I122_T0.5210.97
20_P62_V0.5200.97
86_Y113_K0.5140.97
35_A43_L0.5110.97
85_N108_Q0.5110.97
55_V59_I0.5100.97
23_L66_A0.5080.97
33_T58_T0.5070.97
82_D117_L0.5050.97
38_Q41_N0.5040.97
24_A27_V0.5030.97
90_N94_A0.5020.97
15_L18_F0.5000.97
83_W114_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0pA 5 0.9844 100 0.116 Contact Map
3m1xA 3 0.9766 100 0.119 Contact Map
1xrgA 3 0.9844 100 0.121 Contact Map
3k0tA 3 0.9688 100 0.122 Contact Map
3v4dA 3 1 100 0.122 Contact Map
1qahA 3 1 100 0.123 Contact Map
2dyyA 3 0.9844 100 0.126 Contact Map
1x25A 3 0.9922 100 0.132 Contact Map
3l7qA 3 0.9688 100 0.141 Contact Map
2b33A 3 0.9844 100 0.147 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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