GREMLIN Database
YBHS - Inner membrane transport permease YbhS
UniProt: P0AFQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13675
Length: 377 (354)
Sequences: 11371 (9451)
Seq/√Len: 502.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_I336_T5.0291.00
57_G100_I4.8871.00
91_L103_L4.6031.00
94_K100_I3.7151.00
87_N90_E3.6071.00
109_D113_Q3.5111.00
16_V20_R3.1211.00
14_L229_C3.0891.00
93_A97_A3.0471.00
85_S94_K3.0171.00
11_V232_I2.9241.00
319_A323_A2.8021.00
92_I96_Q2.7361.00
95_M103_L2.6441.00
222_T225_E2.6201.00
94_K99_K2.4691.00
15_C232_I2.4481.00
88_R92_I2.4431.00
243_L265_F2.4231.00
20_R23_V2.3891.00
15_C236_F2.3751.00
268_S333_F2.3681.00
351_V355_L2.3501.00
141_Y145_I2.3141.00
12_R16_V2.2731.00
355_L359_A2.2721.00
281_L367_L2.2611.00
273_L361_A2.2141.00
61_E88_R2.1851.00
270_L358_I2.1291.00
57_G85_S2.1221.00
359_A363_M2.1121.00
247_L251_F2.0751.00
90_E94_K2.0591.00
150_Q153_R2.0451.00
11_V15_C2.0351.00
274_S361_A2.0181.00
53_K81_D2.0071.00
58_I71_T2.0011.00
106_I110_F2.0001.00
88_R105_V1.9801.00
36_P39_L1.9521.00
61_E105_V1.9311.00
277_G361_A1.8781.00
137_F141_Y1.8691.00
271_F333_F1.8621.00
18_E230_K1.8411.00
60_L67_A1.8341.00
325_T331_R1.7451.00
360_S364_F1.7331.00
105_V126_I1.7081.00
267_I354_V1.6891.00
55_R83_T1.6761.00
178_I181_H1.6701.00
36_P42_I1.6701.00
326_Y331_R1.6671.00
62_Q111_A1.6651.00
60_L64_S1.6541.00
238_G272_L1.6421.00
326_Y332_Y1.6201.00
55_R81_D1.6021.00
271_F275_T1.6001.00
260_S263_I1.5991.00
335_S353_N1.5781.00
17_K207_E1.5751.00
320_V323_A1.5681.00
235_Y269_S1.5681.00
346_I349_V1.5481.00
242_M268_S1.5461.00
352_V356_F1.5371.00
64_S67_A1.5371.00
89_Q92_I1.5301.00
339_S345_N1.5261.00
314_I325_T1.5241.00
23_V26_P1.5231.00
61_E108_V1.5181.00
93_A96_Q1.4961.00
90_E93_A1.4911.00
263_I340_L1.4431.00
235_Y273_L1.4281.00
322_R326_Y1.4211.00
36_P46_G1.4101.00
356_F360_S1.4031.00
72_H75_T1.3841.00
59_L91_L1.3761.00
162_E165_I1.3741.00
187_A190_I1.3721.00
60_L63_R1.3711.00
39_L43_F1.3391.00
239_M269_S1.3391.00
284_T371_K1.3331.00
131_E134_T1.3271.00
155_E158_G1.3241.00
270_L354_V1.3151.00
100_I103_L1.3071.00
41_F45_Y1.3041.00
139_Q143_E1.2981.00
366_G370_L1.2901.00
262_L266_F1.2891.00
205_A208_W1.2841.00
89_Q93_A1.2801.00
69_D72_H1.2781.00
323_A327_I1.2701.00
207_E230_K1.2411.00
224_T228_L1.2371.00
270_L361_A1.2341.00
356_F359_A1.2301.00
163_P166_D1.2261.00
140_G144_G1.2241.00
339_S343_A1.2241.00
105_V124_Q1.2191.00
201_S292_A1.2161.00
162_E166_D1.2151.00
248_V252_I1.2131.00
319_A322_R1.2091.00
274_S357_L1.2061.00
328_I331_R1.2051.00
149_W153_R1.2031.00
66_A111_A1.1931.00
161_F165_I1.1901.00
300_A304_S1.1871.00
246_M268_S1.1861.00
67_A111_A1.1851.00
354_V358_I1.1811.00
347_P351_V1.1801.00
288_N291_N1.1731.00
75_T84_I1.1671.00
186_G191_I1.1621.00
186_G189_T1.1591.00
331_R335_S1.1441.00
184_I195_I1.1441.00
189_T333_F1.1371.00
333_F336_T1.1351.00
274_S364_F1.1231.00
236_F240_L1.1181.00
109_D112_E1.1091.00
323_A326_Y1.1001.00
200_T204_V1.0971.00
267_I340_L1.0951.00
332_Y356_F1.0941.00
11_V225_E1.0891.00
138_V145_I1.0871.00
281_L368_T1.0821.00
170_R173_F1.0781.00
111_A115_E1.0781.00
165_I169_T1.0761.00
43_F46_G1.0751.00
302_L305_I1.0721.00
281_L364_F1.0621.00
95_M100_I1.0601.00
363_M367_L1.0601.00
225_E229_C1.0601.00
65_E68_L1.0471.00
104_V125_V1.0391.00
317_M320_V1.0351.00
318_P322_R1.0341.00
73_T76_G1.0321.00
164_L168_Q1.0271.00
88_R103_L1.0261.00
92_I126_I1.0241.00
335_S339_S1.0181.00
19_T236_F1.0161.00
358_I362_V1.0151.00
138_V141_Y1.0111.00
277_G364_F1.0051.00
20_R24_R1.0041.00
224_T369_W1.0031.00
185_P189_T1.0011.00
17_K21_Q1.0001.00
42_I46_G0.9971.00
247_L250_V0.9961.00
36_P40_L0.9901.00
66_A114_M0.9831.00
11_V228_L0.9721.00
274_S360_S0.9701.00
112_E116_R0.9671.00
143_E147_Q0.9661.00
284_T368_T0.9631.00
74_M142_V0.9631.00
147_Q150_Q0.9601.00
349_V352_V0.9591.00
184_I187_A0.9541.00
191_I195_I0.9531.00
317_M322_R0.9521.00
15_C229_C0.9471.00
332_Y353_N0.9461.00
85_S100_I0.9441.00
164_L171_Y0.9431.00
185_P192_M0.9361.00
182_F186_G0.9341.00
326_Y329_P0.9331.00
229_C233_P0.9321.00
17_K20_R0.9301.00
332_Y335_S0.9291.00
37_L41_F0.9271.00
278_M300_A0.9271.00
277_G368_T0.9261.00
200_T203_V0.9241.00
314_I317_M0.9231.00
39_L42_I0.9201.00
320_V324_V0.9161.00
166_D169_T0.9161.00
39_L46_G0.9151.00
305_I308_S0.9141.00
36_P43_F0.9121.00
85_S90_E0.9101.00
207_E212_T0.9091.00
202_L205_A0.9051.00
262_L265_F0.8991.00
91_L94_K0.8951.00
67_A106_I0.8941.00
57_G94_K0.8941.00
189_T192_M0.8931.00
207_E211_G0.8931.00
277_G365_I0.8911.00
14_L221_I0.8881.00
280_L368_T0.8851.00
185_P194_V0.8811.00
65_E69_D0.8791.00
148_I153_R0.8751.00
348_V352_V0.8751.00
204_V207_E0.8751.00
142_V145_I0.8741.00
26_P29_W0.8701.00
19_T23_V0.8701.00
148_I152_Q0.8701.00
272_L276_L0.8691.00
88_R91_L0.8691.00
129_G132_P0.8691.00
221_I226_L0.8681.00
160_T167_V0.8681.00
286_T291_N0.8671.00
263_I266_F0.8671.00
182_F193_T0.8661.00
43_F47_I0.8651.00
149_W152_Q0.8631.00
103_L106_I0.8621.00
102_G138_V0.8611.00
301_F305_I0.8581.00
137_F145_I0.8521.00
113_Q116_R0.8511.00
129_G133_N0.8501.00
294_Q297_L0.8491.00
68_L71_T0.8491.00
190_I193_T0.8461.00
125_V128_D0.8451.00
41_F44_G0.8441.00
336_T341_F0.8381.00
160_T166_D0.8361.00
30_L34_V0.8351.00
147_Q151_M0.8351.00
186_G195_I0.8331.00
301_F304_S0.8311.00
71_T75_T0.8301.00
209_E289_Q0.8291.00
63_R108_V0.8281.00
60_L71_T0.8241.00
361_A365_I0.8241.00
329_P332_Y0.8231.00
231_L273_L0.8171.00
205_A209_E0.8161.00
132_P136_N0.8141.00
309_G313_Q0.8141.00
261_L265_F0.8131.00
164_L169_T0.8091.00
197_A204_V0.8061.00
176_A181_H0.8021.00
345_N349_V0.7991.00
56_V60_L0.7981.00
182_F192_M0.7981.00
306_M312_F0.7971.00
94_K97_A0.7971.00
281_L284_T0.7951.00
281_L371_K0.7921.00
364_F368_T0.7911.00
19_T233_P0.7901.00
239_M243_L0.7891.00
12_R15_C0.7851.00
169_T172_W0.7831.00
70_F106_I0.7761.00
227_L369_W0.7721.00
25_D28_S0.7711.00
147_Q152_Q0.7701.00
183_I187_A0.7691.00
350_L353_N0.7691.00
279_G283_S0.7661.00
160_T165_I0.7641.00
56_V104_V0.7641.00
353_N357_L0.7601.00
146_W150_Q0.7601.00
304_S307_L0.7581.00
133_N136_N0.7571.00
231_L276_L0.7561.00
40_L43_F0.7551.00
263_I350_L0.7551.00
137_F140_G0.7541.00
282_I286_T0.7531.00
39_L48_N0.7481.00
246_M264_L0.7471.00
190_I194_V0.7451.00
68_L72_H0.7441.00
39_L47_I0.7431.00
129_G134_T0.7421.00
22_I32_A0.7421.00
192_M195_I0.7411.00
40_L249_S0.7391.00
179_S183_I0.7381.00
345_N350_L0.7381.00
268_S337_L0.7361.00
302_L306_M0.7311.00
64_S111_A0.7301.00
163_P167_V0.7281.00
167_V170_R0.7271.00
197_A200_T0.7251.00
15_C19_T0.7231.00
139_Q145_I0.7221.00
232_I236_F0.7221.00
365_I369_W0.7221.00
243_L261_L0.7211.00
281_L285_I0.7201.00
329_P333_F0.7181.00
216_L226_L0.7181.00
62_Q109_D0.7181.00
350_L354_V0.7151.00
87_N91_L0.7151.00
164_L173_F0.7141.00
18_E22_I0.7121.00
189_T195_I0.7111.00
66_A71_T0.7101.00
161_F164_L0.7091.00
56_V82_A0.7091.00
201_S296_A0.7071.00
45_Y48_N0.7071.00
57_G103_L0.7051.00
325_T328_I0.7031.00
37_L42_I0.7031.00
205_A292_A0.7031.00
36_P41_F0.7021.00
270_L357_L0.6991.00
181_H189_T0.6981.00
200_T207_E0.6971.00
227_L280_L0.6941.00
187_A191_I0.6931.00
13_A16_V0.6921.00
142_V146_W0.6901.00
130_S133_N0.6901.00
243_L246_M0.6871.00
325_T329_P0.6871.00
176_A180_Q0.6851.00
122_P125_V0.6851.00
56_V61_E0.6841.00
131_E135_A0.6801.00
336_T353_N0.6791.00
332_Y340_L0.6771.00
55_R101_R0.6761.00
286_T295_V0.6731.00
150_Q154_A0.6721.00
140_G145_I0.6721.00
59_L103_L0.6721.00
66_A69_D0.6711.00
185_P193_T0.6691.00
178_I182_F0.6681.00
39_L44_G0.6671.00
19_T240_L0.6671.00
139_Q142_V0.6661.00
75_T82_A0.6661.00
360_S363_M0.6631.00
362_V366_G0.6611.00
264_L337_L0.6591.00
37_L40_L0.6571.00
158_G161_F0.6561.00
166_D171_Y0.6561.00
11_V229_C0.6551.00
267_I350_L0.6551.00
207_E226_L0.6541.00
168_Q173_F0.6461.00
212_T215_A0.6441.00
67_A70_F0.6431.00
160_T164_L0.6431.00
151_M154_A0.6431.00
69_D73_T0.6431.00
148_I151_M0.6421.00
160_T163_P0.6411.00
129_G135_A0.6411.00
357_L360_S0.6401.00
190_I195_I0.6391.00
246_M250_V0.6391.00
136_N139_Q0.6381.00
184_I192_M0.6341.00
180_Q183_I0.6341.00
231_L235_Y0.6321.00
67_A71_T0.6321.00
103_L126_I0.6321.00
184_I190_I0.6321.00
81_D84_I0.6311.00
339_S353_N0.6301.00
85_S88_R0.6291.00
240_L243_L0.6291.00
336_T340_L0.6281.00
235_Y276_L0.6271.00
304_S328_I0.6231.00
189_T193_T0.6211.00
180_Q195_I0.6191.00
301_F308_S0.6191.00
42_I45_Y0.6181.00
59_L85_S0.6161.00
302_L309_G0.6161.00
160_T168_Q0.6121.00
165_I168_Q0.6111.00
201_S204_V0.6101.00
329_P336_T0.6090.99
353_N356_F0.6070.99
206_R209_E0.6070.99
187_A193_T0.6060.99
185_P195_I0.6060.99
241_A245_C0.6040.99
60_L106_I0.6040.99
309_G314_I0.6010.99
124_Q127_T0.6010.99
44_G253_L0.6000.99
200_T276_L0.5990.99
185_P190_I0.5970.99
59_L62_Q0.5970.99
339_S349_V0.5960.99
56_V102_G0.5960.99
263_I354_V0.5950.99
206_R211_G0.5950.99
217_L226_L0.5940.99
45_Y252_I0.5930.99
14_L226_L0.5930.99
38_L42_I0.5910.99
301_F306_M0.5890.99
104_V123_I0.5890.99
91_L95_M0.5880.99
195_I241_A0.5880.99
306_M311_I0.5870.99
231_L277_G0.5870.99
253_L256_P0.5870.99
122_P166_D0.5850.99
305_I309_G0.5840.99
140_G143_E0.5840.99
159_Q166_D0.5840.99
44_G48_N0.5830.99
22_I233_P0.5780.99
102_G107_P0.5780.99
208_W211_G0.5760.99
208_W213_M0.5760.99
23_V27_S0.5760.99
323_A329_P0.5750.99
57_G61_E0.5720.99
300_A305_I0.5710.99
179_S182_F0.5710.99
73_T152_Q0.5700.99
181_H184_I0.5670.99
265_F268_S0.5670.99
62_Q106_I0.5660.99
44_G47_I0.5640.99
107_P124_Q0.5630.99
32_A35_I0.5630.99
291_N294_Q0.5620.99
202_L207_E0.5620.99
254_G257_Y0.5570.99
163_P168_Q0.5550.99
36_P45_Y0.5550.99
185_P191_I0.5540.99
138_V142_V0.5520.99
204_V208_W0.5510.99
15_C233_P0.5480.99
161_F167_V0.5470.99
80_I83_T0.5460.99
113_Q122_P0.5430.99
358_I361_A0.5430.99
92_I95_M0.5430.99
147_Q154_A0.5420.99
40_L44_G0.5410.99
36_P44_G0.5410.99
56_V59_L0.5390.99
181_H187_A0.5390.99
351_V354_V0.5390.99
166_D170_R0.5380.99
85_S91_L0.5380.99
141_Y144_G0.5380.99
41_F46_G0.5370.99
77_S82_A0.5360.99
246_M261_L0.5350.99
212_T220_E0.5350.99
303_P306_M0.5330.99
314_I322_R0.5310.99
220_E223_R0.5300.99
134_T138_V0.5300.99
177_A180_Q0.5290.99
275_T279_G0.5270.99
130_S134_T0.5260.99
265_F269_S0.5260.99
203_V207_E0.5250.99
167_V172_W0.5250.99
361_A364_F0.5250.99
355_L358_I0.5250.99
306_M309_G0.5240.98
357_L361_A0.5240.98
182_F187_A0.5230.98
177_A181_H0.5210.98
336_T357_L0.5210.98
138_V146_W0.5200.98
206_R210_R0.5200.98
26_P30_L0.5200.98
266_F270_L0.5170.98
278_M364_F0.5150.98
330_A334_V0.5150.98
304_S308_S0.5140.98
304_S330_A0.5130.98
159_Q164_L0.5130.98
28_S32_A0.5130.98
95_M98_G0.5110.98
263_I267_I0.5110.98
215_A219_T0.5100.98
38_L41_F0.5090.98
155_E159_Q0.5060.98
197_A201_S0.5060.98
349_V353_N0.5050.98
40_L46_G0.5050.98
237_L241_A0.5050.98
348_V351_V0.5050.98
146_W149_W0.5040.98
327_I330_A0.5040.98
189_T194_V0.5030.98
161_F166_D0.5020.98
128_D134_T0.5010.98
253_L279_G0.5010.98
58_I64_S0.5000.98
303_P307_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.366 99.5 0.735 Contact Map
2p0sA 2 0.3263 97.6 0.858 Contact Map
3hdgA 2 0.3077 12.4 0.952 Contact Map
4tllA 1 0.4456 12.2 0.952 Contact Map
2wswA 3 0.4271 8.2 0.956 Contact Map
4ea3A 2 0.7427 7.2 0.957 Contact Map
3cg4A 1 0.305 6.4 0.958 Contact Map
3cnbA 1 0.2785 6 0.958 Contact Map
2kogA 1 0.122 5.9 0.959 Contact Map
4mldA 2 0.305 5.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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